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1. 发明公开

EP3126396A4 ANTI-DEATH RECEPTOR 3 (DR3) ANTAGONISTIC ANTIBODIES WITH REDUCED AGONISTIC ACTIVITY 审中-公开
标题翻译： ANTAGONISTISCHE ANTI-DEATH-REZEPTOR 3（DR3）-ANTIKÖRPERMIT VERRINGERTER AGONISTISCHERAKTIVITÄT
公开(公告)号：EP3126396A4
公开(公告)日：2017-09-06
申请号：EP15772970
申请日：2015-04-03
申请人： KYOWA HAKKO KIRIN CO LTD
发明人： MILLS DAVID , TOMIZUKA KAZUMA , LAUDENSLAGER JOHN , NIWA RINPEI , TSUCHIYA MAMI
IPC分类号： C07K16/28
CPC分类号： C07K16/2875 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： According to the present invention, anti-death receptor 3 (DR3) antagonistic IgG antibodies and antibody fragments thereof, wherein the antibodies and the antibody fragments thereof display a decreased agonistic activity or no agonistic activity for DR3 through their binding, an antibody compositions and an antibody fragment compositions comprising them, a nucleotide sequence encoding the antibody or the antibody fragment, a vector comprising the nucleotide sequences, an amino acid sequences of the antibodies or the antibody fragments, a method of producing the antibodies or the antibody fragments thereof, and a method of decreasing the agonistic potency of an antibody against DR3 through its binding, are provided.
摘要翻译：根据本发明，抗DR3拮抗IgG抗体及其抗体片段，其中抗体及其抗体片段通过它们的结合显示对DR3的激动活性降低或无激动活性，抗体组合物和包含它们的抗体片段组合物，编码抗体或抗体片段的核苷酸序列，包含所述核苷酸序列的载体，所述抗体或所述抗体片段的氨基酸序列，产生所述抗体或其抗体片段的方法，以及提供了通过其结合降低抗体对抗DR3的激动效力的方法。

2. 发明公开

EP2905290A4 HETERODIMERIC PROTEIN COMPOSITION 审中-公开
标题翻译：异二聚体蛋白组成
公开(公告)号：EP2905290A4
公开(公告)日：2016-05-25
申请号：EP13843485
申请日：2013-10-04
申请人： KYOWA HAKKO KIRIN CO LTD
发明人： NIWA RINPEI , TSUCHIYA MAMI , MURAKAMI TAKUYA , TEZUKA YUTA
IPC分类号： C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12P21/02
CPC分类号： C07K16/2833 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/41 , C07K2317/64 , C07K2317/72 , C07K2317/732 , C07K2317/734
摘要： [Problem] With respect to the previously known heterodimer proteins, their production efficiency was low and unstable, and specific production, separation and purification of heterodimer protein molecules were difficult. Accordingly, there is a need for a heterodimer protein composition that can be efficiently and stably produced, a purification method and a preparation method of the protein composition. [Means for Solution] According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising CL-Fc prepared by fusion of an immunoglobulin light chain constant region (CL) and Fc region, and also has a deletion or substitution of Cys residues involved in disulfide bonds between CL and CH1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a DNA and a vector encoding the protein composition thereof are provided

3. 发明公开

EP2543727A4 MODIFIED ANTIBODY COMPOSITION 有权
标题翻译： MODIFIZIERTEANTIKÖRPERZUSAMMENSETZUNG
公开(公告)号：EP2543727A4
公开(公告)日：2013-11-20
申请号：EP11750612
申请日：2011-02-28
申请人： KYOWA HAKKO KIRIN CO LTD
发明人： NIWA RINPEI , TSUCHIYA MAMI
IPC分类号： C12N15/09 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2887 , C07K2317/21 , C07K2317/41 , C07K2317/522 , C07K2317/526 , C07K2317/53 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Among N-glycoside-linked sugar chains which are bound to the Fc region of an antibody, sugar chains which are bound to Asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among N-glycoside-linked sugar chains which bind to the Fc region of the antibody, a method for controlling extra sugar chains which are bound to Asn residues at positions other than position 297 according to the EU index is required. An antibody variant composition, comprising amino acid residues of an Asn-X-Ser/Thr (X represents an amino acid residue other than Pro) sequence at positions other than positions 297 to 299 according to the EU index in an Fc region of a human IgG antibody, in which at least one amino acid substitution selected from an amino acid substitution of Asn to other amino acid residue, an amino acid substitution of X to Pro and an amino acid substitution of Ser/Thr to other amino acid residue is carried out, and a fragment of the antibody variant composition.
摘要翻译：在与抗体的Fc区结合的N-糖苷连接的糖链中，与297位的Asn结合的糖链与抗体在血液中的活性和稳定性有关，但可能存在额外的糖链结合于除297以外的位置的氨基酸残基对抗体恒定区介导的活性具有影响，并且可能引起作为治疗性抗体制剂的均匀性问题。因此，需要在与抗体的Fc区结合的N-糖苷连接的糖链中，根据EU指数来控制与位置297以外的位置上的Asn残基结合的额外糖链的方法。一种抗体变体组合物，其包含根据人类Fc区中的EU索引的位置297-299以外的位置处的Asn-X-Ser / Thr（X代表Pro以外的氨基酸残基）序列的氨基酸残基 IgG抗体，其中进行选自Asn至其他氨基酸残基的氨基酸取代，X至Pro的氨基酸取代和Ser / Thr至其他氨基酸残基的氨基酸取代中的至少一个氨基酸取代和抗体变体组合物的片段。

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