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    • 8. 发明申请
    • Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
    • 游离B环黄酮和黄烷作为治疗剂的混合物的配制
    • US20030232763A1
    • 2003-12-18
    • US10462030
    • 2003-06-13
    • Unigen Pharmaceuticals, Inc.
    • Qi Jia
    • A61K031/7048A61K031/353
    • A61K36/539A61K31/35A61K31/353A61K31/7048A61K36/11A61K36/15A61K36/185A61K36/28A61K36/47A61K36/48A61K36/484A61K36/486A61K36/53A61K36/54A61K36/60A61K36/74A61K36/906A61K36/9062
    • The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compoundsnullFree-B-ring flavonoids and flavansnullfor use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
    • 本发明提供由两种特定类别的化合物 - 游离B-环类黄酮和黄烷的混合物组成的新型组合物,用于预防和治疗由COX-2和5-LO介导的疾病和病症 途径。 本发明还提供了同时抑制环氧合酶-2(COX-2)和5-脂氧合酶(5-LO)酶,降低cox-2 mRNA产生的新方法。 最后,本发明包括减肥和血糖控制的方法。 本发明的方法包括向有需要的宿主施用有效量的本发明组合物和药学上可接受的载体。 本发明一般涉及由环氧合酶-2(COX-2)和5-脂氧合酶(5-LO)途径介导的疾病和病症的预防和治疗,包括但不限于与这样的病症有关的救济关节不适和疼痛 作为骨关节炎,类风湿性关节炎以及过度使用引起的其他损伤。