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1. 发明公开

EP4273237A1 TRANSAMINASE MUTANT AND APPLICATION THEREOF 审中-公开
公开(公告)号：EP4273237A1
公开(公告)日：2023-11-08
申请号：EP21924110.6
申请日：2021-07-06
申请人： Asymchem Laboratories (Tianjin) Co., Ltd.
发明人： HONG, Hao , JAMES, Gage , XIAO, Yi , ZHANG, Na , JIAO, Xuecheng , MA, Yulei , MOU, Huiyan , WANG, Zujian , SUN, Kaihua , LI, Xiang , ZHAO, Tong , CAO, Shan
IPC分类号： C12N9/10 , C12N15/54 , C12P13/00 , C12P17/12 , C12P17/14
摘要： Provided are transaminase mutants and uses thereof. The transaminase mutant is obtained by one or more amino acid mutations occurring in SEQ ID NO: 2 or is a mutant with a conserved amino acid mutation obtained by taking the sequence SEQ ID NO: 1 of a wild-type CvTA transaminase as a reference. Compared with wild-type transaminases, the catalytic activity of the mutant is improved to different degrees, so that the production efficiency of chiral amine compound synthesis may be improved.

2. 发明公开

EP3975978A1 SYSTEMS AND METHODS FOR STABILIZING EMULSIONS 审中-公开
公开(公告)号：EP3975978A1
公开(公告)日：2022-04-06
申请号：EP20818441.6
申请日：2020-06-03
申请人： Dropworks, Inc.
发明人： DUNN, Matthew Ryan , LARSEN, Andrew Carl , PERKINS, Christopher Michael
IPC分类号： A61K8/06 , B01F17/00 , C07C237/06 , C08F2/22 , C11D1/94 , C12P17/14

3. 发明授权

EP2097423B1 AMINOTHIAZOLE MACROCYCLES, THEIR USE AS ANTIBACTERIAL COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION 有权
标题翻译： AMINOTHIAZOLMAKROCYCLEN，它们的使用作为抗菌化合物并处理其
公开(公告)号：EP2097423B1
公开(公告)日：2011-03-02
申请号：EP07863118.1
申请日：2007-12-19
申请人： Novartis AG
发明人： LAMARCHE, Matthew J. , LEEDS, Jennifer A. , KRASTEL, Philipp , NAEGELI, Hans-Ulrich
IPC分类号： C07D513/22 , C12N1/20 , C12P17/14 , A61K31/429 , A61P31/00
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and to methods for obtaining such compounds.

4. 发明公开

EP1888740A2 MIKROORGANISMEN BURKHOLDERIA RHIZOXINA, NEUE ENDOSYMBIONTEN AUS RHIZOPUS SP. UND VERFAHREN ZUR HERSTELLUNG VON RHIZOXIN UND / ODER RHIZOXIN-DERIVATEN UNTER VERWENDUNG DIESER MIKROORGANISMEN 有权
标题翻译：微生物鼻疽rhizoxina，从根霉新共生体。及其制造方法根瘤菌素和/或根瘤菌素衍生物使用本微生物
公开(公告)号：EP1888740A2
公开(公告)日：2008-02-20
申请号：EP06753237.4
申请日：2006-06-01
申请人： Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- (HKI)
发明人： HERTWECK, Christian , PARTIDA-MARTINEZ, Laila, P.
IPC分类号： C12N1/20 , C12P17/14 , C12P17/16
CPC分类号： C12P17/16 , C12R1/01
摘要： The invention relates to a method for producing rhizoxin and derivatives of rhizoxin. The aim of the invention is to produce novel micro-organisms that synthesise rhizoxin or derivatives of rhizoxin, and to provide a method for producing rhizoxin or derivatives thereof, without the disadvantages of prior art and in a simpler manner with a higher yield. To this end, bacterial symbionts of Rhizopus sp., in the form of Burkholderia Rhizoxina DSM 17360 or other Burkholderia Rhizoxina strains, are isolated, cultivated and used for the fermentative production of rhizoxin and/or derivatives of rhizoxin in a submerged culture, and the rhizoxin and/or the derivatives thereof are subsequently isolated from the culture supernatant.

5. 发明公开

EP1838863A1 METHODS FOR THE PRODUCTION OF ANSAMITOCINS 审中-公开
标题翻译：用于生产ansamitocins
公开(公告)号：EP1838863A1
公开(公告)日：2007-10-03
申请号：EP05853651.7
申请日：2005-12-12
申请人： Immunogen, Inc.
发明人： KUO, Cynthia , BYNG, Graham S. , WIDDISON, Wayne C.
IPC分类号： C12P17/18 , A61K39/40 , A61K39/44 , A61K39/395 , C12P17/14 , C12P17/16
CPC分类号： C12P17/188
摘要： A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.

6. 发明公开

EP1561820A4 NOVEL SUBSTANCE FKI-1033 AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：新物质FKI-1033和工艺及其生产
公开(公告)号：EP1561820A4
公开(公告)日：2007-08-22
申请号：EP02780072
申请日：2002-11-12
申请人： KITASATO INST
发明人： OMURA SATOSHI , SHIOMI KAZURO , MASUMA ROKURO
IPC分类号： A01N43/72 , A01N63/04 , A61P33/00 , A61P43/00 , C07K11/02 , C12P17/00 , C12P17/14 , C12P21/02 , C12R1/645 , A61K31/395 , C07D273/00
CPC分类号： C07K11/02 , A01N43/72 , C12P17/14 , C12R1/645
摘要： The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.

7. 发明公开

EP1808492A1 Synthesis of intermediates for the preparation of pramipexol 审中-公开
标题翻译： Herstellung von Pramipexol的Synthese von Zwischenproduktenfürdie
公开(公告)号：EP1808492A1
公开(公告)日：2007-07-18
申请号：EP07000277.9
申请日：2007-01-08
申请人： Dipharma Francis S.r.l.
发明人： Riva, Sergio , Fassi, Paola , Scarpellini, Michele , Allegrini, Pietro , Razzetti, Gabriele
IPC分类号： C12P17/14 , C12P41/00 , C07D277/82
CPC分类号： C12P17/14 , C07D277/82 , C12P41/005
摘要： A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof

wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof,

wherein R 1 is straight or branched C 1 -C 6 alkyl, optionally substituted with phenyl; and the asterisk * and R have the meanings defined above, with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
摘要翻译：制备式（I）的酸作为单独的（R）对映异构体或（S）的酸的方法或其盐，其中R是被保护的氨基; 并且星号*表示立体碳原子，包括使式（II）的酯作为（R，S）对映异构体或其盐的混合物，其中R 1是直链或支链C 1 -C 6烷基，任选地被苯基取代; 和星号*和R具有上述定义，与来自南极念珠菌的脂肪酶在有效获得包含式（I）的酸的混合物作为单独的（R）对映体的条件下，和式（II）的酯），作为个体（S）对映异构体; 随后水解后者以获得式（I）的酸作为个体（S）对映异构体; 如果需要，将式（I）的酸作为（R）或（S）对映异构体转化为其盐。

8. 发明授权

EP0865498B1 VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN ARYLMILCHSÄURE-HALTIGEN CYCLODEPSIPEPTIDEN MIT 24 RINGATOMEN 失效
标题翻译：用于生产取代ARYLMILCHSÄURE含环缩酚酸肽24个环原子
公开(公告)号：EP0865498B1
公开(公告)日：2002-10-23
申请号：EP96939916.1
申请日：1996-11-25
申请人： BAYER AG
发明人： JESCHKE, Peter , BONSE, Gerhard , THIELKING, Gerhard , ETZEL, Winfried , HARDER, Achim , MENCKE, Norbert , KLEINKAUF, Horst , ZOCHER, Rainer , IINUMA, Katsuharu , MIYAMOTO, Kouichi
IPC分类号： C12P17/14
CPC分类号： C07D273/00 , C12P1/00 , C12P17/14 , Y10S435/911
摘要： The invention relates to a new process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms of the formula (I), in which R?1, R2, R3, R4¿ have the meanings given in the description, with the aid of fungal strains of the Agonomycetales class or enzymatic preparations isolated therefrom.

9. 发明授权

EP0849267B1 Furoindolizines 失效
公开(公告)号：EP0849267B1
公开(公告)日：2001-09-26
申请号：EP97122290.6
申请日：1997-12-17
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Mizukami, Tamio , Ogawa, Harumi , Nakai, Ryuichiro , Asai, Akira , Yamashita, Yoshinori , Ando, Katsuhiko , Agatsuma, Tsutomu , Akinaga, Shiro , Ouchi, Kozo , Kawasaki, Hideki
IPC分类号： C07D491/16 , A61K31/40 , C07D487/04 , C12P17/14 , C12N1/14
CPC分类号： C07D487/04 , C12P17/14

10. 发明公开

EP0826678A1 Process for preparing optically active benzothiazepine compound, and intermediate therefor 失效
标题翻译：一种制备光学活性的苯并硫氮杂化合物和中间体为此过程
公开(公告)号：EP0826678A1
公开(公告)日：1998-03-04
申请号：EP97114700.4
申请日：1997-08-25
申请人： TANABE SEIYAKU CO., LTD.
发明人： Kometani, Tadashi , Matsumae, Hiroaki , Shibatani, Takeji
IPC分类号： C07D281/10 , C12P17/14
CPC分类号： C07D281/10 , C12P17/14
摘要： Powdery aggregate of 2-phenyl-1,5-benzothiazepin-3,4(2H,5H)-dione compound:
wherein Ring A and Ring B are benzene ring having optionally substituent selected from lower alkyl, lower alkoxy and halogen, which is prepared by admixing solution of the compound (II) in polar organic solvent with solvent which does not substantially dissolve the compound (II) but is miscible with said polar organic solvent, and separating and collecting the resultant particles of the compound (II). Said aggregate of the compound (II) can be converted into optically active 3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one compounds (I) on industrial scale, which are useful as intermediate for various medicaments.
摘要翻译： 2-苯基-1,5-苯并硫氮杂-3,4（2H，5H） - 二酮化合物的粉末状集聚体： worin环A和环B是任选具有取代基选自低级烷基，低级烷氧基和卤素的苯环，所有这些是通过混合在极性有机溶剂中的化合物（II）的溶液用溶剂基本上不溶解化合物（II），但是可混溶的与所述极性有机溶剂，并分离和收集所得颗粒中的化合物的制备（II），所述化合物（II）的聚集体可以在工业规模上，这是被转换成光学活性的3-羟基-2-苯基-2,3-二氢-1,5-苯并硫氮杂-4（5H） - 酮化合物（I）可用作中间体的各种药物。

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