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1. 发明公开

CN107072817A 用于短脉冲激光眼科手术的系统审中-实审
公开(公告)号：CN107072817A
公开(公告)日：2017-08-18
申请号：CN201580056331.X
申请日：2015-10-09
申请人：卡尔蔡司医疗技术股份公司
发明人：米夏埃尔·斯特凡·里尔 , 德尔伯特·彼得·安德鲁斯 , 托比亚斯·达姆 , 罗伯特·波姆伦克 , 延斯·林林 , 托马斯·沃尔韦伯 , 斯特凡·厄斯特赖希 , 米夏埃尔·贝格特 , 鲁珀特·梅纳帕切 , 埃克哈德·法比安 , 埃万盖洛斯·帕帕斯塔索普洛斯 , 马丁·屈纳 , 迪特马尔·施泰因梅茨 , 霍尔格·海因茨 , 萨沙·科克 , 斯特凡·拉夸 , 托马斯·诺比斯
IPC分类号： A61F9/008
CPC分类号： A61F9/00834 , A61B3/102 , A61B3/13 , A61B90/25 , A61F9/00825 , A61F2009/00855 , A61F2009/00861 , A61F2009/0087 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897
摘要：本发明涉及一种用于短脉冲激光眼科手术的系统(100)，具有：短脉冲激光系统(200)；手术显微镜(300)和控制单元(500)；壳体(110)以及第一铰接臂(120)，在该第一铰接臂上固定有手术显微镜(300)的显微镜头(320)；以及第二铰接臂(130)，在该第二铰接臂上固定有短脉冲激光系统(200)的应用器头(220)，显微镜头和应用器头能够彼此连接。本发明还涉及一种患者接口(600)和用于对系统的控制单元(500)进行编码的计算机程序产品；此外还涉及一种用于对应用器头(220)和显微镜头(320)进行定位的方法，一种用于利用用于眼科手术的短脉冲激光系统切开小口的方法和参照方法。其目的因此是描述一种用于短脉冲激光眼科手术的系统和方法，利用该系统和方法能够改善手术结果和典型的工作流程，提高手术执行的效率和手术的安全性。这通过用于短脉冲激光眼科手术的系统(100)和短脉冲激光系统(200)实现，在该短脉冲激光系统中，射束引导件(230)穿过相应的铰接臂(130)延伸，以及该射束引导件通过不仅能够彼此不依赖地而且也能够彼此连接的系统的应用器头(220)和显微镜头(320)地在三维空间中移动，此外通过简单操作的、带有一体的触目镜(610)的患者接口(600)、用于执行切小口的方法的计算机程序产品以及利用具有标记的患者接口(600)的顺序工作的参考方法实现。

2. 发明公开

CN107019592A 一种内路实施的施莱姆氏管手术治疗系统无效
公开(公告)号：CN107019592A
公开(公告)日：2017-08-08
申请号：CN201710330779.7
申请日：2017-05-11
申请人：天津优视眼科技术有限公司
发明人：王宁利 , 王怀洲 , 田洁 , 赵士勇
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/0008 , A61F2009/00861 , A61F2009/00891
摘要：本发明设计一种内路实施的施莱姆氏管手术治疗系统，包括介入针，支架，推管，眼科导管，内路推送器，导管推送轮，推管推送轮，三通，灌注管，激光设备。所述眼科导管上设有三通，三通连接灌注管。眼科导管末端连接激光设备，导管内部设有光纤，导管前端使用段插入内路推送器，内路推送器上设有导管推送轮和推管推送轮。内路推送器前端连接介入针，位于介入针内部的眼科导管前端上带有支架，支架后端的眼科导管上带有推管。本发明的治疗系统能够有效的降低眼压，并且提高手术稳定性，避免不必要的创伤，降低操作难度。

3. 发明申请

US20160296372A1 Laser Methods for Creating an Antioxidant Sink in the Crystalline Lens for the Maintenance of Eye Health & Physiology and Slowing Presbyopia Development 审中-公开
标题翻译：用于在晶状体中形成抗氧化剂水槽的激光方法，用于维持眼睛健康和生理学以及减轻老花眼发育
公开(公告)号：US20160296372A1
公开(公告)日：2016-10-13
申请号：US15183444
申请日：2016-06-15
申请人： Raymond I. Myers
发明人： Raymond I. Myers
IPC分类号： A61F9/008
CPC分类号： A61F9/00802 , A61F9/008 , A61F2009/00861 , A61F2009/0087 , A61F2009/00887 , A61F2009/00891 , A61F2009/00895
摘要： Systems and methods of laser treatment of the intact crystalline lens to increase ionic transport of antioxidants in specific areas where flexural changes and transparency reduction come from lens aging. Microchannels created in patterns and grids placed strategically in the inner lens carry antioxidants from the source—the anterior and the epithelium—into areas scarce or void of transport mechanisms (and thus scarce of antioxidants). A variety of patterns are utilized to facilitate ions traveling along new pathways.
摘要翻译：激光处理完整晶状体的系统和方法，以增加抗弯剂在透镜老化过程中弯曲变化和透明度降低的特定区域的离子运输。在内镜中战略性地形成的图案和网格中的微通道将源自前体和上皮的抗氧化剂进入缺少运输机制（因此缺乏抗氧化剂）的区域。利用各种图案来促进离子沿新路径行进。

4. 发明申请

US20140121652A1 Laser Methods for Creating an Antioxidant Sink in the Crystalline Lens for the Maintenance of Eye Health & Physiology and Slowing Presbyopia Development 审中-公开
标题翻译：用于在晶状体中形成抗氧化剂水槽的激光方法，用于维持眼睛健康和生理学以及减轻老花眼发育
公开(公告)号：US20140121652A1
公开(公告)日：2014-05-01
申请号：US13790968
申请日：2013-03-08
申请人： Raymond I Myers
发明人： Raymond I Myers
IPC分类号： A61F9/008
CPC分类号： A61F9/00802 , A61F9/008 , A61F2009/00861 , A61F2009/0087 , A61F2009/00887 , A61F2009/00891 , A61F2009/00895
摘要： Systems and methods of laser treatment of the intact crystalline lens to increase ionic transport of antioxidants in specific areas where flexural changes and transparency reduction come from lens aging. Microchannels created in patterns and grids placed strategically in the inner lens carry antioxidants from the source—the anterior and the epithelium—into areas scarce or void of transport mechanisms (and thus scarce of antioxidants). A variety of patterns are utilized to facilitate ions traveling along new pathways.
摘要翻译：激光处理完整晶状体的系统和方法，以增加抗弯剂在透镜老化过程中弯曲变化和透明度降低的特定区域的离子运输。在内镜中战略性地形成的图案和网格中的微通道将源自前体和上皮的抗氧化剂进入缺少运输机制（因此缺乏抗氧化剂）的区域。利用各种图案来促进离子沿新路径行进。

5. 发明公开

EP3067005A1 LASER SURGERY APPARATUS FOR CONTACT LASER SURGERY 有权
标题翻译： LASERCHIRURGIEVORRICHTUNGFÜRKONTAKTLASERCHIRURGIE
公开(公告)号：EP3067005A1
公开(公告)日：2016-09-14
申请号：EP15000757.3
申请日：2015-03-13
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Miller, R.J. Dwayne , Uschold, Stephanie , Kruber, Sebastian , Hansen, Nils-Owe
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , A61B17/3211 , A61C3/02 , A61B17/16 , A61C1/00
CPC分类号： A61F9/00821 , A61B17/3211 , A61B18/203 , A61B18/22 , A61B2018/00107 , A61B2018/202 , A61B2018/2233 , A61B2018/2272 , A61B2018/2288 , A61F9/00802 , A61F9/00836 , A61F9/009 , A61F2009/00861 , A61N5/0625 , A61N2005/063 , A61N2005/0644 , A61N2005/067
摘要： The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmitting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface. The contact laser surgery apparatus further comprises a pulsed laser source (2) adapted to provide pulse durations in the femtosecond, picosecond and/or nanosecond range, and light transmitting means (9) connecting said laser source (2) to said optical fiber (4) of said scalpel (3) for conveying laser radiation from said laser source (2) to said optical fiber (4) such that the conveyed laser light is emitted at said uncoated contact surface of the fiber tip.
摘要翻译：本发明涉及一种用于接触式激光手术的激光手术装置以及使用该激光手术装置的方法。激光手术装置（1）包括用于接触激光手术的接触式激光手术刀（3），所述接触激光手术刀（4）包括IR激光辐射透射材料的光纤（4），并终止于光纤尖端（5）具有露出的芯区域，以及用于保持所述纤维并用于定位所述手术刀（3）的支撑装置。所述纤维尖端（5）是锥形的并且设置在解剖刀（3）的远端，用于接触待切割的组织，并且包括用于传递激光辐射的未涂覆的接触表面（6）和至少部分反射的引导表面提供使得由所述光纤（4）引导到所述光纤尖端（5）的激光辐射将至少部分地被所述引导表面反射并通过所述未涂覆的接触表面发射。接触式激光手术装置还包括适于在飞秒，皮秒和/或纳秒范围内提供脉冲持续时间的脉冲激光源（2）和将所述激光源（2）连接到所述光纤（4）的光发射装置），用于将来自所述激光源（2）的激光辐射传送到所述光纤（4），使得所传送的激光在所述光纤尖端的所述未涂覆的接触表面处发射。

6. 发明授权

EP2991729B8 SYSTEMS FOR THE TREATMENT OF EYE CONDITIONS 有权
公开(公告)号：EP2991729B8
公开(公告)日：2018-09-05
申请号：EP14730263.2
申请日：2014-04-29
申请人： Tear Film Innovations, Inc.
发明人： KELLEHER, Brian, S. , GAMBHIR, Kabir
IPC分类号： A61F9/007 , A61N5/06 , A61F7/00 , A61N7/02 , A61F9/009 , A61N7/00 , A61B17/00 , A61H5/00 , A61F9/008 , A61H23/02
CPC分类号： A61F9/009 , A61B2017/00084 , A61F7/00 , A61F9/00718 , A61F9/0079 , A61F9/008 , A61F9/00802 , A61F2007/0002 , A61F2007/0088 , A61F2009/00861 , A61H5/00 , A61H23/02 , A61H23/0245 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/025 , A61H2201/0257 , A61H2201/0285 , A61H2201/10 , A61H2201/501 , A61H2201/5028 , A61H2201/5043 , A61H2201/5061 , A61H2201/5082 , A61H2201/5092 , A61H2201/5097 , A61H2230/505 , A61N5/0624 , A61N5/0625 , A61N7/00 , A61N7/02 , A61N2005/0626 , A61N2005/0643 , A61N2005/0663
摘要： Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

7. 发明申请

WO2016146237A1 LASER SURGERY APPARATUS FOR CONTACT LASER SURGERY 审中-公开
标题翻译：激光手术器械联系激光手术
公开(公告)号：WO2016146237A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/000291
申请日：2016-02-19
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.
发明人： MILLER, R.J. Dwayne , USCHOLD, Stephanie , KRUBER, Sebastian , HANSEN, Nils-Owe
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , A61B17/3211 , A61C3/02 , A61B17/16 , A61C1/00
CPC分类号： A61F9/00821 , A61B17/3211 , A61B18/203 , A61B18/22 , A61B2018/00107 , A61B2018/202 , A61B2018/2233 , A61B2018/2272 , A61B2018/2288 , A61F9/00802 , A61F9/00836 , A61F9/009 , A61F2009/00861 , A61N5/0625 , A61N2005/063 , A61N2005/0644 , A61N2005/067
摘要： The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmitting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface. The contact laser surgery apparatus further comprises a pulsed laser source (2) adapted to provide pulse durations in the femtosecond, picosecond and/or nanosecond range, and light transmitting means (9) connecting said laser source (2) to said optical fiber (4) of said scalpel (3) for conveying laser radiation from said laser source (2) to said optical fiber (4) such that the conveyed laser light is emitted at said uncoated contact surface of the fiber tip.
摘要翻译：本发明涉及一种用于接触式激光手术的激光手术装置以及使用该激光手术装置的方法。激光手术装置（1）包括用于接触激光手术的接触式激光手术刀（3），所述接触激光手术刀（4）包括IR激光辐射透射材料的光纤（4），并终止于光纤尖端（5）具有露出的芯区域，以及用于保持所述纤维并用于定位所述手术刀（3）的支撑装置。所述纤维尖端（5）是锥形的并且设置在解剖刀（3）的远端，用于接触待切割的组织，并且包括用于传递激光辐射的未涂覆的接触表面（6）和至少部分反射的引导表面提供使得由所述光纤（4）引导到所述光纤尖端（5）的激光辐射将至少部分地被所述引导表面反射并通过所述未涂覆的接触表面发射。接触式激光手术装置还包括适于在飞秒，皮秒和/或纳秒范围内提供脉冲持续时间的脉冲激光源（2）和将所述激光源（2）连接到所述光纤（4）的光发射装置），用于将来自所述激光源（2）的激光辐射传送到所述光纤（4），使得所传送的激光在所述光纤尖端的所述未涂覆的接触表面处发射。

8. 发明授权

EP2991729B1 SYSTEMS FOR THE TREATMENT OF EYE CONDITIONS 有权
公开(公告)号：EP2991729B1
公开(公告)日：2018-08-01
申请号：EP14730263.2
申请日：2014-04-29
申请人： Tear Film Innovations, Inc.
发明人： KELLEHER, Brian, S. , GAMBHIR, Kabir
IPC分类号： A61F9/007 , A61N5/06 , A61F7/00 , A61N7/02 , A61F9/009 , A61N7/00 , A61B17/00 , A61H5/00 , A61F9/008 , A61H23/02
CPC分类号： A61F9/009 , A61B2017/00084 , A61F7/00 , A61F9/00718 , A61F9/0079 , A61F9/008 , A61F9/00802 , A61F2007/0002 , A61F2007/0088 , A61F2009/00861 , A61H5/00 , A61H23/02 , A61H23/0245 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/025 , A61H2201/0257 , A61H2201/0285 , A61H2201/10 , A61H2201/501 , A61H2201/5028 , A61H2201/5043 , A61H2201/5061 , A61H2201/5082 , A61H2201/5092 , A61H2201/5097 , A61H2230/505 , A61N5/0624 , A61N5/0625 , A61N7/00 , A61N7/02 , A61N2005/0626 , A61N2005/0643 , A61N2005/0663
摘要： Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

9. 发明公开

EP3206643A2 SYSTEME FÜR DIE KURZPULS-LASER-AUGENCHIRURGIE 审中-公开
标题翻译： SYSTEMEFÜRDIE KURZPULS-LASER-AUGENCHIRURGIE
公开(公告)号：EP3206643A2
公开(公告)日：2017-08-23
申请号：EP15781898.0
申请日：2015-10-09
申请人： Carl Zeiss Meditec AG
发明人： RILL, Michael, Stefan , ANDREWS, Peter , DAMM, Tobias , POMRAENKE, Robert , RINGLING, Jens , WOLLWEBER, Thomas , OESTREICH, Stephan , BERGT, Michael , MENAPACE, Rupert , FABIAN, Ekkehard , PAPASTATHOPOULOS, Evangelos , KÜHNER, Martin , STEINMETZ, Dietmar , HEINZ, Holger , KOCH, Sascha , LAQUA, Stephan , NOBIS, Thomas
IPC分类号： A61F9/008
CPC分类号： A61F9/00834 , A61B3/102 , A61B3/13 , A61B90/25 , A61F9/00825 , A61F2009/00855 , A61F2009/00861 , A61F2009/0087 , A61F2009/00872 , A61F2009/00882 , A61F2009/00897
摘要： The invention relates to a system for short pulse laser eye surgery (100) comprising a short pulse laser system (200), an operational microscope (300) and a control unit (500), a housing (110) and a first articulated arm (120) on which a microscope head (320) of the operational microscope (300) is fixed and a second articulated arm (130) on which the applicator head (220) of the short-pulse laser system (200) is fixed, said two heads can be connected to each other. The invention also relates to a patient interface (600) and to a computer program product for coding a control unit (500) of the system. The invention further relates to a method for positioning an applicator head (220) and a microscope head (320), to methods for carrying out incisions using a short pulse laser system for eye surgery and referencing methods. The aim of the invention is to provide systems and methods for short pulse laser eye surgery in which the quality of operating result and also the typical operating sequence are improved, as well as improving the efficiency of the operating procedure and the safety of the operation. Said aim is achieved by means of a system for short-pulse laser eye surgery (100) and a short pulse laser system (200) comprising beam guiding means (230) which pass through the corresponding articulated arm (130), and due to the applicator head (220) and a microscope head (320) of the system which can be moved in a three-dimensional volume independently from each other as well as connected together, also due to an easy to handle patient interface (600) having a one-part contact glass (610), a computer programme product for the methods for carrying out the incision and to sequentially working referencing methods with patient interfaces (600) which contain the markings.
摘要翻译：（200），操作显微镜（300）和控制单元（500），外壳（110）和第一关节臂（100）的短脉冲激光眼科手术系统（100）（300）的显微镜头（320）固定在其上的第二铰接臂（130）和其上固定有短脉冲激光系统（200）的施加头（220）的第二铰接臂（130）磁头可以相互连接。本发明还涉及用于编码系统的控制单元（500）的患者接口（600）和计算机程序产品。本发明还涉及一种用于定位施加器头（220）和显微镜头（320）的方法，涉及用于使用用于眼睛手术和参考方法的短脉冲激光系统执行切割的方法。本发明的目的是提供短脉冲激光眼科手术的系统和方法，其中操作结果的质量和典型的操作顺序得到改善，并且提高了操作过程的效率和操作的安全性。所述目标通过用于短脉冲激光眼科手术（100）的系统和包括穿过相应的关节臂（130）的束引导装置（230）的短脉冲激光系统（200）来实现，并且由于也由于易于操作的患者界面（600）而具有一个可相对彼此独立并且连接在一起的三维体积中移动的施用头（220）和显微镜头（320） - 部分接触玻璃（610），一种用于执行切口的方法的计算机程序产品，以及用包含标记的患者接口（600）顺序地处理参考方法。

10. 发明授权

EP3067005B1 LASER SURGERY APPARATUS FOR CONTACT LASER SURGERY 有权
标题翻译：激光手术器械
公开(公告)号：EP3067005B1
公开(公告)日：2017-11-08
申请号：EP15000757.3
申请日：2015-03-13
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Miller, R.J. Dwayne , Maier, Stephanie , Kruber, Sebastian , Hansen, Nils-Owe
IPC分类号： A61B18/20 , A61B18/22 , A61N5/06 , A61B17/3211 , A61C3/02 , A61B17/16 , A61C1/00
CPC分类号： A61F9/00821 , A61B17/3211 , A61B18/203 , A61B18/22 , A61B2018/00107 , A61B2018/202 , A61B2018/2233 , A61B2018/2272 , A61B2018/2288 , A61F9/00802 , A61F9/00836 , A61F9/009 , A61F2009/00861 , A61N5/0625 , A61N2005/063 , A61N2005/0644 , A61N2005/067
摘要： The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmitting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface. The contact laser surgery apparatus further comprises a pulsed laser source (2) adapted to provide pulse durations in the femtosecond, picosecond and/or nanosecond range, and light transmitting means (9) connecting said laser source (2) to said optical fiber (4) of said scalpel (3) for conveying laser radiation from said laser source (2) to said optical fiber (4) such that the conveyed laser light is emitted at said uncoated contact surface of the fiber tip.

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