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1. 发明公开

EP2789602A1 Omega-halo-2-alkynal, method for producing same, and method for producing conjugated Z-alken-yn-yl acetate using same 有权
标题翻译： ω-卤代-2-炔醛，其制备方法，从而用于共轭Z-烯烃 - 炔基乙酸酯的制备方法
公开(公告)号：EP2789602A1
公开(公告)日：2014-10-15
申请号：EP14163480.8
申请日：2014-04-04
申请人： SHIN-ETSU CHEMICAL CO., LTD
发明人： Yamashita, Miyoshi , Fukumoto, Takehiko , Kinsho, Takeshi
IPC分类号： C07C67/10 , C07C69/145 , C07C45/51 , C07C47/24
CPC分类号： C07C67/10 , C07C17/2635 , C07C45/42 , C07C45/43 , C07C47/24 , C07C67/11 , C07C69/145 , C07C21/22
摘要： Provided is a method for industrially producing a conjugated Z-alken-yn-yl acetate such as Z-13-hexadecen-11-yn-yl acetate which is a sex pheromone component of a pine processionary moth, and an intermediate for the conjugated Z-alken-yn-yl acetate under mild conditions at a high yield. More specifically, provided is a method for producing a conjugated Z-alken-yn-yl acetate (5) comprising the steps of: reacting an ω-halo-2-alkynal (1) with an alkylidene triphenylphosphorane (3) through a Wittig reaction to obtain a conjugated Z-alken-yn-yl halide (4), and acetoxylating the conjugated Z-alken-yn-yl halide (4) into a conjugated Z-alken-yn-yl acetate (5).
摘要翻译：提供了一种用于在工业上制备共轭的Z-链烯炔基乙酸酯的方法：如Z-13十六碳烯-11-炔基乙酸酯的所有其是松树processionary蛾的性信息素组分，以及中间的共轭的Z- 温和的条件下 - 烯烃 - 炔基乙酸酯以高收率。更具体地，提供了一种用于制备共轭的Z-链烯炔基乙酸酯（5）包括以下步骤的方法：使至E-卤代-2-炔醛（1）与通过Wittig反应的烷叉triphenylphosphoranes（3）以得到共轭Z-烯烃 - 炔基卤化物（4），和共轭acetoxylating的Z烯烃 - 炔基卤化物（4）成共轭的Z-烯烃 - 炔基乙酸酯（5）。

2. 发明公开

EP1487776A1 ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME 审中-公开
标题翻译： Sereure- UND ESTERVERBINDUNGEN UND VERFAHREN ZU DEREN ANWENDUNG
公开(公告)号：EP1487776A1
公开(公告)日：2004-12-22
申请号：EP03718068.4
申请日：2003-03-26
申请人： SMITHKLINE BEECHAM CORPORATION
发明人： THOMPSON, SCOTT, K. , KALLANDER, Lara, S. , MA, Chun , MARINO, Joseph, P. , LEE, Dennis
IPC分类号： C07C205/00 , C07C229/00 , C07C69/76 , C07C51/23 , C07C213/00 , C07C43/00 , C09B11/02
CPC分类号： C07D213/38 , C07B2200/07 , C07C45/515 , C07C47/24 , C07C217/18 , C07C217/22 , C07C217/36 , C07C217/58 , C07C2601/08
摘要： Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
摘要翻译：公开了具有下式的化合物：其药学上可接受的盐或溶剂化物和含有该化合物的药物组合物，其中结构变量如本文所定义。本发明的化合物，盐和溶剂化物可用作LXR激动剂。

3. 发明公开

EP1138660A1 PROCESSES FOR THE PREPARATION OF (p-CHLOROPHENYL)PROPANOL DERIVATIVES 审中-公开
标题翻译：丙烯醇（P-CHLOROPHENYL）丙醛衍生物
公开(公告)号：EP1138660A1
公开(公告)日：2001-10-04
申请号：EP99973408.0
申请日：1999-11-29
申请人： Nissan Chemical Industries, Ltd.
发明人： MATSUMOTO, Hiroo Nissan Chemical Industries, Ltd. , KAMIKAWAJI, Minako Nissan Chemical Industries, Ltd , HORIUCHI, Takashi Nissan Chemical Industries, Ltd.
IPC分类号： C07C29/14 , C07C33/46 , C07C17/16 , C07C25/02 , C07B61/00 , B01J31/04
CPC分类号： C07C17/16 , C07C29/14 , C07C45/512 , C07C25/02 , C07C47/24 , C07C33/46
摘要： A process for the preparation of an alcohol compound (1), characterized by subjecting p-iodochlorobenzene to Pd coupling with allyl alcohol in the presence of tetramethylammonium chloride, followed by reduction, and a process for the preparation of a compound (2), characterized by brominating the alcohol compound (1) obtainable by said process:
摘要翻译：一种制备醇化合物（1）的方法，其特征在于在氯化四甲基铵存在下使对氯代苯与烯丙醇进行Pd偶联，然后还原，以及制备化合物（2）的方法，其特征在于通过溴化通过所述方法获得的醇化合物（1）：

4. 发明授权

EP0803493B1 Process for producing 4-substituted-2-butenals 失效
标题翻译：一种用于制备4-取代的-2- butenals过程
公开(公告)号：EP0803493B1
公开(公告)日：2000-01-05
申请号：EP97106817.6
申请日：1997-04-24
申请人： KURARAY CO., LTD.
发明人： Iwasaki, Hideharu , Onishi, Takashi
IPC分类号： C07C67/293 , C07C69/007 , C07C69/145 , C07C47/24 , C07C47/195 , C07C45/72 , C07C45/74 , C07C69/16
CPC分类号： C07C45/74 , C07C67/293 , C07C47/24 , C07C69/007 , C07C69/145

5. 发明授权

EP0775103B1 RETINOIC ACID X-RECEPTOR LIGANDS 失效
标题翻译：视黄酸X受体配体
公开(公告)号：EP0775103B1
公开(公告)日：1999-06-09
申请号：EP95930430.4
申请日：1995-07-29
申请人： F. HOFFMANN-LA ROCHE AG
发明人： KLAUS, Michael , LOVEY, Allen, John , MOHR, Peter , ROSENBERGER, Michael
IPC分类号： C07C57/50 , A61K31/19 , C07C57/62
CPC分类号： C07F9/4056 , C07C45/29 , C07C45/298 , C07C45/63 , C07C47/24 , C07C47/277 , C07C57/50 , C07C2601/16 , C07D333/24 , C07C47/453 , C07C47/34 , C07C47/238 , C07C47/546 , C07C47/235
摘要： Compounds of formula (I) wherein R?1-R7, R10¿, X and the dotted bond have the meaning given in the specification, bind selectively to retinoid RXR receptors and are useful as antiproliferative agents for dermatological and oncological indications.

6. 发明公开

EP0846670A1 CYCLOHEXANE DERIVATIVES AND LIQUID-CRYSTAL COMPOSITIONS 失效
标题翻译：环己烷衍生物和液晶组合物
公开(公告)号：EP0846670A1
公开(公告)日：1998-06-10
申请号：EP96926607.1
申请日：1996-08-08
申请人： CHISSO CORPORATION
发明人： KATO, Takashi , MATSUI, Shuichi , MIYAZAWA, Kazutoshi , HACHIYA, Norihisa , NAKAGAWA, Etsuo
IPC分类号： C07C22/08 , C07C25/18 , C07C25/24 , C07C43/174 , C07C43/176 , C07C43/192 , C07C43/225 , C07C69/75 , C07C69/773 , C07C255/50 , C07C255/54
CPC分类号： C07C17/263 , C07C17/2632 , C07C17/266 , C07C17/354 , C07C22/08 , C07C25/18 , C07C25/24 , C07C43/225 , C07C45/41 , C07C45/513 , C07C47/238 , C07C47/24 , C07C69/753 , C07C69/76 , C07C69/88 , C07C69/90 , C07C255/50 , C07C255/54 , C07C255/55 , C07C2601/14 , C09K19/3003 , C09K19/3028 , C09K19/3048 , C09K19/3068 , C09K19/42 , C09K19/46
摘要： Novel liquid crystalline compounds and liquid crystal compositions comprising the compound are provided which liquid crystalline compounds have a high dielectric anisotropy, high voltage holding ratio at temperatures in which the compounds are employed, low threshold voltage, and improved solubility with other liquid crystal materials at low temperatures; and the liquid crystalline compounds are cyclohexane derivatives expressed by the following general formula (1)
wherein R 1 represents an alkyl group having 1 to 15 carbon atoms, at least one non-adjacent methylene group (-CH 2 -) in the alkyl group may be replaced by -O-, -S-, -CH=CH-, or -C≡C-; L 1 , L 2 , L 3 , and L 4 independently represent H or F; X represent a halogen atom, CF 3 , OCF 3 , OCHF 2 , CN, or NCS; and Z 1 and Z 2 independently represent -(CH 2 ) 2 -, -CH=CH-, -COO-, or a covalent bond.

7. 发明公开

EP0803493A2 Process for producing 4-substituted-2-butenals 失效
标题翻译： Verfahren zum Herstellen von 4-substitutionierten-2-Butenalen
公开(公告)号：EP0803493A2
公开(公告)日：1997-10-29
申请号：EP97106817.6
申请日：1997-04-24
申请人： KURARAY CO., LTD.
发明人： Iwasaki, Hideharu , Onishi, Takashi
IPC分类号： C07C67/293 , C07C69/007 , C07C69/145 , C07C47/24 , C07C47/195 , C07C45/72
CPC分类号： C07C45/74 , C07C67/293 , C07C47/24 , C07C69/007 , C07C69/145
摘要： Described is a process for producing a 4-substituted-2-butenal represented by the following formula (1);
(wherein X represents an acyloxy group or halogen atom; R represents hydrogen atom, an aliphatic hydrocarbon group or an aromatic hydrocarbon group; and these hydrocarbon groups can be substituted with hydroxyl group, an alkoxy group, an aryloxy group, an acyl group or an alkoxycarbonyl group),
which is useful as synthetic intermediate of pharmaceuticals, agricultural chemicals and the like,
comprising subjecting a substituted acetaldehyde represented by the following formula (2);

X-CH 2 -CHO (2)

(wherein X has the same meaning as defined above),to the reaction with an aldehyde represented by the following formula (3);

R-CH 2 -CHO (3)

(wherein R has the same meaning as defined above)
in the presence of an amino carboxylic acid.
摘要翻译：描述了由下式（1）表示的4-取代-2-丁烯醛的制备方法。（其中X表示酰氧基或卤素原子; R表示氢原子，脂族烃基或芳香族烃基;这些烃基可以被羟基，烷氧基，芳氧基，酰基基团或烷氧基羰基），其可用作药物，农药等的合成中间体，包括使由下式（2）表示的取代乙醛进行处理; 与下式（3）表示的醛反应的X-CH 2 -CH（其中X具有与上述相同的含义）。在氨基羧酸存在下，R-CH2-CHO（其中R具有与上述相同的含义）。

8. 发明公开

EP0656878A4 SYNTHESIS OF HALOENONES AND ARYL OR ALKYL SUBSTITUTED ENONES OR ALKENES. 失效
标题翻译：芳香烃和芳基或烷基取代的芳香族或碱基的合成。
公开(公告)号：EP0656878A4
公开(公告)日：1995-07-05
申请号：EP93921208
申请日：1993-08-25
申请人： NEW YORK UNIVERSITY
发明人： MCNELIS, EDWARD
IPC分类号： C07C35/29 , C07C45/51 , C07C45/65 , C07C45/68 , C07C47/24 , C07C49/227 , C07C49/23 , C07C49/235 , C07C49/687 , C07C49/693 , C07C49/697 , C07C49/798 , C07C49/813 , C07C45/30
CPC分类号： C07C49/813 , C07C35/29 , C07C45/512 , C07C45/65 , C07C45/68 , C07C47/24 , C07C49/227 , C07C49/23 , C07C49/235 , C07C49/687 , C07C49/693 , C07C49/697 , C07C49/798
摘要： Alternative methods for synthesizing haloenones and haloalkenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, using such haloenones and haloalkenes.

9. 发明公开

EP0647696A1 Cyclohexane derivative 失效
标题翻译： Cyclohexanderivat。
公开(公告)号：EP0647696A1
公开(公告)日：1995-04-12
申请号：EP93116355.4
申请日：1993-10-08
申请人： Chisso Corporation
发明人： Onji, Yuichi , Ushioda, Makoto , Matsui, Shuichi , Kondo, Tomoyuki , Goto, Yasuyuki
IPC分类号： C09K19/30 , C07C25/24 , C07C43/225
CPC分类号： C07C17/23 , C07C17/093 , C07C17/16 , C07C17/2635 , C07C25/24 , C07C43/225 , C07C45/513 , C07C45/59 , C07C45/62 , C07C45/68 , C07C2601/14 , C09K19/3003 , C09K19/3028 , C09K2019/0444 , C07C25/18 , C07C47/457 , C07C47/24 , C07C49/697
摘要： A novel liquid crystal material having an alkenyl group at the end of the molecule, and having a low viscosity, and when the compound is added, being able to reduce the threshold voltage of the resulting display element, is provided, the compound being expressed by the formula (I),

wherein X is a F atom, a trifluoromethyl group, a trifluoromethoxy group or a difluoromethoxy group, -A- is 1,4-cyclohexylene or 1,4-phenylene, -B- is 1,4-cyclohexylene, l is 0, 1 or 2, m is 0, 1 or 2, l+m≧1, Z is -CH₂CH₂- or single bond, n is an integer of 0 to 4, R is a H atom or a linear or branched alkyl group of 1-7C, and when R is an alkyl group, the double bond has a trans-configuration. The compounds of the present invention are suitable as liquid crystal material for STN display element, and further is chemically stable; hence it is possible to prepare a composition having a superior multiplex characteristic and capable of effecting a low voltage drive.
摘要翻译：一种在分子末端具有烯基并具有低粘度的新型液晶材料，并且当添加化合物时能够降低所得显示元件的阈值电压，化合物由式（I），其中X是F原子，三氟甲基，三氟甲氧基或二氟甲氧基，-A-是1,4-亚环己基或1,4-亚苯基，-B-是1， 4-亚环己基，l为0,1或2，m为0,1或2,1，m + 1，Z为-CH 2 CH 2 - 或单键，n为0〜4的整数，R为H 原子或1-7C的直链或支链烷基，当R为烷基时，双键具有反式构型。本发明的化合物适用于STN显示元件的液晶材料，并且化学稳定; 因此可以制备具有优异的多重特性并能够进行低电压驱动的组合物。

10. 发明公开

EP0588915A1 AZULENIC RETINOID COMPOUNDS, COMPOSITIONS AND METHODS 失效
标题翻译： AZULENISCHE，维甲酸类化合物，组合物和方法。
公开(公告)号：EP0588915A1
公开(公告)日：1994-03-30
申请号：EP92912944.0
申请日：1992-03-18
申请人： UNIVERSITY OF HAWAII
发明人： ASATO, Alfred, E. , LIU, Robert, S., H.
IPC分类号： A61K31 , A61P17 , A61P35 , C07C33 , C07C45 , C07C47 , C07C49 , C07C57 , C07C63 , C07C69 , C07C233 , C07C251
CPC分类号： C07C251/18 , A61K31/07 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/275 , C07C33/16 , C07C33/34 , C07C33/44 , C07C45/298 , C07C45/44 , C07C45/515 , C07C45/67 , C07C45/74 , C07C47/225 , C07C47/24 , C07C47/445 , C07C47/548 , C07C49/23 , C07C57/42 , C07C63/66 , C07C69/608 , C07C69/65 , C07C69/76 , C07C2602/30
摘要： De nouveaux composés et compositions thérapeutiques rétinoïdes azuléniques sont décrits, ainsi que leur procédé de production et leur utilisation en tant qu'agents anticancéreux et agents de prévention du cancer. Les compositions selon la présente invention trouveront aussi leur utilisation dans le traitement de dermatoses telles que l'acné et le psoriasis, ainsi que dans des traitements dermatologiques tels que le traitement et l'effacement des rides.

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