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1. 发明公开

CN104395732A 使用无纤维的透反射探针对分析物浓度的无创测量无效
公开(公告)号：CN104395732A
公开(公告)日：2015-03-04
申请号：CN201380023695.9
申请日：2013-04-04
申请人：格罗夫器械股份有限公司
发明人： H.哈琼马 , S.库恩
IPC分类号： G01N21/31 , G01N21/35 , G01N21/49 , G01N21/17 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/14532 , A61B5/0051 , A61B5/1455 , A61B5/6816 , A61B5/6826 , A61B2560/0431 , A61B2562/0233 , A61B2562/146 , F04C2270/041 , G01N21/1717 , G01N21/314 , G01N21/359 , G01N21/474 , G01N21/49 , G01N33/49 , G01N2021/3148 , G01N2021/4709 , G01N2021/475 , G01N2201/0221 , G01N2201/0631 , G01N2201/0636
摘要：一种使用无纤维的透反射探针(20)无创测量样本基质(22)中的目标分析物浓度的方法和设备。其包括将由至少两种不同波长成分构成的电磁辐射束引导到样本基质(22)，并将背向散射辐射传导到检测器(18)，检测器输出指示出样本基质(22)中的两个波长的差异吸收率的信号。透反射探针(20)包括具有内反射表面(52)的锥形管状壳体(50)、具有外反射表面(45)的光杆(40)和检测窗(46)，检测窗充当探针和样本基质(22)表面之间的界面。所述方法和设备尤其用于测量包含血液的组织(22)中的葡萄糖浓度。

2. 发明申请

US20130267799A1 NONINVASIVE MEASUREMENT OF ANALYTE CONCENTRATION USING A FIBERLESS TRANSFLECTANCE PROBE 审中-公开
公开(公告)号：US20130267799A1
公开(公告)日：2013-10-10
申请号：US13441467
申请日：2012-04-06
申请人： Hannu Harjunmaa , Stevan Kun
发明人： Hannu Harjunmaa , Stevan Kun
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14532 , A61B5/0051 , A61B5/1455 , A61B5/6816 , A61B5/6826 , A61B2560/0431 , A61B2562/0233 , A61B2562/146 , F04C2270/041 , G01N21/1717 , G01N21/314 , G01N21/359 , G01N21/474 , G01N21/49 , G01N33/49 , G01N2021/3148 , G01N2021/4709 , G01N2021/475 , G01N2201/0221 , G01N2201/0631 , G01N2201/0636
摘要： A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix using a fiberless transflectance probe is described. It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix and conducting the backscattered radiation to a detector which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix. The transflectance probe comprises a tapered tubular housing having an inner reflective surface, an optical rod having an outer reflective surface, and a detection window which serves as an interface between the probe and the surface of the sample matrix. The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue containing blood.

3. 发明授权

US06563992B1 Small diameter diffuse reflectance probe 失效
标题翻译：小直径漫反射探头
公开(公告)号：US06563992B1
公开(公告)日：2003-05-13
申请号：US09347479
申请日：1999-07-02
申请人： Walter M. Doyle
发明人： Walter M. Doyle
IPC分类号： G02B604
CPC分类号： G01J3/02 , G01J3/0218 , G01N21/4738 , G01N21/474 , G01N2021/475 , G02B6/262 , G02B6/2848 , G02B6/3818
摘要： The invention relates to a fiber-optic coupled diffuse reflectance probe that is adapted to detachably connect to a bifurcated fiber bundle. The probe includes a solid light guide for separating the bundle from the target within a small-diameter probe body. A probe of this construction is especially useful for analyzing high temperature and high pressure targets, through relatively small fittings, as is required in polymer extrusion applications. The solid light guide may extend along all or along a lesser portion of the probe body's length. Its fiber-end may be coupled directly to the illumination and detector fibers or indirectly, and at some distance from the fibers, by way of a lens or a hollow light guide. Its target-end may be exposed to terminate in a direct face-to-face relationship with the target, or it may be located behind an intermediate window. The solid light guide is characterized by a target-end refracting surface that minimizes stray light. In particular, such surface is designed to ensure that light internally reflected from that surface with bounce back to the detector fiber at angles that are outside of the detector fiber's field of view. The preferred surface is a beveled plane, but other flat and nonflat surfaces are possible. The target-end refracting surface also tends to ensure that reflections from the window surfaces, if present, are returned to the detector fiber at angles outside of its field of view. The window itself may be canted too to help ensure that rays which are unusually divergent due to imperfections are still returned to the the detector fiber at angles outside of its field of view.
摘要翻译：本发明涉及一种适于可分离地连接到分叉纤维束的光纤耦合漫反射探头。探针包括用于在小直径探针体内将束与靶分离的固体光导。这种结构的探针通过相对较小的配件，如聚合物挤出应用中所需要的，用于分析高温和高压目标特别有用。固体光导可以沿着探头主体的长度的全部或沿着较小部分延伸。其光纤端可以直接耦合到照明和检测器光纤，或者通过透镜或中空光引导件间接地，并且与纤维在一定距离处。其目标端可能暴露于与目标的直接面对面关系终止，或者它可能位于中间窗后。固体光导的特征在于使杂散光最小化的目标端折射表面。特别地，这种表面设计成确保从该表面内部反射的光以检测器光纤的视场外的角度反射回检测器光纤。优选的表面是斜面，但是其他平坦和非平坦表面也是可能的。目标端折射表面也倾向于确保来自窗表面的反射（如果存在）在其视场外的角度返回到检测器光纤。窗口本身也可以是倾斜的，以帮助确保由于缺陷而异常发散的射线仍然以其视野外的角度返回到检测器光纤。

4. 发明公开

EP2896347A1 SCATTERED LIGHT MEASUREMENT DEVICE 有权
标题翻译： LENS测量装置
公开(公告)号：EP2896347A1
公开(公告)日：2015-07-22
申请号：EP13836526.7
申请日：2013-09-09
申请人： Olympus Corporation
发明人： ITO, Ryosuke
IPC分类号： A61B1/00 , G01N21/17 , G01N21/27
CPC分类号： G01N21/474 , A61B1/00167 , A61B1/042 , A61B1/07 , A61B5/0059 , G01N2021/4745 , G01N2021/475
摘要： Included are: an optical measurement apparatus (1) including a light source (10) that emits light including at least light of measurement target wavelength, an optical detector (12) that detects, via a branching unit, light received by a scattered light measurement probe (101), a branching unit (11) that guides the light from the light source (10) to the scattered light measurement probe (101) and guides the light from the scattered light measurement probe (101) to the optical detector (12), and a control unit (13) that evaluates scattering characteristics of a surface layer of an object to be examined based on the light detected by the optical detector (12), and the scattered light measurement probe (101) including a fiber (102) that connects to the optical measurement apparatus (1) at one end thereof, propagates the light from the light source to irradiate the object to be examined, comes in contact with the object to be examined at another end thereof, receives light that has irradiated the object to be examined, propagated inside the object to be examined, and returned thereto, and guides the light to the optical detector (12) as an optical signal, the fiber (102) including a core (1020) that propagates light and has an approximately-rod-shaped core having a diameter determined according to the scattering characteristics of the object to be examined.

5. 发明公开

EP1493123A1 MODIFICATION OF THE NORMALIZED DIFFERENCE METHOD FOR REAL-TIME OPTICAL TOMOGRAPHY 审中-公开
标题翻译：为实时光学层析成像的归一化差的方法的变形例
公开(公告)号：EP1493123A1
公开(公告)日：2005-01-05
申请号：EP03717000.8
申请日：2003-04-07
申请人： Barbour, Randall L. , Pei, Yaling
发明人： Barbour, Randall L. , Pei, Yaling
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G01N21/359 , G01N21/4795 , G01N21/49 , G01N2021/1787 , G01N2021/475 , G01N2201/0826 , G01N2201/0833
摘要： Computation -saving techniques and stability-adding techniques provide for fast, accurate reconstructions of a time series of images involving large scale 3D problems, such as real-time image recovery in an optical tomography imaging system. A system equation for a target medium (116) such as a tissue is solved using a Normalized Difference Method (NDM) (250). Because of the inherent stability of the NDM solutions, a weight matrix (W) of the system equation can be provided for a given point in a time series (220), then reused without recalculation at subsequent points. Further saving are achieved by decomposing W using singular value decomposition or direst matrix decomposition, transforming it to reduce its dimensions, and/or scaling it to achieve a more stable numerical solution. Values of measured energy (112) emerging from the target medium are back-substituted into the system equation for the different points to obtain the target medium properties.

6. 发明申请

US20040010397A1 Modification of the normalized difference method for real-time optical tomography 有权
标题翻译：用于实时光学层析成像的归一化差分法的修改
公开(公告)号：US20040010397A1
公开(公告)日：2004-01-15
申请号：US10408511
申请日：2003-04-07
发明人： Randall L. Barbour , Yaling Pei
IPC分类号： G06F015/00
CPC分类号： G06T11/006 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G01N21/359 , G01N21/4795 , G01N21/49 , G01N2021/1787 , G01N2021/475 , G01N2201/0826 , G01N2201/0833
摘要： Computation-saving techniques and stability-adding techniques provide for fast, accurate reconstructions of a time series of images involving large-scale 3D problems, such as real-time image recovery in an optical tomography imaging system. A system equation for a target medium (116) such as tissue is solved using a Normalized Difference Method (NDM) (250). Because of the inherent stability of the NDM solutions, a weight matrix (W) of the system equation can be provided for a given point in a time series (220), then reused without recalculation at subsequent points. Further savings are achieved by decomposing W using singular value decomposition or direct matrix decomposition, transforming it to reduce its dimensions, and/or scaling it to achieve a more stable numerical solution. Values of measured energy (112) emerging from the target medium are back-substituted into the system equation for the different points to obtain the target medium properties.
摘要翻译：计算节省技术和稳定性增加技术提供了涉及大规模3D问题的时间序列图像的快速，精确重建，例如光学层析成像系统中的实时图像恢复。使用归一化差分法（NDM）（250）解决诸如组织的目标介质（116）的系统方程式。由于NDM解决方案的固有稳定性，可以为时间序列（220）中的给定点提供系统方程的权重矩阵（W），然后在后续点重新计算。通过使用奇异值分解或直接矩阵分解来分解W来实现进一步的节省，将其变换以减小其尺寸，和/或缩放以实现更稳定的数值解。从目标介质出现的测量能量（112）的值被替代为不同点的系统方程，以获得目标介质特性。

7. 发明授权

US6008889A Spectrometer system for diagnosis of skin disease 失效
标题翻译：光谱仪系统诊断皮肤病
公开(公告)号：US6008889A
公开(公告)日：1999-12-28
申请号：US843605
申请日：1997-04-16
申请人： Haishan Zeng , Harvey Lui , Calum MacAulay , Branko Palcic , David I. McLean
发明人： Haishan Zeng , Harvey Lui , Calum MacAulay , Branko Palcic , David I. McLean
IPC分类号： A61B5/00 , A61B5/103 , G01N21/64 , G01N21/65 , G01B9/02 , G01N11/00
CPC分类号： G01N21/474 , A61B5/0059 , A61B5/0071 , A61B5/444 , G01N21/645 , G01N21/6486 , G01N21/65 , G01N2021/475 , G01N2021/6417 , G01N2021/656 , G01N2201/0627
摘要： Apparatus for diagnosis of a skin disease site using spectral analysis includes a light source for generating light to illuminate the disease site and a probe unit optically connected to the light source for exposing the disease site to light to generate fluorescence and reflectance light. The probe unit also collects the generated fluorescence and reflectance light and transmits this light to a spectrometer to be analysed. The spectrometer generates and displays spectral measurements of the fluorescence light and the reflectance light which in together assist the user in diagnosing the disease site. The apparatus makes use of a conventional personal computer using a plug-in spectrometer card to provide a compact and low cost system. The system performs combined fluorescence and reflectance spectral analysis in a quick and efficient manner to provide a powerful tool for dermatologic diagnosis.
摘要翻译：用于使用光谱分析诊断皮肤疾病部位的装置包括用于产生照亮疾病部位的光的光源和与光源光学连接的探针单元，用于将疾病部位暴露于光以产生荧光和反射光。探针单元还收集产生的荧光和反射光，并将该光传输到要分析的光谱仪。光谱仪产生和显示荧光和反射光的光谱测量，这些在一起协助用户诊断疾病部位。该装置利用使用插入式光谱仪卡的常规个人计算机来提供紧凑且低成本的系统。该系统以快速有效的方式进行组合荧光和反射光谱分析，为皮肤病诊断提供强大的工具。

8. 发明授权

US3751643A System for performing spectral analyses under computer control 失效
公开(公告)号：US3751643A
公开(公告)日：1973-08-07
申请号：US3751643D
申请日：1972-05-23
申请人： IBM
发明人： DILL F , KONNERTH K
IPC分类号： G01B11/06 , G06F17/00 , G01B9/02 , G01B19/08
CPC分类号： G01B11/0633 , G01N21/55 , G01N21/8422 , G01N2021/475 , G01N2021/551 , G01N2201/0826 , G01N2201/0833
摘要： Measurements of physical attributes such as dielectric film thickness that are susceptible to spectral analysis are accomplished rapidly and accurately by a spectrophotometric system in which a programmed digital computer operating concurrently with the optical scanning means automatically performs the calibrating, normalizing and data reducing functions that otherwise must be carried out as time-consuming human, mechanical or analog electronic operations. The control over the optical data handling operations exercised by the computer eliminates the need for mechanically or electronically adjusting the optical apparatus to meet changing system conditions, whether periodic or aperiodic. Source light is transmitted through a rotating variable-wavelength interference filter which acts during one-half of its cycle to transmit light of varying wavelength through a fiber-optic reference path directly to the optical data acquisition apparatus, while acting in the next half-cycle to transmit light of such varying wavelength indirectly to said data acquisition apparatus through a measurement path. In the present example, where film thickness is the attribute being measured, the measurement path comprises a bifurcated fiber-optic bundle, one branch of which is used to carry the light of variable wavelength to the sample, and the other branch of which carries light reflected from the sample to the aforesaid data acquisition apparatus. A computer program enables light passed through the reference path in one half-cyle to calibrate the system for measuring optical transmission or reflectance in the next half-cycle. Reduction of relative reflectance data to absolute reflectance data (needed for the accurate determination of film thickness) is accomplished by additional computer programs whose algorithms are based upon the discovery that all graphs of absolute reflectance versus wavelength for film samples of a given material having different thicknesses are bounded by a common pair of wave envelopes.

9. 发明授权

US09329124B2 Scattered light measurement apparatus 有权
标题翻译：分散光测量装置
公开(公告)号：US09329124B2
公开(公告)日：2016-05-03
申请号：US14638167
申请日：2015-03-04
申请人： OLYMPUS CORPORATION
发明人： Ryosuke Ito
IPC分类号： G01N21/55 , G01N21/47 , A61B1/00 , A61B1/04 , A61B1/07
CPC分类号： G01N21/474 , A61B1/00167 , A61B1/042 , A61B1/07 , A61B5/0059 , G01N2021/4745 , G01N2021/475
摘要： A scattered light measurement apparatus includes an optical measurement apparatus, and a scattered light measurement probe configured to irradiate an object with light from the optical measurement apparatus, configured to receive light from the object, and configured to output the received light to the optical measurement apparatus. The optical measurement apparatus includes: a light source configured to emit light including at least light of a measurement target wavelength; first and second optical detectors configured to detect the light received by the scattered light measurement probe; a branching unit configured to guide the light from the light source to the scattered light measurement probe and guide the light from the scattered light measurement probe to the first and second optical detectors; and a control unit configured to evaluate scattering characteristics of a surface layer of the object based on the light detected by the first and second optical detectors.
摘要翻译：散射光测量装置包括光学测量装置和被配置为从物体照射来自光学测量装置的光的散射光测量探头，被配置为将所接收的光输出到光学测量装置。光学测量装置包括：光源，被配置为发射至少包括测量目标波长的光的光; 第一和第二光学检测器，被配置为检测由散射光测量探针接收的光; 分支单元，被配置为将来自光源的光引导到散射光测量探针，并将来自散射光测量探针的光引导到第一和第二光学检测器; 以及控制单元，其被配置为基于由所述第一和第二光学检测器检测到的光来评估所述物体的表面层的散射特性。

10. 发明申请

US20130256534A1 OPTICAL ANALYZER FOR IDENTIFICATION OF MATERIALS USING REFLECTANCE SPECTROSCOPY 有权
标题翻译：使用反射光谱鉴别材料的光学分析仪
公开(公告)号：US20130256534A1
公开(公告)日：2013-10-03
申请号：US13836854
申请日：2013-03-15
申请人： INNOVATIVE SCIENCE TOOLS, INC.
发明人： Ronald H Micheels , Don J Lee
IPC分类号： G01N21/25
CPC分类号： G01N21/255 , G01J3/021 , G01J3/0218 , G01J3/18 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N21/8507 , G01N21/9508 , G01N2021/475 , G01N2021/4759 , G01N2201/0627 , G01N2201/0631 , G02B6/4298
摘要： A device and method for identifying solid and powdered materials use near-infrared reflection spectroscopy combined with multivariate calibration methods for analysis of the spectral data. Near-infrared reflection spectroscopy is employed within either the 700-1100 nm or the 900-1700 nm wavelength range to identify solid or powdered materials and determine whether they match specific known materials. Uses include identifying solid and powdered materials with a fast measurement cycle time of about 2 to 15 seconds and with a method that requires no sample preparation, as well as quantitative analysis to determine the concentration of one or more chemical components in a solid or powdered sample that consists of a mixture of components. A primary application involving identification analysis verification of the identify and purity of powdered materials used for fabricating drug tablets and capsules for quality control purposes.
摘要翻译：用于识别固体和粉末材料的装置和方法使用近红外反射光谱结合多变量校准方法来分析光谱数据。在700-1100nm或900-1700nm波长范围内采用近红外反射光谱法来鉴定固体或粉末材料，并确定它们是否与特定的已知材料相匹配。用途包括以大约2至15秒的快速测量周期时间识别固体和粉末材料，并采用不需要样品制备的方法，以及定量分析来确定固体或粉末样品中一种或多种化学成分的浓度它由组分的混合物组成。涉及用于制造药物片剂和胶囊用于质量控制目的的粉末材料的鉴定和纯度的识别分析验证的主要应用。

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