专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06291528B1 Prostaglandin E1/F2 in combination with prostaglandin F2&agr; for enhancing female sexual arousal 失效
标题翻译：前列腺素E1 / F2与前列腺素F2alpha联合用于增强女性性唤起
公开(公告)号：US06291528B1
公开(公告)日：2001-09-18
申请号：US09422031
申请日：1999-10-20
申请人： Nathan Earl Scott
发明人： Nathan Earl Scott
IPC分类号： A61K315575
CPC分类号： A61K31/5575 , A61K9/0034 , A61K31/557 , A61K2300/00
摘要： A method of treating and a composition for treating female sexual arousal dysfunction, comprising administering to the patient a unit dose of a formulation comprising an effective amount of a prostaglandin, selected from prostaglandin E1, prostaglandin E2, pharmaceutically acceptable salts thereof and physiologically acceptable esters thereof, wherein the prostaglandin is formulated with prostaglandin F2&agr;, together with a pharmaceutically acceptable delivery medium and/or a lubricant.
摘要翻译：一种治疗方法和用于治疗女性性唤醒功能障碍的组合物，其包括向患者施用单位剂量的包含有效量的前列腺素（选自前列腺素E1，前列腺素E2，其药学上可接受的盐和其生理学上可接受的酯）的制剂，其中前列腺素与前列腺素F2α配制，以及药学上可接受的递送介质和/或润滑剂。

2. 发明授权

US06531485B2 Prostaglandin agonists 失效
标题翻译：前列腺素激动剂
公开(公告)号：US06531485B2
公开(公告)日：2003-03-11
申请号：US09446099
申请日：1999-12-16
申请人： Kimberly O. Cameron , Paul A. DaSilva-Jardine
发明人： Kimberly O. Cameron , Paul A. DaSilva-Jardine
IPC分类号： A61K315575
CPC分类号： C07D333/28 , C07C405/00 , C07D209/08 , C07D217/16 , C07D277/24 , C07D311/20 , C07D317/54
摘要： This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
摘要翻译：本发明涉及前列腺素激动剂，使用这种前列腺素激动剂的方法，含有这种前列腺素激动剂的药物组合物和含有这种前列腺素激动剂的试剂盒。前列腺素激动剂可用于治疗包括骨质疏松症在内的骨疾病。

3. 发明授权

US06197821B1 Endothelin antagonist 有权
标题翻译：内皮素拮抗剂
公开(公告)号：US06197821B1
公开(公告)日：2001-03-06
申请号：US09355270
申请日：1999-07-27
申请人： Ryuji Ueno
发明人： Ryuji Ueno
IPC分类号： A61K315575
CPC分类号： A61K31/5575 , A61K31/557
摘要： The present invention provides an antagonist for endothelin which is considered to have a relation to hypertension, Buerger is disease, asthma, eyegrounds diseases, and the like. Said endothelin antagonist contains 15-keto-prostaglandin E compounds, especially 13,14-dihydro-15-keto-16-mono or dihalo-prostaglandins.
摘要翻译：本发明提供了内皮素的拮抗剂，其被认为与高血压有关，Buerger是疾病，哮喘，眼底疾病等。所述内皮素拮抗剂含有15-酮前列腺素E化合物，特别是13,14-二氢-15-酮-16-单或二卤代前列腺素。

4. 发明授权

US06414022B2 Cyclopentane(ENE)heptenoic or heptenoic acids and derivatives thereof useful as therapeutic agents 有权
标题翻译：环戊烷（ENE）庚烯或庚烯酸及其衍生物可用作治疗剂
公开(公告)号：US06414022B2
公开(公告)日：2002-07-02
申请号：US09919318
申请日：2001-07-31
申请人： Robert M. Burk
发明人： Robert M. Burk
IPC分类号： A61K315575
CPC分类号： A61K31/5585 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C405/0058 , Y10S514/912
摘要： The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
摘要翻译：本发明涉及7- [5-羟基-2-（羟基烃基或杂原子取代的羟基烃基）-3-羟基 - 环戊基（烯基）]庚酸或庚烯酸和所述酸的衍生物，其中一个或多个所述羟基被醚基取代。本发明的化合物是有效的眼睛低血压剂，特别适用于治疗青光眼。

5. 发明授权

US06172109B2 13-Thia prostaglandins for use in glaucoma therapy 失效
标题翻译：用于青光眼治疗的13-Thia前列腺素
公开(公告)号：US06172109B2
公开(公告)日：2001-01-09
申请号：US09077507
申请日：1998-06-03
申请人： Paul W. Zinke , Mark R. Hellberg
发明人： Paul W. Zinke , Mark R. Hellberg
IPC分类号： A61K315575
CPC分类号： C07C405/0033
摘要： 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
摘要翻译： 13-thia前列腺素可用于治疗青光眼和高眼压症。还公开了包含所述前列腺素的眼科药物组合物。

6. 发明授权

US06767920B2 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure 失效
标题翻译： 3,7或3和7和硫代前列腺酸衍生物作为降低眼内压的药物
公开(公告)号：US06767920B2
公开(公告)日：2004-07-27
申请号：US10346828
申请日：2003-01-16
申请人： Robert M. Burk , Mark Holoboski , Mari F. Posner
发明人： Robert M. Burk , Mark Holoboski , Mari F. Posner
IPC分类号： A61K315575
CPC分类号： A61K31/559 , A61K31/5575 , Y10S514/913
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein hatched lines represent the &agr; configuration, a triangle represents the &bgr; configuration, a wavy line represents the &agr; configuration or the &bgr; configuration and a dotted line represents the presence or absence of a double bond; A and B are independently selected from the group consisting of O, S and CH2; provided that at least one of A or B is S; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 or Y is O, OH, OCOR2, halogen or cyano; Z is CH2 or a covalent bond; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl or alkenyl and R3 is benzothienyl, benzofuranyl, naphthyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR.
摘要翻译：本发明提供一种治疗眼高血压或青光眼的方法，其包括向具有高眼压症或青光眼的动物施用治疗有效量的由通式I表示的化合物;其中阴影线表示α构型，三角形表示β构型波浪线表示α构型或β构型，虚线表示双键的存在或不存在; A和B独立地选自O，S和CH 2;条件是至少一个A 或B是S; D表示共价键或CH 2，O，S或NH; X是CO 2 R，CONR 2，CH 2 OR，P（O）（OR）2，CONRSO 2 R SONR2或Y是O，OH，OCOR 2，或氰基; Z是CH 2或共价键; R是H或R 2; R 1是H，R 2，苯基或COR 2; R 2是C 1 -C 5低级烷基或烯基，R 3是苯并噻吩基，苯并呋喃基，萘基或其取代的衍生物，其中取代基可以选自由C 1 -C 5烷基，卤素，CF 3，CN，NO 2，NR 2，CO 2 R和OR组成的组。

7. 发明授权

US06706755B2 Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents 有权
标题翻译：环戊烷庚烷（烯）酰基磺酰胺，2-烷基或2-芳基烷基或2-杂芳基烯基衍生物作为治疗剂
公开(公告)号：US06706755B2
公开(公告)日：2004-03-16
申请号：US10228412
申请日：2002-08-26
申请人： David W. Old , Robert M. Burk
发明人： David W. Old , Robert M. Burk
IPC分类号： A61K315575
CPC分类号： C07C405/0041
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein a hatched line represents the &agr; configuration, a triangle represents the &bgr; configuration, a straight line, e.g. at the 9, 11 or 15 position represents either the &agr; or &bgr; configuration, a dotted line represents the presence or absence of a double bond; a wavy line represents a cis or trans bond; X is O, S, NH or (CH2)n; n is 0 or an integer of from 1 to 4; Y is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl, pyridinyl, thiazolyl, benzothienyl, benzofuranyl, naphthyl, or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, N(R2)2, CO2R2 and OR2; Z is (CH2)n or a covalent bond; R is C1-C6 lower alkyl or Z-CF3 or mesylate or triflate; R1 is H, R2 or COR2; and R2 is H or C1-C5 lower alkyl or 9, 11 or 15 esters thereof.
摘要翻译：本发明提供一种治疗眼高血压或青光眼的方法，其包括向具有高眼压症或青光眼的动物施用治疗有效量的由通式I表示的化合物;其中阴影线表示α构型，三角形表示β 配置，直线，例如在9,11或15位置表示α或β构型，虚线表示存在或不存在双键; 波浪线代表顺式或反式键; X为O，S，NH或（CH 2）n; n为0或1至4的整数; Y为C 1 -C 5正烷基，C 3 -C 7环烷基，苯基呋喃基，噻吩基，吡啶基，噻唑基，苯并噻吩基，苯并呋喃基，萘基或其取代的衍生物，其中取代基可以选自C 1 -C 5烷基，卤素，CF 3，CN，NO 2，N（R 2） 2，CO 2 R 2和OR 2; Z是（CH 2）n或共价键; R是C 1 -C 6低级烷基或Z-CF 3或甲磺酸酯或三氟甲磺酸酯; R 1是H，R 2，或COR 2; 和R 2是H或C 1 -C 5低级烷基或9,11或15个酯。

8. 发明授权

US06531504B2 Prostanoic acid derivatives as agents for lowering intraocular pressure 有权
标题翻译：前列腺酸衍生物作为降低眼内压的药物
公开(公告)号：US06531504B2
公开(公告)日：2003-03-11
申请号：US09859770
申请日：2001-05-17
申请人： Robert M. Burk , Todd S. Gac
发明人： Robert M. Burk , Todd S. Gac
IPC分类号： A61K315575
CPC分类号： C07D333/62 , A61K31/381 , A61K31/5575 , C07D333/28 , C07D333/60
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein hatched lines represent the &agr; configuration, a triangle represents the &bgr; configuration and a dotted line represents the presence or absence of a double bond; A and B are CH2; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 or Y is O, OH, OCOR2, halogen or cyano; Z is CH2 or a covalent bond; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl or alkenyl and R3 is benzothienyl, benzofuranyl, naphthyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR.
摘要翻译：本发明提供一种治疗眼高血压或青光眼的方法，其包括向具有高眼压症或青光眼的动物施用治疗有效量的由通式I表示的化合物;其中阴影线表示α构型，三角形表示β构型并且虚线表示双键的存在或不存在; A和B为CH 2; D表示共价键或CH 2，O，S或NH; X为CO 2 R，CONR 2，CH 2 OR，P（O），CONRSO 2 R SONR2或Y为O，OH，OCOR 2，卤素或氰基; Z为CH 2或共价键; R为H或R 2; R 1为H，R 2，苯基或COR 2; R 2为C 1 -C 5低级烷基或烯基， R3是苯并噻吩基，苯并呋喃基，萘基或其取代衍生物，其中取代基可以选自C1-C5烷基，卤素，CF3，CN，NO2，NR2，CO2R和OR。

9. 发明授权

US06288119B1 11,15-O-dialkylprostaglandin E derivatives, process for producing the same, and drugs containing the same as the active ingredient 有权
标题翻译： 11,15-O-二烷基前列腺素E衍生物，其制备方法和含有与活性成分相同的药物
公开(公告)号：US06288119B1
公开(公告)日：2001-09-11
申请号：US09355626
申请日：1999-08-02
申请人： Shuichi Ohuchida , Takayuki Maruyama
发明人： Shuichi Ohuchida , Takayuki Maruyama
IPC分类号： A61K315575
CPC分类号： A61K31/5575 , C07C405/00
摘要： The present invention provides 11,15-O-dialkyl prostaglandin E derivatives of formula (I) (wherein all symbols are as described in Specification), or non-toxic salts thereof or cyclodextrin clathrates thereof, processes for the preparation thereof and pharmaceutical compositions containing them as active ingredient. A compound of formula (I) binds strongly and acts on EP3 receptor which is a subtype of PGE2 receptor and therefore is useful for prevention and/or treatment of liver diseases, kidney diseases, pancreatitis, myocardial infarction etc.
摘要翻译：本发明提供式（I）（其中所有符号如说明书中所述）的11,15-O-二烷基前列腺素E衍生物或其无毒盐或环糊精包合物，其制备方法和含有它们作为活性成分。式（I）化合物强烈结合并作用于作为PGE2受体亚型的EP3受体，因此可用于预防和/或治疗肝脏疾病，肾脏疾病，胰腺炎，心肌梗死等。

10. 发明授权

US06716876B2 Cyclopentane(ENE)heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents 失效
标题翻译：环戊烷（ENE）庚烯或庚酸及其衍生物可用作治疗剂
公开(公告)号：US06716876B2
公开(公告)日：2004-04-06
申请号：US10087867
申请日：2002-02-28
申请人： Robert M. Burk
发明人： Robert M. Burk
IPC分类号： A61K315575
CPC分类号： A61K31/5585 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C405/0058 , Y10S514/912
摘要： The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
摘要翻译：本发明涉及7- [5-羟基-2-（羟基烃基或杂原子取代的羟基烃基）-3-羟基 - 环戊基（烯基）]庚酸或庚烯酸和所述酸的衍生物，其中一个或多个所述羟基被醚基取代。本发明的化合物是有效的眼睛低血压剂，特别适用于治疗青光眼。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式