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1. 发明专利

JP2006213603A Adhesive composition for pasting on skin and adhesive sheet for pasting on skin 有权
标题翻译：用于粘贴皮肤和粘合片的粘合剂组合物
公开(公告)号：JP2006213603A
公开(公告)日：2006-08-17
申请号：JP2005025287
申请日：2005-02-01
申请人： Lintec Corp , リンテック株式会社
发明人： TAKANASHI TAKAYA , HOSHI MASARU , OKABE HIDEAKI
IPC分类号： A61K9/70 , A61F13/02 , A61K47/32 , C09J7/02 , C09J133/06 , C09J175/04
摘要： PROBLEM TO BE SOLVED: To provide an adhesive composition for pasting on a skin while maintaining prescribed cohesive force, capable of obtaining the adhesive having high wettability or followability against the skin, and an adhesive sheet for pasting to the skin, equipped with such an adhesive layer.
SOLUTION: This adhesive sheet for pasting on the skin consisting of a supporting body and the adhesive layer laminated on the back side of the supporting material is provided by constituting the adhesive layer by an adhesive obtained by cross-linking the adhesive composition obtained by adding (B) a long chain isocyanate-based cross-linking agent having ≥2 isocyanate groups in its molecule to (A) an adhesive component containing (a) a (meth)acrylic acid ester copolymer having a cross-linkable functional group, (b) a (meth)acrylic oligomer and (c) a (meth)acrylic polymer without having the cross-linkable functional group if desired.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种粘合剂组合物，用于在保持规定的内聚力的同时保持规定的内聚力，能够获得具有高润湿性或对皮肤的追随性的粘合剂，以及粘贴到皮肤上的粘合片，这样的粘合剂层。解决方案：通过将获得的粘合剂组合物交联而获得的粘合剂构成粘合剂层来提供粘合在由支撑体构成的皮肤上的粘合片和层叠在支撑材料的背面上的粘合剂层通过在（A）含有（a）具有可交联官能团的（甲基）丙烯酸酯共聚物的粘合剂组分中加入（B）分子中具有≥2个异氰酸酯基团的长链异氰酸酯基交联剂（B）（b）（甲基）丙烯酸低聚物和（c）如果需要，不具有可交联官能团的（甲基）丙烯酸聚合物。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006045158A Method for producing percutaneously absorbable type pharmaceutical preparation 有权
标题翻译：生产可吸收型类药物制剂的方法
公开(公告)号：JP2006045158A
公开(公告)日：2006-02-16
申请号：JP2004230922
申请日：2004-08-06
申请人： Lintec Corp , リンテック株式会社
发明人： HOSHI MASARU , ISHIKAWA KENICHI
IPC分类号： A61K9/70 , A61K31/164 , A61L15/58 , A61P17/00 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a method for effectively producing a percutaneously absorptive type pharmaceutical preparation having an adhesive layer uniformly and stably containing percutaneously absorbable medicine of the both of solution and crystal states on the surface of a carrier even when the preparation has no proper solvent.
SOLUTION: The method comprises preparing a coating mixture by mixing and dispersing in an adhesive layer-forming material a medicine of more amount than the saturation solubility at normal temperature, which medicine is solid at normal temperature, hardly-soluble or insoluble in toluene or ethyl acetate and soluble in the solid of the adhesive layer-forming material, forming a coated layer on the surface of the carrier or the surface of a release sheet by using the coating mixture, heat-treating the obtained matter at a temperature higher than the melting point of the medicine, then cooling the heat-treated matter to form an adhesive layer containing the medicine, and adhering on the adhesive layer a release sheet when forming a coated layer on the surface of the carrier, or, a carrier when forming a coated layer on the surface of a release sheet.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种有效地制备经皮吸收型药物制剂的方法，其具有在载体表面上均匀且稳定地含有溶液和晶体状态的经皮吸收药物的粘合剂层，即使制备没有适当的溶剂。解决方案：该方法包括通过在粘合剂层形成材料中混合并分散在常温下的饱和溶解度以上的药物来制备涂料混合物，该药物在常温下为固体，难溶或不溶于甲苯或乙酸乙酯，并溶解在粘合剂层形成材料的固体中，通过使用涂布混合物在载体表面或剥离片的表面上形成涂层，在更高的温度下热处理所得物质然后冷却热处理物以形成含有药物的粘合剂层，并且在载体的表面上形成涂层时粘附在粘合剂层上，或者在载体的表面上粘附有剥离片在剥离片的表面上形成涂层。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2009007310A Film-formed preparation and method for producing the same 有权
标题翻译：成膜方法及其制备方法
公开(公告)号：JP2009007310A
公开(公告)日：2009-01-15
申请号：JP2007171817
申请日：2007-06-29
申请人： Lintec Corp , Zeria Pharmaceut Co Ltd , ゼリア新薬工業株式会社 , リンテック株式会社
发明人： SUZUKI EIJI , YANAGIMOTO KAISA , HOSHI MASARU , TAKEMURA KOUJI , KOBAYASHI SHOJIRO
IPC分类号： A61K31/5415 , A61K9/24 , A61K31/451 , A61K47/22 , A61K47/26 , A61K47/32 , A61P1/12 , A61P43/00 , C07D453/02
摘要： PROBLEM TO BE SOLVED: To provide a film-formed preparation excellent in the masking effect for a bitter taste component and a method for producing the same.
SOLUTION: This film-formed preparation is characterized by having water-swellable gel-forming layers containing acesulfame potassium or sucralose which are laminated directly or as mediated by an intermediate layer, at both of the sides of a medicine-containing layer containing mequitazine or loperamide hydrochloride.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种具有优异的苦味成分掩蔽效果的成膜剂及其制备方法。解决方案：该成膜制剂的特征在于含有乙酰磺胺酸钾或三氯蔗糖的水溶胀性凝胶形成层，其直接层压或由中间层介导，在含药层的两侧包含甲基it嗪或盐酸洛哌丁胺。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2008249465A Probe array and its manufacturing method 审中-公开
标题翻译：探索阵列及其制造方法
公开(公告)号：JP2008249465A
公开(公告)日：2008-10-16
申请号：JP2007090780
申请日：2007-03-30
申请人： Lintec Corp , リンテック株式会社
发明人： HOSHI MASARU , TAKANASHI TAKAYA
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a simply-manufacturable probe array capable of reducing consumption of a liquid sample, and its manufacturing method. SOLUTION: This probe array is equipped with a planar probe fixing sheet 2A comprising a base material 21A and a probe immobilization layer 22A; a transparent planar thermally-fusible first cover sheet 3A positioned on the probe immobilization layer 22A side of the probe fixing sheet 2A; and a planar thermally-fusible second cover sheet 4A positioned on the base material 21A side of the probe fixing sheet 2A. Full fringe parts of the first cover sheet 3A and the second cover sheet 4A are thermally fused, and a clearance for constituting a liquid introduction space 6A is provided between the probe immobilization layer 22A of the probe fixing sheet 2A and the first cover sheet 3A. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够降低液体样品的消耗的简单可制造的探针阵列及其制造方法。解决方案：该探针阵列装备有包括基材21A和探针固定层22A的平面探针固定片2A; 定位在探针固定片2A的探针固定层22A侧的透明平面热熔第一覆盖片3A; 以及位于探针固定片2A的基材21A侧的平面的热熔第二覆盖片4A。第一覆盖片3A和第二覆盖片4A的全部边缘部分被热熔合，并且在探针固定片2A的探针固定层22A和第一覆盖片3A之间设置用于构成液体引入空间6A的间隙。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008037794A Oral administering agent 有权
标题翻译：口腔管理代理
公开(公告)号：JP2008037794A
公开(公告)日：2008-02-21
申请号：JP2006213892
申请日：2006-08-04
申请人： Lintec Corp , リンテック株式会社
发明人： SUGIURA YUSAKU , HOSHI MASARU , OKABE HIDEAKI
IPC分类号： A61K47/32 , A61K9/70
摘要： PROBLEM TO BE SOLVED: To provide an oral administering agent having a gel-forming laminate unit which can rapidly be gelled with a small amount of water to form gel of sufficient strength.
SOLUTION: The oral administering agent has a drug-containing layer and the gel-forming laminate unit. Furthermore, the gel-forming laminate unit is provided with a first water-swellable gel-forming layer having
摘要翻译：要解决的问题：提供一种具有凝胶形成层压单元的口服给药剂，其可以用少量的水快速凝胶化以形成足够强度的凝胶。口服给药剂具有药物含有层和凝胶形成层压单元。此外，凝胶形成层压单元设置有具有<10μm厚度的第一水溶胀性凝胶形成层和通过含有聚乙烯吡咯烷酮的夹层层压到第一水溶胀性凝胶形成层的第二水溶胀性凝胶形成层层，厚度<10μm。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2006160617A Orally administering preparation 有权
标题翻译： ORALLY管理准备
公开(公告)号：JP2006160617A
公开(公告)日：2006-06-22
申请号：JP2004350024
申请日：2004-12-02
申请人： Lintec Corp , リンテック株式会社
发明人： TAKANASHI TAKAYA , NOGAMI HIDESHI , HOSHI MASARU
IPC分类号： A61K47/32 , A61K9/70 , A61K31/135 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an orally administering preparation improved with ease for swallowing, easiness and safety on taking and a masking effect of the taste, smell, etc., of a medicine.
SOLUTION: This orally administering preparation 1a having a medicine-containing layer 11a, water-swelling gel-forming layers 13a, 13b, a middle layer 12a installed between the medicine-containing layer 11a and water-swelling gel-forming layer 13a, and a middle layer 12b installed between the medicine-containing layer 11a and the water-swelling gel-forming layer 13b is provided with that the medicine-containing layer 11a contains a hardly water soluble polymer as a base agent, the middle layers 12a, 12b contain a polyvinylpyrrolidone and the water swelling gel-forming layers 13a, 13b are installed in a state that each of them are directly laminated with the middle layers 12a, 12b, at the outermost layer of the orally administering preparation 1a.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种口服给药制剂，其易于吞咽，易于服用和安全，并且具有药物的味道，气味等的掩蔽作用。解决方案：这种具有药物含有层11a，水溶胀凝胶形成层13a，13b，安装在药物含有层11a和水溶胀凝胶形成层13a之间的中间层12a的口服给药制剂1a 并且设置在含药层11a和水溶胀性凝胶形成层13b之间的中间层12b具有含药层11a含有难溶性聚合物作为基剂，中间层12a， 12b包含聚乙烯吡咯烷酮，并且水溶胀凝胶形成层13a，13b以与口服制剂1a的最外层的中间层12a，12b直接层压的状态安装。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006137717A Orally administered drug 有权
标题翻译： ORALLY ADMINISTERD DRUG
公开(公告)号：JP2006137717A
公开(公告)日：2006-06-01
申请号：JP2004329813
申请日：2004-11-12
申请人： Lintec Corp , リンテック株式会社
发明人： HOSHI MASARU , NOGAMI HIDESHI , TAKANASHI TAKAYA
IPC分类号： A61K9/06
摘要： PROBLEM TO BE SOLVED: To provide an orally administered drug which is one having a drug-containing layer and a water-swellable gel-forming layer which, even when the water-swellable gel-forming agent contained in the water-swellable gel-forming layer has an insufficient degree of crosslinking, can form a sufficiently strong gel when swollen with moisture such as saliva in the oral cavity of a patient. SOLUTION: The orally administered drug is one having a drug-containing layer and a water-swellable gel-forming layer, wherein the drug-containing layer contains a polyvalent metal compound which forms a polyvalent metal ion, and the water-swellable gel-forming layer contains a water-swellable gel-forming agent capable of being crosslinked with the polyvalent metal ion, and the water-swellable gel-forming layer forms the outermost layer of the drug while it is directly laid on the drug-containing layer. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供具有药物含有层和水溶胀性凝胶形成层的口服给药药物，即使在水溶胀性物质中含有水溶胀性凝胶形成剂时凝胶形成层的交联程度不足，当患者的口腔中的水分如唾液肿胀时，可形成足够坚固的凝胶。解决方案：口服药物是具有药物含有层和水溶胀性凝胶形成层的药物，其中药物含有层含有形成多价金属离子的多价金属化合物，并且水溶胀性凝胶形成层含有能够与多价金属离子交联的水溶胀性凝胶形成剂，并且水溶胀性凝胶形成层形成药物的最外层，同时直接放置在含药层上。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2004275329A Silicone adhesive composition for dermal pasting material, and dermal pasting material using the same 有权
公开(公告)号：JP2004275329A
公开(公告)日：2004-10-07
申请号：JP2003069429
申请日：2003-03-14
申请人： Lintec Corp , リンテック株式会社
发明人： HOSHI MASARU , TAKANASHI TAKAYA , OKABE HIDEAKI
IPC分类号： A61K9/70 , A61F13/02 , A61L15/58
摘要： PROBLEM TO BE SOLVED: To provide a silicone adhesive composition for a dermal pasting material with improved holding capability while keeping the adhesive characteristics the silicone adhesive intrinsically has, and the dermal pasting material.
SOLUTION: The silicone adhesive composition for the dermal pasting material comprises 0.1-20 pts.mass of acrylic polymer with a reactive functional group other than the hydroxy group relative to 100 pts.mass of organo-siloxane polymer with the hydroxy group at the distal end, and a crosslinking agent, which is reactive to the reactive functional group in the acrylic polymer but not reactive to the hydroxy group in the organo-siloxane polymer, is mixed in the quantity equivalent to 0.1-1 of the reactive functional group in the acrylic polymer.
COPYRIGHT: (C)2005,JPO&NCIPI

9. 发明专利

JP2004358027A Deodorant composition and water soluble deodorant 有权
公开(公告)号：JP2004358027A
公开(公告)日：2004-12-24
申请号：JP2003161758
申请日：2003-06-06
申请人： Lintec Corp , リンテック株式会社
发明人： HOSHI MASARU , YOKOYAMA WATARU , OKABE HIDEAKI
IPC分类号： A61L9/01
摘要： PROBLEM TO BE SOLVED: To provide a water soluble deodorant element manufactured without solving or decaying a hydrolyzable base material and having a superior fixing property of the deodorant.
SOLUTION: This deodorant composition is formed by dissolving a polymer soluble to an organic solvent and soluble to water in the organic solvent, and distributing deodorizer therein. The deodorant composition is coated on or contained in a base material having hydrolyzability and organic solvent resistance so as to be formed into a hydrolyzable deodorant.
COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2005053817A Laminate sheet for keratin amelioration 有权
标题翻译：复合片层压板
公开(公告)号：JP2005053817A
公开(公告)日：2005-03-03
申请号：JP2003285087
申请日：2003-08-01
申请人： Lintec Corp , Rohto Pharmaceut Co Ltd , リンテック株式会社 , ロート製薬株式会社
发明人： HOSHI MASARU , TAKANASHI TAKAYA , NAKAHARA KANAME , SATO NORIKAZU , HASHINO KYOKO , MORISHITA KANAE
IPC分类号： A61F13/02 , A61K8/02 , A61K8/03 , A61K8/30 , A61K8/34 , A61K8/40 , A61K8/42 , A61K8/72 , A61K9/70 , A61Q19/00 , A61K7/00
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/345 , A61K8/42 , A61Q19/007
摘要： PROBLEM TO BE SOLVED: To prepare a laminate sheet for keratin amelioration that contains a large amount of a humectant containing glycerol, dissipates a humectant to a pasted part by pasting to skin and keeps moisture retaining effect on the skin not only during pasting but also after release.
SOLUTION: This laminate sheet for keratin amelioration comprises an adhesive sheet for fixation equipped with an adhesive layer on a substrate for an adhesive sheet and a pad for moisture retention equipped with a humectant-containing polymer layer on a substrate for a pad. The laminate sheet for keratin amelioration is obtained by fixing the substrate for the pad as the pad for moisture retention on the adhesive layer of the adhesive sheet for fixation so as to bring the substrate into contact with the adhesive layer. The laminate sheet comprises 25-55 wt.% of glycerol as a humectant and 30-60 wt.% of humectants containing glycerol in 100 wt.% of the humectant-containing polymer layer.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了制备含有大量含有甘油的湿润剂的角蛋白改良层压片材，通过粘贴皮肤将湿润剂散发到糊状部分，并且不仅在粘贴时保持对皮肤的保湿作用也是在发布后。解决方案：用于角蛋白改良的层压片包括在用于粘合片的基底上具有粘合剂层的固定用粘合片和用于垫的衬底上装有保湿剂的聚合物层的保湿垫。通过将用于保持的垫的衬垫固定在粘合片的粘合剂层上以固定以使衬底与粘合剂层接触来获得用于角蛋白改善的层压片。层压片材包含25-55重量％的作为保湿剂的甘油和30-60重量％的含有100重量％保湿剂聚合物层中甘油的保湿剂。版权所有（C）2005，JPO＆NCIPI

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