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91. 发明公开

EP1488818A4 PREFILLED SYRINGE WITH PLUNGER BACKWARD MOVEMENT LIMITING MECHANISM 有权转让
标题翻译：与机构预充式注射器用于限制反向运动的活塞
公开(公告)号：EP1488818A4
公开(公告)日：2006-06-14
申请号：EP03744519
申请日：2003-03-11
申请人： BECTON DICKINSON CO , KIRIN BREWERY
发明人： HATO SEIICHI
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315
CPC分类号： A61M5/31501 , A61M5/31505 , A61M2005/3117 , A61M2005/3139 , A61M2005/31506 , A61M2005/31508
摘要： A prefilled syringe capable of eliminating the possibility of occurrence of such a malpractice that injection in an injection-sealed area inside a barrel is contaminated due to the contact thereof with the surface of an injection non-sealed area by the erroneous backward movement of the plunger of the prefilled syringe, comprising plunger backward movement limiting members (48) and (54) for limiting the backward movement of the plunger by the engagement of the barrel (12) with the plunger (14), whereby the injection (L) filled in the injection- sealed area (32) of the barrel (12) can be prevented from coming into contact with the surface of the injection non-sealed area (34) by the backward movement of the plunger (14).

92. 发明公开

EP1559715A4 N-¬2-CHLORO-4-(6,7-DIMETHOXY-4-QUINOLYL)OXY|PHENYL|-N'-(5-METHYL-3-ISOXAZOLYL)UREA SALT IN CRYSTALLINE FORM 有权转让
标题翻译： N-2-氯-4-（6,7-二甲氧基-4-苯乙烯基）氧基|苯基| -N' - （5-甲基-3-异辛酰基）硬脂酸锌
公开(公告)号：EP1559715A4
公开(公告)日：2006-03-29
申请号：EP03756734
申请日：2003-10-21
申请人： KIRIN BREWERY
发明人： MATSUNAGA NAOKI , YOSHIDA SATOSHI , YOSHINO AYAKO , NAKAJIMA TATSUO
IPC分类号： A61K31/4709 , A61P9/10 , A61P17/06 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D413/12
CPC分类号： C07D413/12
摘要： It is intended to provide crystals of a pharmaceutically acceptable salt of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N’-(5-methyl-3-isoxazolyl)urea. The salt crystals are used in treating a disease selected from the group consisting of tumor, diabetic retinopathy, rheumatoid arthritis, psoriasis, atheroma arteriosclerosis, Kaposi’s sarcoma and exudative age-related macular degeneration. The salt crystals have properties appropriate for preparations for oral administration.

93. 发明公开

EP1563084A4 TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有降低朊蛋白的转基因活性的有蹄类动物及其用途
公开(公告)号：EP1563084A4
公开(公告)日：2006-03-01
申请号：EP03783271
申请日：2003-11-10
申请人： HEMATECH LLC , KIRIN BREWERY
发明人： ROBL JAMES , KUROIWA YOSHIMI , COLLAS PHILIPPE , SULLIVAN EDDIE , KASINATHAN POOTHAPPILLAI , TOMIZUKA KAZUMA , ISHIDA ISAO
IPC分类号： A01K67/027 , C07K16/00 , C12N5/02 , C12N5/07 , C12N5/10 , C12N5/12 , C12N5/16 , C12N15/00 , C12N15/12 , C12N15/85 , C12P21/00 , C12P21/08 , C12Q1/68 , C12N5/06
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K16/00 , C07K2317/12 , C07K2317/21 , C12N2800/30
摘要： The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.

94. 发明公开

EP1611785A1 Cloning of transgenic ungulate animals comprising artificial chromosomes 审中-公开
标题翻译： Klonieren von transgenen Huftieren mitkünstlichenChromosomen
公开(公告)号：EP1611785A1
公开(公告)日：2006-01-04
申请号：EP05019454.7
申请日：2002-02-21
申请人： Kirin Brewery Company, Limited , Hematech, LLC
发明人： The designation of the inventor has not yet been filed
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： C12N15/8771
摘要： The invention is directed in part to totipotent cells that have one or more artificial chromosomes; processes for producing such cells; processes for using such cells (e.g., nuclear transfer); transgenic embryos and transgenic animals cloned from such cells; and processes for producing such embryos and animals.
摘要翻译：本发明部分地涉及具有一个或多个人造染色体的全能细胞; 生产这种细胞的方法; 使用这种细胞的过程（例如核转移）; 从这些细胞克隆的转基因胚胎和转基因动物; 以及用于生产这种胚胎和动物的方法。

95. 发明公开

EP1466925A4 ANTIBODIES AGAINST FIBROBLAST GROWTH FACTOR 23 有权转让
标题翻译：单克隆抗体抗成纤维细胞生长因子23
公开(公告)号：EP1466925A4
公开(公告)日：2006-01-04
申请号：EP03701009
申请日：2003-01-06
申请人： KIRIN BREWERY
发明人： YAMAZAKI YUJI , SHIMADA TAKASHI , YAMASHITA T
IPC分类号： A61K39/00 , A61P19/08 , C07K14/50 , C07K16/22 , C12P21/08 , C07K16/18 , A61K39/395 , A61P3/00 , A61P13/12 , A61P35/00 , C12N15/00 , C12Q1/00 , G01N33/53 , G01N33/577
CPC分类号： C07K14/50 , A61K39/00 , A61K2039/505 , C07K16/22
摘要： It is intended to provide antibodies against fibroblast growth factor 23. Namely, antibodies having an activity of controlling phosphate metabolism or vitamin D metabolism and corresponding to the following (a), (b) or (c), which are obtained by immunizing an animal with a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1 or a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution or addition of one to several amino acids and having a fibroblast growth factor 23 activity. (a) An antibody recognizing an amino acid sequence of the 180- to 194 positions or the 237- to 251-positions in the amino acid sequence represented by SEQ ID NO:1. (b) An antibody produced by a hybridoma represented by the accession number FERM BP-7838, FERM BP-7839, FERM BP-7840 or FERM BP-8268. (c) An antibody competing with an antibody produced by a hybridoma represented by the accession number FERM BP-7838, FERM BP-7839, FERM BP-7840 or FERM BP-8268.

96. 发明公开

EP1426437A4 PROCESS FOR PRODUCING FERMENTED ALCOHOLIC DRINK 审中-公开
标题翻译：用于生产酒精饮料的发酵方法
公开(公告)号：EP1426437A4
公开(公告)日：2006-01-04
申请号：EP02713233
申请日：2002-03-28
申请人： KIRIN BREWERY
发明人： YASUI TETSUJI , HORI TOSHIHIKO , MATSUURA CHIKAKO , TAYAMA TOMOHIRO , ITO TOSHIYA
IPC分类号： C12C1/02 , C12C7/00 , C12C7/01 , C12C7/04 , C12C11/00 , C12C1/16 , C12C1/18 , C12C12/00
CPC分类号： C12C7/04 , C12C7/01
摘要： The present invention provides a process for producing wort with reduced content of a stale flavor-causing substance for the purpose of producing fermented alcoholic beverages such as beer and the like, in which the generation of a stale flavor is suppressed, and to provide a process for producing fermented alcoholic beverages such as beer and the like, in which the generation of a stale flavor is suppressed by using the wort obtained by said process. It becomes possible to produce fermented alcoholic beverages such as beer and the like, in which the generation of a stale flavor is suppressed, as a result of reducing a stale flavor-causing substance in wort by adjusting the grist fineness of a cereal raw material that are used for producing fermented alcoholic beverages such as beer and the like, i.e. by grinding the grains of a cereal raw material more coarsely than usual. The grist fineness of a cereal raw material can be evaluated by the EBC husk fraction by applying the trans-2-nonenal-poteintial in total filtrated wort as an indicator and adjusted thereby.

97. 发明公开

EP1505149A4 METHYLOTROPH PRODUCING MAMMALIAN TYPE SUGAR CHAIN 有权转让
标题翻译：哺乳动物典型的链食糖生产的甲基有机体
公开(公告)号：EP1505149A4
公开(公告)日：2005-11-16
申请号：EP03720967
申请日：2003-04-28
申请人： KIRIN BREWERY , AIST
发明人： KOBAYASHI KAZUO , KITAGAWA YOSHINORI , KOMEDA TOSHIHIRO , KAWASHIMA NAGAKO , JIGAMI Y , CHIBA Y
IPC分类号： C07K16/24 , C12N1/14 , C12N1/19 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/24 , C12N9/60 , C12N9/88 , C12P19/04 , C12P19/26 , C12P21/00 , C12P21/02 , C12N5/10 , C12N15/62
CPC分类号： C12P19/26 , C07K16/243 , C07K2317/21 , C12N1/14 , C12N9/0006 , C12N9/0008 , C12N9/1048 , C12N9/1051 , C12N9/2488 , C12N9/60 , C12N9/88 , C12N9/93 , C12P21/02 , C12Y101/01085 , C12Y101/03013 , C12Y102/01012 , C12Y302/01024 , C12Y402/01019 , C12Y603/02006
摘要： It is intended to provide a process for producing a glycoprotein having a mammalian type sugar chain characterized by comprising transferring and expressing α-1,2-mannosidase in a sugar chain biosynthesis pathway gene mutant of a methylotroph yeast under the control by a potent promoter, culturing in a medium the methylotroph yeast cells having a foreign gene transferred thereinto, and then harvesting the glycoprotein having the mammalian type sugar chain from the culture medium. Using a newly bred methylotroph yeast carrying a sugar chain mutation, a neutral sugar chain identical with a high mannose type sugar chain produced by mammalian cells such as human cells or a glycoprotein having such a neutral sugar chain can be produced in a large amount at a high purity. By transferring a gene in a mammalian type sugar chain biosynthesis pathway into the above-described mutant, a mammalian type sugar chain such as a hybrid sugar chain or a complex sugar chain or a protein having a mammalian type sugar chain can be efficiently produced.

98. 发明公开

EP1310554A4 POLYPEPTIDES CONTROLLING PHOSPHORIC ACID METABOLISM, CALCIUM METABOLISM, CALCIFICATION AND VITAMIN D METABOLISM AND DNAS ENCODING THE SAME 有权
标题翻译：磷酸代谢CHECKED在多肽中，钙代谢，钙化和维生素D代谢和用于该编码DNA分子
公开(公告)号：EP1310554A4
公开(公告)日：2005-07-13
申请号：EP01958379
申请日：2001-08-10
申请人： KIRIN BREWERY
发明人： YAMASHITA TAKEYOSHI , SHIMADA TAKASHI , MIZUTANI SATORU , FUKUMOTO SEIJI
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/02 , A61P3/14 , A61P13/12 , A61P19/00 , A61P19/08 , A61P19/10 , A61P35/00 , C07K14/47 , C07K14/50 , C07K14/705 , C12P21/08 , C12N15/09 , A61K38/17 , A61K39/395 , C07K7/08 , C07K16/18
CPC分类号： C07K14/50 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705
摘要： DNAs encoding the following polypeptides (a), (b), (c) and (d); (a) a polypeptide comprising an amino acid sequence represented by SEQ ID NO:2 or 4; (b) a polypeptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:2 or 4 by the deletion, substitution or addition of one to several amino acids and having an activity of inducing hypophosphatemia, an activity of inhibiting phosphoric acid transportation, an activity of inhibiting calcification or an activity of controlling vitamin D metabolism in vivo ; (c) a polypeptide comprising a partial sequence of the amino acid sequence represented by SEQ ID NO:2 wherein the partial sequence contains at least the amino acid sequence ranging from the 34th to 201st amino acids in the above-described amino acid sequence; and (d) a polypeptide comprising a partial sequence of the amino acid sequence represented by SEQ ID NO:2 wherein the partial sequence: (i) contains at least the amino acid sequence ranging from the 34th to 201st amino acids in the above-described amino acid sequence; (ii) comprises an amino acid sequence having the deletion, substitution or addition of one to several amino acids; and (iii) has an activity of inducing hypophosphatemia, an activity of inhibiting phosphoric acid transportation, an activity of inhibiting calcification or an activity of controlling vitamin D metabolism in vivo .

99. 发明公开

EP0950712A4 YEAST VECTORS AND PROCESS FOR PRODUCING PROTEINS WITH THE USE OF THE SAME 失效
标题翻译：酵母载体和为贵用于蛋白质的生产流程。
公开(公告)号：EP0950712A4
公开(公告)日：2005-03-02
申请号：EP97935860
申请日：1997-08-22
申请人： KIRIN BREWERY
发明人： KONDO KEIJI , MIURA YUTAKA
IPC分类号： C07K14/43 , C12N1/19 , C12N9/26 , C12N15/56 , C12N15/81 , C12N15/90 , C12N15/68 , C12P21/02
CPC分类号： C12N9/2411 , C07K14/43 , C12N9/2408 , C12N15/815 , C12N15/905 , C12Y302/01001
摘要： Vectors which are to be integrated onto yeast chromosomes by multi-copying; and vectors which are to be integrated onto yeast chromosomes by multi-copying and show improved stability of expression units on the chromosomes. These vectors are ones each containing a marker gene for selecting a transformant, a shortened promoter sequence linked to the marker gene to thereby serve as an operator, and a sequence homologous with the chromosomal DNA of Candida utilis, optionally together with a heterogenous gene or a gene originating in C. utilis. It is linearized by cleaving with restriction enzymes within the homologous DNA sequence or at both ends of the same and, thus, enables the integration of the heterogenous gene or the gene originating in C. utilis onto the chromosomal DNA of C. utilis via homologous recombination.

100. 发明公开

EP1508630A1 DEVICE FOR MANUFACTURING DLC FILM-COATED PLASTIC CONTAINER 有权
标题翻译： VORRICHTUNG ZUR HERSTELLUNG EINES MIT EINEM DLC-FILM BESCHICHTETENKUNSTSTOFFBEHÄLTERS
公开(公告)号：EP1508630A1
公开(公告)日：2005-02-23
申请号：EP03730627.1
申请日：2003-05-26
申请人： Kirin Brewery Company, Ltd.
发明人： YAMASAKI, Teruyuki, c/o KIRIN BREWERY COMPANY, LTD , SHIRAKURA, Akira, c/o KIRIN BREWERY COMPANY, LTD , ANDO, Hideyasu, c/o KIRIN BREWERY COMPANY, LTD
IPC分类号： C23C16/26 , B65D23/02
CPC分类号： C23C16/26 , B65D23/02 , C23C16/045
摘要： It is an object of the present invention to generate stable plasma and carry out continuous discharge while at the same time preventing the adherence of dust to a mouth side electrode by arranging the mouth side electrode outside the container to face a container side electrode. The apparatus for manufacturing a DLC film coated plastic container according to the present invention includes a container side electrode which forms one portion of a pressure-reducing chamber which houses a plastic container, and a mouth electrode arranged above the opening of said plastic container, wherein said container side electrode and said mouth side electrode are made to face each other via an insulating ' body which forms a portion of said pressure-reducing chamber, source gas supply means which supply a source gas that is converted to plasma for coating the inner wall surface of said plastic container with a DLC film includes a source gas inlet pipe formed from an insulating material provided in said pressure-reducing chamber to introduce said source gas supplied to said pressure-reducing chamber to the inside of said plastic container, exhaust means which exhaust gas inside said pressure-reducing chamber from above the opening of said plastic container are provided, and high frequency supply means which supply a high frequency is connected to said container side electrode.
摘要翻译：本发明的目的是产生稳定的等离子体并进行连续放电，同时通过将口侧电极设置在容器外部以面对容器侧电极来防止灰尘附着到口侧电极。根据本发明的用于制造DLC薄膜包衣塑料容器的设备包括：容器侧电极，其形成容纳塑料容器的减压室的一部分;以及设置在所述塑料容器的开口上方的口电极，所述容器侧电极和所述嘴侧电极通过形成所述减压室的一部分的绝缘体相互面对，源气体供给装置，其供给转换成等离子体的源气体，以涂覆内壁具有DLC膜的所述塑料容器的表面包括由设置在所述减压室中的绝缘材料形成的源气体入口管，以将供应到所述减压室的源气体引入所述塑料容器的内部，排气装置提供了从所述塑料容器的开口的上方的所述减压室内的废气，嗨供给高频率的gh频率供给装置连接到所述容器侧电极。

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