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1. 发明公开

CN1078382A 一种用于容纳和分离一种最好是血浆的流体成为它的各个组分的容器失效
公开(公告)号：CN1078382A
公开(公告)日：1993-11-17
申请号：CN92114309.5
申请日：1992-11-11
申请人：于内斯有限公司
发明人： N·E·霍尔姆
IPC分类号： A61J1/05
CPC分类号： B01D21/262 , A61J1/1418 , A61M2202/045 , A61M2202/0452 , A61M2202/0454 , B01D2221/10 , Y10T436/25125 , Y10T436/25375
摘要：容纳和分离血浆成各组分的容器有两密封连接的部分。一容器部分和另一容器部分的相邻部分都由固体材料制成，两容器部分拧旋成一体。容器部分有容纳各自流体组分的腔，邻接部分有连接通道使各腔互连，各容器部分在通道中拧旋成一体。通道各端形成阀座以容纳封闭分离的容器部分的各腔的阀件。阀件有互邻件保证阀件间距离超过容器部分连接态下阀座间的距离、但小于容器部分分离运动时阀座所处位置间的距离。还有保持装置使阀件不接合阀座。

2. 发明公开

CN1173140A 从血浆中分离纤维蛋白I的方法和设备失效
公开(公告)号：CN1173140A
公开(公告)日：1998-02-11
申请号：CN95197451.3
申请日：1995-12-01
申请人：布里斯托尔-迈尔斯斯奎布公司
发明人： N·E·霍尔姆 , P·A·D·爱德华森
IPC分类号： B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要：通过围绕中心轴的离心作用分离血液成分例如纤维蛋白单体的装置,它包括由围绕旋转轴同心配置的圆筒外壁(72)和圆筒内壁(71)以及上壁(73)和下壁(74)限定的第一环形室(70),其中下壁由可在第一室内移动的活塞(55)构成。该装置包括在第一室下面,通过第一通道(4)与第一室连通的第二室(75),它由第一室的圆筒外壁(72)和下壁(74)以及另一下壁(76)确定。该装置还包括设在第二室内的密封室(45),它包含许多隔室,用于容纳有促进上述分离作用的各组合物。

3. 发明授权

CN1031316C 用于容纳和分离最好是血浆的流体成为其各组分的容器失效
公开(公告)号：CN1031316C
公开(公告)日：1996-03-20
申请号：CN92114309.5
申请日：1992-11-11
申请人：于内斯有限公司
发明人： N·E·霍尔姆
IPC分类号： A61J1/05
CPC分类号： B01D21/262 , A61J1/1418 , A61M2202/045 , A61M2202/0452 , A61M2202/0454 , B01D2221/10 , Y10T436/25125 , Y10T436/25375
摘要：容纳和分离血浆成各组分的容器有两密封连接的部分。一容器部分和另一容器部分的相邻部分都由固体材料制成，两容器部分拧旋成一体。容器部分有容纳各自流体组分的腔，邻接部分有连接通道使各腔互连，各容器部分在通道中拧旋成一体。通道各端形成阀座以容纳封闭分离的容器部分的各腔的阀件。阀件有互邻件保证阀件间距离超过容器部分连接态下阀座间的距离、但小于容器部分分离运动时阀座所处位置间的距离。还有保持装置使阀件不接合阀座。

4. 发明公开

CN1377890A 从血浆中分离纤维蛋白的方法和设备无效
公开(公告)号：CN1377890A
公开(公告)日：2002-11-06
申请号：CN01125202.2
申请日：1995-12-01
申请人：布里斯托尔-迈尔斯斯奎布公司
发明人： N·E·霍尔姆 , P·A·D·爱德华森
IPC分类号： C07K14/435 , B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要：通过围绕中心轴的离心作用分离血液成分例如纤维蛋白单体的装置,它包括由围绕旋转轴同心配置的圆筒外壁(72)和圆筒内壁(71)以及上壁(73)和下壁(74)限定的第一环形室(70),其中下壁由可在第一室内移动的活塞(55)构成。该装置包括在第一室下面,通过第一通道(4)与第一室连通的第二室(75),它由第一室的圆筒外壁(72)和下壁(74)以及另一下壁(76)确定。该装置还包括设在第二室内的密封室(45),它包含许多隔室,用于容纳有促进上述分离作用的各组合物。

5. 发明授权

CN1083284C 从血浆中分离纤维蛋白的方法和设备失效
公开(公告)号：CN1083284C
公开(公告)日：2002-04-24
申请号：CN95197451.3
申请日：1995-12-01
申请人：布里斯托尔-迈尔斯斯奎布公司
发明人： N·E·霍尔姆 , P·A·D·爱德华森
IPC分类号： B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要：通过围绕中心轴的离心作用分离血液成分例如纤维蛋白单体的装置，它包括由围绕旋转轴同心配置的圆筒外壁(72)和圆筒内壁(71)以及上壁(73)和下壁(74)限定的第一环形室(70)，其中下壁由可在第一室内移动的活塞(55)构成。该装置包括在第一室下面，通过第一通道(4)与第一室连通的第二室(75)，它由第一室的圆筒外壁(72)和下壁(74)以及另一下壁(76)确定。该装置还包括设在第二室内的密封室(45)，它包含许多隔室，用于容纳有促进上述分离作用的各组合物。

6. 发明授权

US06514273B1 Device for removal of thrombus through physiological adhesion 有权
标题翻译：通过生理粘附去除血栓的装置
公开(公告)号：US06514273B1
公开(公告)日：2003-02-04
申请号：US09532629
申请日：2000-03-22
申请人： Larry Voss , William Stephen Tremulis
发明人： Larry Voss , William Stephen Tremulis
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61B17/22 , A61B17/22031 , A61B17/221 , A61B2017/00287 , A61B2017/22002 , A61B2017/22034 , A61B2017/2212 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61M2025/0042 , A61M2025/109 , A61M2202/045
摘要： A device that is useful for removing obstructions from vessels. Various embodiments and methods of use are contemplated for the effective removal of obstructions. The disclosed devices utilize a thrombogenic material to promote the formation of fibrin bonds, thus enhancing adhesion. It is further contemplated that the disclosed devices may be used in all vasculature including the cerebral vasculature and the neurovasculature.
摘要翻译：一种可用于清除血管阻塞物的装置。考虑到各种实施例和使用方法来有效地去除障碍物。所公开的装置利用血栓形成材料促进纤维蛋白键的形成，从而增强粘附性。进一步预期，所公开的装置可用于包括脑血管系统和神经血管系统在内的所有脉管系统中。

7. 发明授权

US06495051B1 Methods for preparing blood or plasma component solutions with improved concentrations 失效
标题翻译：用于制备浓度提高的血液或血浆成分溶液的方法
公开(公告)号：US06495051B1
公开(公告)日：2002-12-17
申请号：US09677094
申请日：2000-09-29
申请人： Gautom Bhaskar , Glenn Jorgensen
发明人： Gautom Bhaskar , Glenn Jorgensen
IPC分类号： A01N102
CPC分类号： B01D21/262 , A61M1/3693 , A61M2202/0449 , A61M2202/045 , B01D2221/10 , B04B2005/0485
摘要： A method for separating a blood component, e.g., fibrin monomer, from blood or plasma. The method utilizes a container with a reaction chamber for receiving the plasma. The reaction chamber is defined by a wall and an agent is supplied to the reaction chamber for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The method also utilizes a device for centrifuging the reaction chamber with the plasma and the agent to a degree sufficient for separating the non-cross-linked fibrin polymer from the plasma, for depositing the polymer on the outer wall of the reaction chamber, and for expelling the remaining plasma from the reaction chamber. A solvent is supplied to the reaction chamber for dissolving the non-cross-linked fibrin polymer. The solvent is supplied to the reaction chamber in a first amount for dissolving the non-cross-linked fibrin polymer which is less than the total amount of solvent for dissolving the polymer. The remaining solvent is supplied to the reaction chamber in one or more portions to flush the reaction chamber and other portions of the device and recover additional non-cross-linked fibrin polymer.
摘要翻译：一种将血液成分例如纤维蛋白单体与血液或血浆分离的方法。该方法利用具有用于接收等离子体的反应室的容器。反应室由壁限定，并且将试剂供应到反应室以将血浆的纤维蛋白原含量转化为非交联的纤维蛋白聚合物。该方法还利用了用等离子体和试剂将反应室离心至足以将非交联的纤维蛋白聚合物与等离子体分离的程度的装置，用于将聚合物沉积在反应室的外壁上，从反应室排出剩余的等离子体。将溶剂供应到反应室以溶解非交联的纤维蛋白聚合物。将溶剂以第一量供给反应室，以溶解小于溶解聚合物的溶剂的总量的非交联纤维蛋白聚合物。将剩余的溶剂以一个或多个部分供应到反应室中以冲洗反应室和该装置的其它部分，并回收另外的非交联的纤维蛋白聚合物。

8. 发明授权

EP0794824B1 METHOD AND DEVICE FOR SEPARATING FIBRIN MONOMER FROM BLOOD PLASMA 失效
标题翻译：方法和装置用于分离纤维蛋白用等离子体
公开(公告)号：EP0794824B1
公开(公告)日：2008-08-20
申请号：EP95942533.1
申请日：1995-12-01
申请人： Vivolution A/S
发明人： HOLM, Niels, Erik , EDWARDSON, Peter, Andrew, David
IPC分类号： B01D21/26 , G01N33/49 , B01L3/14 , B04B5/04
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added. The separation of fibrin monomer from the plasma fraction in the second chamber is carried out during continued centrifugation whereby a fibrin polymer is deposited on the cylindrical outer wall of said second chamber, whereafter the fluid fraction collected at the bottom of the second chamber is transferred while influenced by the piston body to the first chamber. The fraction with fibrin polymer remaining in the second chamber is substantially deposited on the cylindrical wall and is caused to be dissolved by addition of a solvent and by centrifugation, whereafter it is transferred to a receiving container by passing after addition of a binder to the enzyme through a filter removing said enzyme, whereby a fibrin monomer containing solution is provided.

9. 发明申请

US20150272562A1 DEVICE AND METHOD FOR PREPARING AND ADMINISTERING ONE-COMPONENT FIBRIN SEALANT 审中-公开
标题翻译：用于制备和管理单组分纤维素密封剂的装置和方法
公开(公告)号：US20150272562A1
公开(公告)日：2015-10-01
申请号：US14668341
申请日：2015-03-25
申请人： Ethicon, Inc. , Omrix Biopharmaceuticals Ltd.
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
IPC分类号： A61B17/00 , A61K38/48 , A61M3/00 , A61K38/36
CPC分类号： A61B17/00491 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/106 , A61M3/005 , A61M2202/045 , C12Y304/21005
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
摘要翻译：本文提供了用于制备和递送纤维蛋白密封剂到表面的系统及其使用方法。在一个实施例中，系统包括：a。一定量的液体混合物置于容器内，该混合物包括：I.血纤蛋白或II。纤维蛋白原和因子II; 和b。设置在容器内的树脂床，容器能够与容器流体连通，其中当流体连通时，混合物通过容器导致改变小分子抑制剂和/或诱导剂的浓度在混合物中，有利于血纤维蛋白凝块的形成。

10. 发明授权

US5824230A Method and device for separating a component such as fibrin I from blood plasma 失效
标题翻译：用于将诸如纤维蛋白I的组分与血浆分离的方法和装置
公开(公告)号：US5824230A
公开(公告)日：1998-10-20
申请号：US745119
申请日：1996-11-07
申请人： Niels Erik Holm , Peter A. D. Edwardson
发明人： Niels Erik Holm , Peter A. D. Edwardson
IPC分类号： A61K38/16 , A61M1/02 , A61M1/36 , B01D21/01 , B01D21/08 , B01D21/20 , B04B3/00 , B04B5/04 , C07K1/14 , C07K14/78 , G01N33/49 , B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/262 , B04B5/0442 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D2221/10 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added. The separation of fibrin monomer from the plasma fraction in the second chamber is carried out during continued centrifugation whereby a fibrin polymer is deposited on the cylindrical outer wall of said second chamber, whereafter the fluid fraction collected at the bottom of the second chamber is transferred while influenced by the piston body to the first chamber. The fraction with fibrin polymer remaining in the second chamber is substantially deposited on the cylindrical wall and is caused to be dissolved by addition of a solvent and by centrifugation, whereafter it is transferred to a receiving container by passing after addition of a binder to the enzyme through a filter removing said enzyme, whereby a fibrin monomer containing solution is provided.
摘要翻译：用于通过离心从血液中分离组分（例如纤维蛋白单体）的方法和装置涉及将抗凝血剂加入到装置中的第一环形室中，其中环形室由圆柱形外壁和圆柱形内壁，两个壁围绕公共轴线同轴地延伸，以及由顶壁和底壁延伸。顶壁或底壁由在第一室内可移动的活塞体形成。该方法还包括围绕所述公共轴的装置的离心，以将血液基本上分离成细胞部分和血浆级分，随后将所得血浆级分转移到受活塞体影响的第二腔室，该第二腔室由外圆柱形壁。外圆柱形壁与所述公共轴线同轴延伸，由此在加入合适的酶的同时使具有纤维蛋白I的级分在第二腔室中分离。在连续离心过程中进行纤维蛋白单体与第二室中的血浆级分的分离，由此纤维蛋白聚合物沉积在所述第二腔室的圆柱形外壁上，此后在第二腔室的底部收集的流体馏分被转移，同时受到活塞体到第一腔室的影响。保留在第二腔室中的纤维蛋白聚合物的级分基本上沉积在圆柱形壁上，并通过加入溶剂并通过离心使之溶解，然后通过向粘合剂中加入粘合剂而将其转移到接收容器中通过除去所述酶的过滤器，从而提供含有纤维蛋白单体的溶液。

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