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    • 9. 发明申请
    • AMMONIA SCAVENGER
    • WO1984000885A1
    • 1984-03-15
    • PCT/US1983001365
    • 1983-09-09
    • ORGANON TEKNIKA CORPORATION
    • ORGANON TEKNIKA CORPORATIONHOF, Craig, R.POLAK, Robert, B.THOMPSON, Ralph, Preston
    • A61K09/50
    • C02F1/281B01D15/00B01J20/048B01J20/28026B01J20/3085B01J2220/62C01B25/34
    • A new and useful particulate magnesium phosphate product (MGP) and method of use therefor for removing ammonia from aqueous solutions, e.g., recirculating dialysate solutions and intragastrointestinal fluids as may result from the hydrolysis of urea. This particulate magnesium phosphate product (MGP) acts as a remarkably effective scavenger wherein under equilibrium conditions only about six (6) grams of the novel product are required to bind the ammonia (more exactly, ammonium ions) liberated from one (1) gram of the urea, a result far superior to traditional zirconium phosphate (ZP) prior art materials which under ideal conditions require about 17-20 grams of ZP per gram of urea. The novel particulate magnesium phosphate product can be exploited in one embodiment as a replacement for the older ZP materials used to remove ammonia produced by enzymatic hydrolysis of urea in recirculating dialysis systems utilizing disposable cartridges. In another embodiment, in a new encapsulated product (comprising a water-insoluble, membranous wall, permeable to urea and/or ammonia and water, while impermeable to urease enzyme, wherein the wall surrounds a core of urease and the novel particulate magnesium phosphate product) is disclosed, which can also be used as in in vivo or in vitro scavenger. This particulate MGP product can also be used for the removal of ammonium ions either produced by enzymatic or non-enzymatic hydrolysis of urea or proteins or amino acids or available as NH4 from its native source. Two methods are also disclosed for the preparation of the particulate magnesium phosphate product.
    • 一种新的和有用的颗粒状磷酸镁产品(MGP)及其用于从水溶液中除去氨的方法,例如可能由尿素水解导致的循环透析液和肠胃内液体。 这种颗粒状磷酸镁产品(MGP)起着非常有效的清除剂的作用,其中在平衡条件下,仅需要约六(6)克的新产物来结合从一(1) 尿素的结果远远优于传统的磷酸锆(ZP)现有技术的材料,其在理想条件下需要约17-20克ZP /克尿素。 在一个实施方案中,新型颗粒状镁磷酸盐产品可用于代替用于通过利用一次性药筒在循环透析系统中尿素酶水解产生的氨的较旧ZP材料。 在另一个实施方案中,在新的包封的产品(包含不溶于尿素和/或氨和水的水不溶性的膜壁,虽然对尿素酶是不可渗透的,其中壁围绕脲酶的核心和新的颗粒状磷酸镁产物 ),其也可以在体内或体外清除剂中使用。 这种颗粒状MGP产品也可用于去除通过酶或非酶水解尿素或蛋白质或氨基酸或从其天然来源获得的NH4 +产生的铵离子。 还公开了制备颗粒状镁磷酸盐产品的两种方法。