专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06831153B2 Gene and methods for diagnosing neuropsychiatric disorders and treating such disorders 失效
标题翻译：用于诊断神经精神障碍和治疗这种病症的基因和方法
公开(公告)号：US06831153B2
公开(公告)日：2004-12-14
申请号：US10127124
申请日：2002-04-19
申请人： Wade H. Berrettini
发明人： Wade H. Berrettini
IPC分类号： C07K100
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： A mammalian 22444 gene and gene products which are predictive of a susceptibility or predisposition to various neuropsychiatric disorders are provided. Methods of predicting an individual's susceptibility to developing or having a neuropsychiatric disorder via detection of these diagnostic markers are also provided. In addition, compositions and methods for identifying compositions for use in the treatment of neuropsychiatric disorders via these genes and gene products are described.
摘要翻译：提供哺乳动物22444基因和预测各种神经精神障碍的易感性或倾向性的基因产物。还提供了通过检测这些诊断标记来预测个体发展或具有神经精神障碍的易感性的方法。另外，描述了通过这些基因和基因产物鉴定用于治疗神经精神障碍的组合物的组合物和方法。

2. 发明授权

US06818744B1 p53 regulatory protein called RB18A and uses thereof 失效
标题翻译：称为RB18A的p53调节蛋白及其用途
公开(公告)号：US06818744B1
公开(公告)日：2004-11-16
申请号：US09581472
申请日：2000-08-14
申请人： Raymond Frade
发明人： Raymond Frade
IPC分类号： C07K100
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/00
摘要： This invention relates to a new protein called RB18A for “Recognized By PAb18O1 moAntibody”, which is a p53 regulatory protein, to the nucleotide sequence encoding said protein, and to the diagnostic and therapeutic applications thereof, in particular for the diagnosis, prevention or treatment of neoplasia.
摘要翻译：本发明涉及一种称为RB18A的新蛋白质，其为编码所述蛋白质的核苷酸序列以及其诊断和治疗应用，特别是用于诊断，预防或治疗的“PAb18O1 moAntibody”（其为p53调节蛋白）的瘤形成。

3. 发明授权

US06815532B2 ATR-2 cell cycle checkpoint 失效
标题翻译： ATR-2细胞周期检查点
公开(公告)号：US06815532B2
公开(公告)日：2004-11-09
申请号：US09957837
申请日：2001-09-21
申请人： Kate Loughney , Kathleen S. Keegan
发明人： Kate Loughney , Kathleen S. Keegan
IPC分类号： C07K100
CPC分类号： C12N9/12
摘要： Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.

4. 发明授权

US06759516B2 Methods of identifying antigen gene sequences 失效
标题翻译：识别抗原基因序列的方法
公开(公告)号：US06759516B2
公开(公告)日：2004-07-06
申请号：US09861451
申请日：2001-05-21
申请人： Robert John Moore , Timothy James Doran
发明人： Robert John Moore , Timothy James Doran
IPC分类号： C07K100
CPC分类号： C12N15/1086 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/30 , C07K2319/21 , C07K2319/41 , C07K2319/42 , C07K2319/43 , Y10S530/82 , Y10S530/825
摘要： The present invention relates to method of identifying gene sequences of potential vaccine antigens. Also included are gene sequences and the polypeptides encoded by the gene sequences as well as the use of such sequences to induce a protective immune response in animals. Particularly, the invention relates to identifying potential antigen gene sequences of Mycoplasma, preferably Mycoplasma hyopneumoniae. In one aspect of the present invention there is provided a method of identifying expression proteins translated from a nucleotide sequence in an expression vector, said method comprising the use of a marker co-expressed with a protein translated from the nucleotide sequence. In a further aspect of the present invention there is provided a method of identifying a therapeutic antigenic gene sequence encoding a therapeutic antigenic protein of a disease, from a sample of nucleotide sequences. Preferably the marker is a polyHis tag.
摘要翻译：本发明涉及鉴定潜在疫苗抗原基因序列的方法。还包括基因序列和由基因序列编码的多肽以及这些序列在动物中诱导保护性免疫应答的用途。特别地，本发明涉及鉴定支原体，优选猪肺炎支原体的潜在的抗原基因序列。在本发明的一个方面，提供了鉴定从表达载体中的核苷酸序列翻译的表达蛋白质的方法，所述方法包括使用与从核苷酸序列翻译的蛋白质共表达的标记物。在本发明的另一方面，提供了从核苷酸序列的样品鉴定编码疾病的治疗性抗原性蛋白质的治疗性抗原基因序列的方法。优选地，标记是polyHis标签。

5. 发明授权

US06713608B2 Purified heat shock protein complexes 失效
标题翻译：纯化的热休克蛋白复合物
公开(公告)号：US06713608B2
公开(公告)日：2004-03-30
申请号：US10176418
申请日：2002-06-20
申请人： Erik S. Wallen , Jan Roigas , Pope L. Moseley
发明人： Erik S. Wallen , Jan Roigas , Pope L. Moseley
IPC分类号： C07K100
CPC分类号： C07K14/4702 , C07K14/39 , G01N33/6872 , G02B5/305 , Y10S435/803
摘要： A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so product is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in all elution product.
摘要翻译：提供了一种用于纯化热休克蛋白复合物的方法，其包括将含有热休克蛋白与肽，多肽，变性蛋白或抗原相关的热休克蛋白复合物的溶液加入到含有ADP基质的柱中以结合的步骤热休克蛋白与ADP基质复合，并将含有ADP的缓冲液加入到柱中以除去洗脱产物中的热休克蛋白复合物。此外，提供了一种合成热休克蛋白复合物并纯化该复合物的方法，所述产物包括以下步骤：将热休克蛋白加入到ADP基质柱中以将其与基质结合，加入肽，多肽，变性蛋白或抗原的溶液将其结合到热休克蛋白作为热休克蛋白复合物，并向该柱中加入含有ADP的缓冲液以除去所有洗脱产物中的复合物。

6. 发明授权

US06713607B2 Effector proteins of Rapamycin 失效
标题翻译：雷帕霉素的效应蛋白
公开(公告)号：US06713607B2
公开(公告)日：2004-03-30
申请号：US09950634
申请日：2001-09-13
申请人： Thomas J. Caggiano , Yanqiu Chen , Amedeo A. Failli , Katherine L. Molnar-Kimber , Koji Nakanishi
发明人： Thomas J. Caggiano , Yanqiu Chen , Amedeo A. Failli , Katherine L. Molnar-Kimber , Koji Nakanishi
IPC分类号： C07K100
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/705 , G01N33/68
摘要： This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.
摘要翻译：本发明包括哺乳动物来源的新型雷帕霉素-FKBP12结合蛋白，用于鉴定，设计和合成免疫调节，抗再狭窄或抗肿瘤剂，以及蛋白质片段和对应于DNA的DNA，cDNA，反义RNA和DNA片段蛋白质。本发明还包括分离蛋白质的方法和与蛋白质相关的治疗用途。

7. 发明授权

US06699688B1 Human platelet F11 receptor 失效
标题翻译：人血小板F11受体
公开(公告)号：US06699688B1
公开(公告)日：2004-03-02
申请号：US09397243
申请日：1999-09-16
申请人： Elizabeth Kornecki , Malgorzata B. Sobocka
发明人： Elizabeth Kornecki , Malgorzata B. Sobocka
IPC分类号： C07K100
CPC分类号： G01N33/566 , C07H21/04 , C07K14/705 , G01N2500/00
摘要： The present invention is directed to isolated nucleic acid molecules encoding human platelet F11 receptors. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of the human platelet F11 receptor in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify human platelet F11 receptor function, and a method for isolating other human platelet F11 receptor molecules. DNA oligomers capable of hybridizing to the nucleic acid molecule encoding the human platelet F11 receptor are provided, which can be used to detect human platelet F11 receptor in a sample.
摘要翻译：本发明涉及编码人血小板F11受体的分离的核酸分子。还提供了包含核酸分子的表达载体和宿主细胞，以及用于增加或降低宿主细胞中人血小板F11受体表达的方法。本发明还提供了筛选物质改变人血小板F11受体功能的能力的方法，以及分离其他人血小板F11受体分子的方法。提供能够与编码人血小板F11受体的核酸分子杂交的DNA寡聚体，其可用于检测样品中的人血小板F11受体。

8. 发明授权

US06693184B1 DNA molecules encoding splice variants of the human melanocortin 1 receptor protein 失效
标题翻译：编码人黑素皮质素1受体蛋白的剪接变体的DNA分子
公开(公告)号：US06693184B1
公开(公告)日：2004-02-17
申请号：US09868552
申请日：2001-06-18
申请人： Andrew D. Howard , Douglas J. MacNeil , Leonardus H. T. Van Der Ploeg
发明人： Andrew D. Howard , Douglas J. MacNeil , Leonardus H. T. Van Der Ploeg
IPC分类号： C07K100
CPC分类号： C07K14/723
摘要： The present invention relates to DNA molecules encoding splice variants of the melanocortin-1 receptor (MC-R1) protein belonging to the rhodopsin sub-family of G-protein coupled receptors, recombinant vectors comprising DNA molecules encoding MC-R1B protein, recombinant host cells which contain a recombinant vector encoding MC-R1B, the human MC-R1B protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of MC-R1B proteins disclosed throughout this specification.
摘要翻译：本发明涉及编码属于G蛋白偶联受体的视紫质亚族的黑皮质素-1受体（MC-R1）蛋白的剪接变体的DNA分子，包含编码MC-R1B蛋白的DNA分子的重组载体，重组宿主细胞其包含编码MC-R1B的重组载体，由DNA分子编码的人MC-R1B蛋白，以及鉴定本说明书中公开的MC-R1B蛋白的选择性激动剂和拮抗剂的方法。

9. 发明授权

US06693177B1 Process for preparation of a biomarker specific for O-acetylated sialic acid useful for diagnosing, monitoring treatment outcome, and predicting relapse of lymphoblastic leukemia 有权
标题翻译：制备用于诊断，监测治疗结果和预测淋巴细胞白血病复发的O-乙酰化唾液酸特异性生物标志物的方法
公开(公告)号：US06693177B1
公开(公告)日：2004-02-17
申请号：US09453555
申请日：1999-12-03
申请人： Chitra Mandal , Santanu Pal , Mitali Chatterjee
发明人： Chitra Mandal , Santanu Pal , Mitali Chatterjee
IPC分类号： C07K100
CPC分类号： C07K16/065
摘要： The invention relates to a novel process for preparation of a biomarker specific for O-acetylated sialic acid and useful for the diagnosis, monitoring outcome of treatment and prediction of relapse of acute lymphoblastic leukemia, said process comprising the steps of (I) separating serum from the blood of patients of acute lymphoblastic leukemia; (ii) separation of low molecular weight fractions and galactose binding proteins from the serum on affinity matrix; (iii) passing the galactose free protein fraction obtained in step (ii) over another affinity matrix to capture O-acetyl sialic acid specific protein fraction; (iv) eluting specific protein fraction with a buffer at alkaline pH in the range of 8.0-11.0 followed by immediate neutralization of the fraction; (v) passing O-acetyl sialic acid specific protein obtained in step (iv) over Agarose column to get O-acetyl sialic acid specific antibody and eluting the said antibody with an appropriate buffer at acidic pH, followed by immediate neutralization of the fraction and dialyzing the neutralized protein to get purified disease specific antibody as biomarker and a method of diagnosing, monitoring outcome of treatment and prediction of relapse of acute lymphoblastic leukemia using the biomarker obtained by the novel process.
摘要翻译：本发明涉及一种制备O-乙酰化唾液酸特异性生物标志物的新方法，可用于诊断，监测治疗结果和预测急性成淋巴细胞白血病复发，所述方法包括以下步骤：（I）将血清从急性淋巴细胞性白血病患者的血液; （ii）在亲和基质上从血清中分离低分子量级分和半乳糖结合蛋白; （iii）使步骤（ii）中获得的无半乳糖的蛋白质级分超过另一种亲和基质以捕获O-乙酰唾液酸特异性蛋白质级分; （iv）用碱性pH在8.0-11.0范围内的缓冲液洗脱特定蛋白质级分，随后立即中和该级分; （v）在琼脂糖柱上通过步骤（iv）中获得的O-乙酰唾液酸特异性蛋白质，得到O-乙酰唾液酸特异性抗体，并在酸性pH下用合适的缓冲液洗脱所述抗体，然后立即中和该级分，透析中和的蛋白质以获得纯化的疾病特异性抗体作为生物标志物，并使用通过新方法获得的生物标志物诊断，监测治疗结果和预测急性淋巴细胞白血病复发的方法。

10. 发明授权

US06692926B1 Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their use 失效
标题翻译：显示配体结合活性的重组人SM-11044结合受体蛋白及其用途
公开(公告)号：US06692926B1
公开(公告)日：2004-02-17
申请号：US09786681
申请日：2001-04-30
申请人： Toshinari Sugasawa , Jun Hidaka , Hajime Kawakami
发明人： Toshinari Sugasawa , Jun Hidaka , Hajime Kawakami
IPC分类号： C07K100
CPC分类号： C07K14/705 , A61K38/00
摘要： Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof; recombinant human SMBPs isolated from the transformed cells or the cellular membrane fractions thereof; a screening system for human SMBP agonists/antagonists characterized by utilizing the transformed cells, the cellular membrane fractions thereof or the isolated recombinant human SMBPs; and human SMBP agonists or antagonists obtainable by the screening system, are provided by deleting the polythymidine sequence from the base sequence of the 3′-untranslated region.
摘要翻译：设计用于在升高的水平上表达重组人SMBP至可测量其配体结合活性的程度的转化细胞及其细胞膜级分; 从转化细胞或其细胞膜级分分离的重组人SMBP; 其特征在于利用转化的细胞，其细胞膜级分或分离的重组人SMBP2的人SMBP激动剂/拮抗剂的筛选系统; 和通过筛选系统可获得的人SMBP激动剂或拮抗剂，通过从3'非翻译区的碱基序列中缺失多胸苷序列来提供。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式