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1. 发明公开

EP2205252A4 INHIBITION OF DENDRITIC CELL-DRIVEN REGULATORY T CELL ACTIVATION AND POTENTIATION OF TUMOR ANTIGEN-SPECIFIC T CELL RESPONSES BY INTERLEUKIN-15 AND MAP KINASE INHIBITOR 有权
标题翻译：树突状细胞通过受控T细胞激活和增强肿瘤抗原特异性T细胞应答的抑制白细胞介素15和MAP激酶抑制剂
公开(公告)号：EP2205252A4
公开(公告)日：2012-02-15
申请号：EP08834390
申请日：2008-09-27
申请人： UNIV ARKANSAS
发明人： CANNON MARTIN J , KOZAK KELLIE J , O'BRIEN TIMOTHY J
IPC分类号： A61K35/14 , A61K38/20 , C12N5/0784 , C12N5/08
CPC分类号： C12N5/0636 , A61K38/2086 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N5/0639 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要： The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided.

2. 发明公开

EP2222839A4 METHODS AND COMPOSITIONS FOR MODULATING DIFFERENTIATION OF PLURIPOTENTIAL CELLS 无效
标题翻译：方法和组合物调制多能干细胞的分化
公开(公告)号：EP2222839A4
公开(公告)日：2012-02-01
申请号：EP08856546
申请日：2008-12-03
申请人： SANBIO INC
发明人： AIZMAN IRINA
IPC分类号： C12N5/0735 , C12N5/08
CPC分类号： C12N5/0663 , C12N2501/42 , C12N2510/00

3. 发明公开

EP2173864A4 LOW RIGIDITY GELS FOR MSC GROWTH MODULATION 失效转让
标题翻译：具有低电阻MSC长调节GELS
公开(公告)号：EP2173864A4
公开(公告)日：2011-09-14
申请号：EP08779877
申请日：2008-06-30
申请人： FUNAKI MAKOTO
发明人： FUNAKI MAKOTO , WINER JESSAMINE
IPC分类号： C12N5/0775 , C12N5/08
CPC分类号： C12N5/0068 , C12N5/0663 , C12N2533/30 , C12N2533/52 , C12N2533/54

4. 发明公开

EP2250497A4 CELL PROCESSING AND/OR ENRICHMENT METHODS 有权
标题翻译：细胞处理和/或浓缩过程
公开(公告)号：EP2250497A4
公开(公告)日：2011-08-24
申请号：EP09712569
申请日：2009-02-18
申请人： GENETIC TECHNOLOGIES LTD
发明人： MANTZARIS DEBBIE , ALLMAN RICHARD
IPC分类号： G01N33/483 , C12N5/073 , C12Q1/68 , C12N5/08 , C12N5/06
CPC分类号： C12N5/0603

5. 发明公开

EP2167648A4 METHODS AND COMPOSITIONS FOR OPTIMIZED EXPANSION AND IMPLANTATION OF MESENCHYMAL STEM CELLS 无效转让
标题翻译：方法和组合优化的扩展和植入骨髓间充质干细胞
公开(公告)号：EP2167648A4
公开(公告)日：2011-07-06
申请号：EP08771942
申请日：2008-06-25
申请人： REGENERATIVE SCIENCES LLC
发明人： CENTENO CHRISTOPHER J , KEOHAN CRISTIN
IPC分类号： A61K35/12 , A61K45/00 , C12N5/00 , C12N5/0775 , C12N5/08
CPC分类号： A61K35/28 , A61K9/0019 , A61K35/19 , A61K2035/124 , C12N5/0663 , C12N2500/84 , C12N2502/115
摘要： Compositions and methods are provided for the optimized expansion and implantation of mesenchymal stem cells into a patient in need thereof. Autologous mesenchymal stem cells (MSCs) to a patient in need of MSCs are harvested, expanded within novel growth parameters under the influence of autologous growth factors located on the patient's platelets.

6. 发明公开

EP1551225A4 CRYOPRESERVATION OF HAPTENIZED TUMOR CELLS 审中-公开
标题翻译：冷冻保存半抗原的肿瘤细胞
公开(公告)号：EP1551225A4
公开(公告)日：2011-05-25
申请号：EP03757476
申请日：2003-06-10
申请人： AVAX TECHNOLOGIES INC , UNIV JEFFERSON
发明人： BERD DAVID , ERDILE LORNE F , MOKYR MARGALIT B
IPC分类号： C12N1/04 , A01N20060101 , A01N1/00 , A01N1/02 , A61K9/19 , A61K35/12 , A61K39/00 , A61K39/39 , A61K47/26 , A61K47/42 , C12N5/06 , C12N5/08
CPC分类号： A01N1/0221 , A01N1/02

7. 发明公开

EP2262891A4 EXTRACELLULAR MATRIX COMPOSITIONS 有权
标题翻译：细胞外基质组合物
公开(公告)号：EP2262891A4
公开(公告)日：2011-04-20
申请号：EP09706122
申请日：2009-01-30
申请人： HISTOGEN INC
发明人： NAUGHTON GAIL K , ZIEGLER FRANK , BAUMGARTNER MARK , NICKEY KYLE
IPC分类号： C12N5/071 , C12N5/077 , C12N5/08
CPC分类号： A61L27/3895 , A61L27/34 , A61L29/085 , A61L31/10 , C12N5/0068 , C12N5/0627 , C12N5/0656 , C12N2500/02 , C12N2500/90 , C12N2501/165 , C12N2501/415 , C12N2533/90 , C08L89/00
摘要： The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible three-dimensional surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions useful in a variety of medical and therapeutic applications.

8. 发明公开

EP2307045A1 METHODS AND COMPOSITIONS 审中-公开
标题翻译：方法和组合物
公开(公告)号：EP2307045A1
公开(公告)日：2011-04-13
申请号：EP09766134.2
申请日：2009-06-18
申请人： University Court of the University of Edinburgh
发明人： GREGORY, Christopher , POUND, John David , BOURNAZOU, lrini
IPC分类号： A61K38/40 , C12N5/06 , C12N5/08
CPC分类号： A61K38/40 , C12N5/0642 , C12N2501/998
摘要： The invention relates to methods for modulating granulocyte activation and migration, use of such methods in the treatment of diseases and compositions which may be employed in such methods and uses. In particular, the modulation of granulocyte activation/migration is achieved by increasing or decreasing the amount of lactoferrin in the vicinity of said granulocytes.

9. 发明公开

EP2283118A1 METHOD OF EFFECTING DE-DIFFERENTIATION OF A CELL 审中-公开
标题翻译：程序，旨在确保分化。CELL
公开(公告)号：EP2283118A1
公开(公告)日：2011-02-16
申请号：EP08874225.9
申请日：2008-10-21
申请人： Agency for Science, Technology And Research
发明人： FENG, Bo , JIANG, Jianming , NG, Huck Hui , LUFKIN, Thomas , KRAUS, Petra
IPC分类号： C12N5/08 , C12N5/10
CPC分类号： C12N5/0696 , C12N2501/38 , C12N2501/602 , C12N2501/603 , C12N2501/606 , C12N2510/00
摘要： The invention provides a method of effecting de-differentiation of an at least partially differentiated cell or of maintaining pluripotency and/or self-renewing characteristics of an undifferentiated cell. The method comprises increasing the amount or the activity of an Err protein, or a functional fragment thereof, in the cell.

10. 发明公开

EP2277993A1 METHOD FOR PRODUCING ENDOTHELIAL CELLS (VARIANTS) 有权
标题翻译： VERFAHREN ZUR PRODUKTION VON ENDOTHELZELLEN（VARIANTEN）
公开(公告)号：EP2277993A1
公开(公告)日：2011-01-26
申请号：EP08873385.2
申请日：2008-12-24
申请人： Obshhestvo S Ogranichennojj Otvetstvennost' Ju "Laboratorija Kletochnykh Tekhnologijj"
发明人： KISELJOV, Sergejj L'vovich , LAGAR'KOVA, Marija Andreevna
IPC分类号： C12N5/08
CPC分类号： C12N5/069 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/15 , C12N2501/155 , C12N2501/165 , C12N2506/02 , C12N2533/54
摘要： The invention relates to biotechnology, in particular to producing endothelial cells from human embryonic stem cells and to the use thereof. The inventive method for producing endothelial cells from human embryonic stem cells involves differentiating human embryonic stem cells on a substrate and in a synthetic medium that provide targeted direct differentiation of hESCs into endothelial cells based on a mixture of DMEM/F12 and a KO serum substitute having VEGF, SCF, BMP4, bFGF and TGFbeta growth factors and taken in effective quantities, wherein TGFbeta is introduced on 3rd-6th day of differentiation. A differentiation medium based on the mixture of DMEM/F12 with fetal bovine serum having VEGF, SCF and bFGF growth factors can be also used. The separation is carried out on 3rd-9th day according to an immunological selection method using markers specific for endothelial cells and, afterwards, the thus produced endothelial cells are cultivated in the abovementioned medium at the plating density of not less than 50,000 cells per cm 2 .
摘要翻译：本发明涉及生物技术，特别涉及从人类胚胎干细胞产生内皮细胞及其应用。用于从人胚胎干细胞产生内皮细胞的本发明的方法包括在基质和合成培养基中分化人胚胎干细胞，所述培养基基于DMEM / F12和KO血清替代物的混合物将hESC靶向直接分化为内皮细胞，所述混合物具有 VEGF，SCF，BMP4，bFGF和TGFbeta生长因子，有效量，其中TGFbeta在分化第3〜6天引入。还可以使用基于DMEM / F12与具有VEGF，SCF和bFGF生长因子的胎牛血清的混合物的分化培养基。根据使用对内皮细胞特异性标记的免疫学选择方法，在第3〜9天进行分离，之后，将上述制作的内皮细胞以不小于50,000个细胞/ cm 2的电镀密度培养在上述培养基中。

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