专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

GB2097785A NOVEL PURINE DERIVATIVES 未知
公开(公告)号：GB2097785A
公开(公告)日：1982-11-10
申请号：GB8122732
申请日：1979-05-03
申请人： BRISTOL MYERS CO
IPC分类号： C07D473/40 , A61K31/52 , A61K31/522 , A61P1/00 , A61P11/08 , C07D473/00 , C07D473/18 , C07D43/02

2. 发明专利

PA8550201A1 ANALOGOS DE PROSTAGLANDINA 未知
公开(公告)号：PA8550201A1
公开(公告)日：2003-02-14
申请号：PA8550201
申请日：2002-07-11
申请人： HOFFMANN LA ROCHE
发明人： WALKER KEITH ADRIAN MURRAY , ELWORTHY TODD RICHARD , MIRZADEGAN TARANEH , ROEPEL MICHAEL GARRET , SMITH DAVID BERNARD
IPC分类号： C02F1/00 , A61K31/20 , A61K31/4015 , A61K31/4025 , A61K31/4178 , A61P1/16 , A61P7/02 , A61P11/06 , A61P15/00 , A61P15/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P27/06 , A61P29/00 , A61P37/06 , C07D207/08 , C07D207/12 , C07D207/24 , C07D207/26 , C07D207/27 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07C177/00 , C07D43/02
摘要： LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA 1 O A ISOMEROS INDIVIDUALES, MEZCLAS RACEMICAS O NO RACEMICAS DE ISOMEROS, O A SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN LA QUE A, B, DE R1 A R6 Y Z TIENEN LOS SIGNIFICADOS DEFINIDOS EN LA REIVINDICACION 1. LA INVENCION SE REFIERE ADEMAS A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS, AL USO DE ESTOS COMPUESTOS COMO PRINCIPIOS ACTIVOS TERAPEUTICOS Y A METODOS DE OBTENCION DE DICHOS COMPUESTOS.

3. 发明专利

PA8603601A1 NUEVOS DERIVADOS DE INDOL COMO INHIBIDORES DEL FACTOR XA. 未知
公开(公告)号：PA8603601A1
公开(公告)日：2004-11-26
申请号：PA8603601
申请日：2004-05-19
申请人： AVENTIS PHARMA GMBH
发明人： NAZARE MARC , RITTER KURT , WEHNER VOLKMAR , LAUX VOLKER
IPC分类号： A61P7/02 , C07D413/14 , C07D473/02 , C07D475/02 , C07D487/02 , C07D43/02
摘要： ALA PRESENTEINVENCION SE REFIERE A COMPUESTOS DE LA FORMULA I, EN LA QUE R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G Y M TIENE LOS SIGNIFICADOS INDICADOS EN LAS REIVINDICACIONES. LOS COMPUESTOS DE LA FORMULA I SON COMPUESTOS FARMACOLOGICAMENTE ACTIVOS VALIOSOS. MUESTRAN UN FUERTE EFECTO ANTITROMBOTICO Y SON ADECUADOS, POR EJEMPLO, PARA LA TERAPIA Y PROFILAXIS DE TRASTORNOS CARDIOVASCULARES TALES COMO ENFERMEDADES TROMBOEMBOLICAS O REESTENOSIS. SON INHIBIDORES REVERSIBLES DE LAS ENZIMAS DE LA COAGULACION SANGUINEA FACTOR XA (FXA) Y/A FACTOR VIIA (FVIIA) Y, EN GENERAL, PUEDEN APLICARSE EN SITUACIONES EN LAS QUE ESTA PRESENTE UNA ACTIVIDAD INDESEADA DEL FACTOR XA Y/O FACTOR VII O EN SITUACIONES PARA CUYA CURACION O PREVENCION SE DESEA LA INHIBICION DEL FACTOR XA Y/O FACTOR VIIA. ADEMAS, LA INVENCION SE REFIERE A PROCESOS PARA LA PREPARACION DE COMPUESTOS DE LA FORMULA I, A SU USO, EN PARTICULAR COMO INGREDIENTES ACTIVOS EN PRODUCTOS FARMACEUTICOS, Y A PREPARACIONES FARMACEUTICAS QUE LOS CONTIENEN

4. 发明专利

PE20040120A1 DERIVADOS DE QUINOLINA COMO ANTAGONISTAS DE NPY 未知
公开(公告)号：PE20040120A1
公开(公告)日：2004-03-06
申请号：PE2003000111
申请日：2003-01-31
申请人： HOFFMANN LA ROCHE
发明人： PFLIEGER PHILIPPE , NETTEKOVEN MATTHIAS HEINRICH , MATTEI PATRIZIO , MUELLER WERNER
IPC分类号： A61K31/365 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/00 , A61P1/14 , A61P3/04 , A61P3/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P43/00 , C07D215/42 , C07D215/46 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/02 , C07D417/02 , C07D43/02
摘要： SE REFIERE A DERIVADOS DE QUINOLINA COMO ANTAGONISTAS DEL NEUROPEPTIDO Y (NPY), DE FORMULA I DONDE R1 Y R2 SON HIDROGENO, ALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ALQUILCARBONILO, CICLOALQUILCARBONILO, ARILO, ARALQUILO, ENTRE OTROS; O JUNTOS CON EL ATOMO DE N SON UN ANILLO HETEROCICLICO DE 5-10 ESLABONES QUE PUEDEN TENER UN SEGUNDO HETEROATOMO COMO N U O, Y ESTE ANILLO PUEDE TENER UNO O VARIOS SUSTITUYENTES COMO ALQUILO O ALCOXI; R3 ES HIDROGENO, ALQUILO, AMINO O HALOGENO; R4 ES HIDROGENO, HALOGENO, HETEROCICLILO, AMINO O ALQUILO; A ES UN ANILLO HETEROCICLICO SATURADO DE 5 A 7 ESLABONES QUE CONTIENE UN N QUE ESTA UNIDO AL ANILLO QUINOLINA Y PUEDE TENER UN SEGUNDO HETEROATOMO COMO O, S O N, Y ESTA EVENTUALMENTE SUSTITUIDOS DE UNA A TRES VECES POR ALQUILO, ALCOXI, HIDROXI, AMINO, ACETILAMINO, CIANO, HIDROXIALQUILO, ALCOXIALQUILO,ENTRE OTROS.SON COMPUESTOS PREFERIDOS: (2-METIL-4-PIRROLIDIN-1-IL-QUINOLIN-7-IL)-AMIDA DEL ACIDO CICLOPROPANOCARBOXILICO, 2,2-DIMETIL-N-(2-METIL-4-PIRROLIDIN-1-IL-QUINOLIN-7-IL)-PROPIONAMIDA, 4-(2-METIL-4-PIRROLIDIN-1-IL-QUINOLIN-7-ILAMINO)-BENZONITRILO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE OBTENCION DEL COMPUESTO Y A UNA COMPOSICION FARMACEUTICA .EL COMPUESTO PUEDE SER USADO PARA EL TRATAMIENTO Y PROFILAXIS DE LA ARTRITIS,ENFERMEDADES CARDIOVASCULARES,DIABETES,FALLO RENAL,TRANSTORNOS DE COMIDA Y OBESIDAD

5. 发明专利

AU4035672A DIBENZOCYCLOHEPTENE DERIVATIVES 未知
公开(公告)号：AU4035672A
公开(公告)日：1973-09-27
申请号：AU4035672
申请日：1972-03-23
申请人： HOFFMANN LA ROCHE
发明人： MAYER HANS JOHANN , WAGNER JANS PETER
IPC分类号： C07C47/453 , C07C49/563 , C07C57/50 , C07C61/39 , C07C61/40 , C07C62/32 , C07C62/38 , C07C271/24 , C07D209/48 , C07D339/06 , C07C91/02 , C07C87/24 , C07C87/26 , C07C87/40 , C07C91/14 , C07C103/12 , C07C103/19 , C07C103/34 , C07C103/58 , C07C103/86 , C07C119/00 , C07C125/06 , C07C131/00 , C07D31/00 , C07D43/02 , C07D51/70 , C07D87/22

6. 发明专利

DK109041C 未知
公开(公告)号：DK109041C
公开(公告)日：1968-03-11
申请号：DK113764
申请日：1964-03-06
申请人： PHILIP MORRIS INC
IPC分类号： A24B15/26 , A61K36/81 , C07D43/02 , A24B15/02
摘要： 1,024,284. Treating tobacco. PHILIP MORRIS Inc. March 6, 1964 [March 7, 1963], No. 9677/64. Heading A2C. In continuous process for selective removal and recovery of alkaloid from tobacco which includes the steps of extraction of tobacco with organic solvent, contacting the resultant alkaloid-laden solvent extract with brine to remove alkaloid selectively from the extract, re-cycling the alkaloid-relieved solvent to tobacco, recovering alkaloid from the brine and re-cycling the alkaloid-relieved brine for contacting with further alkaloid-laden solvent, the alkaloidladen solvent is contacted with the brine at a temperature substantially below that at which alkaloid untimately is recovered from the brine and at a pH below about 6.5, the resultant alkaloid-enriched brine is then warmed to a temperature at which an alkaloid phase separates from the brine, and the alkaloid phase is thereafter physically removed from the brine. The solvent and brine are contacted at a temperature below 10C and at a pH below 4.0. The pH of the alkaloid-enriched brine is increased to between 5.5 and 8, prior to recovery of the alkaloid. The tobacco is treated with organic solvent at a pH between 5.5 and 8, the moisture content of the tobacco being between 10 and 25%.

7. 发明专利

DZ2320A1 未知
公开(公告)号：DZ2320A1
公开(公告)日：2002-12-28
申请号：DZ970170
申请日：1997-09-29
申请人： SMITHKLINE BEECHAM CORP
IPC分类号： C07D223/00 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4704 , A61K31/495 , A61K31/52 , A61K31/55 , A61K31/551 , A61K33/243 , A61K45/06 , A61P9/00 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D223/16 , C07D233/56 , C07D233/64 , C07D235/18 , C07D235/22 , C07D243/14 , C07D401/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D487/00 , C07D43/02
摘要： Benzodiazepine compounds (I) of formula (I'; R = H), and their salts, are new: R1 = 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 3-4C oxoalkenyl, 3-4C oxoalkynyl, 1-4C aminoalkyl, 3-4C aminoalkenyl, 3-4C aminoalkynyl, (all optionally substituted by one A and one or more R10 or R7), H or R7; A = 3-6C cycloalkyl, Het or Ar; R7 = COR8, COC(R')2R9, C(S)R8, S(O)mOR', S(O)mNR'R'', PO(OR'), PO(OR')2, NO2 or tetrazolyl; R8 = OR', NR'R'', NR'SO2R', NR'OR' or OC(R')2COOR'; R9 = OR', CN, S(O)rR', S(O)mN(R')2, COR', CON(R')2 or COOR'; R10 = 1-6C alkyl, 1-6C oxoalkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C alkyloxy, 1-6C alkylamino, S(O)r-(1-6C alkyl) (all optionally substituted by A), H, OH, NH2, S(O)rH, OR11, CN, NR'R11, NO2, CF3, S(O)rCF3, COOR' or CON(R')2; R11 = R', COR', CON(R')2, COOR', S(O)mR' or S(O)mN(R')2; R2 = a group of formula (a)-(i); W = (CHRg)a-U-(CHRg)b; U = bond, CO, C(Rg)2, C(=CRg2), S(O)k, O, NRg, CRgORg, CRg(ORk)C(Rg)2, C(Rg)2CRg(ORk), COC(Rg)2, C(Rg)2C(O), CONRi, NRiCO, OC(O), C(O)O, C(S)O, OC(S), C(S)NRg, NRgC(S), S(O)2NRg, NRgS(O)2, N=N, NRgNRg, NRgC(Rg)2, C(Rg)2NRg, C(Rg)2O, OC(Rg)2, CC or CRg=CRg; G = NRe, S or O; Rg = H, 1-6C alkyl (optionally substituted by Het, 3-7C cycloalkyl or Ar) or Het, 3-7C cycloalkyl or Ar; Rk = Rg, CORg or COORf; Ri = Rg or 1-6C alkyl (substituted by 1-3 halo, CN, N(Rg)2, ORg, SRg, COORg or CON(Rg)2); Rf = H, Ar, or 1-6C alkyl (optionally substituted by Ar); Re = Rg or (CH2)kCOORg; Rb, Rc = H, A, 1-6C alkyl (optionally substituted by A), halo, CF3, ORf, S(O)kRf, CORf, NO2, N(Rf)2, CON(Rf)2 or CH2N(Rf)2; or Rb+Rc complete a 5-6 membered aromatic or non-aromatic carbocyclic or heterocyclic ring (optionally mono- to tri- substituted by halo, CF3, 1-4C alkyl, ORf, S(O)kRf, CORf, COORf, OH, NO2, N(Rf)2, CON(Rf)2, CH2N(Rf)2 or methylenedioxy; Q = C-Ry, and one Q may also be N; R' = H, Ar, 3-6C cycloalkyl or 1-6C alkyl (optionally substituted by Ar or (3-6C cycloalkyl); R'' = R', COR' or COOR'; Ry = H, halo, ORg, SRg, CN, NRgRk, NO2, CF3, S(O)rCF3, COORg, CORg, CON(Rg)2 or 1-6C alkyl (optionally substituted by halo, ORg, SRg, CN, NRgR'', NO2, CF3, S(O)rR', COORg, CORg or CON(Rg)2); a, b, k, r, s = 0-2; m = 1 or 2; u, v = 0 or 1. Also defined is a variable R''' = H, A, 1-6C alkyl (optionally substituted by A), halo, CF3, ORf, S(O)kRf, CORf, NO2, N(Rf)2, CON(Rf)2 or CH2N(Rf)2 which is not shown in the formula. Also claimed is a composition comprising (I), a carrier, and optionally an antineoplastic agent or inhibitor of bone resorption. Intermediates (II) of formula (I'; R = 1-6C alkyl).

8. 发明专利

IN145767B HOMOCYSTEINE THIOLACTONE A PROCESS FOR THE PREPARATION OF N-6-CHLORONICOTINOYL-D,L- 未知
公开(公告)号：IN145767B
公开(公告)日：1978-12-16
申请号：IN1234CA1977
申请日：1977-08-09
申请人： SIGMA TAU IND FARMACEUTI
发明人： TERESA R M , PAOLO D W
IPC分类号： C07D409/12 , A61K20060101 , A61K31/44 , A61K31/4433 , A61K31/455 , A61K31/585 , A61P1/16 , A61P3/06 , C07C69/68 , C07D20060101 , C07D213/26 , C07D213/56 , C07D213/80 , C07D213/82 , C07D309/30 , C07D333/20 , C07D333/36 , C07D401/00 , C07D43/02
摘要： N-6-chloronicotinoyl-d,l-homocysteine thiolactone of the formula (1) and method for its preparation are described. The compound has antilipolytic activity and is useful in compositions for treatment of conditions of elevated free fatty acid and triglyceride plasma levels.

9. 发明专利

CH523252A Procédé de préparation de nouveaux esters de l'acide nicotinique 未知
公开(公告)号：CH523252A
公开(公告)日：1972-05-31
申请号：CH248070
申请日：1970-02-20
申请人： ROUSSEL UCLAF
发明人： FRANCOIS CLEMENCE
IPC分类号： C07D213/80 , C07D43/02

10. 发明专利

DE1456603A1 未知
公开(公告)号：DE1456603A1
公开(公告)日：1969-01-02
申请号：DE1456603
申请日：1966-10-22
申请人： IMP TOBACCO COMPANY
发明人： GABRIEL LEWIS JAMES
IPC分类号： A24B15/24 , B01J8/16 , B01J8/30 , C07D43/02
摘要： 1,114,440. Treating tobacco. IMPERIAL TOBACCO CO. (OF GREAT BRITAIN AND IRELAND) Ltd. 7 Oct., 1966 [6 Nov., 1965], No. 47136/65. Heading A2C. [Also in Division F4] A method of maintaining a cohesive material in a fluidized state comprises urging gas through the material and simultaneously mechnically agitating the material. The method is particularly applicable to the removal of nicotine from ground tobacco. The tobacco, treated with alkali, is fed to a composite cylinder 10, comprising chambers 11, 12 and 13, through an inlet 16. Overflow passages 17 and 18 ensure distribution of the tobacco to chambers 12 and 13. The treated tobacco emerges through outlet 20. Steam is applied through inlet 14 and emerges, charged with nicotine, through outlet 15. The cylinder 10 is vibrated in a horizontal plane through arms 21, 22, 23 and 24 connected to suitable eccentric drives.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式