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1. 发明授权

EP2512444B1 MIXTURES OF PLANTS IN SPAGYRIC MOTHER TINCTURE FOR DRY COUGH IN BABIES 有权
标题翻译：植物混合物。在一个spagyric酊反对宝宝干咳
公开(公告)号：EP2512444B1
公开(公告)日：2017-03-22
申请号：EP09828425.0
申请日：2009-12-17
申请人： Marzano Ancora, Monica
发明人： Marzano Ancora, Monica
IPC分类号： A61K9/02 , A61K41/00 , A61K35/64 , A61K36/17 , A61K36/185 , A61K36/24 , A61K36/35 , A61K36/42 , A61K36/53 , A61K36/71 , A61K36/736 , A61K36/81
CPC分类号： A61K36/42 , A61K9/02 , A61K36/17 , A61K36/185 , A61K36/24 , A61K36/35 , A61K36/53 , A61K36/71 , A61K36/736 , A61K36/81 , A61K41/0004 , A61K2300/00

2. 发明公开

EP2345405A1 Substance pour restaurer une co-expression et une interaction normales entre les protéines LOX et NRAGE 审中-公开
标题翻译： Substanz zur Wiederherstellung der normalen CoEexpression und Interaktion zwischen LOX-und NRAGE-Proteinen
公开(公告)号：EP2345405A1
公开(公告)日：2011-07-20
申请号：EP10186248.0
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique (C.N.R.S) , Universite Claude Bernard Lyon I
发明人： Bouez, Charbel , Gleyzal, Claudine , Orly, Isabelle , Andre, Valérie , Sommer, Pascal , Reymermier, Corinne , Damour, Odile , Perrier, Eric
IPC分类号： A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
摘要： L'invention concerne une substance pour restaurer une co-expression et une interaction normales entre les protéines LOX et NRAGE.
L'invention concerne en particulier l'utilisation d'une quantité efficace d'au moins une substance modulant l'expression et/ou l'activité de LOX ayant la séquence ID N°1 et/ou modulant l'expression et/ou l'activité de NRAGE ayant la séquence ID N°2 pour la fabrication d'une composition destinée à moduler l'interaction entre les protéines LOX et NRAGE pour réguler l'équilibre entre les phénomènes cellulaires de prolifération, de différenciation et d'apoptose, en particulier dans les cas où l'équilibre entre ces phénomènes est perturbé, notamment dans les cas où l'interaction entre LOX et NRAGE est absente ou altérée.
L'invention permet notamment de prévenir ou traiter le vieillissement de la peau, un lichen plan, une maladie de la réaction du greffon contre l'hôte (GVH), un eczéma, un psoriasis, et un cancer, en particulier un cancer épithélial, en particulier un cancer épithélial cutané, de type basocellulaire, ou de type spinocellulaire
摘要翻译：使用调节具有序列（SEQ ID No.1：未定义）和/或调节具有序列（SEQ ID No）的NRAGE的表达和/或活性的LOX的表达和/或活性的物质（I） 2：未定义），用于制备组合物以调节LOX和NRAGE蛋白质之间的相互作用并调节细胞增殖，分化和凋亡现象之间的平衡，特别是在LOX和NRAGE之间的相互作用不存在的情况下，或改变。包括以下独立权利要求：（1）调节LOX和NRAGE之间的相互作用的活性成分的鉴定，以便当相互作用不存在或改变时改善LOX和NRAGE之间的相互作用，并预防或治疗细胞平衡状态在增殖，分化和凋亡之间，不存在或改变，包括活性成分与能够表达具有包含（SEQ ID No.1：未定义）和/或蛋白质NRAGE的蛋白质的蛋白质LOX的活细胞接触，所述蛋白质具有包括（SEQ ID No.2：未定义）和LOX和/或NRAGE的表达分析的序列，以鉴定调节LOX和/或NRAGE的表达和/或活性的活性成分，以改善增殖，分化和细胞凋亡; （2）制备组合物，其包括使用鉴定方法鉴定活性成分，并将活性成分与赋形剂混合以形成化妆品，中性药物，皮肤制剂或药物组合物，以预防或治疗增殖，分化之间的细胞平衡状态细胞凋亡不存在或改变; 和（3）NRAGE的定位方法，包括使用抗NRAGE抗体来检测和定位NRAGE的存在，在包含角化细胞的重建皮肤模型中，或皮肤部分，优选来自其表皮呈现的人的皮肤部分增殖，分化和凋亡之间的细胞平衡不存在或改变的状态。活性：调味剂; 皮肤; 抗炎; 止痒; 免疫抑制; 银屑病; 抑制细胞生长。作用机制：LOX基因表达调节剂; NRAGE基因表达调节剂。测试（I）通过角质形成细胞表达LOX的信使RNA的能力。结果表明（I）显着表达了LOX信使RNA。

3. 发明公开

EP1374881A4 A PHARMACEUTICAL PREPARATION FOR ASTHMA 有权
标题翻译：药剂师ASTHMAPRÄPARAT
公开(公告)号：EP1374881A4
公开(公告)日：2004-04-21
申请号：EP01274052
申请日：2001-11-01
申请人： LI HONGFEN
发明人： LI HONGFEN
IPC分类号： A61K33/06 , A61K35/64 , A61K36/00 , A61K36/06 , A61K36/17 , A61K36/238 , A61K36/355 , A61K36/481 , A61K36/538 , A61K36/539 , A61K36/634 , A61K36/65 , A61K36/734 , A61K36/736 , A61K36/756 , A61P11/06 , A61K35/78
CPC分类号： A61K36/8966 , A61K36/17 , A61K36/238 , A61K36/28 , A61K36/344 , A61K36/355 , A61K36/481 , A61K36/484 , A61K36/487 , A61K36/535 , A61K36/538 , A61K36/539 , A61K36/56 , A61K36/634 , A61K36/65 , A61K36/718 , A61K36/734 , A61K36/736 , A61K36/756 , A61K36/79 , A61K36/8998 , A61K36/904 , A61K2300/00
摘要： The present invention disclosed a pharmaceutical preparation of Chinese herb which consists of Kidney-reinforcing and antiasthma herbs, wherein said Chinese herbs comprises Ferilla Frutescens, Prunus Armeniaca, Glycyrrhiza Uralensis, Scutellaria Baicalensis, Coptis Chinesis, Tusilago Farfara, Stemona Sessilifolia, Fritllaria Cirrhosa, Pheretima Aspergillum, Psoralea Corylifolia, Codonopsis Pilosula, Hordeum Vulgara, Massa Fermentata Medicalis, Schisandra Chinensis, Gypsum. The preparation has been used in China for 20 years, and in Israel for more than 5 years. It has cured thousands of patients suffering from asthma, with the effective rate of 93%. The present pharmaceutical preparation can relieve cough, expel phlegm, resist the airway allergic inflammation reaction, improve the pulmonary function and the partial pressure of the oxygen in blood, increase CD2, CD4, CD4/CD8, reduce IgE in blood, and increase CAMP, reduce CGMP in blood, stabilize clasmatoblasts, inhibit the release of histamine, stop asthmatic attack. As is shown in the electron microscope, the preparation protects pneumonocytes, increase the pneumonocytes of type 2, and recover the vital capacity. It can be applied to hormone depending patients for adjusting the decrease of the cerebral ganglia hypophysis adrenal axes. To further demonstrate the curative effect, a study of clinical observation was carried out in the Tel-Hashomer Hospital in Israel, which proved the effect was quit remarkable.

4. 发明申请

US20140227239A1 GROWTH HORMONE SECRETAGOGUE 审中-公开
标题翻译：生长激素秘密
公开(公告)号：US20140227239A1
公开(公告)日：2014-08-14
申请号：US14003171
申请日：2012-03-02
申请人： Toshio Gokita , Ikuko Kamada , Kiwamu Suzuki , Hiroaki Kambayashi
发明人： Toshio Gokita , Ikuko Kamada , Kiwamu Suzuki , Hiroaki Kambayashi
IPC分类号： A61K31/7076 , A61K31/05 , A61K36/63 , A61K36/17 , A61K31/7048 , A61K36/06 , A61K36/87
CPC分类号： A61K31/7076 , A61K9/2054 , A61K9/4875 , A61K31/05 , A61K31/7048 , A61K36/06 , A61K36/15 , A61K36/17 , A61K36/63 , A61K36/87
摘要： It is an object of the present invention to provide a growth hormone secretagogue that is excellent in effect of promoting secretion of a growth hormone and is orally available. The growth hormone secretagogue of the present invention contains one or more selected from the group consisting of S-adenosylmethionine and/or a salt thereof, a Siberian larch extract, an olive extract, and a stilbene-based compound as an active ingredient. S-adenosylmethionine and/or the salt thereof may be a form itself of chemically synthesized S-adenosylmethionine and/or the salt thereof, or may be a microbial cell or a culture containing S-adenosylmethionine and/or the salt thereof. The stilbene-based compound may be an extract extracted from a Vitaceae plant or a Gnetaceae plant. The olive extract may be an extract separated from a fruit of olive.
摘要翻译：本发明的目的是提供一种生长激素促分泌素，其在促进生长激素分泌的作用方面是优异的并且是可口服的。本发明的生长激素促分泌素含有选自S-腺苷甲硫氨酸和/或其盐，西伯利亚落叶松提取物，橄榄提取物和芪类化合物作为活性成分的一种或多种。 S-腺苷甲硫氨酸和/或其盐可以是化学合成的S-腺苷甲硫氨酸和/或其盐本身的形式，或者可以是微生物细胞或含有S-腺苷甲硫氨酸和/或其盐的培养物。芪类化合物可以是从维他螨科植物或芸苔科植物提取的提取物。橄榄提取物可以是从橄榄果实分离的提取物。

5. 发明申请

US20110144209A1 USE OF VASOCONSTRICTORS 审中-公开
标题翻译： VASOCONSTRICTORS的使用
公开(公告)号：US20110144209A1
公开(公告)日：2011-06-16
申请号：US12982117
申请日：2010-12-30
申请人： Oron ZACHAR
发明人： Oron ZACHAR
IPC分类号： A61K31/16 , A61K31/135 , A61P35/00
CPC分类号： A61F7/00 , A61F2007/0036 , A61F2007/0045 , A61K9/0014 , A61K33/24 , A61K36/17 , A61K36/752 , A61K36/81 , A61K36/9068 , A61K41/0052 , A61K45/06 , A61K2300/00
摘要： There is disclosed the topical dermal use of vasocontrictor substances for regulating body temperature to treat cancer by inducing hyperthermia and treat, prevent or delay the onset of anesthetic induced hypothermia. Kits containing appropriate materials and instructions, and other embodiments, are also disclosed.
摘要翻译：公开了通过诱导高热治疗，预防或延迟麻醉诱导的低体温的发作来调节体温以治疗癌症的血管收缩剂物质的局部皮肤用途。还公开了包含适当的材料和说明书以及其它实施方案的试剂盒。

6. 发明申请

US20080226749A1 Pharmaceutical composition for inhibiting the syndrome of snoring and preparation thereof 审中-公开
标题翻译：用于抑制打鼾综合征及其制备的药物组合物
公开(公告)号：US20080226749A1
公开(公告)日：2008-09-18
申请号：US12073827
申请日：2008-03-11
申请人： Shuenn-Jyi Sheu , Hsiao-Yin Yeh , Wu-Che Wen , Ching-Che Lin , Chen-Ying Chiang
发明人： Shuenn-Jyi Sheu , Hsiao-Yin Yeh , Wu-Che Wen , Ching-Che Lin , Chen-Ying Chiang
IPC分类号： A61K33/06 , A61K36/00 , A61P11/00
CPC分类号： A61K36/74 , A61K36/17 , A61K36/484 , A61K36/54 , A61K36/736 , A61K45/06 , A61K2300/00
摘要： The present invention discloses a pharmaceutical composition for inhibiting a snore symptom, which comprises medicinal material of Uncaria rhynchophylla. The above pharmaceutical composition of the present invention also comprises medicinal materials of Uncaria rhynchophylla, Ephedra, Prunus armeniaca, and Glycyrrhiza uralensis.
摘要翻译：本发明公开了一种抑制鼻涕症状的药物组合物，其包括钩藤属（Uncaria rhynchophylla）的药用物质。本发明的上述药物组合物还包括乌贼属（Uncaria rhynchophylla），麻黄（Amepia rhynchophylla），麻黄（Prunus armeniaca）和甘草（Glycyrrhiza uralensis））的药用材料。

7. 发明授权

US07371727B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07371727B2
公开(公告)日：2008-05-13
申请号：US10899806
申请日：2004-07-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

8. 发明授权

US07255884B2 Composition for treatment of asthma 有权
标题翻译：用于治疗哮喘的组合物
公开(公告)号：US07255884B2
公开(公告)日：2007-08-14
申请号：US10683984
申请日：2003-10-02
申请人： Hongfen Li
发明人： Hongfen Li
IPC分类号： A61K36/00 , A61K36/236 , A61K36/718 , A61K36/736
CPC分类号： A61K36/8966 , A61K36/17 , A61K36/238 , A61K36/28 , A61K36/344 , A61K36/355 , A61K36/481 , A61K36/484 , A61K36/487 , A61K36/535 , A61K36/538 , A61K36/539 , A61K36/56 , A61K36/634 , A61K36/65 , A61K36/718 , A61K36/734 , A61K36/736 , A61K36/756 , A61K36/79 , A61K36/8998 , A61K36/904 , A61K2300/00
摘要： A pharmaceutical preparation of Chinese herbal medicines for tonifying the kidneys and alleviating asthma is disclosed herein. The Chinese herbal medicines include Perilla Frutescens, Prunus Armeniaca, Glycyrrhiza Uralensis, Scutellaria Baicalensis, Coptis Chinesis, Tusilago Farfara, Stemona Sessilifolia, Fritillaria Cirrhosa, Pheretima Aspergillum, Psoralaea Corylifolia, Codonopsis Pilosula, Hordeum Vulgara, Massa Fermentata Medicalis, Schisandra Chinesis, and Gypsum. The preparation is used to treat thousands of patients suffering from asthma with an effective rate of 93%. The present preparation can relieve cough, expel phlegm, resist airway allergic inflammation reaction, improve pulmonary function, partial pressure of the oxygen in the blood, increase CD2, CD4, CD4/CD8, reduce IgE in blood, increase CAMP, reduce CGMP, stabilize mast cells, and inhibit the release of histamine, which make it capable of stopping an asthma attack.
摘要翻译：本文公开了用于调节肾脏和减轻哮喘的中草药药物制剂。中草药包括紫苏，紫薇，黄连，黄连，，olia olia olia olia olia，um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um um 。该制剂用于治疗数千例哮喘患者，有效率为93％。本制剂可缓解咳嗽，排泄痰，抵抗气道过敏性炎症反应，改善肺功能，血液中氧气分压，增加CD <2>，CD 4， CD 3 / CD 8，降低血液中的Iκ，增加CAMP，减少CGMP，稳定肥大细胞，并抑制组胺的释放，使其能够停止哮喘发作。

9. 发明申请

US20060193925A1 Side effect-relieving agents and/or hypoglycemic effect enhancers for thiazolidine compounds 审中-公开
标题翻译：噻唑烷化合物的副作用缓解剂和/或降血糖效应增强剂
公开(公告)号：US20060193925A1
公开(公告)日：2006-08-31
申请号：US11410884
申请日：2006-04-26
申请人： Yasuo Morimoto , Tomoko Maegawa
发明人： Yasuo Morimoto , Tomoko Maegawa
IPC分类号： A61K33/06 , A61K36/185 , A61K36/48
CPC分类号： A61K45/06 , A61K31/427 , A61K31/4439 , A61K33/04 , A61K36/17 , A61K36/232 , A61K36/234 , A61K36/238 , A61K36/284 , A61K36/346 , A61K36/484 , A61K36/534 , A61K36/538 , A61K36/539 , A61K36/605 , A61K36/634 , A61K36/65 , A61K36/708 , A61K36/725 , A61K36/73 , A61K36/744 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to a side effect-relieving agent for thiazolidine compounds which comprises a crude drug mixture as an active ingredient comprising Ephedrae Herba, Glycyrrhizae Radix and Gypsum Fibrosum each of which is in a form of ground powders, extracts or mixtures of powders and extracts; and a hypoglycemic effect enhancer for thiazolidine compounds which comprises a crude drug mixture as an active ingredient comprising Ephedrae Herba, Glycyrrhizae Radix and Gypsum Fibrosum each of which is in a form of ground powders, extracts or mixtures of powders and extracts. Using the preparation according to the present invention, body weight gain, which is a side effect of thiazolidine compounds, can be relieved and the hypoglycemic effect of the thiazolidine compounds can be enhanced.
摘要翻译：本发明涉及一种噻唑烷化合物的副作用缓解剂，其包含作为活性成分的生药物混合物，其包含麻黄，甘草和石膏，其各自为研磨粉末，提取物或粉末混合物，以及提取物和用于噻唑烷化合物的降血糖效应增强剂，其包含作为活性成分的生药物混合物，其包含麻黄，甘草和石膏，其各自为研磨粉末，提取物或粉末和提取物的混合物。使用本发明的制剂可以缓解作为噻唑烷化合物的副作用的体重增加，提高噻唑烷化合物的降血糖作用。

10. 发明申请

US20040076688A1 Anti-hemorrhoid composition and process for its manufacture 失效
标题翻译：抗痔疮组合物及其制造方法
公开(公告)号：US20040076688A1
公开(公告)日：2004-04-22
申请号：US10274267
申请日：2002-10-21
发明人： Chan Sik Park
IPC分类号： A61K035/78 , A61K033/12 , A61K033/06
CPC分类号： A61K36/8888 , A61K33/00 , A61K36/17 , A61K36/258 , A61K36/40 , A61K36/484 , A61K36/534 , A61K36/65 , A61K36/708 , A61K36/714 , A61K36/756 , A61K45/06 , Y10S514/882 , A61K2300/00
摘要： The composition and process for preparing an anti-hemorrhoid composition which comprises providing a predetermined effective amount of natural substances of the genera Glycyrrhizae Radix, Testudinis Carapax, Cervi Parvum Cornu, Rhei Rhizoma, Ephedrae Herba, Natrii Sulfas, Moutan Radicis Cortx, Menthae Herba, Pinelliae Rhizoma, Pasoniae Radix, Acontii Tuber, Corni Fructus, Gypsum, Ginseng Radix, Cinnabaris, Talcum and Pelladendri Radix in an aqueous medium to form an initial mixture, extracting the initial mixture with water at a temperature of about 70null-80null C. for 1-2 hours to produce an aqueous mixture, filtering the aqueous mixture to produce a filtrate, and evaporating the filtrate to a moisture content of 30% to produce an extract which can be used as a treatment for hemorrhoid diseases.
摘要翻译：一种制备抗痔疮组合物的组合物和方法，其包括提供预定有效量的甘草，卡拉帕克氏菌，藜草，莱氏根，麻黄，纳氏沙门氏菌，Moutan Radicis Cortx，Menthae Herba等的天然物质， Pinelliae Rhizoma，Pasoniae Radix，Acontii Tuber，Corni Fructus，Gypsum，Ginseng Radix，Cinnabaris，Talcum and Pelladendri Radix在水性介质中形成初始混合物，在约70°-80°C的温度下用水萃取初始混合物处理1-2小时以制备含水混合物，过滤含水混合物以产生滤液，并将滤液蒸发至含水量为30％，以产生可用作治疗痔疮疾病的提取物。

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