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1. 发明公开

CN105448640A 具有温控供气装置的电离室有权转让
公开(公告)号：CN105448640A
公开(公告)日：2016-03-30
申请号：CN201510501116.8
申请日：2015-08-14
申请人：布鲁克道尔顿有限公司
发明人：安德列亚斯·布雷肯费尔德 , 马丁·恩格尔
IPC分类号： H01J49/10 , H01J49/16
CPC分类号： H01J49/0486 , C03B19/12 , C04B35/14 , H01J49/0422 , H01J49/044 , H01J49/045 , H01J49/0477 , H01J49/10 , Y02P40/57
摘要：本发明涉及与质谱仪连接的电离室。电离室有温控块，温控块有进气口和气道，气道始于进气口并通向出气口。温控装置沿气道放置，从而确保气道中流动的气体在进入电离室之前达到特定温度，即被加热或冷却。温控块具有成型件，所述成型件通过溶胶-凝胶工艺制成并且所述气道的结构结合在所述成型件中。

2. 发明公开

CN109643636A 带有辅助加热气体喷流的低温等离子体探针有权
公开(公告)号：CN109643636A
公开(公告)日：2019-04-16
申请号：CN201780052694.5
申请日：2017-07-24
申请人：史密斯探测公司
发明人： V·贝尔库特 , T·D·索尔
IPC分类号： H01J49/10 , H01J49/16 , H01J49/26 , H01J27/02 , G01N27/62 , G01N30/72
CPC分类号： H01J49/062 , H01J49/0027 , H01J49/0404 , H01J49/0477 , H01J49/105 , H01J49/26
摘要：本发明公开了一种低温等离子体探针和质谱系统以及使用低温等离子体探针的方法。在一种实施方式中，该低温等离子体探针包括一个进气毛细管，提供从样品表面到质谱仪的离子流；至少一个低温等离子体管，提供低温等离子体气体；至少一个加热气体管，向样品表面提供加热气体，其中，加热气体增强样品表面的样品的解吸和电离。

3. 发明授权

CN105448640B 具有温控供气装置的电离室有权转让
公开(公告)号：CN105448640B
公开(公告)日：2017-06-13
申请号：CN201510501116.8
申请日：2015-08-14
申请人：布鲁克道尔顿有限公司
发明人：安德列亚斯·布雷肯费尔德 , 马丁·恩格尔
IPC分类号： H01J49/10 , H01J49/16
CPC分类号： H01J49/0486 , C03B19/12 , C04B35/14 , H01J49/0422 , H01J49/044 , H01J49/045 , H01J49/0477 , H01J49/10 , Y02P40/57
摘要：本发明涉及与质谱仪连接的电离室。电离室有温控块，温控块有进气口和气道，气道始于进气口并通向出气口。温控装置沿气道放置，从而确保气道中流动的气体在进入电离室之前达到特定温度，即被加热或冷却。温控块具有成型件，所述成型件通过溶胶‑凝胶工艺制成并且所述气道的结构结合在所述成型件中。

4. 发明授权

US07132670B2 Apparatus and method for ion production enhancement 有权
公开(公告)号：US07132670B2
公开(公告)日：2006-11-07
申请号：US11015190
申请日：2004-12-16
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

5. 发明申请

US20050274905A1 Apparatus and method for ion production enhancement 有权
标题翻译：用于离子生产增强的装置和方法
公开(公告)号：US20050274905A1
公开(公告)日：2005-12-15
申请号：US11155070
申请日：2005-06-16
申请人： Timothy Joyce , Jean-Luc Truche , Jian Bai
发明人： Timothy Joyce , Jean-Luc Truche , Jian Bai
IPC分类号： H01J27/00 , H01J49/16
CPC分类号： H01J49/164 , H01J49/0422 , H01J49/0477 , H01J49/0486
摘要： The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.
摘要翻译：本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。离子源还可以包括温度传感器。加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。还公开了具有基于基质的离子源的质谱仪系统。还提供了使用被加热到预定温度的气体产生离子的方法。

6. 发明授权

US4804839A Heating system for GC/MS instruments 失效
标题翻译： GC / MS仪器加热系统
公开(公告)号：US4804839A
公开(公告)日：1989-02-14
申请号：US070458
申请日：1987-07-07
申请人： Carolyn C. Broadbent , John C. Fjeldsted
发明人： Carolyn C. Broadbent , John C. Fjeldsted
IPC分类号： G01N27/62 , G01N30/30 , G01N30/72 , H01J49/04
CPC分类号： H01J49/0477 , G01N30/7206 , G01N2030/3015
摘要： In a gas chromatograph/mass spectrometer (GC/MS) instrument, an improved heating system includes an interface between the gas chromatograph and mass spectrometer portions of the instrument, a radiator located within a vacuum chamber of the mass spectrometer, a thermal coupler attaching the interface to the radiator, and a heat source which directly heats the interface and indirectly heats the radiator via conduction through the thermal coupler. The heating system uses a single heating element located externally to the vacuum system of the mass spectrometer to produce a multiplicity of temperatures for the interface and various portions of the mass spectrometer.

7. 发明申请

US20160086784A1 IONIZATION CHAMBER WITH TEMPERATURE-CONTROLLED GAS FEED 有权
标题翻译：具有温度控制气体进料的离子室
公开(公告)号：US20160086784A1
公开(公告)日：2016-03-24
申请号：US14826388
申请日：2015-08-14
申请人： Bruker Daltonik GmbH
发明人： Andreas BREKENFELD , Martin ENGEL
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/0486 , C03B19/12 , C04B35/14 , H01J49/0422 , H01J49/044 , H01J49/045 , H01J49/0477 , H01J49/10 , Y02P40/57
摘要： The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material.
摘要翻译：本发明涉及一种用于连接到质谱仪的电离室。电离室具有温度控制块，其具有气体入口和气体通道，其从气体入口开始并导入气体出口。温度控制装置沿着气体通道定位，并且确保在气体通道中流动的气体在进入电离室之前被带到特定温度，即被加热或冷却。温度控制块具有形成部分，其中结合有气体通道的结构，并且其通过溶胶 - 凝胶法制造，例如由玻璃或陶瓷材料制成。

8. 发明申请

US20050072918A1 Apparatus and method for ion production enhancement 有权
公开(公告)号：US20050072918A1
公开(公告)日：2005-04-07
申请号：US10966278
申请日：2004-10-15
申请人： Jean-Luc Truche , Jian Bal
发明人： Jean-Luc Truche , Jian Bal
IPC分类号： H01J49/04 , H01J49/16 , H01J49/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

9. 发明授权

US06593568B1 Atmospheric pressure ion sources 有权
标题翻译：大气压离子源
公开(公告)号：US06593568B1
公开(公告)日：2003-07-15
申请号：US09324401
申请日：1999-06-02
申请人： Craig M. Whitehouse , Bruce A. Andrien, Jr. , Michael A. Sansone , Clement Catalano
发明人： Craig M. Whitehouse , Bruce A. Andrien, Jr. , Michael A. Sansone , Clement Catalano
IPC分类号： B01D5944
CPC分类号： H01J49/0477 , H01J49/0404 , H01J49/044
摘要： An Atmospheric Pressure Ion (API) source is configured for Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) operating modes. The API source includes a multipurpose heater assembly mounted in the API source chamber. The multipurpose heater supplies heat to the API chamber endplate, bath gas and entrance end of the capillary orifice into vacuum as well as supplying electrical connections to the API source elements. An additional heater is configured at the exit end of the capillary orifice into vacuum. With this configuration, the bath gas, endplate and capillary entrance temperature can be set independent of gas flow rate. The capillary exit and entrance temperatures can be set independently as well. The multipurpose endplate heater combined with the capillary exit heater allows the optimization of API source performance over a wide range of operating conditions and analytical applications.
摘要翻译：大气压离子（API）源被配置用于电喷雾（ES）和大气压化学电离（APCI）操作模式。 API源包括安装在API源室中的多用途加热器组件。多功能加热器将API室端板，浴室气体和毛细孔入口端的热量提供到真空中，并向API源元件提供电气连接。另外的加热器配置在毛细管孔的出口端进入真空。通过这种配置，浴气，终板和毛细管入口温度可独立于气体流量设定。毛细管出口和入口温度也可以独立设置。多用途终板加热器与毛细管出口加热器相结合，可以在广泛的操作条件和分析应用中优化API源性能。

10. 发明申请

WO1995019638A2 ION SPRAY WITH INTERSECTING FLOW 审中-公开
标题翻译：离子喷雾与交联流
公开(公告)号：WO1995019638A2
公开(公告)日：1995-07-20
申请号：PCT/CA1995000014
申请日：1995-01-09
申请人： MDS HEALTH GROUP LIMITED , COVEY, Thomas, R. , ANACLETO, Joseph, F.
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： H01J49/04
CPC分类号： H01J49/165 , G01N30/7246 , H01J49/044 , H01J49/0477
摘要： Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube (40') producing a flow in a first direction of charged droplets (50'). A flow of heated gas (60), in a second direction different from the first direction, intersects the droplet flow at a region (64) upstream of an orifice (20'). The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice (20'), providing a focusing effect. Ions are drawn through the orifice (20') into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and an increase in the number of charges on them, without degrading the ions.
摘要翻译：来自液相色谱仪或其它样品源的液体优选由高速同轴气体射流辅助通过毛细管（40'）喷射，产生沿带电液滴（50'）的第一方向的流动。在与第一方向不同的第二方向上的加热气体（60）的流动在孔口（20'）上游的区域（64）处与液滴流相交。流动紊乱地混合，第二流有助于蒸发液滴以产生离子并帮助将蒸发的液滴移向孔口（20'），从而提供聚焦效果。离子通过孔口（20'）被吸入质量分析器并进行分析。或者，液体和加热气体的流动可以彼此指向并且通过孔口与轴线成直角，并且可以使用孔口的吸入效应来朝向其喷射液滴，或者可以使用第三气流这个目的加热的相交气流通常提供10至100倍的灵敏度（每秒离子计数）的增加。加热液滴羽流还允许控制离子的去饱和和其上的电荷数量的增加，而不降低离子。

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