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    • 4. 发明公开
    • PORTABLE ELECTRONIC SYSTEM FOR THE ANALYSIS OF TIME-VARIABLE GASEOUS FLOWS
    • 便携式电子系统用于分析时变气体流动
    • EP3167270A1
    • 2017-05-17
    • EP15753766.3
    • 2015-07-02
    • Nanotech Analysis S.r.l.s.
    • MENSA, GianpieroCORREALE, Raffaele
    • G01N1/22H01J49/04B01L3/00H01J49/00G01N30/72
    • G01N30/722G01N30/7206H01J49/0018H01J49/0427
    • A portable system 1 for analyzing gaseous flows that vary over time is described, the system comprising a sampling chamber 18, a gas sampling module 7, an ion filtering module 8 and an ion detecting module 9. The sampling chamber 18 is suitable to be kept at a controlled sampling pressure Pc, and is configured to receive at least one gaseous flow F having a gaseous composition to be analyzed that is variable over time. The gas sampling module 7, arranged in fluidic communication with the sampling chamber 18, is configured to adjust an input gaseous flow Fi of gas particles from the sampling chamber 18, and an output gaseous flow Fo from the sampling module 7, so as to reproduce inside the sampling module 7 a gaseous composition representative of the gaseous composition to be analyzed. The gas sampling module 7 is further configured to ionize said gas particles and to emit the produced ions, so as to generate an ion flow I having an ion composition representative of the gaseous composition to be analyzed. The sampling module 7 is also suitable to maintain inside it a controlled ionization pressure Pi, and it is also configured in such a way that the input gaseous flow Fi comprises a plurality of micro-flows at a molecular or predominantly molecular regime, at the sampling pressure Pc, and the output gaseous flow Fo is a flow at a molecular or predominantly molecular regime, at the ionization pressure Pi. The ion filtering module 8 is operatively connected to the sampling module 7 to receive the ion flow I, and is configured to controllably select at least one type of ion present in the ion flow I and to generate a corresponding at least one homogeneous ion beam I′, having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module 9 is operatively connected to the ion filtering module 8 to receive the at least one ion beam I′, and is configured to measure the intensity of the at least one ion beam I′ and to generate a corresponding electric signal S representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed.
    • 描述了用于分析随时间变化的气流的便携式系统1,该系统包括采样室18,气体采样模块7,离子过滤模块8和离子检测模块9.采样室18适于保持 处于受控采样压力Pc处,并且被配置成接收具有随时间变化的待分析气体组分的至少一个气流F. 布置成与采样室18流体连通的气体采样模块7构造成调节来自采样室18的气体颗粒的输入气体流量Fi和来自采样模块7的输出气体流量Fo,以便再现 在采样模块7内部提供代表待分析气体组合物的气态组合物。 气体采样模块7还被配置为将所述气体粒子离子化并发射产生的离子,以便产生具有代表待分析气体组分的离子组成的离子流I. 采样模块7也适合于在其内部保持受控的电离压力P 1,并且其还被配置为使得输入气体流量F 1在分子或主要分子状态下包括多个微流量 压力Pc,并且输出气体流量Fo是在电离压力Pi下的分子或主要分子状态下的流量。 离子过滤模块8可操作地连接到采样模块7以接收离子流I,并且被配置为可控制地选择存在于离子流I中的至少一种类型的离子并且生成相应的至少一个均匀离子束I ',具有代表待分析气体组合物中相应气体颗粒浓度的强度。 离子检测模块9可操作地连接到离子过滤模块8以接收至少一个离子束I',并且被配置为测量至少一个离子束I'的强度并且产生相应的电信号S代表 的待分析气体组合物中相应气体颗粒的浓度。
    • 6. 发明申请
    • CALIBRATION OF MASS SPECTROMETRY SYSTEMS
    • 质谱系统校准
    • US20130043380A1
    • 2013-02-21
    • US13661486
    • 2012-10-26
    • AGILENT TECHNOLOGIES, INC.
    • RAFFAELE CORREALE
    • H01J49/04H01J49/26
    • G01N1/2202G01N30/722H01J49/0009H01J49/0427
    • A method for operating a mass spectrometer (MS) includes establishing a pressure differential across a membrane wherein an upstream pressure in a calibrant gas inlet line on an upstream side of the membrane is greater than a downstream pressure in an ion source on a downstream side of the membrane; flowing a calibrant gas from the calibrant gas inlet line, through a nano-scale orifice of the membrane, and into the ion source; and maintaining the upstream pressure at a constant value. The calibrant may be flowed at a low flow rate. An MS system includes a membrane interposed between a calibrant gas introduction system and a mass spectrometer. The membrane may include an orifice of nano-scale diameter.
    • 用于操作质谱仪(MS)的方法包括建立跨膜的压力差,其中膜上游侧的校准气体入口管线中的上游压力大于离子源的下游侧的离子源的下游压力 膜; 将来自校准气体入口管线的校准气体通过膜的纳米级孔口流入离子源; 并将上游压力保持在恒定值。 校准物可以以低流速流动。 MS系统包括插入校准气体导入系统和质谱仪之间的膜。 膜可以包括纳米级直径的孔口。
    • 7. 发明申请
    • GC-MS ANALYSIS APPARATUS
    • GC-MS分析仪
    • US20110006201A1
    • 2011-01-13
    • US12831921
    • 2010-07-07
    • Raffaele Correale
    • Raffaele Correale
    • B01D59/44
    • G01N1/2202G01N30/722H01J49/0422
    • GC-MS analysis apparatus has an interface section between GC and MS sections, which is located with respect to the direction of an analyte flow downstream of the GC section and upstream of the MS section. The interface section comprises at least one membrane with at least one orifice capable of establishing a molecular flow condition in the analyte passing between the GC and MS sections through the membrane. The membrane is subjected to a pressure differential such that the pressure pa in a region located upstream of the membrane is higher than the pressure pb in a region located downstream of the membrane.
    • GC-MS分析装置具有在GC和MS部分之间的界面部分,其相对于GC部分的下游和MS部分的上游处的分析物流的方向定位。 所述界面部分包括至少一个具有至少一个孔的膜,所述孔能够通过所述膜在GC和MS部分之间通过分析物建立分子流动状态。 使膜受到压差,使得位于膜上游的区域中的压力pa高于位于膜下游的区域中的压力pb。