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1. 发明申请

US20190192597A1 METHOD FOR PREPARING AN EXTRACT OF CHRYSANTHEMUM MORIFOLIUM WITH AN EFFECT OF TREATING SKIN DISEASES, EXTRACT OF CHRYSANTHEMUM MORIFOLIUM WITH AN EFFECT OF TREATING SKIN DISEASES AND PHARMACEUTICAL COMPOSITION CONTAINING THE EXTRACT 审中-公开
公开(公告)号：US20190192597A1
公开(公告)日：2019-06-27
申请号：US15852748
申请日：2017-12-22
申请人： Industrial Technology Research Institute
发明人： I-Horng PAN , Hsin-Jan YAO , Chu-Hsun LU , Shu-Fang WEN , Po-Yao HSU , Ming-Han LI , Kai-An CHUANG , Chih-Hsuan CHANG
IPC分类号： A61K36/287 , A61K9/00 , A61P17/06 , A61P17/04
CPC分类号： A61K36/287 , A61K9/0014 , A61K2236/19 , A61K2236/51 , A61K2236/53 , A61P17/04 , A61P17/06
摘要： The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

2. 发明申请

US20180263272A1 PROCESS FOR CONVERTING BERRY AND FRUIT MATERIALS TO ANTIMICROBIALLY ACTIVE FRACTIONS 审中-公开
公开(公告)号：US20180263272A1
公开(公告)日：2018-09-20
申请号：US15537349
申请日：2015-12-17
申请人： TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
发明人： Riitta PUUPPONEN-PIMIÄ , Liisa NOHYNEK , Tuija KÖSSÖ , Mirja MOKKILA
IPC分类号： A23N7/01 , A23N7/08 , A23L5/30 , A61K36/738 , A61K36/87 , A61K8/9789
CPC分类号： A23N7/01 , A23L5/30 , A23N7/08 , A23Y2220/00 , A23Y2280/00 , A61K8/9789 , A61K36/73 , A61K36/738 , A61K36/87 , A61K2236/00 , A61K2236/13 , A61K2236/15 , A61K2236/19 , A61K2236/37 , A61K2800/10 , A61K2800/74 , A61Q17/005 , A61Q19/00 , C12P17/06 , C12P19/02 , C12P19/14 , A61K2300/00
摘要： The invention relates to process for converting berry and/or fruit materials to fractions comprising bioactive compounds, said process comprising the steps, where at least one berry material or fruit material selected from berries, fruits, by-products, side streams and waste materials originating from berries or fruits, and any combinations thereof is sieved whereby a seed fraction is separated from a skin fraction, the seed fraction is subjected to sanding and a seed coat fraction comprising surface layer of the seeds and a sanded seed fraction comprising the sanded seeds are obtained.

3. 发明申请

US20180104297A1 HYDROLYSATE OF WATER EXTRACT OF SYZYGIUM SAMARANGENSE, AND PREPARATION PROCESS AND USE THEREOF 审中-公开
公开(公告)号：US20180104297A1
公开(公告)日：2018-04-19
申请号：US15409103
申请日：2017-01-18
申请人： MHBT CO., LTD.
发明人： Chun-Hui CHIANG
IPC分类号： A61K36/61 , A61K8/97 , A61Q19/02 , A61Q19/00 , A61Q19/08 , A61K9/00 , C12N9/50
CPC分类号： A61K36/61 , A61K8/66 , A61K8/9789 , A61K2236/19 , A61K2236/331 , A61K2236/53 , A61K2800/74 , A61L26/0057 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C12N9/63 , C12Y304/22033
摘要： Disclosed herein are a hydrolysate of water extract of Syzygium samarangense and a preparation process thereof. Also disclosed herein is a composition which comprises the hydrolysate of water extract of Syzygium samarangense. The composition is suitable for whitening skin, enhancing the moisture-retaining capacity of skin, improving wound healing, and reducing oxidative stress.

4. 发明授权

US09771342B2 Monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones 有权
公开(公告)号：US09771342B2
公开(公告)日：2017-09-26
申请号：US14328216
申请日：2014-07-10
申请人： Food Industry Research and Development Institute
发明人： Ming-Jen Cheng , Ping-Hsun Yang , Ming-Der Wu , Shie-Jea Lin , Gwo-Fang Yuan , Yen-Lin Chen , Hsuen-Chun Liao , Kai-Ping Chen
IPC分类号： A01N63/04 , C07D307/86 , A61K31/365 , A61K31/426 , A61K31/455 , A61K45/06 , C12P17/04 , C12R1/645 , A61K36/899 , B01D15/18 , B01D15/42
CPC分类号： C07D307/86 , A61K31/365 , A61K31/426 , A61K31/455 , A61K36/899 , A61K45/06 , A61K2236/19 , B01D15/18 , B01D15/424 , C12P17/04 , C12R1/645 , A61K2300/00
摘要： The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses to of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

5. 发明申请

US20170071996A1 MEMORY IMPROVING COMPOSITION, PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译：记忆改善组合物，制备方法及其用途
公开(公告)号：US20170071996A1
公开(公告)日：2017-03-16
申请号：US15252528
申请日：2016-08-31
申请人： INFINITUS (CHINA) COMPANY LTD.
发明人： Yong ZHOU , Xiaolei GUO , Chung Wah MA
IPC分类号： A61K36/52 , A61K31/685 , A23L33/105 , A61K36/185 , A61K36/076 , A61K36/77 , A61K38/01 , A61K31/185
CPC分类号： A61K36/52 , A23L33/105 , A23V2002/00 , A61K31/185 , A61K31/685 , A61K36/076 , A61K36/185 , A61K36/62 , A61K36/77 , A61K38/011 , A61K2236/15 , A61K2236/19 , A61K2236/331 , A61K2236/53 , A61K2300/00
摘要： The present invention relates to the technical field of health food, and discloses a memory improving composition and the preparation method and use thereof. The composition is made from Arillus Longan, Poria, Semen Nelumbinis, enzymatic extract of Semen Juglandis, phosphatidylserine and taurine. In the present invention, the sovereign drug Arillus Longan is combined with ministerial drugs Poria and Semen Nelumbinis to synergistically achieve the effect of nourishing heart for tranquillization and tonifying kidney & invigorating spleen. They are further combined with enzymatic extract of Semen Juglandis improving brain metabolism and enhances memory, functional factor phosphatidylserine increasing fluidity and enhances plasticity of cell membrane, and taurine improving memory, to achieve the purpose of memory improvement together. All kinds of raw materials are medicine homologous and new resource food, which are safe, have no toxic and side effects, and thus can be consumed as health food over a long period of time.
摘要翻译：本发明涉及保健食品的技术领域，并且公开了一种记忆改善组合物及其制备方法和用途。该组合物由龙眼龙眼，茯苓，精液奈瑟菌，精液提取物，磷脂酰丝氨酸和牛磺酸制成。在本发明中，龙眼主药药物茯苓和精液Nelumbinis与茯苓和精液Nelumbinis结合起来，协同实现滋养心脏镇静和补肾益肾的作用。进一步与Semen Juglandis的酶促提取物结合，改善脑代谢，增强记忆力，功能因子磷脂酰丝氨酸增加流动性，增强细胞膜的可塑性，提高记忆力，达到记忆改善的目的。各种原料均为药物同源和新资源食品，安全无毒副作用，可长期作为保健食品食用。

6. 发明授权

US09497980B2 Reduction of non-starch polysaccharides and alpha-galactosides in soy flour by means of solid-state fermentation using cellulolytic bacteria isolated from different environments 有权
标题翻译：通过使用从不同环境分离的纤维素分解菌的固态发酵，还原大豆粉中的非淀粉多糖和α-半乳糖苷
公开(公告)号：US09497980B2
公开(公告)日：2016-11-22
申请号：US14376214
申请日：2013-01-29
申请人： Universidad de Chile
发明人： Jaime Moisés Romero Ormazabal , Rafael José Daniel Opazo Salas
IPC分类号： A23L1/20 , A23K1/00 , C12N1/20 , A61K36/48 , C12R1/465 , C12R1/01 , A61K35/74
CPC分类号： A23K10/12 , A23K50/30 , A23K50/40 , A23K50/80 , A23L11/00 , A23L11/07 , A23L11/09 , A61K35/74 , A61K36/48 , A61K2236/19 , C12N1/20 , C12R1/01 , C12R1/465 , Y02A40/818
摘要： The invention relates to a method for fermenting soy flour in the solid state in order to reduce non-starch polysaccharides and alpha-galactosides, said method comprising the following steps: a) preparation of the fermentation substrate; b) inoculation of the substrate with selected celluloytic bacterial strains; c) incubation; and, optionally, d) drying of the product, which generates a product with: an increase in protein of between 12 and 15% compared to non-fermented soy flour, degradation of the alpha-galactosides of more than 90% compared to non-fermented soy flour, a reduction in non-starch polysaccharides (NSPs) of between 15 and 25%, an amino acid profile similar to that of non-fermented soy flour, and immune-stimulating effects.
摘要翻译：本发明涉及一种固态发酵大豆粉以减少非淀粉多糖和α-半乳糖苷的方法，所述方法包括以下步骤：a）制备发酵底物; b）用选择的纤维素细菌菌株接种底物; c）孵化; 并且任选地，d）干燥产物，其产生产物：与非发酵大豆粉相比，蛋白质的增加为12至15％，与非发酵大豆粉相比，α-半乳糖苷的降解超过90％发酵的大豆粉，非淀粉多糖（NSP）的减少在15至25％之间，类似于非发酵大豆粉的氨基酸分布和免疫刺激作用。

7. 发明申请

US20160279090A1 NUTRITIONAL SUPPLEMENT AND PROCESS OF PREPARATION 审中-公开
标题翻译：营养补充和准备过程
公开(公告)号：US20160279090A1
公开(公告)日：2016-09-29
申请号：US15081713
申请日：2016-03-25
申请人： Anne-Marie Kosi-Kupe
发明人： Anne-Marie Kosi-Kupe
IPC分类号： A61K31/26 , A61K36/31 , A61K35/747
CPC分类号： A61K31/26 , A23L19/00 , A23L33/105 , A23L33/135 , A23V2002/00 , A23Y2220/03 , A23Y2220/13 , A23Y2220/15 , A23Y2220/63 , A23Y2220/67 , A23Y2220/73 , A23Y2220/79 , A23Y2240/75 , A23Y2300/25 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A61K35/745 , A61K35/747 , A61K36/31 , A61K2236/19 , A61K2300/00
摘要： Processes for producing a nutritional supplement that contains sulforaphane, and supplements formed thereby. Such a process includes combining a cruciferous vegetable, for example, broccoli sprouts, with at least one strain of Lactobacillus to form a mixture, causing the mixture to undergo lactic fermentation, transform a glucosinolate within the cruciferous vegetable to sulforaphane, and yield a fermented mixture that contains sulforaphane, and then producing from the fermented mixture a supplement that can be ingested by an individual.
摘要翻译：用于生产含有萝卜硫素的营养补充剂的方法以及由此形成的补充剂。这种方法包括将十字花科植物例如西兰花芽苗与至少一种乳杆菌菌株组合以形成混合物，使混合物进行乳酸发酵，将十字花科蔬菜中的硫代葡萄糖苷转化为萝卜硫素，并产生发酵混合物其含有萝卜硫素，然后从发酵混合物中产生可由个体摄取的补充物。

8. 发明申请

US20160243176A1 EXTRACTS FROM PLANTS OF THE MORINGACEAE FAMILY AND METHODS OF MAKING 审中-公开
标题翻译：来自植物的植物提取物及其制备方法
公开(公告)号：US20160243176A1
公开(公告)日：2016-08-25
申请号：US15026054
申请日：2014-10-30
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： Ilya Raskin , Carrie Waterman
IPC分类号： A61K36/185 , A23K20/10 , A61K31/7034
CPC分类号： A61K36/185 , A23K20/10 , A23L33/105 , A23L33/125 , A23L33/30 , A23V2002/00 , A61K8/97 , A61K31/7034 , A61K2236/00 , A61K2236/15 , A61K2236/17 , A61K2236/19 , A61K2236/33 , A61K2236/331 , A61K2236/53 , A61K2800/10 , A61Q19/00
摘要： The present application is directed to materials and methods for producing extracts from a plant of the Moringaceae family having high concentrations of moringa isothiocyanates. The present disclosure is based in part on the discovery that the enzyme necessary to convert moringa glucosinolates (MGLs) into moringa isothiocyanates (MICs) (i.e., myrosinase) can be activated by simply injuring fresh leaves or sprouts of a plant of the Moringaceae family, without first subjecting the plant material to harsh conditions, such as harsh temperatures and drying conditions.
摘要翻译：本申请涉及用于生产具有高浓度异硫氰酸酯的芒of科植物的提取物的材料和方法。本公开部分地基于以下发现：将葡萄糖异硫氰酸酯（MGL）转化成异硫氰酸酯（MICs）（即黑芥子酶）是必需的酶，可以通过简单地损伤萱草科植物的新鲜叶子或芽苗来活化，没有首先使植物材料受到苛刻的条件，例如恶劣的温度和干燥条件。

9. 发明申请

US20160184376A1 Method for Promoting ATP Production and Mitochondrial Activity, and Immunostimulating in Type 2 Diabetic Patients 审中-公开
标题翻译：促进ATP生产和线粒体活性的方法，以及2型糖尿病患者的免疫刺激
公开(公告)号：US20160184376A1
公开(公告)日：2016-06-30
申请号：US15062899
申请日：2016-03-07
申请人： OSATO INTERNATIONAL INC.
发明人： Yukiyasu Hayashi , Chandan K. Sen
IPC分类号： A61K36/185
CPC分类号： A61K36/185 , A61K2236/19
摘要： An object of the present invention is to confirm the safety of a fermented papaya preparation in type 2 diabetic patients while determining its effect on ATP production and mitochondria to find further health advantages for type 2 diabetic patients. The present invention provides an ATP production promoter for promoting ATP production in type 2 diabetic patients and a mitochondrial activity promoter for promoting mitochondrial activity in the patients, each comprising a fermented papaya product as an active ingredient. The present invention also provides an immunostimulant for type 2 diabetic patients, based on promoting ATP production and/or mitochondrial activity in type 2 diabetic patients, comprising a fermented papaya preparation as an active ingredient.
摘要翻译：本发明的目的是确定2型糖尿病患者的发酵番木瓜制剂的安全性，同时确定其对ATP生产和线粒体的作用，以找到2型糖尿病患者的进一步健康优势。本发明提供了用于促进2型糖尿病患者中ATP产生的ATP产生促进剂和用于促进患者线粒体活性的线粒体活性启动子，每一种包含发酵木瓜产品作为活性成分。基于促进2型糖尿病患者的ATP产生和/或线粒体活性，本发明还提供了一种用于2型糖尿病患者的免疫刺激剂，其包含发酵番木瓜制剂作为活性成分。

10. 发明授权

US09351511B2 Method for modifying polyphenol containing plant materials and medical uses of modified polyphenol plant containing materials 有权
标题翻译：用于修饰多酚含植物材料的修饰方法和含有修饰多酚植物材料的医疗用途
公开(公告)号：US09351511B2
公开(公告)日：2016-05-31
申请号：US12663688
申请日：2008-06-05
申请人： Anna Berggren , Jan Alenfall , Mikael Nilsson , Inger Bjorck , Yvonne Granfeldt
发明人： Anna Berggren , Jan Alenfall , Mikael Nilsson , Inger Bjorck , Yvonne Granfeldt
IPC分类号： A61K36/45 , A23L1/105 , A23L1/30 , A61K35/747 , A61K36/00
CPC分类号： A23L33/105 , A23L33/135 , A23V2002/00 , A61K35/747 , A61K36/00 , A61K2236/19 , A61K2300/00 , A23V2250/2132 , A23V2200/328 , A23V2250/5036 , A23V2250/628 , A23V2250/708 , A23V2250/5118
摘要： The present invention relates to a method for modifying polyphenol containing plant material(s), wherein said method comprises: mixing at least one polyphenol containing material and at least one solvent to provide a mixture; heating the mixture to eliminate bacterial species present to provide a heated mixture; adding at least one polyphenol modifying strain of lactic acid bacteria and optionally at least one protein source, in optional order or simultaneously, to the heated mixture to provide a fermentation mixture; and subjecting the fermentation mixture to conditions suitable for fermentation of the fermentation mixture to provide a mixture of modified polyphenol containing plant material(s); and optionally eliminating the polyphenol modifying strain of lactic acid bacteria to provide a mixture of modified polyphenol containing plant material(s) free from living lactic acid bacteria.
摘要翻译：本发明涉及一种用于修饰含有多酚的植物材料的方法，其中所述方法包括：将至少一种含有多酚的材料和至少一种溶剂混合以提供混合物; 加热混合物以消除存在的细菌物质以提供加热的混合物; 将至少一种乳酸菌多酚修饰菌株和任选的至少一种蛋白质源以任选的顺序或同时加入到加热的混合物中以提供发酵混合物; 并使发酵混合物经受适合于发酵混合物发酵的条件，以提供含有修饰多酚的植物材料的混合物; 并且任选地除去乳酸菌的多酚修饰菌株以提供不含活的乳酸菌的含有修饰多酚的植物材料的混合物。

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