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1. 发明专利

JP2013018759A Method for producing solid preparation 审中-公开
标题翻译：生产固体制剂的方法
公开(公告)号：JP2013018759A
公开(公告)日：2013-01-31
申请号：JP2011155210
申请日：2011-07-13
申请人： Lintec Corp , リンテック株式会社
发明人： TAKANO YOICHI , TOMIOKA SHIORI , MIYATA TAKESHI , MATSUSHIMA MASARU
IPC分类号： A61K9/48 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a solid preparation capable of producing easily a solid preparation involving a drug.SOLUTION: This method for producing a solid preparation includes: a step for forming a plurality of intermediate bodies including respectively an edible film having thermal deformation property and a pair of holding substrates installed so as to sandwich the edible film and having thermal deformation property; a step for forming a recessed part in the intermediate body by a heating pressurizing formation method; a step for obtaining a drug-filled body by filling a drug into the recessed part, after removing a holding substrate on the recessed part side of an intermediate body; a step in which a holding substrate on the recessed part side of another intermediate body is removed, and the exposed edible film is piled on the drug-filled body so that the recessed part is faced to the recessed part of the drug-filled body, and then each edible film is joined on the peripheral part of the recessed part, to thereby obtain a joined body; and a protection substrate removal step for obtaining the solid preparation by removing a residual protection substrate from the surface of the joined body.
摘要翻译：待解决的问题：提供能够容易地制备涉及药物的固体制剂的固体制剂的制备方法。该固体制剂的制造方法包括：分别形成具有热变形特性的可食用膜的多个中间体的形成工序以及夹持可食用膜并具有热变形的一对保持基板属性; 通过加热加压形成方法在中间体中形成凹部的步骤; 在中间体的凹部侧除去保持基板之后，通过将药剂填充到凹部来获得药物填充体的工序; 除去另一中间体的凹部侧的保持基板的步骤，将该可露出的可食用膜堆叠在药物填充体上，使得凹部朝向药物填充体的凹部，然后将每个可食用膜接合在凹部的周边部分上，从而获得接合体; 以及保护基板去除步骤，用于通过从接合体的表面去除残留的保护基板来获得固体制剂。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012201612A Percutaneous absorption type adhesive skin patch agent kit 有权
标题翻译： PERCUTANEOUS吸收型粘合皮肤护理剂套件
公开(公告)号：JP2012201612A
公开(公告)日：2012-10-22
申请号：JP2011066234
申请日：2011-03-24
申请人： Lintec Corp , リンテック株式会社
发明人： GOTO RYOTA , TANBA TAKUYA , MIYATA TAKESHI , MATSUSHIMA MASARU
IPC分类号： A61K31/192 , A61K9/70 , A61K31/405 , A61K47/10
摘要： PROBLEM TO BE SOLVED: To provide a percutaneous absorption type adhesive skin patch agent kit exerting a favorable analgesic effect while preventing esterification of a non-steroidal analgesic anti-inflammatory agent having a carboxyl group in the molecule and l-menthol.SOLUTION: The percutaneous absorption type adhesive skin patch agent kit 10 has a first adhesive skin patch agent 1 including a first drug containing part 11 containing the non-steroidal analgesic anti-inflammatory agent having a carboxyl group in the molecule and l-menthol, and further a second adhesive skin patch agent 2 including a second drug containing part 21 substantially free from the non-steroidal analgesic anti-inflammatory agent. The non-steroidal analgesic anti-inflammatory agent is preferably at least one selected from of a group composed of indomethacin, ketoprofen, flurbiprofen, diclofenac, loxoprofen, ketorolac and felbinac. The adhesive area of the adhesive skin patch agent 2 of the second adhesive skin patch agent 2 has preferably a larger adhesive area than that of the adhesive skin patch agent 1 of the adhesive skin patch agent 1.
摘要翻译：要解决的问题：提供一种经皮吸收型粘合剂皮肤贴剂，其具有良好的镇痛作用，同时防止在分子中具有羧基的非甾体止痛抗炎剂和l-薄荷醇的酯化。皮肤吸收型粘合剂皮肤贴剂10具有第一粘合性皮肤贴剂1，其包含第一药物含有部分11，其含有分子中具有羧基的非甾体止痛抗炎剂，薄荷醇，以及另外的第二粘合剂皮肤贴剂2，其包含基本上不含非甾体止痛抗炎剂的第二药物含有部分21。非甾体止痛抗炎剂优选为选自吲哚美辛，酮洛芬，氟比洛芬，双氯芬酸，洛索洛芬，酮咯酸和联苯乙酸组成的组中的至少一种。粘合剂皮肤贴剂2的粘合剂皮肤贴剂2的粘合剂区域优选具有比粘合性皮肤贴剂1的粘合性皮肤贴剂1更大的粘合面积。版权所有（C）2013 ，JPO＆INPIT

3. 发明专利

JP2012197244A Adhesive body for cuticle peeling 审中-公开
标题翻译：胶粘剂粘合体
公开(公告)号：JP2012197244A
公开(公告)日：2012-10-18
申请号：JP2011062135
申请日：2011-03-22
申请人： Lintec Corp , リンテック株式会社
发明人： TATSUNO TOMOKO , MIYAZAKI KENTARO , MATSUSHIMA MASARU
IPC分类号： A61K8/81 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an adhesive body for cuticle peeling capable of peeling uniformly and efficiently cuticle, even when being applied to a portion having great unevenness.SOLUTION: This adhesive body 10 for cuticle peeling has a base material film 1, an adhesive layer 2 formed on one surface of the base material film 1, and a frame member 4 installed on the base material film 1, wherein the average thickness of the base material film 1 is 1-4.9 μm. The Young's modulus of the base material film 1 is preferably 1-10 GPa. The frame member 4 is provided on a peripheral part of the base material film 1. The average thickness of the adhesive layer 2 is preferably 5-200 μm.
摘要翻译：要解决的问题：即使当施加到具有很大不均匀性的部分时，提供能够均匀且有效地剥离角质层的角质层剥离用粘合体。解决方案：用于角质层剥离的粘合体10具有基材膜1，形成在基材膜1的一个表面上的粘合剂层2和安装在基材膜1上的框架构件4，其中平均基材膜1的厚度为1-4.9μm。基材膜1的杨氏模量优选为1-10GPa。框架构件4设置在基材膜1的周边部分上。粘合剂层2的平均厚度优选为5-200μm。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2012181449A Pseudo adhesive label 有权
标题翻译： PSEUDO粘合标签
公开(公告)号：JP2012181449A
公开(公告)日：2012-09-20
申请号：JP2011045520
申请日：2011-03-02
申请人： Lintec Corp , リンテック株式会社
发明人： TOMITA DAISUKE , MATSUSHIMA MASARU
IPC分类号： G09F3/02 , B42D11/00
摘要： PROBLEM TO BE SOLVED: To provide a pseudo adhesive label which hardly causes tear on a surface substrate at positions other than a separation line when the surface substrate is peeled off from a pseudo adhesive layer and has excellent workability.SOLUTION: A pseudo adhesive label 10 is formed by laminating a surface substrate, a pseudo adhesive layer to be pseudo-bonded to the surface substrate, and a pressure-sensitive adhesive layer in this order. The surface substrate can be peeled off from the pseudo adhesive layer by being divided into label parts 18, 19 along a separation line 20. The separation line 20 is formed by arranging first to third cutting lines 21 to 23 composed of multiple cuts arranged at intervals so that the separation line 20 has a double linear shape. In order to close the interval between the adjacent first cutting lines 21 from both sides, the cuts of the second and third cutting lines 22, 23 are arranged in the vicinity of the interval.
摘要翻译：要解决的问题：提供一种在将表面基材从假粘合剂层剥离时，在分离线以外的位置处难以引起表面基板上的撕裂的伪粘合标签，并且具有优异的可加工性。解决方案：通过将表面基材，待粘合到假表面基底上的假粘合剂层和压敏粘合剂层依次层压形成伪粘合标签10。通过沿着分隔线20分割成标签部分18,19，可以将表面基材从假粘合剂层剥离。分离线20通过布置由间隔排列的多个切口构成的第一至第三切割线21至23而形成使得分离线20具有双线性形状。为了从两侧封闭相邻的第一切割线21之间的间隔，第二切割线22和第三切割线23的切口配置在间隔附近。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2013018758A Solid preparation 审中-公开
标题翻译：固体制剂
公开(公告)号：JP2013018758A
公开(公告)日：2013-01-31
申请号：JP2011155209
申请日：2011-07-13
申请人： Lintec Corp , リンテック株式会社
发明人： TAKANO YOICHI , TOMIOKA SHIORI , MIYATA TAKESHI , MATSUSHIMA MASARU
IPC分类号： A61K47/38 , A61K9/52 , A61K47/02 , A61K47/32
摘要： PROBLEM TO BE SOLVED: To provide a solid preparation capable of staying inside the stomach after being taken, and discharging a drug surely to the inside of the stomach.SOLUTION: This solid preparation 1 has a pair of edible films 10, a space part 20 formed by bonding each peripheral part of the pair of edible films 10, and a drug containing part 30 stored in the space part 20. The volume ratio of the drug containing part 30 to the volume of the space part 20 interior is 0.5-0.95. Inert gas is filled in the space part 20. The shape of the space part is approximately spherical. Further, the edible film 10 has an adhesion preventing layer 11, a gel forming layer 12 and a bonding layer 13.
摘要翻译：待解决的问题：提供能够在被摄取后保持在胃内的固体制剂，并且将药物确保地排出到胃内。
解决方案：该固体制剂1具有一对可食用膜10，通过粘合一对可食用膜10的每个周边部分形成的空间部分20和存储在空间部分20中的药物容纳部分30。药物含有部分30与空间部分20内部体积的比例为0.5-0.95。惰性气体填充在空间部分20中。空间部分的形状近似为球形。此外，可食用膜10具有防粘连层11，凝胶形成层12和接合层13.版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2012201613A Percutaneous absorption plaster kit 有权
标题翻译： PERCUTANEOUS吸收式塑料袋
公开(公告)号：JP2012201613A
公开(公告)日：2012-10-22
申请号：JP2011066236
申请日：2011-03-24
申请人： Lintec Corp , リンテック株式会社
发明人： TANBA TAKUYA , GOTO RYOTA , MIYATA TAKESHI , MATSUSHIMA MASARU
IPC分类号： A61K31/465 , A61K9/70 , A61K45/00 , A61P17/16 , A61P25/34 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a percutaneous absorption plaster kit capable of sufficiently exhibiting efficacy of individual drugs even if different drugs are used together.SOLUTION: The percutaneous absorption plaster kit 10 includes: a first plaster 1 containing a first drug; and a second plaster 2 containing a second drug different from the first drug. The first plaster 1 is constructed of a first drug containing part 11 containing the first drug and a first supporting substrate 12. The second plaster 2 is constructed of a second drug containing part 21 containing the second drug and a second supporting substrate 22. Preferably, the first drug is nicotine and the second drug is an anti-inflammatory agent.
摘要翻译：待解决的问题：提供能够充分显示单个药物的功效的经皮吸收膏药试剂，即使不同的药物一起使用也是如此。经皮吸收膏药套件10包括：含有第一药物的第一膏药1; 和含有不同于第一药物的第二药物的第二膏药2。第一膏药1由包含第一药物的第一药物容纳部分11和第一支持基底12构成。第二膏药2由含有第二药物的第二药物容纳部分21和第二支持基底22构成。优选地，第一种药物是尼古丁，第二种药物是抗炎剂。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2011037023A Release film 有权
标题翻译：发布电影
公开(公告)号：JP2011037023A
公开(公告)日：2011-02-24
申请号：JP2009183686
申请日：2009-08-06
申请人： Lintec Corp , リンテック株式会社
发明人： TAKAHASHI AKIRA , MATSUSHIMA MASARU
IPC分类号： B32B27/00
摘要： PROBLEM TO BE SOLVED: To provide a release film which is good in dimensional stability even when exposed to high temperatures. SOLUTION: The release film 20 includes a belt-shaped base material film 10, a first resin layer 11 formed on one surface 10A side of the base material film 10, and a second resin layer 12 formed on the other surface 10B side of the base material film 10. The base material film 10 is biaxially oriented, and its dimensional change ratio measured before and after the film 10 is heat-treated at 130°C for 10 min. is 0.5% or below in the length direction and 0.2% or below in the width direction. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供即使暴露在高温下也具有良好的尺寸稳定性的剥离膜。解决方案：剥离膜20包括带状基材膜10，形成在基材膜10的一个表面10A侧上的第一树脂层11和形成在另一个表面10B侧的第二树脂层12 基材膜10是双轴取向的，并且在130℃下对膜10进行热处理10分钟之前测量的尺寸变化率。在长度方向上为0.5％以下，宽度方向为0.2％以下。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2009091371A Method of application of wrinkle-stretch bonding sheet, and wrinkle-stretch bonding sheet 有权
标题翻译：皱纹粘合片的应用方法和缠绕粘合片
公开(公告)号：JP2009091371A
公开(公告)日：2009-04-30
申请号：JP2009007313
申请日：2009-01-16
申请人： Lintec Corp , リンテック株式会社
发明人： MATSUSHIMA MASARU , OKABE HIDEAKI
IPC分类号： A61K8/81 , A61K8/02 , A61Q19/00 , C09J7/02 , C09J11/06 , C09J131/04 , C09J133/02 , C09J139/06
摘要： PROBLEM TO BE SOLVED: To provide a method of application of a wrinkle-stretch bonding sheet in which bonding and fixation on the skin are ensured, and the wrinkle-stretch effect is high, and to provide the wrinkle-stretch bonding sheet.
SOLUTION: The method of application of the wrinkle-stretch bonding sheet is a method of application of the wrinkle-stretch bonding sheet which comprises laminating a base material layer having air permeability and flexibility and an adhesive layer including a polymeric material having water solubility or water swellability, wherein the adhesive layer has the complex modulus of 5×10
6 -5×10
9 dyne/cm
2 at the strain of 0.1% at the temperature of 35°C and the frequency of 1 Hz; and the adhesive layer is soaked by water, lotion or serum, thereby the self-adhesive property is generated, the adhesive layer is adhered to the skin while the wrinkle of the skin is stretched, the predetermined time of the status that the adhesive layer is adhered and fixed to the skin is continued, thereafter the wrinkle stretch bonding sheet is wetted with water, and removed from the skin.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种皱纹拉伸粘合片的应用方法，其中确保了皮肤上的粘结和固定，并且皱纹拉伸效果高，并且提供皱纹拉伸粘合片。解决方案：皱纹拉伸粘合片的施用方法是应用皱纹拉伸粘合片的方法，其包括层叠具有透气性和柔性的基材层和包含具有水的聚合物的粘合剂层溶解度或水溶胀性，其中粘合剂层的复数模量为5×10 -6 /秒> 5×10 9 /秒> dyne / cm 2 在35℃的温度和1Hz的频率下的应变为0.1％; 并且粘合剂层被水，洗剂或血清浸泡，从而产生自粘性，粘合层粘附到皮肤上，同时使皮肤的皱纹被拉伸，粘合剂层的状态的预定时间粘附并固定在皮肤上，然后将皱纹拉伸粘合片用水润湿，并从皮肤上除去。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2012200348A Adhesive material for stratum corneum exfoliation 有权
标题翻译：粘结材料用于钢筋混凝土
公开(公告)号：JP2012200348A
公开(公告)日：2012-10-22
申请号：JP2011066235
申请日：2011-03-24
申请人： Lintec Corp , リンテック株式会社
发明人： TATSUNO TOMOKO , MIYAZAKI KENTARO , MATSUSHIMA MASARU
IPC分类号： A61L15/58
摘要： PROBLEM TO BE SOLVED: To provide an adhesive material for stratum corneum exfoliation, which exhibits high unevenness followability of the surface of skin (especially skin of elbow, knee and heel) and can uniformly and efficiently exfoliate the stratum corneum.SOLUTION: The adhesive material 10 for stratum corneum exfoliation includes: a support 1; a soft layer 2 which is arranged on the support 1; and an adhesive agent layer (adhesive agent layer for stratum corneum exfoliation) 3 which is arranged on the soft layer 2. The storage elastic modulus of the soft layer 2 at 32°C is 5.0×10to 1.6×10Pa. When the storage elastic modulus of the adhesive agent layer 3 at 32°C is X[Pa] and the storage elastic modulus of the soft layer 2 at 32°C is Y[Pa], it is preferable that the following relation is satisfied: 0.003≤Y/X≤0.8.
摘要翻译：要解决的问题：提供用于角质层剥离的粘合剂材料，其表现出皮肤表面（特别是肘部，膝部和脚跟的皮肤）的高不均匀性的追随性，并且能够均匀有效地剥离角质层。解决方案：用于角质层剥离的粘合剂材料10包括：支撑体1; 布置在支撑件1上的软层2; 和软层2上的粘合剂层（角质层剥离用粘合剂层）3。软层2在32℃下的储存弹性模量为5.0×10 3 至1.6×10 6 Pa。当粘合剂层3在32℃下的储能弹性模量为X [Pa]，软层2在32℃下的储能弹性模量为Y [Pa]时，优选满足以下关系： 0.003≤Y/X≤0.8。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2012193137A Transdermal absorption type additive agent 审中-公开
标题翻译：超吸收型添加剂
公开(公告)号：JP2012193137A
公开(公告)日：2012-10-11
申请号：JP2011057253
申请日：2011-03-15
申请人： Lintec Corp , リンテック株式会社
发明人： TANBA TAKUYA , GOTO RYOTA , MIYATA TAKESHI , MATSUSHIMA MASARU
IPC分类号： A61K9/70 , A61K31/045 , A61K31/192 , A61K45/00 , A61K47/10 , A61P29/00
摘要： PROBLEM TO BE SOLVED: To provide a transdermal absorption type additive agent which prevents a nonsteroidal analgesic/antiphlogistic agent having a carboxyl group in a molecule and I-menthol from being esterified, and exhibits a favorable analgesic effect.SOLUTION: The transdermal absorption type additive agent 1a has a support base 10a, and a first medicine containing part 11a and a second medicine containing part 12a which are formed on the support base 10 and contain medicines. The first medicine containing part 11a contains the nonsteroidal analgesic/antiphlogistic agent having the carboxyl group in the molecule, and the second medicine containing part 12a contains the I-menthol and does not substantially contain the nonsteroidal analgesic/antiphlogistic agent. It is preferable that the nonsteroidal analgesic/antiphlogistic agent is felbinac. A transdermal absorption progressing agent for progressing the absorption of the medicine into a skin is contained in the first medicine containing part 11a. An interval 13a as a prohibition tool for prohibiting the transition of the medicine is formed between the first medicine containing part 11a and the second medicine containing part 12a.
摘要翻译：待解决的问题：提供一种防止分子中具有羧基的非甾体镇痛/消炎药和I-薄荷醇的经皮吸收型添加剂酯化，显示出良好的止痛效果。解决方案：经皮吸收型添加剂1a具有支撑基底10a和形成在支撑基底10上并含有药物的第一药物含有部分11a和第二药物包含部分12a。含有第一药物的部分11a含有分子中具有羧基的非甾体镇痛/消炎剂，第二药物含有部分12a含有I-薄荷醇，实质上不含非甾体镇痛/消炎剂。非甾体镇痛/消炎剂优选为联苯乙酸。在第一药剂容纳部11a中含有用于使药物吸收进入皮肤的经皮吸收进程剂。在第一药剂容纳部11a和第二药剂收容部12a之间形成有用于禁止药物转移的禁止工具的间隔13a。版权所有（C）2013，JPO＆INPIT

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