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1. 发明授权

US08674081B2 Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma 失效
标题翻译：在癌细胞和肿瘤基质上表达的显性和亚显性表位引发多价免疫应答的方法和组合物
公开(公告)号：US08674081B2
公开(公告)日：2014-03-18
申请号：US13179042
申请日：2011-07-08
申请人： Zhiyong Qiu , Adrian Ion Bot
发明人： Zhiyong Qiu , Adrian Ion Bot
IPC分类号： C07H21/02
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/4748 , C07K14/705
摘要： The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译：本发明提供了一种通过向有需要的受试者提供包含编码包含CTL表位PSMA288-297和PRAME425-433或交叉反应性类似物的多肽的核酸构建体的免疫原性组合来治疗癌症的方法。在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效抗癌免疫应答的方法和组合物。

2. 发明申请

US20060205032A1 hSLIM modulates immune responses 审中-公开
标题翻译： hSLIM调节免疫反应
公开(公告)号：US20060205032A1
公开(公告)日：2006-09-14
申请号：US11183324
申请日：2005-07-18
申请人： Mary Faris , Sandra Lee , Zhiyong Qiu , David Brandt
发明人： Mary Faris , Sandra Lee , Zhiyong Qiu , David Brandt
IPC分类号： C12P21/06 , C07H21/04 , C07K14/705
CPC分类号： C07K14/4705
摘要： Human SLIM polypeptides for use in modulating STAT-dependent gene transcription.
摘要翻译：用于调节STAT依赖性基因转录的人SLIM多肽。

3. 外观设计

USD981468S1 Selfie stick tripod 有权
公开(公告)号：USD981468S1
公开(公告)日：2023-03-21
申请号：US29849136
申请日：2022-08-09
申请人： Zhiyong Qiu
设计人： Zhiyong Qiu

4. 发明申请

US20110230548A1 MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN 审中-公开
标题翻译：多媒体矢量及其设计方法
公开(公告)号：US20110230548A1
公开(公告)日：2011-09-22
申请号：US13032635
申请日：2011-02-22
申请人： Adrian Ion Bot , David C. Diamond , Zhiyong Qiu
发明人： Adrian Ion Bot , David C. Diamond , Zhiyong Qiu
IPC分类号： A61K48/00 , C12N15/85 , C12N5/10 , C12N15/86
CPC分类号： C12N15/111 , A61K39/00 , C12N15/1135 , C12N15/85 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2840/20
摘要： Embodiments of the present invention relate to multicistronic vectors and methods for their design. Methods and compositions of the invention include a vector including at least two cistrons, wherein a first cistron includes a first promoter and a first nucleic acid sequence encoding one or more therapeutic agents, and wherein a second cistron comprises a second promoter and a second nucleic acid sequence encoding one or more RNA molecules that interfere with the expression of a biological response modifier or the therapeutic agent, wherein the expression of the first sequence is under control of the first promoter and expression of the second sequence is under control of the second promoter.
摘要翻译：本发明的实施方案涉及多顺反子载体及其设计方法。本发明的方法和组合物包括包含至少两个顺反子的载体，其中第一顺反子包含第一启动子和编码一种或多种治疗剂的第一核酸序列，并且其中第二顺反子包含第二启动子和第二核酸编码干扰生物反应调节剂或治疗剂表达的一种或多种RNA分子的序列，其中第一序列的表达在第一启动子的控制下，第二序列的表达受第二启动子的控制。

5. 发明授权

US07999088B2 Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma 有权
标题翻译：在癌细胞和肿瘤基质上表达的显性和亚显性表位引发多价免疫应答的方法和组合物
公开(公告)号：US07999088B2
公开(公告)日：2011-08-16
申请号：US11454616
申请日：2006-06-16
申请人： Zhiyong Qiu , Adrian Ion Bot
发明人： Zhiyong Qiu , Adrian Ion Bot
IPC分类号： C07H21/02 , C12K15/11
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/4748 , C07K14/705
摘要： The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译：本发明提供了一种通过向有需要的受试者提供包含编码包含CTL表位PSMA288-297和PRAME425-433或交叉反应性类似物的多肽的核酸构建体的免疫原性组合来治疗癌症的方法。在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。

6. 外观设计

USD978228S1 Selfie stick tripod 有权
公开(公告)号：USD978228S1
公开(公告)日：2023-02-14
申请号：US29838337
申请日：2022-05-12
申请人： Zhiyong Qiu
设计人： Zhiyong Qiu

7. 发明授权

US08252916B2 Expression vectors encoding epitopes of target-associated antigens and methods for their design 有权
标题翻译：编码靶标相关抗原表位的表达载体及其设计方法
公开(公告)号：US08252916B2
公开(公告)日：2012-08-28
申请号：US10837217
申请日：2004-04-30
申请人： John J. L. Simard , David C. Diamond , Zhiyong Qiu , Xiang-Dong Lei
发明人： John J. L. Simard , David C. Diamond , Zhiyong Qiu , Xiang-Dong Lei
IPC分类号： C07H21/04 , C07K1/00
CPC分类号： G01N33/6848 , A61K39/00 , A61K39/0011 , A61K2039/53 , A61K2039/6075 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N15/85 , C12N2760/16122 , C12N2840/203 , G01N33/68 , G01N33/6845 , G01N2500/00
摘要： The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.
摘要翻译：本文公开的本发明涉及鉴定适用于表位释放的多肽的方法，包括例如鉴定感兴趣的表位的步骤; 提供包括所述表位的底物多肽序列，其中所述底物多肽允许蛋白酶体加工; 在支持蛋白酶体处理底物多肽的条件下使底物多肽与包含蛋白酶体的组合物接触; 并测定表位的释放。本发明还涉及包含持续用作表位表达盒的载体。本发明涉及表位簇区域和涉及包含表位簇区域的载体。本发明还涉及一种激活T细胞的方法，包括使底物多肽与APC接触并使APC与T细胞接触。

8. 发明申请

US20120148613A1 MULTIVALENT ENTRAIN-AND-AMPLIFY IMMUNOTHERAPEUTICS FOR CARCINOMA 审中-公开
标题翻译：多发性放射治疗和放大免疫球蛋白
公开(公告)号：US20120148613A1
公开(公告)日：2012-06-14
申请号：US13336523
申请日：2011-12-23
申请人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
发明人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
IPC分类号： A61K39/00 , A61P35/00
CPC分类号： A61K39/0011 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K39/00 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70539 , C12N15/8509
摘要： The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译：本发明提供了通过向有需要的受试者提供包含质粒和肽或其类似物的免疫原性组合来治疗细胞增殖性疾病如癌症的方法。在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。

9. 发明授权

US08045586B2 Method and apparatus for transmitting overhead information 有权
标题翻译：用于发送开销信息的方法和装置
公开(公告)号：US08045586B2
公开(公告)日：2011-10-25
申请号：US11958043
申请日：2007-12-17
申请人： Jianbin Huang , Tianxiang Wang , Zhiyong Qiu , Guixue Zhao , Feng Zhang , Jun Feng , Dejun Li , Yongjun Tu , Xiaobin Song
发明人： Jianbin Huang , Tianxiang Wang , Zhiyong Qiu , Guixue Zhao , Feng Zhang , Jun Feng , Dejun Li , Yongjun Tu , Xiaobin Song
IPC分类号： H04J3/24
CPC分类号： H04J3/1611 , H04J2203/0035 , H04W52/58
摘要： A method provided by the present invention for transmitting overhead information, includes dividing and reforming overhead information into at least two overhead parts, inserting the at least two overhead parts into overhead bytes of at least two corresponding data frames, and transmitting the at least two overhead parts via the at least two data frames which are microwave frames. Overhead information transmitting apparatus and overhead information receiving apparatus are also provided by the present invention. With the method and apparatus of the present invention, the channel bandwidth resources occupied by the overhead bytes or each microwave frame are greatly reduced. If the saved channel bandwidth is used for performing the error correction code on the transmitted information, the code gain is improved and the sensitivity requirement on the receiver is reduced so that the cost of a microwave transmitting system is reduced eventually.
摘要翻译：本发明提供的用于发送开销信息的方法包括：将开销信息划分和重构为至少两个开销部分，将至少两个开销部分插入到至少两个相应数据帧的开销字节中，以及发送至少两个开销经由至少两个数据帧的部件是微波帧。本发明还提供了开销信息发送装置和开销信息接收装置。利用本发明的方法和装置，由开销字节或每个微波帧占用的信道带宽资源大大降低。如果保存的信道带宽用于对发送的信息执行纠错码，则可以提高码增益，减少对接收机的灵敏度要求，从而最终降低微波发射系统的成本。

10. 发明授权

US07232682B2 Expression vectors encoding epitopes of target-associated antigens and methods for their design 有权
标题翻译：编码靶标相关抗原表位的表达载体及其设计方法
公开(公告)号：US07232682B2
公开(公告)日：2007-06-19
申请号：US10777053
申请日：2004-02-10
申请人： John J. L. Simard , David C. Diamond , Zhiyong Qiu , Xiang-Dong Lei
发明人： John J. L. Simard , David C. Diamond , Zhiyong Qiu , Xiang-Dong Lei
IPC分类号： C12N15/12 , A61K39/00 , A61K38/00 , A01N43/00 , C07K14/435
CPC分类号： G01N33/6848 , A61K39/00 , A61K39/0011 , A61K2039/53 , A61K2039/6075 , C07K14/47 , C07K14/4748 , C07K2319/00 , C12N15/85 , C12N2760/16122 , C12N2840/203 , G01N33/68 , G01N33/6845 , G01N2500/00
摘要： The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette and also vectors including epitope cluster regions. The housekeeping epitope(s) can be derived from a target-associated antigen. The housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.
摘要翻译：本文公开的本发明涉及鉴定适用于表位释放的多肽的方法，包括例如鉴定感兴趣的表位的步骤; 提供包括所述表位的底物多肽序列，其中所述底物多肽允许蛋白酶体加工; 在支持蛋白酶体处理底物多肽的条件下使底物多肽与包含蛋白酶体的组合物接触; 并测定表位的释放。本发明还涉及包含持续用作表位表达盒的载体以及包括表位簇区的载体。可以从目标相关抗原得到持续表位。可以通过免疫蛋白酶体处理从盒的翻译产物中释放能够释放的清洁剂表位。本发明还涉及一种激活T细胞的方法，包括使底物多肽与APC接触并使APC与T细胞接触。

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