专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US08710069B2 Opioid-nornicotine codrugs combinations for pain management 失效
标题翻译：阿片 - 降烟碱类药物组合治疗疼痛
公开(公告)号：US08710069B2
公开(公告)日：2014-04-29
申请号：US12934861
申请日：2009-03-27
申请人： Joseph R. Holtman , Peter A. Crooks , Ujjwal Chakraborty
发明人： Joseph R. Holtman , Peter A. Crooks , Ujjwal Chakraborty
IPC分类号： A61K31/44 , A61K31/35 , C07D405/00 , C07D221/22
CPC分类号： A61K31/485 , A61K47/55
摘要： The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.
摘要翻译：本发明涉及疼痛管理领域，更具体地涉及包含阿片样物质和降烟碱的协同药物组合物，其已被组合以形成单一化学制剂实体。当施用该药物时，其产生对疼痛的协同镇痛作用。

92. 发明申请

US20140106375A1 Secreted Tumor-Associated Cytochrome as a Blood-Based Biomarker for Cancer 审中-公开
标题翻译：分泌肿瘤相关细胞色素作为基于血液的癌症生物标志物
公开(公告)号：US20140106375A1
公开(公告)日：2014-04-17
申请号：US14028224
申请日：2013-09-16
申请人： University of Kentucky Research Foundation
发明人： Rolf Joseph CRAVEN
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57407 , G01N33/57423 , G01N33/743 , G01N2800/50 , G01N2800/52
摘要： Disclosed herein are methods for detecting Pgrmc1 in bodily fluids, e.g., blood, plasma and serum, wherein detection of Pgrmc1 is a biomarker for the presence of cancer, e.g., lung cancer or head or neck cancer. Pgrmc1 levels in bodily fluids may be used to predict patient prognosis, e.g., survival and response to therapy.
摘要翻译：本文公开了用于检测体液（例如血液，血浆和血清）中的Pgrmc1的方法，其中Pgrmc1的检测是癌症存在的生物标志物，例如肺癌或头颈癌。体液中的Pgrmc1水平可用于预测患者预后，例如存活和对治疗的反应。

93. 发明申请

US20140004327A1 FEW-LAYER GRAPHENE NANORIBBON AND A METHOD OF MAKING THE SAME 审中-公开
标题翻译： FAY-LAYER GRAPHENE NANORIBBON及其制造方法
公开(公告)号：US20140004327A1
公开(公告)日：2014-01-02
申请号：US13538308
申请日：2012-06-29
申请人： Douglas Robert Strachan , Joseph Kelly Stieha , David Patrick Hunley , Stephen Lee Johnson, JR.
发明人： Douglas Robert Strachan , Joseph Kelly Stieha , David Patrick Hunley , Stephen Lee Johnson, JR.
IPC分类号： C01B31/04 , B05D3/10 , B82Y40/00 , B82Y30/00
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/184 , C01B2204/06
摘要： A method of preparing graphene nanoribbons from a few-layer graphene film includes the steps of growing or placing a few-layer graphene film on a substrate, applying nanoparticles to a surface of the few-layer graphene layer on the substrate and performing chemical vapor etching. The resulting few-layer graphene nanoribbon has a thickness of between about 0.3 nm and about 50.0 nm and a width of between about 1.0 nm and about 20.0 nm.
摘要翻译：从几层石墨烯薄膜制备石墨烯纳米带的方法包括以下步骤：在衬底上生长或放置几层石墨烯膜，将纳米颗粒施加到衬底上的几层石墨烯层的表面上，并进行化学气相蚀刻。所得的几层石墨烯纳米纤维的厚度为约0.3nm至约50.0nm，宽度为约1.0nm至约20.0nm。

94. 发明申请

US20130321585A1 System and Method for 3D Imaging using Structured Light Illumination 审中-公开
公开(公告)号：US20130321585A1
公开(公告)日：2013-12-05
申请号：US13964094
申请日：2013-08-11
申请人： Laurence G. Hassebrook , Daniel L. Lau , Henry G. Dietz
发明人： Laurence G. Hassebrook , Daniel L. Lau , Henry G. Dietz
IPC分类号： H04N13/02
CPC分类号： G06K9/00 , G01B11/2513 , G01B11/254 , G06K9/00006 , G06K9/00201 , G06K9/2036 , G06K2209/40 , G06K2209/401 , G06T7/521 , G06T2207/30196 , H04N13/204 , H04N13/254 , Y10S902/03
摘要： A biometrics system captures and processes a handprint image using a structured light illumination to create a 2D representation equivalent of a rolled inked handprint. A processing unit calculates 3D coordinates of the hand from the plurality of images and maps the 3D coordinates to a 2D flat surface to create a 2D representation equivalent of a rolled inked handprint.

95. 发明授权

US08592193B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08592193B1
公开(公告)日：2013-11-26
申请号：US13399406
申请日：2012-02-17
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
IPC分类号： C12N9/16 , C12N9/18 , A61K38/46 , C07H21/04
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导的病症的目前公开的主题的方法包括向个体施用有效量的本文所公开的BChE多肽变体以降低可卡因浓度。

96. 发明授权

US08580240B1 Compounds and methods for reducing the occurrence of post-surgical adhesions 有权
标题翻译：用于减少手术后粘连发生的化合物和方法
公开(公告)号：US08580240B1
公开(公告)日：2013-11-12
申请号：US12622239
申请日：2009-11-19
申请人： Thomas Dziubla , Eugene Kaplan , John Mark Medley, Jr.
发明人： Thomas Dziubla , Eugene Kaplan , John Mark Medley, Jr.
IPC分类号： A61K31/74
CPC分类号： C08F220/28 , A61L31/048 , A61L31/145 , A61L31/16 , A61L2300/25 , A61L2300/44 , A61L2300/442 , C08F2220/1825 , C08F2220/286 , C08L33/00
摘要： Compounds and methods for reducing the occurrence of a post-surgical adhesion are provided. The compounds can include acrylic acid groups and ethylene glycol groups, and can be directed to an area of damaged tissue by the incorporation of a fibrin targeting peptide. The compounds can further include a brush-like portion, capable of creating a steric barrier between a damaged tissue or organ and adjacent tissues or organs, and a targeting portion, capable of directing the compounds to a damaged tissue or organ. Methods of detecting damaged tissue and kits are also provided.
摘要翻译：提供了用于减少术后粘连发生的化合物和方法。所述化合物可以包括丙烯酸基团和乙二醇基团，并且可通过引入纤维蛋白靶向肽而导向受损组织的区域。化合物还可以包括能够在受损组织或器官与相邻组织或器官之间产生空间屏障的刷状部分，以及能够将化合物引导至受损组织或器官的靶向部分。还提供了检测损伤的组织和试剂盒的方法。

97. 发明授权

US08575218B2 Thiol-containing compounds for the removal of elements from tissues and formulations therefor 有权
标题翻译：用于从组织中除去元素的硫醇化合物及其制剂
公开(公告)号：US08575218B2
公开(公告)日：2013-11-05
申请号：US13041798
申请日：2011-03-07
申请人： Boyd E. Haley , David A. Atwood , Niladri Gupta
发明人： Boyd E. Haley , David A. Atwood , Niladri Gupta
IPC分类号： A01N37/12 , A01N37/10 , A01N43/00
CPC分类号： A61K31/198 , A61K31/216 , A61K31/695 , A61K31/795 , B01D53/64 , B01D2253/106 , B01D2253/25 , B01D2257/602 , B01D2258/0283 , B01D2258/0291 , C07F7/1804
摘要： Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.
摘要翻译：公开了用于改善重金属毒性和/或氧化应激的方法和药物制剂，其包括施用根据本公开的药学有效量的配体。配体具有以下通式：其中R1包括苯，吡啶，吡啶-4-酮，萘，蒽，菲或烷基，R2包括氢，烷基，芳基，羧基，羧酸酯，有机基团或生物基团 R 3包括烷基，芳基，羧基，羧酸酯，有机基团或生物基团，X包括氢，锂，钠，钾，铷，铯，ium，烷基，芳基，羧基，羧酸酯，硫代磷酸酯，N 乙酰半胱氨酸，巯基乙酸，巯基丙酸，硫代水杨酸，有机基团或生物基团，n独立地等于1-10，m = 1-6，Y包括氢，聚合物，二氧化硅或二氧化硅负载的底物，Z包括氢，烷基，芳基，羧基，羧酸酯，羟基，NH 2，HSO 3，卤素，羰基，有机基团，生物基团，聚合物，二氧化硅或二氧化硅负载的基质。

98. 发明授权

US08546415B2 Bis-pyridino containing compounds for the use in the treatment of CNS pathologies 有权
标题翻译：用于治疗中枢神经系统病变的含双吡啶的化合物
公开(公告)号：US08546415B2
公开(公告)日：2013-10-01
申请号：US12714219
申请日：2010-02-26
申请人： Peter A. Crooks , Linda P. Dwoskin , Joshua Ayers , Vladimir Grinevich , Sangeetha Sumithran
发明人： Peter A. Crooks , Linda P. Dwoskin , Joshua Ayers , Vladimir Grinevich , Sangeetha Sumithran
IPC分类号： A61K31/435
CPC分类号： C07D215/10 , C07D213/06 , C07D213/22 , C07D217/10 , C07D401/14
摘要： N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.
摘要翻译：尼古丁的N-n-烷基化将尼古丁从激动剂转化成特异性用于神经元烟碱乙酰胆碱受体亚型的拮抗剂，其介导尼古丁诱发的多巴胺释放。构象限制的类似物在该位点表现出高亲和力和选择性，并且由于其作为血脑屏障胆碱转运蛋白底物的能力，能够进入大脑。

99. 发明授权

US08487158B2 B. braunii, race B gene for a triterpene methyltransferase enzyme and uses thereof 有权
公开(公告)号：US08487158B2
公开(公告)日：2013-07-16
申请号：US12489038
申请日：2009-06-22
申请人： Joseph Chappell , Shigeru Okada , Scott Kinison , Tom Niehaus
发明人： Joseph Chappell , Shigeru Okada , Scott Kinison , Tom Niehaus
IPC分类号： C12N15/29 , C12N15/52 , C12N15/82
摘要： Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In another aspect, a method of producing a methylated triterpene is provided. The method comprises providing a metabolizable carbon source to a host cell transfected with a nucleic acid molecule that encodes a triterpene methyltransferase under conditions sufficient for production of a methylated triterpene. The method optionally further comprises isolating the methylated triterpene produced by the host cell.

100. 发明授权

US08445231B2 Cytochrome P450s and uses thereof 有权
公开(公告)号：US08445231B2
公开(公告)日：2013-05-21
申请号：US13199349
申请日：2011-08-26
申请人： Joseph Chappell , Lyle F. Ralston
发明人： Joseph Chappell , Lyle F. Ralston
IPC分类号： C12N1/00 , C12N1/06 , C12N5/00 , C12N5/07
CPC分类号： C12N9/0073 , C12N9/0077 , C12N15/8243 , C12N15/8279 , C12P7/00 , C12P7/02 , C12Y114/13 , C12Y114/13078 , C12Y114/13119
摘要： The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式