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2. 发明申请

WO9708262A3 Helicenes exhibiting enhanced optical rotatory power 审中-公开
标题翻译： Helicenes表现出增强的旋光力
公开(公告)号：WO9708262A3
公开(公告)日：1997-04-24
申请号：PCT/US9613553
申请日：1996-08-21
申请人： KATZ THOMAS J , NUCKOLLS COLIN P , UNIV COLUMBIA
发明人： KATZ THOMAS J , NUCKOLLS COLIN P
IPC分类号： C07C50/36 , C07C69/00 , G02F1/361 , F21V9/00 , C07C49/115 , C07C255/00 , C07C325/00 , C08F261/10 , C08F269/00 , C08F271/02 , C08F273/00 , F21V9/14 , G02F1/035 , G02F1/13
CPC分类号： G02F1/3617 , C07C50/36 , C07C69/33 , C07C2603/54 , G02F1/361 , G02F1/3612 , G02F1/3616
摘要： This invention provides an aggregate of a compound capable of forming helical structures such that the aggregate is capable of achieving a specific rotation of at least 100,000° for plane polarized light having a wavelength of 589 nm.
摘要翻译：本发明提供具有以下结构的化合物：其中环A和B表示独立的电子接受环体系，其中R1，R2，R3，R4，R5，R6，R7和R8相同或不同，为H，取代或未取代的，饱和或不饱和的烷基，烯基，环烷基，芳基或芳基烷基，-SR，-NRR'，-OR，-OC（O）R，SC（O）R，-SCR，其中R和R'独立地是取代或未取代的，饱和或不饱和的烷基，烯基，环烷基，芳基或芳基烷基。本发明还提供了包含具有上述结构的化合物或其合适的衍生物的薄膜。本发明还提供了包含具有上述结构的化合物或其合适的衍生物的液晶显示装置和非线性光学装置。最后，本发明提供了一种实现高阶非线性电光响应的方法，包括将本发明化合物或其衍生物的合适样品与合适的光源接触。

3. 发明申请

WO8604234A3 THROMBOXANE ANTAGONISTS IN THE TREATMENT OF HORMONE-DEPENDENT NEOPLASIAS 审中-公开
标题翻译：治疗依赖于雌激素的血栓素拮抗剂
公开(公告)号：WO8604234A3
公开(公告)日：1986-09-12
申请号：PCT/GB8600028
申请日：1986-01-16
申请人： NAT RES DEV , SENIOR JUDITH , TROUGHTON KAY MARIE
发明人： SENIOR JUDITH , TROUGHTON KAY MARIE
IPC分类号： C07C281/06 , A61K31/175 , A61K31/557 , C07C67/00 , C07C239/00 , C07C313/00 , C07C323/44 , C07C325/00 , C07C337/06 , C07C405/00 , C07D493/00
CPC分类号： C07C405/0091 , A61K31/175 , A61K31/557
摘要： Compounds having thromboxane antagonist activity are of use in the treatment of hormone-dependent neoplasias for example oestrogen-dependent neoplasias. Thromboxane antagonists of particular value are compounds of formula (I) wherein formula (II) represents one of the divalent cyclic groups (III). The letters a and b indicating in each case the points of attachment of the substituents R1 and CV(R2)-NV'R, respectively; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, (b) reduction of the double bond, (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups, (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atoms separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy groups; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R2 is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -NH.CO.NH-R3 or -NH.CS.NH-R3 wherein R3 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom.

4. 发明申请

WO9420062A3 BALANOIDS 审中-公开
公开(公告)号：WO9420062A3
公开(公告)日：1996-08-15
申请号：PCT/US9402283
申请日：1994-03-02
申请人： NICHOLS GINA M & LF , SPHINX PHARMA CORP , HALL STEVEN EDWARD , BALLAS LAWRENCE M , KULANTHAIVEL PALANIAPPAN , BOROS CHRISTIE , JIANG JACK B , JAGDMANN GUNNAR ERIK JR , LAI YEN SHI , BIGGERS CHRISTOPHER K , HU HONG , HALLOCK YALI , HUGHES PHILIP F , DEFAUW JEAN MARIE , LYNCH MICHAEL PATRICK , LAMPE JOHN WILLIAM CROSSLEY , MENALDINO DAVID STEVEN , HEERDING JULIA MARIE , JANZEN WILLIAM P , HOLLINSHEAD SEAN PATRICK
发明人： HALL STEVEN EDWARD , BALLAS LAWRENCE M , KULANTHAIVEL PALANIAPPAN , BOROS CHRISTIE , JIANG JACK B , JAGDMANN GUNNAR ERIK JR , LAI YEN-SHI , BIGGERS CHRISTOPHER K , HU HONG , HALLOCK YALI , HUGHES PHILIP F , DEFAUW JEAN MARIE , LYNCH MICHAEL PATRICK , LAMPE JOHN WILLIAM CROSSLEY , MENALDINO DAVID STEVEN , HEERDING JULIA MARIE , JANZEN WILLIAM P , HOLLINSHEAD SEAN PATRICK , NICHOLS JEFFREY BAILEY
IPC分类号： C07D333/36 , A61K31/165 , A61K31/24 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/50 , A61K31/55 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07C69/734 , C07C233/23 , C07C233/41 , C07C235/48 , C07C235/54 , C07C235/84 , C07C255/52 , C07C311/09 , C07C325/00 , C07D207/14 , C07D207/48 , C07D211/56 , C07D223/12 , C07D257/04 , C07D307/22 , C07D313/04 , C07D337/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07F9/572 , A61K
CPC分类号： C07D257/04 , C07C235/54 , C07C255/52 , C07C311/09 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/14 , C07D207/48 , C07D211/56 , C07D223/12 , C07D313/04 , C07D337/04 , C07D401/12 , C07D417/12 , C07F9/5721
摘要： A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases related to protein kinase C in animals, especially humans and is especially indicated for treatment of inflammatory diseases.
摘要翻译：公开了一类新型的治疗化合物，称为平衡物。平衡蛋白在蛋白激酶C的同种型中具有蛋白激酶C抑制活性和选择性。平衡物可用于治疗动物，特别是人类中与蛋白激酶C相关的疾病，并且特别用于治疗炎性疾病。

5. 发明申请

WO8800940A3 HEXASUBSTITUTED CYCLOHEXANE COMPOUNDS 审中-公开
标题翻译： HEXASUTERTITUTED CYCLOHEXANE化合物
公开(公告)号：WO8800940A3
公开(公告)日：1988-02-25
申请号：PCT/EP8700318
申请日：1987-06-19
申请人： MERCK PATENT GMBH , PRAEFCKE KLAUS , KOHNE BERND , DORSCH DIETER , RIEGER BERNHARD
发明人： PRAEFCKE KLAUS , KOHNE BERND , DORSCH DIETER , RIEGER BERNHARD
IPC分类号： C07C43/18 , C07C41/00 , C07C43/196 , C07C43/20 , C07C45/00 , C07C49/76 , C07C67/00 , C07C69/75 , C07C213/00 , C07C227/00 , C07C231/00 , C07C233/16 , C07C241/00 , C07C253/00 , C07C313/00 , C07C325/00 , C08F2/46 , C08F2/48 , C08F2/54 , C08F4/06 , C08F4/28 , C08F4/42 , C08F4/46 , C09K19/06 , C09K19/30 , C09K19/34 , C07C93/24 , C07C117/00
CPC分类号： C07C247/00 , C09K19/3001 , C09K19/34
摘要： Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases.

6. 发明申请

WO8800940A2 HEXASUBSTITUTED CYCLOHEXANE COMPOUNDS 审中-公开
标题翻译：六取代环己烷化合物
公开(公告)号：WO8800940A2
公开(公告)日：1988-02-11
申请号：PCT/EP8700318
申请日：1987-06-19
申请人： MERCK PATENT GMBH
发明人： PRAEFCKE KLAUS , KOHNE BERND , DORSCH DIETER , RIEGER BERNHARD
IPC分类号： C07C43/18 , C07C41/00 , C07C43/196 , C07C43/20 , C07C45/00 , C07C49/76 , C07C67/00 , C07C69/75 , C07C213/00 , C07C227/00 , C07C231/00 , C07C233/16 , C07C241/00 , C07C253/00 , C07C313/00 , C07C325/00 , C08F2/46 , C08F2/48 , C08F2/54 , C08F4/06 , C08F4/28 , C08F4/42 , C08F4/46 , C09K19/06 , C09K19/30 , C09K19/34
CPC分类号： C07C247/00 , C09K19/3001 , C09K19/34
摘要： Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases.
摘要翻译：六取代的环己烷化合物可以用作盘状液晶相的组分。

7. 发明申请

WO1991015474A1 PEROXY ACID BLEACH PRECURSORS AND DETERGENT COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：过氧酸漂白前驱物和含有它们的洗涤剂组合物
公开(公告)号：WO1991015474A1
公开(公告)日：1991-10-17
申请号：PCT/US1991001700
申请日：1991-03-14
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , HARDY, Frederick, Edward
IPC分类号： C07C325/00
CPC分类号： C07D295/13 , C07C233/91 , C07C305/06 , C07C305/24 , C07C309/15 , C07C309/51 , C11D3/3917
摘要： Novel highly water-soluble peroxyacid bleach precursor compounds are described of general formula (I), where R is methyl or ethyl, A is a C2-C6 alkylene, or phenylene group and Y is a sulphate, sulphonate quaternary ammonium or morpholinium group. Laundry bleaching and detergent compositions containing a source of alkaline hydrogen peroxide and one of said peroxyacid bleach precursor compounds provide enhanced bleaching and reduced colour and fabric damage relative to that provided by conventional precursors, at wash temperatures from 10 DEG C to 60 DEG C.
摘要翻译：描述了通式（I）的新型高度水溶性过氧酸漂白剂前体化合物，其中R是甲基或乙基，A是C2-C6亚烷基或亚苯基，Y是硫酸根，磺酸根季铵或吗啉基。含有碱性过氧化氢源和所述过氧酸漂白剂前体化合物之一的洗衣漂白剂和洗涤剂组合物在10℃至60℃的洗涤温度下提供了增强的漂白和相对于常规前体提供的颜色和织物损伤。

8. 发明申请

WO8900422A3 THIOSULPHINIC ACID DERIVATIVES, THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES, AND DRUGS CONTAINING THEM 审中-公开
标题翻译：硫唑嘌呤酸衍生物，它们在治疗炎症疾病中的应用，以及含有它们的药物
公开(公告)号：WO8900422A3
公开(公告)日：1989-03-09
申请号：PCT/EP8800628
申请日：1988-07-12
申请人： BOEHRINGER MANNHEIM GMBH
发明人： DORSCH WALTER , WAGNER HILDEBERT
IPC分类号： A61K31/33 , A61K31/10 , A61K31/21 , A61K31/255 , A61K31/35 , A61K31/44 , A61K31/445 , A61K31/535 , A61K36/896 , A61P9/00 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C325/00 , C07C331/00 , C07C381/00 , C07D521/00 , C07C161/00
CPC分类号： A61K31/35 , A61K31/21 , A61K31/44 , A61K31/445 , A61K31/535 , C07C381/00 , Y10S514/825 , Y10S514/826
摘要： Thiosulphinic acid derivatives, drugs containing these compounds, and their medicinal use. It has been discovered that thiosulphinic acid derivatives possess excellent anti-inflammatory properties. These compounds are particularly advantageous in the treatment of inflammatory processes induced by the platelet activation factor (PAF) in the bronchi.

9. 发明申请

WO8704427A3 PROSTAGLANDIN SYNTHESIS 审中-公开
标题翻译：前列腺素合成
公开(公告)号：WO8704427A3
公开(公告)日：1987-12-03
申请号：PCT/GB8700019
申请日：1987-01-15
申请人： NAT RES DEV
发明人： JONES ROBERT LESLIE , WILSON NORMAN HAPPER
IPC分类号： C07C69/03 , C07B61/00 , C07C51/00 , C07C51/353 , C07C59/125 , C07C59/205 , C07C59/80 , C07C67/00 , C07C67/347 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/82 , C07C325/00 , C07C327/24 , C07C405/00 , C07D493/08 , C07C69/708
CPC分类号： C07D493/08 , C07C59/80 , C07C405/0091
摘要： A process for the preparation of a compound of formula (I), wherein X and X' each represents hydrogen or together represent a bridging group -CH2-, -CH2-CH2- or -O-; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, with the proviso that in the modified group the double bond is not in the alpha-beta position relative to the ring; (b) reduction of the double bond; (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups; (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom, with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atomes separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy group; R2 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R3, R4, R5 and R6 are each hydrogen, or R3 and R4 together and/or R5 and R6 together represent the second bond of a carbon-carbon double bond; comprises effecting a Diels Alder reaction between a diene of formula (II) and a dienophile of formula (III), wherein X, X' and R2 are as defined for (I); Y is R1 or a precursor therefor in which a double bond is present and/or the terminal group is in different form, either being a free carboxy group rather than the carboxy group derivative present in R1 or being a carboxy group derivative rather than the free carboxy group present in R1; and R and R' are either each hydrogen or together represent the third bond of a carbon-carbon triple bond; and where appropriate thereafter, in either order, reducing the double bond or bonds in the ring of the Diels Alder adduct and/or converting the group Y to the group R1. The compounds prepared by this process are of value as intermediates for the preparation of biologically active compounds.
摘要翻译：制备式（I）化合物的方法，其中X和X'各自代表氢或一起代表桥基-CH 2 - ， - CH 2 -CH 2 - 或-O-; R1是6-羧基己-2-烯基或其修饰，其中该基团被以下的一个或两个或更多个的适当组合改变：（a）改变双键的位置，与条件是在修饰基团中双键不在相对于环的α-β位; （b）减少双键; （c）通过减少一个或两个亚甲基或增加一个至六个亚甲基而改变链长; （d）分别用氧或硫原子分别置换一个或两个亚甲基，条件是在修饰基团中氧或硫原子相对于双键碳原子或羧基处于α位或其衍生物，并且至少2个碳原子分离任何一对氧原子和/或硫原子; 和（e）形成羧基的酰胺，酯或盐衍生物; R2是直接或通过氧或硫原子被芳基取代的脂族烃基或脂族烃基; 并且R3，R4，R5和R6各自为氢，或者R3和R4一起和/或R5和R6一起表示碳 - 碳双键的第二键; 包括在式（II）的二烯与式（III）的亲二烯体之间进行狄尔斯阿尔德反应，其中X，X'和R2如对（I）所定义; Y是R 1或其中存在双键的前体和/或末端基团是不同形式，或者是游离羧基而不是存在于R 1中的羧基衍生物或者是羧基衍生物而不是游离的存在于R1中的羧基; 并且R和R'各自为氢或一起表示碳 - 碳三键的第三键; 然后以任意次序，减少Diels Alder加合物的环中的双键或键和/或将基团Y转化为基团R1。通过该方法制备的化合物作为制备生物活性化合物的中间体是有价值的。

10. 发明授权

EP0703890B1 PROCESS FOR THE PREPARATION OF 3-(METHYLTHIO)PROPANAL 失效
标题翻译：用于生产3-（甲硫基）丙醛
公开(公告)号：EP0703890B1
公开(公告)日：1999-04-07
申请号：EP93922171.9
申请日：1993-09-09
申请人： Novus International, Inc.
发明人： HSU, Yung, C. , RUEST, Dennis, A.
IPC分类号： C07C319/18 , C07C47/02 , C07C325/00
CPC分类号： C07C319/18 , B01J2208/00716 , C07C45/35 , C07C45/783 , C07C45/81 , C07C47/22 , C07C323/22
摘要： A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl mercaptan and a catalyst for the reaction between methyl mercaptan and acrolein. The gaseous acrolein feed stream comprises acrolein vapor and non-condensable gas. Acrolein is transferred from the acrolein feed stream to the reaction medium and reacts with methyl mercaptan in that medium to produce a liquid reaction product containing 3-(methylthio)propanal. The non-condensable gas is separated from the liquid reaction product. The reaction product is divided into a product fraction and a circulating fraction, and the circulating fraction is recycled to the gas/liquid contact zone.

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