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    • 6. 发明公开
    • DEVICE FOR USE IN THE DETECTION OF BINDING AFFINITIES
    • EP4306940A1
    • 2024-01-17
    • EP22185292.4
    • 2022-07-15
    • lino Biotech AG
    • Frutiger, Andreas
    • G01N21/77G01N21/25
    • A device for use in the detection of binding affinities comprises a substrate, and a slab waveguide arranged on the substrate and extending in a longitudinal direction. The slab waveguide (2) comprises an outer surface (20) opposite to the surface facing the substrate. An optical coupler (4) is arranged on the slab waveguide such that the coherent light propagates in the longitudinal direction through the slab waveguide, with an evanescent field of the coherent light propagating along the outer surface of the slab waveguide. At least one sensing spot (3) is arranged on the outer surface (20) of the slab waveguide. The sensing spot comprises affinity elements capable of binding with target molecules, wherein the affinity elements are arranged along a plurality of decoupler lines (34) arranged to form a decoupler grating when the target molecules are bound to the affinity elements. The at least one sensing spot comprises a first straight boundary (30) and a second straight boundary (31) which are arranged parallel to one another and extend in the longitudinal direction, and wherein each decoupler line of the plurality of decoupler lines (34) extends from the first straight boundary (30) to the second straight boundary (31).