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1. 发明授权

US06755786B2 Ultrasonic diagnostic imaging with elevation biplane images 有权
标题翻译：超声诊断成像与高程双平面图像
公开(公告)号：US06755786B2
公开(公告)日：2004-06-29
申请号：US10448517
申请日：2003-05-30
申请人： Janice Frisa , McKee Dunn Poland
发明人： Janice Frisa , McKee Dunn Poland
IPC分类号： A61B812
CPC分类号： G01S15/8925 , A61B8/483 , G01S7/52046 , G01S7/52063 , G01S7/52073 , G01S7/52074 , G01S7/5208 , G01S7/52085 , G01S15/8936 , G01S15/8993
摘要： An ultrasonic diagnostic imaging system is described in which two planes of a volumetric region which are in different elevation planes are scanned in real time. In one embodiment the two planes are scanned in the sector format with a common apex, causing corresponding depths of the two images to be separated by the same distance in elevation. In another embodiment one image plane has a fixed orientation with respect to the imaging probe and the location of the other image plane can be adjusted by the user.
摘要翻译：描述了超声诊断成像系统，其中在不同仰角平面上的体积区域的两个平面被实时扫描。在一个实施例中，两个平面以具有公共顶点的扇形格式扫描，导致两个图像的对应深度在高程上分开相同的距离。在另一个实施例中，一个图像平面相对于成像探针具有固定的取向，另一个图像平面的位置可由用户调整。

2. 发明授权

US06702744B2 Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery 失效
公开(公告)号：US06702744B2
公开(公告)日：2004-03-09
申请号：US10011071
申请日：2001-11-30
申请人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
发明人： Evgenia Mandrusov , Murthy V. Simhambhatla , Syed Hossainy , Eugene T. Michal , Charles Claude , Jessica G. Chiu
IPC分类号： A61B812
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/02007 , A61B5/4839 , A61B17/3478 , Y10S977/905 , Y10S977/915
摘要： A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.

3. 发明授权

US06689066B1 Ultrasonic probe 有权
标题翻译：超声波探头
公开(公告)号：US06689066B1
公开(公告)日：2004-02-10
申请号：US10309390
申请日：2002-12-03
申请人： Masayoshi Omura , Hiroshi Fukuda
发明人： Masayoshi Omura , Hiroshi Fukuda
IPC分类号： A61B812
CPC分类号： A61B8/12 , A61B8/445
摘要： An ultrasonic transducer is provided at the distal end of a sheath included in an inserting portion of an ultrasonic probe for performing ultrasonic diagnosis. The ultrasonic transducer can transmit and receive ultrasound through an acoustic window 38 facing against the ultrasonic transducer through an acoustic medium filled around the ultrasonic transducer. At least the acoustic window is formed of a resin including a mixture of polyamide block and polyether ester block copolymer resin and polyurethane. Thus, multiple reflection, for example, can be reduced in the vicinity of the acoustic windows. Furthermore, the sheath portion may be formed of the same resin. Thus, the sheath portion can be inserted through an endoscope channel, for example, smoothly with less buckling.
摘要翻译：超声波换能器设置在超声波探头的插入部的护套的前端，用于进行超声波诊断。超声波换能器可以通过面向超声换能器的声窗38通过填充在超声波换能器周围的声学介质来发射和接收超声波。至少声窗由包括聚酰胺嵌段和聚醚酯嵌段共聚物树脂和聚氨酯的混合物的树脂形成。因此，例如在声窗附近可以减少多次反射。此外，护套部分可以由相同的树脂形成。因此，护套部可以例如通过内窥镜通道平滑地插入，而弯曲较少。

4. 发明授权

US06679849B2 Ultrasonic tee probe with two dimensional array transducer 有权
标题翻译：超声波探头采用二维阵列传感器
公开(公告)号：US06679849B2
公开(公告)日：2004-01-20
申请号：US10318790
申请日：2002-12-13
申请人： David G. Miller , Michael Peszynski , Heather Beck
发明人： David G. Miller , Michael Peszynski , Heather Beck
IPC分类号： A61B812
CPC分类号： A61B5/6819 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/4488 , A61B8/483 , A61B2562/0204 , A61B2562/046 , G01S7/52033 , G01S7/52036 , G01S7/52061 , G01S7/52074 , G01S7/52079 , G01S15/8925 , G01S15/8927
摘要： A semi-invasive ultrasound imaging system for imaging biological tissue includes a transesophageal probe or a transnasal, transesophageal probe connected to a two-dimensional ultrasound transducer array, a transmit beamformer, a receive beamformer, and an image generator. The two-dimensional transducer array is disposed on a distal portion of the probe's elongated body. The transmit beamformer is connected to the transducer array and is constructed to transmit several ultrasound beams over a selected pattern defined by azimuthal and elevation orientations. The receive beamformer is connected to the transducer array and is constructed to acquire ultrasound data from the echoes reflected over a selected tissue volume. The tissue volume is defined by the azimuthal and elevation orientations and a selected scan range. The receive beamformer is constructed to synthesize image data from the acquired ultrasound data. The image generator is constructed to receive the image data and generate images that are displayed on an image display. Preferably, the image generator is constructed to generate, from the image data, several orthographic projection views over the selected tissue volume.
摘要翻译：用于成像生物组织的半侵入式超声成像系统包括连接到二维超声换能器阵列的经食道探针或经鼻，经食管探针，发射波束形成器，接收波束形成器和图像发生器。二维换能器阵列设置在探头的细长体的远端部分上。发射波束形成器连接到换能器阵列，并被构造成在由方位和仰角定向的选定图案上传输若干超声波束。接收波束成形器连接到换能器阵列，并被构造成从在所选择的组织体积上反射的回波获取超声数据。组织体积由方位角和仰角取向以及选定的扫描范围限定。接收波束形成器被构造成从所获取的超声数据合成图像数据。图像生成器被构造为接收图像数据并生成显示在图像显示器上的图像。优选地，图像生成器被构造为从图像数据生成在所选择的组织体积上的若干正投影视图。

5. 再颁专利

USRE38209E1 Diagnostic ultrasound system 失效
标题翻译：诊断超声系统
公开(公告)号：USRE38209E1
公开(公告)日：2003-08-05
申请号：US09073876
申请日：1998-05-07
申请人： Nobuo Yamazaki , Fumiyasu Sakaguchi
发明人： Nobuo Yamazaki , Fumiyasu Sakaguchi
IPC分类号： A61B812
CPC分类号： G01S7/52071 , G01N29/0609 , G01S7/5206 , G01S15/8979 , G01S15/899
摘要： A diagnostic ultrasound system is provided for displaying a color image of a motion of a tissue scans an ultrasonic pulse signal along a tomographic plane to acquire an electrical echo signal, extracts a Doppler signal from the echo signal, calculates velocity data concerning the motion of the tissue for respective sample points on the tomographic plane on the basis of the Doppler signal, and forms data of a B-mode tomographic image on the basis of the echo signal. The system comprises an element for setting a scale along which each of the velocity data over a measurable band of frequencies of the Doppler signal is assigned to each gradation data for color display, the measurable band of frequencies being limited by a pulse repetition frequency of the ultrasonic pulse signal and a given low-velocity band of the measurable frequency band being enhanced in the gradation data than a remaining velocity band of the measurable band, an element for converting the velocity data into the gradation data according to the scale, an element for blanking either one of the converted gradation data and the calculated velocity data at every sample point when each of them exceeds a specified threshold, and an element for displaying the velocity color image subjected to blanking and superimposed on the B-mode tomographic image.

6. 发明授权

US06589174B1 Technique and apparatus for ultrasound therapy 有权
标题翻译：超声治疗技术与装置
公开(公告)号：US06589174B1
公开(公告)日：2003-07-08
申请号：US09692448
申请日：2000-10-20
申请人： Rajiv Chopra , Michael J. Bronskill
发明人： Rajiv Chopra , Michael J. Bronskill
IPC分类号： A61B812
CPC分类号： A61N7/02 , A61B17/2251 , A61B2018/1861 , A61N2007/0073 , A61N2007/0078 , A61N2007/025 , B06B1/067 , G10K9/122 , G10K11/02
摘要： The present invention is directed to an imaging-compatible device for insertion into a region of tissue under image guidance, which employs ultrasound energy for the generation of thermal lesions. Coagulation can be confined to particular sectors in tissue through rotational control of the device. The depth of coagulation can be controlled through simultaneous modulation of the operating frequencies and powers. Described is a device which comprises a transducer located within a housing suitable for tissue insertion. The transducer comprises at least one piezoceramic element with at least one acoustic matching layer comprising a high acoustic impedance material for generating acoustic energy in narrow passbands around multiple resonant frequencies with high acoustic efficiency. The magnitude and frequency of the electrical power delivered to each element can be manipulated simultaneously providing control over the 3-dimensional shape of the thermal lesion created in tissue.
摘要翻译：本发明涉及用于插入到图像引导下的组织区域中的成像兼容装置，该装置采用超声波能量来产生热损伤。通过设备的旋转控制，凝血可以局限在组织中的特定部分。可以通过同时调制工作频率和功率来控制凝结深度。描述了一种装置，其包括适于组织插入的壳体内的换能器。换能器包括至少一个压电陶瓷元件，其中至少一个声匹配层包括用于在具有高声学效率的多个谐振频率周围的窄通带中产生声能的高声阻抗材料。可以同时操作输送到每个元件的电功率的幅度和频率，从而控制在组织中产生的热损伤的三维形状。

7. 发明授权

US06585660B2 Signal conditioning device for interfacing intravascular sensors having varying operational characteristics to a physiology monitor 有权
公开(公告)号：US06585660B2
公开(公告)日：2003-07-01
申请号：US09861464
申请日：2001-05-18
申请人： Dale Gene Dorando , Paul Michael Hoseit , Michael J. Eberle , Janette D. Gabbrielli , Marc A. Shell
发明人： Dale Gene Dorando , Paul Michael Hoseit , Michael J. Eberle , Janette D. Gabbrielli , Marc A. Shell
IPC分类号： A61B812
CPC分类号： A61B5/0215 , A61B5/743 , A61B2560/0252 , A61B2560/045 , A61B2562/085 , Y10S128/92
摘要： A signal conditioning device is disclosed that interfaces a variety of sensor devices, such as guide wire-mounted pressure sensors, to physiology monitors. The signal conditioning device includes a processor for controlling sensor excitation and signal conditioning circuitry within the signal conditioning device. The processor also supplies signals to an output stage on the signal conditioning device representative of processed sensor signals received by a sensor interface of the signal conditioning device. Power for the signal conditioning device processor is supplied by an excitation signal received from a physiology monitor that drives the output stage. In addition, a temperature compensating current source provides an adjustment current to at least one of a pair of resistive sensor elements to compensate for differences between temperature change upon the pair of resistive sensor elements, thereby facilitating nullifying temperature effects upon the resistive sensor elements.

8. 发明授权

US06475148B1 Medical diagnostic ultrasound-aided drug delivery system and method 有权
标题翻译：医学诊断超声辅助药物输送系统及方法
公开(公告)号：US06475148B1
公开(公告)日：2002-11-05
申请号：US09696411
申请日：2000-10-25
申请人： John I. Jackson , Edward A. Gardner
发明人： John I. Jackson , Edward A. Gardner
IPC分类号： A61B812
CPC分类号： A61B8/481 , A61B5/0456 , A61M31/00 , A61M37/0092
摘要： A method and system is provided for delivering drugs carried by microspheres. A medical diagnostic ultrasound system destroys microspheres in a specific localized area or at a specific time. A region of interest that is a subset of an imaged area is identified for destroying drug-carrying microspheres. The transmit beamformer is configured to transmit acoustic energy for destroying microspheres within that area while minimizing the destruction of microspheres outside of the region of interest. A multidimensional transducer array may provide focusing in three-dimensions for accurately destroying microspheres in the specific region while minimizing the destruction of microspheres outside that region. A trigger responsive to a heart or breathing cycle may control when microspheres are destroyed, providing delivery of drugs at the most opportune time in the cycle.
摘要翻译：提供用于输送由微球携带的药物的方法和系统。医疗诊断超声系统在特定局部区域或特定时间破坏微球。鉴定为成像区域的子集的感兴趣区域用于破坏携带药物的微球体。发射波束形成器被配置为传输用于破坏该区域内的微球的声能，同时最小化感兴趣区域外的微球的破坏。多维换能器阵列可以提供三维聚焦以精确地破坏特定区域中的微球，同时最小化该区域外的微球的破坏。响应于心脏或呼吸循环的触发器可以控制微球被破坏时，在循环中最合适的时间提供药物的递送。

9. 发明授权

US06375615B1 Tissue penetrating catheters having integral imaging transducers and their methods of use 有权
标题翻译：具有整体成像传感器的组织穿透导管及其使用方法
公开(公告)号：US06375615B1
公开(公告)日：2002-04-23
申请号：US09282774
申请日：1999-03-31
申请人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
发明人： J. Christopher Flaherty , Jason B. Whitt , John Y. Chang , David R. Tholfsen , Philip C. Evard , Joshua Makower
IPC分类号： A61B812
CPC分类号： A61B17/3403 , A61B1/3137 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B17/11 , A61B17/12109 , A61B17/12172 , A61B17/3207 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22069 , A61B2017/22072 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00869 , A61B2018/1425 , A61B2090/378 , A61B2090/3784 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61K31/195 , A61M25/0133 , A61M25/0152 , A61M29/00 , A61M29/02 , A61M2025/0076 , A61M2025/018 , A61M2025/1052
摘要： A catheter device that is useable to penetrate from a blood vessel in which the catheter device is positioned to a target location comprises a flexible catheter advanceable into the first blood vessel, a tissue penetrator lumen adapted to receive an operative tissue penetrator which is usable to penetrate from the blood vessel to the target location when properly aimed. Further said catheter including an imaging transducer fixedly mounted on or within the catheter body to provide an imaging signal from which an image of the target location can be obtained. The catheter device may include an imageable marker on the catheter to form on the image obtainable from the imaging signal a penetrator path indication that indicates the path that will be followed by the tissue penetrator when the tissue penetrator exits from the catheter. Alternatively, or addition thereto, the imaging transducer may comprise a plurality of imaging elements which are located so that the penetrator path indication can be obtained. A method of utilizing such a catheter device to bypass an arterial obstruction is also disclosed.
摘要翻译：可用于从其中导管装置定位到目标位置的血管穿透的导管装置包括可推进到第一血管的柔性导管，适于接收可用于穿透的手术组织穿透器的组织穿透器腔从正确瞄准的血管到目标位置。另外所述导管包括固定地安装在导管主体上或导管本体内的成像传感器，以提供成像信号，从该成像信号可以获得目标位置的图像。导管装置可以包括导管上的可成像标记，以在成像信号上形成图像，该穿透器路径指示指示当组织穿透器从导管离开时将由组织穿透器跟随的路径。或者，或者除此之外，成像换能器可以包括多个成像元件，其被定位成可以获得穿透器路径指示。还公开了利用这种导管装置绕过动脉阻塞物的方法。

10. 发明授权

US06248076B1 Ultrasound imaging guidewire with static central core and tip 有权
标题翻译：超声成像导丝带静电中心芯和尖端
公开(公告)号：US06248076B1
公开(公告)日：2001-06-19
申请号：US09625168
申请日：2000-07-25
申请人： David A. White , W. Martin Belef
发明人： David A. White , W. Martin Belef
IPC分类号： A61B812
CPC分类号： A61B8/12 , A61B8/4461 , A61M25/09
摘要： An ultrasound imaging guidewire, that is inserted into a patient's body. The guidewire has a static central core and an imaging guidewire body comprising an acoustical scanning device. The acoustical scanning device can be rotated to obtain 360 degree acoustical images of a site of interest in the patients body. Furthermore, the imaging guidewire includes a connector that permits the imaging guidewire body to be disengaged from the static central core tip so that the imaging guidewire body can be axially translated to obtain multi-position imaging. The imaging guidewire body is axially translated without losing the original guidewire positioning because the static central core maintains its position in the patient's body.
摘要翻译：超声成像导丝，其被插入患者体内。引导线具有静电中心芯和包括声学扫描装置的成像导丝主体。可以旋转声学扫描装置以获得患者身体中感兴趣的部位的360度声学图像。此外，成像引导线包括允许成像导丝主体从静态中心芯尖脱离的连接器，使得成像导丝主体可以被轴向平移以获得多位置成像。成像导丝主体轴向平移而不会损失原始的导丝定位，因为静态中心芯保持其在患者体内的位置。

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