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1. 发明授权

US06825398B2 Seed specific 7S&agr; promoter for expressing genes in plants 有权
标题翻译：种子特异性7Salpha启动子，用于在植物中表达基因
公开(公告)号：US06825398B2
公开(公告)日：2004-11-30
申请号：US10235618
申请日：2002-09-05
申请人： Qi Wang , Patrice Dubois
发明人： Qi Wang , Patrice Dubois
IPC分类号： C12N1509
CPC分类号： C07K14/415 , C12N15/8234
摘要： This invention provides promoters capable of transcribing heterologous nucleic acid sequences in seeds, and methods of modifying, producing, and using the same.
摘要翻译：本发明提供能够转录种子中的异源核酸序列的启动子，以及修饰，产生和使用它们的方法。

2. 发明授权

US06815578B1 Polynucleotide encoding MRE11 binding polypeptide and uses thereof 失效
标题翻译：编码MRE11结合多肽的多核苷酸及其用途
公开(公告)号：US06815578B1
公开(公告)日：2004-11-09
申请号：US09538396
申请日：2000-03-29
申请人： Pramod B. Mahajan , Jinrui Shi
发明人： Pramod B. Mahajan , Jinrui Shi
IPC分类号： C12N1509
CPC分类号： C12N15/8213 , C07K14/415 , C12N15/8241
摘要： The invention provides isolated polynucleotides encoding MRE11 binding polypeptides, recombinant expression cassettes, host cells, and transgenic plants comprising said polynucleotides.
摘要翻译：本发明提供编码MRE11结合多肽，重组表达盒，宿主细胞和包含所述多核苷酸的转基因植物的分离的多核苷酸。

3. 发明授权

US06808900B2 Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof 失效
标题翻译：隐孢子虫小球抗原，其抗体及其诊断和治疗组合物
公开(公告)号：US06808900B2
公开(公告)日：2004-10-26
申请号：US09881556
申请日：2001-06-14
申请人： J. Neil Simonsen
发明人： J. Neil Simonsen
IPC分类号： C12N1509
CPC分类号： C07K14/44 , A61K38/00 , A61K2039/505 , Y02A50/488 , Y10S435/975
摘要： Cloning and expression of genes encoding C. parvum antigenic polypeptides are described as are antibodies that recognize epitopes on these polypeptides. The antigenic polypeptides and antibodies thereto can be used in therapeutic compositions for the prevention and treatment of C. parvum infections, as well as in diagnostic methods for determining the presence of C. parvum infections.
摘要翻译：编码小叶抗原多肽的基因的克隆和表达被描述为识别这些多肽上的表位的抗体。抗原多肽及其抗体可用于预防和治疗小孢子虫感染的治疗组合物中，以及用于确定小球孢菌感染存在的诊断方法。

4. 发明授权

US06770798B1 Nucleic acid sequences coding for thanatin and transformed plants containing them 失效
标题翻译：编码不含蛋白质的核酸序列和含有它们的转化植物
公开(公告)号：US06770798B1
公开(公告)日：2004-08-03
申请号：US09554024
申请日：2000-10-16
申请人： Georges Freyssinet , Richard Derose , Jules Hoffmann
发明人： Georges Freyssinet , Richard Derose , Jules Hoffmann
IPC分类号： C12N1509
CPC分类号： C07K14/43563 , C12N15/8282
摘要： The invention concerns a nucleic acid sequence coding for thanatin, a vector containing it for transforming a host, and plants and plant cells transformed by the nucleic acid.
摘要翻译：本发明涉及编码抑制素的核酸序列，含有其用于转化宿主的载体，以及由核酸转化的植物和植物细胞。

5. 发明授权

US06759571B1 Method of suppressing gene expression in plants 有权
标题翻译：抑制植物基因表达的方法
公开(公告)号：US06759571B1
公开(公告)日：2004-07-06
申请号：US09281528
申请日：1999-03-30
申请人： Dominique Robertson
发明人： Dominique Robertson
IPC分类号： C12N1509
CPC分类号： C12N15/8201
摘要： The introduction of DNA episomes into plant cells to reduce or prevent the expression of endogenous nuclear or chromosomal genes is described. Geminivirus vectors to provide systemic silencing of an endogenous plant gene in a treated plant are described.
摘要翻译：描述了将DNA附加体引入植物细胞以减少或预防内源性核或染色体基因的表达。描述了在受处理的植物中提供内源植物基因的全身沉默的双子病毒载体。

6. 发明授权

US06703541B1 Nematode-upregulated peroxidase gene promoter from nematode-resistant maize line Mp307 有权
标题翻译：来自线虫抗性玉米品系Mp307的线虫上调的过氧化物酶基因启动子
公开(公告)号：US06703541B1
公开(公告)日：2004-03-09
申请号：US09716410
申请日：2000-11-21
申请人： Linas S. Padegimas , Nancy A. Reichert
发明人： Linas S. Padegimas , Nancy A. Reichert
IPC分类号： C12N1509
CPC分类号： C12N9/0065 , C12N9/0004 , C12N15/8237 , C12N15/8239 , C12N15/8285 , Y02A40/164
摘要： The present invention provides a nematode inducible promoter sequence from maize inbred line Mp307, and DNA constructs and transcription cassettes comprising said promoter sequence, a gene encoding a toxin, and a termination sequence. Methods for inducing nematode resistance in plants and transgenic plants resistant to nematode infection are also provided.
摘要翻译：本发明提供了来自玉米近交系Mp307的线虫诱导型启动子序列，以及包含所述启动子序列，编码毒素的基因和终止序列的DNA构建体和转录盒。还提供了在植物中诱导线虫抗性的方法和对线虫感染有抗性的转基因植物。

7. 发明授权

US06680182B1 Expression of recombinant fusion proteins in attenuated bacteria 失效
标题翻译：重组融合蛋白在减毒细菌中的表达
公开(公告)号：US06680182B1
公开(公告)日：2004-01-20
申请号：US08379611
申请日：1995-07-21
申请人： Mohammed Anjam Khan , Bernardo Villarreal-Ramos , Carlos Estenio Hormaeche , Steven Neville Chatfield , Gordon Dougan
发明人： Mohammed Anjam Khan , Bernardo Villarreal-Ramos , Carlos Estenio Hormaeche , Steven Neville Chatfield , Gordon Dougan
IPC分类号： C12N1509
CPC分类号： C12N15/62 , A61K39/00 , C07K14/005 , C07K14/33 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/55 , C12N9/1088 , C12N2710/16622 , C12N2710/20022 , C12N2740/15022 , C12N2770/32122 , Y02A50/412 , Y02A50/423 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： The invention provides a DNA molecule comprising a promoter sequence operably linked to a DNA sequence encoding first and second proteins linked by a hinge region wherein in that the promoter sequence can be one having activity which is induced in response to a change in the surrounding environment and the first protein can be Tetanus toxin C fragment or one or more epitopes thereof. The invention also provides intermediate molecules having a promoter operably linked to a DNA sequence encoding a first antigenic sequence and a hinge region, and at or adjacent the 3′-end thereof one or more restriction sites for the introduction of a second anti-genic sequence. In addition, the invention provides replicable expression vectors containing the DNA fusion proteins expressed therefrom, bacterial transformed with the vectors and the use of the bacteria, in vaccines.
摘要翻译：本发明提供了一种DNA分子，其包含与编码由铰链区连接的第一和第二蛋白质的DNA序列可操作地连接的启动子序列，其中启动子序列可以是具有响应于周围环境变化而诱导的活性的序列，第一种蛋白质可以是破伤风毒素C片段或其一个或多个表位。本发明还提供具有可操作地连接到编码第一抗原序列和铰链区的DNA序列的启动子的中间分子，并且在其3'端或其邻近位置具有用于引入第二抗基因序列的一个或多个限制性位点。此外，本发明提供了在疫苗中含有由其表达的DNA融合蛋白，用载体转化的细菌和细菌的使用的可复制的表达载体。

8. 发明授权

US06670185B1 Compositions and methods for non-targeted activation of endogenous genes 有权
标题翻译：内源基因非靶向激活的组成和方法
公开(公告)号：US06670185B1
公开(公告)日：2003-12-30
申请号：US09479123
申请日：2000-01-07
申请人： John J. Harrington , Bruce Sherf , Stephen Rundlett
发明人： John J. Harrington , Bruce Sherf , Stephen Rundlett
IPC分类号： C12N1509
CPC分类号： C07K14/705 , A61K48/00 , C07K2319/00 , C12N9/003 , C12N15/1096 , C12N15/63 , C12N15/67 , C12N15/85 , C12N15/90 , C12N2800/107 , C12N2800/108 , C12N2800/204 , C12N2800/60 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention also provides methods for isolation of nucleic acid molecules (particularly cDNA molecules) encoding a variety of proteins. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes.
摘要翻译：本发明一般涉及通过原位重组方法激活基因表达或引起基因过度表达。本发明还通常涉及用于在细胞中以比通常在细胞中发现的那些更高的水平表达内源基因的方法。在本发明的一个实施方案中，内源基因的表达在通过激活基因表达的调节序列的非同源或非法重组整合入细胞后被激活或增加。本发明还提供了鉴定，激活，分离和/或表达不能被现有方法发现的基因的方法，因为不需要靶序列进行整合。本发明还提供了分离编码多种蛋白质的核酸分子（特别是cDNA分子）的方法。因此，通过本发明，可以在没有基因的序列，结构，功能或表达谱的事先知识的情况下激活和分离内源基因，包括与人类疾病和发育相关的内源基因。

9. 发明授权

US06646184B2 Trichothecene-resistant transgenic plants 有权
标题翻译：抗逆转录病毒转基因植物
公开(公告)号：US06646184B2
公开(公告)日：2003-11-11
申请号：US10074279
申请日：2002-02-12
申请人： Thomas M. Hohn , Cheryl Peters , John Salmeron
发明人： Thomas M. Hohn , Cheryl Peters , John Salmeron
IPC分类号： C12N1509
CPC分类号： C07H21/04 , C12N9/1029 , C12N15/8209 , C12N15/8242 , C12N15/8274 , C12N15/8282
摘要： The present invention discloses trichothecene-resistant transgenic plants, plant tissues, plant seeds, and plant cells comprising a heterologous polynucleotide encoding a gene product having tricothecene resistance activity that thereby confers trichothecene resistance to the transgenic plants, plant tissues, plant seeds, and plant cells. Trichothecene resistance activity, as used herein, refers to an activity that reduces or inhibits the phytotoxicity of a trichothecene, particularly to a fungus and/or plant. In a particular embodiment, trichothecene resistance activity refers to an activity that transfers an acetate to the C-3 position of a trichothecene such as T-2 toxin, HT-2 toxin, isotrichodermol, diacetoxyscirpenol (“DAS”), 3-deacetylcalonectrin, 3,15-dideacetylcalonectrin, scirpentriol, neosolaniol; 15-acetyldeoxynivalenol, nivalenol, 4-acetylnivalenol (fusarenone-X), 4,15-diacetylnivalenol, 4,7,15-acetylnivalenol, and deoxynivalenol (“DON”) and their various acetylated derivatives. In another particular embodiment, the gene product having trichthecene resistance activity is a 3-O-acetyltransferase from a trichothecene-producing species of Fusarium, such as Fusarium graminearum or Fusarium sporotrichioides.
摘要翻译：本发明公开了头孢霉烯抗性转基因植物，植物组织，植物种子和植物细胞，其包含编码具有三氯生物抗性活性的基因产物的异源多核苷酸，从而赋予转基因植物，植物组织，植物种子和植物细胞的单端孢霉烯抗性。如本文所用，三氯乙炔抗性活性是指减少或抑制单端孢霉烯特别是真菌和/或植物的植物毒性的活性。在一个特定的实施方案中，单端孢霉烯抗性活性是指将乙酸酯转移到单端孢霉烯C-3位的活性，例如T-2毒素，HT-2毒素，异维甲酸，二乙酰氧基甲苯酚（“DAS”），3-脱乙酰基木聚糖， 3,15-二乙酰胆碱，顺丁三醇，新溶胶甘醇; 15-乙酰基过氧化雪腐镰刀菌烯醇，新戊烯醇，4-乙酰基雪腐镰刀菌烯醇（fisarenone-X），4,15-二乙酰基雪腐镰刀菌烯醇，4,7,15-乙酰基雪腐镰刀菌烯醇和脱氧雪腐镰刀菌烯醇（“DON”）及其各种乙酰化衍生物。在另一个具体实施方案中，具有三辛抗性活性的基因产物是来自产生单端孢霉烯的镰刀菌属物种如禾谷镰刀菌（Fusarium graminearum）或孢子镰刀菌（Fusarium sporotrichioides）的3-O-乙酰转移酶。

10. 发明授权

US06632640B1 Vaccine against Staphylococcus intoxication 失效
标题翻译：针对葡萄球菌中毒的疫苗
公开(公告)号：US06632640B1
公开(公告)日：2003-10-14
申请号：US09350755
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： C12N1509
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译：使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导免疫应答的组合物和方法，其用于保护金黄色葡萄球菌描述了ITALIC> 中毒。

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