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1. 发明公开

EP4341702A2 STRUCTURE BASED ISOLATION OF PMHC-RESTRICTED ANTIBODIES 审中-公开
公开(公告)号：EP4341702A2
公开(公告)日：2024-03-27
申请号：EP22808281.4
申请日：2022-05-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： GARCIA, Kenan Christopher , NISHIMIYA, Daisuke , YANG, Xinbo
IPC分类号： G01N33/68 , C40B30/04 , G01N33/53 , C07K14/435 , C07K14/705

2. 发明公开

EP4296673A3 PEPTIDES AND METHODS FOR THE DETECTION OF LYME DISEASE ANTIBODIES 审中-公开
公开(公告)号：EP4296673A3
公开(公告)日：2024-03-20
申请号：EP23206262.0
申请日：2012-11-05
申请人： Zoetis Services LLC
发明人： MEHRA, Rajesh K. , ARON, Kenneth P. , BLEILE, DennisM. , WALKER, Jeremy , CUESICO, Cristina
IPC分类号： C07K14/00 , G01N33/53 , G01N33/543
摘要： Compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens are disclosed. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VIsE protein. Also provided are devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.

3. 发明公开

EP4332583A1 REAGENT MIXING AND LOADING DEVICE AND IMMUNOLOGICAL DETECTION APPARATUS 审中-公开
公开(公告)号：EP4332583A1
公开(公告)日：2024-03-06
申请号：EP22794206.7
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： LAI, Yunfei , HUANG, Xiutao , ZHANG, Fuxing , XIAO, Yujin
IPC分类号： G01N35/04 , G01N1/38 , G01N33/53
摘要： A reagent mixing and loading device (10) and an immunological detection apparatus. The reagent mixing and loading device (10) comprises a transmission mechanism (100), mixing mechanisms (200), a loading mechanism (300) and a driving mechanism (400), wherein the transmission mechanism (100) comprises a first rotating member (110) and a second rotating member (120), the first rotating member (110) being rotatably connected to a plurality of mixing mechanisms (200) arranged at intervals, and the first rotating member (110) being capable of synchronously rotating with the second rotating member (120); the driving mechanism (400) is used to drive the second rotating member (120) to rotate; each mixing mechanism (200) comprises a mixing column (210), a mixing transmission member (220) and a mixing limiting member (230), the mixing transmission member (220) being connected to the mixing column (210) in a sleeved manner and fitting with the second rotating member (120) in an abutting manner; and the loading mechanism (300) comprises a loading box (310) and a loading fitting member (320), the loading box (310) being provided with a reagent hole for the loading box (310) to be placed therein, and the loading fitting member (320) being rotatably arranged in the reagent hole and used for carrying the loading box (310). The reagent mixing and loading device (10) can implement the normal mixing of reagents without the occurrence of problems such as jamming and collision.

4. 发明公开

EP4283295A3 RECOMBINANT POLYCLONAL PROTEINS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：EP4283295A3
公开(公告)日：2024-03-06
申请号：EP23192977.9
申请日：2020-04-30
申请人： Gigagen, Inc.
发明人： JOHNSON, David, Scott , ADLER, Adam, Shultz , MIZRAHI, Rena, Aviva , LIM, Yoong, Weam , ASENSIO, Michael , KEATING, Sheila , LEONG, Renee , LEONG, Jackson
IPC分类号： C07K16/12 , C40B40/10 , G01N33/50 , G01N33/53 , A61P31/04 , A61P31/16 , A61P31/22 , A61P37/06
摘要： The present invention relates to a library of antibody proteins for use in treatment of a subject, wherein the antibody proteins specifically bind antigens, wherein the antibody proteins are encoded by a library of nucleic acids derived from plasmablasts and plasma cells and generated by (a) isolating the plasmablasts and plasma cells into single-cell reaction containers, thereby obtaining millions of single cells, (b) lysing the single cells, (c) purifying and capturing antibody-specific nucleic acids on solid supports such as beads from the millions of single cells in parallele,(d) amplifying nucleic acids that encode heavy and light chain immunoglobulins, (d) subsequently linking said nucleic acids into a library of fused constructs that encode both heavy and light chain immunoglobulin, thereby obtaining the library of nucleic acids wherein the library of nucleic acids comprises natively paired sequences of heavy and light chain immunoglobulins from the millions of single cells, as originally found in the plasmablasts and plasma cells.

5. 发明授权

EP3712614B1 TREATMENT LIQUID FOR USE IN DESORPTION OF STEROID INCLUDED IN CYCLODEXTRIN 有权
公开(公告)号：EP3712614B1
公开(公告)日：2024-03-06
申请号：EP18878307.0
申请日：2018-11-16
发明人： YOSHIMI, Tatsunari , TERUYAMA, Kyoko
IPC分类号： G01N33/53 , G01N33/74 , G01N33/92 , G01N33/543 , G01N33/548

6. 发明公开

EP4328587A2 USE OF A KIT OR DEVICE AND METHOD FOR DETECTING DEMENTIA 审中-公开
公开(公告)号：EP4328587A2
公开(公告)日：2024-02-28
申请号：EP23216032.5
申请日：2019-02-12
申请人： Toray Industries, Inc. , National Center for Geriatrics and Gerontology
发明人： SUZUKI, Kana , YOSHIMOTO, Makiko , KAWAUCHI, Junpei , SUDO, Hiroko , KIDA, Yuho , KOZONO, Satoko , KONDOU, Satoshi , NIIDA, Shumpei , ASANOMI, Yuya , SHIGEMIZU, Daichi , SAKURAI, Takashi
IPC分类号： G01N33/53
摘要： An embodiment according to the present invention provides a kit or device for detection of dementia, and a method for detecting dementia. An embodiment according to the present invention relates to: a kit or device for detection of dementia, including a nucleic acid(s) capable of specifically binding to an miRNA(s) or a complementary strand(s) thereof in a sample from a subject; and a method for detecting dementia, including measuring the miRNA(s) in vitro.

7. 发明公开

EP4293568A3 MICROBEAD 审中-公开
公开(公告)号：EP4293568A3
公开(公告)日：2024-02-28
申请号：EP23207691.9
申请日：2019-01-23
申请人： BGI Shenzhen
发明人： ZHAN, Wenwei , CHEN, Wei , WANG, Weimao , LI, Mei , LI, Yuxiang , WANG, Jian
IPC分类号： G01N33/543 , G01N33/53 , G06K19/06
摘要： A microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) with a code engraved on an outside of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90). The microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) includes a central region (12, 52, 82) and an edge region (11, 51, 81) surrounding the central region (12, 52, 82). An outer contour of the edge region (11, 51, 81) before and after engraving the code is non-circular. The edge region (11, 51, 81) includes a plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The code of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) is engraved on the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). Each bit of the code corresponds to each of the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The present disclosure increases the utilization rate of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90).

8. 发明公开

EP4323768A1 METHOD OF TRACKING MAINTENANCE OF IMMUNOLOGICAL TOLERANCE 审中-公开
公开(公告)号：EP4323768A1
公开(公告)日：2024-02-21
申请号：EP22725950.4
申请日：2022-04-15
申请人： Cour Pharmaceuticals Development Company Inc.
发明人： PUISIS, John , HERRMANN, James , BOYNE, Michael , ELHOFY, Adam , PODOJIL, Joseph , WODARCYK, Greta
IPC分类号： G01N33/53 , G01N33/68

9. 发明公开

EP4323379A2 MAGEC2 IMMUNOGENIC PEPTIDES, BINDING PROTEINS RECOGNIZING MAGEC2 IMMUNOGENIC PEPTIDES, AND USES THEREOF 审中-公开
公开(公告)号：EP4323379A2
公开(公告)日：2024-02-21
申请号：EP22788903.7
申请日：2022-04-14
申请人： Tscan Therapeutics, Inc. , Academisch Ziekenhuis Leiden
发明人： FERRETTI, Andrew, P. , WANG, Yifan , MACBEATH, Gavin , XU, Qikai
IPC分类号： C07K7/06 , A61K38/00 , A61K39/395 , C07K7/00 , G01N33/53

10. 发明公开

EP4316414A1 MEDICAL IMAGE ANALYSIS DEVICE, MEDICAL IMAGE ANALYSIS METHOD, AND MEDICAL IMAGE ANALYSIS SYSTEM 审中-公开
公开(公告)号：EP4316414A1
公开(公告)日：2024-02-07
申请号：EP22779668.7
申请日：2022-02-24
申请人： Sony Group Corporation
发明人： ENOKI Junichiro
IPC分类号： A61B90/20 , G06T7/00 , G01N33/48 , G01N33/53
摘要： Information regarding a tissue present at a boundary of a region to be detected of the tissue is detected with high accuracy.
A medical image analysis device of the presents disclosure includes a region setting unit configured to set, in a processing target image obtained by imaging a biological tissue, a first region and a second region partially overlapping the first region, and a specifying unit configured to specify a first tissue region and a second tissue region, the first tissue region being a region of a tissue included in the first region, the second tissue region being a region of a tissue included in the second region. The specifying unit includes an overlap processing unit configured to process the first tissue region and the second tissue region at least partially overlapping the first tissue region to set a third tissue region.

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