专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

US20110270098A1 APPARATUS AND METHOD FOR MEASURING BLOOD PRESSURE 有权
标题翻译：用于测量血压的装置和方法
公开(公告)号：US20110270098A1
公开(公告)日：2011-11-03
申请号：US13129017
申请日：2009-11-18
申请人： Philip Jan Chowienczyk , Sally Emma Brett , Antoine Yves Marie Guilcher
发明人： Philip Jan Chowienczyk , Sally Emma Brett , Antoine Yves Marie Guilcher
IPC分类号： A61B5/02
CPC分类号： A61B5/02108 , A61B5/02116 , A61B5/022 , A61B5/02225 , A61B5/7271
摘要： The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject's pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject's pulse provides an estimate of the central systolic blood pressure of the subject.
摘要翻译：本申请涉及一种用于估计受试者的中心收缩压（cSBP）的装置和方法，其中受试者脉搏的外周血压波形和受试者心脏周期内的至少两个外周血压测量是并且用传递函数来操纵外周血压波形，以提供对象脉搏的中心血压波形的估计。在受试者的心脏周期内的至少两个外周血压测量和受试者的脉搏的外周血压波形在被检者的外周动脉上的基本相同的点处确定。受试者脉搏的中心血压波形的估计提供了受试者的中心收缩压的估计。

92. 发明授权

US07888030B2 Biomarkers 失效
标题翻译：生物标志物
公开(公告)号：US07888030B2
公开(公告)日：2011-02-15
申请号：US12195979
申请日：2008-08-21
申请人： Asif Naeem Butt , Ramasamyiyer Swaminathan
发明人： Asif Naeem Butt , Ramasamyiyer Swaminathan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The present invention provides circulating biomarkers for conditions associated with metabolic syndrome, including diabetes mellitus, hypertension and congestive heart failure. The biomarkers include plasma DNA, neuron-specific enolase, 11β-hydroxysteroid dehydrogenase, rhodopsin, retinoschisin, RPE65 and cardiac troponin T. Methods and kits for detecting these biomarkers in the prediction, monitoring and diagnosing of disease are provided, particularly for determining mRNA levels thereof in a subject's blood.
摘要翻译：本发明提供了与代谢综合征相关的病症的循环生物标志物，包括糖尿病，高血压和充血性心力衰竭。生物标志物包括血浆DNA，神经元特异性烯醇化酶，11α-羟基类固醇脱氢酶，视紫红质，视网膜素样蛋白，RPE65和心肌肌钙蛋白T.提供了用于在预测，监测和诊断疾病中检测这些生物标志物的方法和试剂盒，特别是用于确定mRNA 受试者血液中的水平。

93. 发明申请

US20100256469A1 Imaging Apparatus and Method 有权
标题翻译：成像设备和方法
公开(公告)号：US20100256469A1
公开(公告)日：2010-10-07
申请号：US12678646
申请日：2008-09-19
申请人： Richard James Cook , Timothy Watson , Frederic Festy
发明人： Richard James Cook , Timothy Watson , Frederic Festy
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/14542 , A61B1/3137 , A61B5/1459
摘要： The invention relates to an apparatus and a method for imaging the vascular structure and vascular blood flow of an organ or tissue and, in particular, relates to a selective wavelength epi-illumination endoscopic imaging apparatus to image vascular tissues and real time capillary blood flow in vivo. The invention also relates to determining the blood oxygen content of the organ or tissue.
摘要翻译：本发明涉及一种用于对器官或组织的血管结构和血管血流进行成像的装置和方法，具体涉及用于对血管组织进行成像和实时毛细血管血流的选择性波长外照射内窥镜成像装置体内。本发明还涉及确定器官或组织的血氧含量。

94. 发明授权

US06995240B1 Treatment of inflammatory disease 失效
标题翻译：治疗炎症性疾病
公开(公告)号：US06995240B1
公开(公告)日：2006-02-07
申请号：US09806955
申请日：1999-10-08
申请人： Gabriel Stavros Panayi , Valerie Mary Corrigall , Mark Duncan Bodman-Smith , Mark Stewart Fife , Jeremy Shaun Lanchbury
发明人： Gabriel Stavros Panayi , Valerie Mary Corrigall , Mark Duncan Bodman-Smith , Mark Stewart Fife , Jeremy Shaun Lanchbury
IPC分类号： C07K14/47 , A61K39/00 , G01N33/53
CPC分类号： C07K14/47 , A61K48/00 , Y10S435/81
摘要： The immunoglobulin heavy chain binding protein BiP(GRP78), or a fragment thereof, provides a reagent for indicating the presence of rheumatoid arthritis (RA). The protein used is a recombinant BiP(GRP78) having a defined sequence. A prognostic and/or diagnostic test for RA may be an ELISA or a Western Blot that utilizes the BiP(GRP78) protein or a fragment thereof. Also disclosed are a method of testing for RA using BiP(GRP78) or a cDNA sequence coding therefor. Further disclosed is a method of treating RA by the BiP(GRP78) protein or corresponding cDNA.
摘要翻译：免疫球蛋白重链结合蛋白BiP（GRP78）或其片段提供了用于指示类风湿性关节炎（RA）存在的试剂。使用的蛋白质是具有确定的序列的重组BiP（GRP78）。 RA的预后和/或诊断测试可以是利用BiP（GRP78）蛋白或其片段的ELISA或Western印迹。还公开了使用BiP（GRP78）或其编码的cDNA序列测试RA的方法。还公开了通过BiP（GRP78）蛋白或相应的cDNA处理RA的方法。

95. 发明申请

US20050100555A1 Homing peptides 审中-公开
标题翻译：归巢肽
公开(公告)号：US20050100555A1
公开(公告)日：2005-05-12
申请号：US10488779
申请日：2002-09-04
申请人： Constantino Pitzalis , Gabriel Panayi
发明人： Constantino Pitzalis , Gabriel Panayi
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K47/42 , A61K49/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K5/08 , C07K5/10 , C07K5/117 , C07K7/06 , C07K7/64 , C07K16/44 , C12Q1/02 , A61K39/00 , C07K14/47 , C12P21/04
CPC分类号： C07K5/1024 , A61K38/00 , C07K1/047 , C07K5/08 , C07K2319/00
摘要： A synovial tissue binding peptide comprises an amino acid sequence motif comprising RLP, SPS, HSS, LSS, TWS, YSS, NQR, DRL or DHR. Preferred motifs comprise HPRLPFA, APNWRLP, SPSPFRA, SPSRFDQ, VSPSRTT, PLSSAQR, TWSATST, THSSATQ, HTHSSNL, PNHSSPH, ADHSSRH, SDYSSRS, QTHNQRY, TNQRLAI, KSTHDRL, PFHDRHS, HPSDRLS or DRLNHQE. Also provided is a method for the identification of peptides capable of binding to a tissue originating from a first mammalian species, the method comprising the steps of: grafting the tissue originating from the first mammalian species into a subject of a second mammalian species having an attenuated immunological response; introducing a plurality of peptides into the second species; and determining the localisation of the peptides within the second species.
摘要翻译：滑膜组织结合肽包含包含RLP，SPS，HSS，LSS，TWS，YSS，NQR，DRL或DHR的氨基酸序列基序。优选的图案包括HPRLPFA，APNWRLP，SPSPFRA，SPSRFDQ，VSPSRTT，PLSSAQR，TWSATST，THSSATQ，HTHSSNL，PNHSSPH，ADHSSRH，SDYSSRS，QTHNQRY，TNQRLAI，KSTHDRL，PFHDRHS，HPSDRLS或DRLNHQE。还提供了用于鉴定能够结合来自第一哺乳动物物种的组织的肽的方法，所述方法包括以下步骤：将来自第一哺乳动物物种的组织移植到具有减毒的第二哺乳动物物种的受试者中免疫反应; 将多种肽引入到第二种中; 并确定肽在第二物种内的定位。

96. 发明授权

US5708161A Nucleoside phosphorothioate derivatives, synthesis and use thereof 失效
标题翻译：核苷硫代磷酸酯衍生物，其合成和用途
公开(公告)号：US5708161A
公开(公告)日：1998-01-13
申请号：US590280
申请日：1996-01-23
申请人： Colin Bernard Reese
发明人： Colin Bernard Reese
IPC分类号： C07D207/48 , C07D209/48 , C07H21/00 , C07H1/02 , C07H21/04
CPC分类号： C07D209/48 , C07D207/48 , C07H21/00 , Y02P20/55
摘要： Inter alia, a process for the production of a nucleoside phosphorothioate derivative corresponding to the following general formula (I): ##STR1## characterized in that it comprises reacting a salt of a nucleoside H-phosphonate corresponding to the following general formula (II): ##STR2## with a thiol transfer agent corresponding to the following general formula (III): R.sup.2 --S--X (III) in the presence of a silylating agent and a base in a suitable solvent; and working-up the reaction mixture to isolate the desired product and change the counter-cation as desired; wherein M.sup.+ represents a suitable counter-cation; R.sup.1 represents an appropriate nucleoside or nucleoside analogue; R.sup.2 represents a desired protecting group, which may ultimately be removable by cleavage of its bond to the sulfur atom; and X represents a leaving group, is disclosed.
摘要翻译：特别地，涉及下列通式（I）的生产核苷硫代磷酸酯衍生物的方法：其特征在于，其包括使对应于下列通式的核苷H-膦酸盐的盐 II）：具有对应于以下通式（III）的硫醇转移剂：在适当溶剂中的甲硅烷基化剂和碱存在下的R 2 -SX（III）：并处理反应混合物以分离所需产物并根据需要改变反离子; 其中M +代表合适的抗衡阳离子; R1代表适当的核苷或核苷类似物; R2表示所需的保护基团，其最终可通过其与硫原子的键断裂而除去; 并且X表示离去基团。

97. 发明授权

US5553197A Devices for use in neural processing 失效
标题翻译：用于神经处理的装置
公开(公告)号：US5553197A
公开(公告)日：1996-09-03
申请号：US167884
申请日：1994-02-18
申请人： Trevor G. Clarkson , John G. Taylor
发明人： Trevor G. Clarkson , John G. Taylor
IPC分类号： G06F15/18 , G06G7/60 , G06N3/04 , G06N3/06 , G06N3/063
CPC分类号： G06N3/0472 , G06N3/049 , G06N3/063
摘要： A device for use in neural processing comprises a plurality of probabilistic RAMs (pRAMs). The output of the pRAMs are connected in common to means for accumulating their output signals and for decaying the result of the accumulation. A thresholding circuit receives the decayed result at its input and produces an output signal when the decayed result exceeds a predetermined level.
摘要翻译： PCT No.PCT / GB92 / 01086 Sec。 371日期1994年2月18日 102（e）1994年2月18日PCT PCT。1992年6月17日PCT公布。出版物WO93 / 00654 日期1993年1月7日用于神经处理的装置包括多个概率RAM（pRAM）。 pRAM的输出共同连接到累积其输出信号和衰减累积结果的装置。阈值电路在其输入处接收衰减结果，并且当衰减结果超过预定电平时产生输出信号。

98. 发明授权

US5475795A Neural processing devices for handling real-valued inputs 失效
标题翻译：用于处理实值输入的神经处理装置
公开(公告)号：US5475795A
公开(公告)日：1995-12-12
申请号：US966028
申请日：1992-12-22
申请人： John G. Taylor , Denise Gorse , Trevor G. Clarkson
发明人： John G. Taylor , Denise Gorse , Trevor G. Clarkson
IPC分类号： G06F15/18 , G06G7/60 , G06N3/04 , G06N99/00
CPC分类号： G06N3/0472
摘要： A device for use in a neural processing network. The network includes a memory having a plurality of storage locations each having stored a number representing a probability. Each storage location is selectively addressible to cause the contents of the location to be read to an input of a comparator. A noise generator inputs to the comparator a random number representing noise. At an output of the comparator, an output signal appears having a first or second value depending on the values of the numbers received from the addressed storage location and the noise generator. The probability of the output signal has a given one of the first and second values determined by the number at the addressed location. The address inputs for the memory are derived from a real-to-spike frequency translator which has real values as its input vector.
摘要翻译： PCT No.PCT / GB91 / 01054 Sec。 371日期1992年12月22日 102（e）日期1992年12月22日PCT Filed 1991年6月28日PCT公布。公开号WO92 / 00573 日期：1992年1月9日。一种用于神经处理网络的装置。网络包括具有多个存储位置的存储器，每个存储位置都存储代表概率的数字。每个存储位置是可选地可寻址的，以使位置的内容被读取到比较器的输入。噪声发生器向比较器输入表示噪声的随机数。在比较器的输出处，根据从寻址的存储位置和噪声发生器接收的数字的值，出现具有第一或第二值的输出信号。输出信号的概率具有由寻址位置处的数量确定的第一和第二值中的给定值。用于存储器的地址输入是从具有真实值作为其输入向量的实际到尖峰频率转换器导出的。

99. 发明授权

US5221606A Reagent and kit for enzyme assay comprising a substrate consonant with given enzyme to be assayed 失效
标题翻译：用于测定包含符合要素测定的基质的基质的酶测试试剂盒
公开(公告)号：US5221606A
公开(公告)日：1993-06-22
申请号：US466425
申请日：1990-03-08
申请人： Anthony C. Richardson , Brian V. Smith , Robert G. Price , Percy F. Praill
发明人： Anthony C. Richardson , Brian V. Smith , Robert G. Price , Percy F. Praill
IPC分类号： C07D213/30 , C07D215/14 , C07D231/26 , C07D239/66 , C07D277/20 , C07D277/36 , C07F9/6541 , C07H15/26 , C12Q1/00 , C12Q1/34 , C12Q1/42 , C12Q1/44
CPC分类号： C12Q1/34 , C12Q1/00 , C12Q2334/00 , Y10S435/975
摘要： This invention relates to enzyme assays and substrates for use in such assays. The presence or absence of certain enzymes in vivo is a useful indicator of illness or deficiency in the organisms concerned. Enzymes are also useful in monitoring microbial growth in fermentors and in the food industry and are important in enzyme-linked immunosorbent assays (ELISA), and in the characterization of bacterial species in culture. Disclosed is a reagent for enzyme assay comprising a substrate consonant with a given enzyme to be assayed, labelled with a chromogenic group which, on action of the given enzyme, is liberated to give a colored product. Also disclosed is a kit for the assay of an enzyme comprising the reagent of the disclosed invention.
摘要翻译： PCT No.PCT / GB88 / 00737 Sec。 371 1990年3月8日第 102（e）1990年3月8日PCT PCT日期：1988年9月7日PCT公布。第WO89 / 02473号公报 1989年3月23日。本发明涉及用于这种测定的酶测定和底物。体内某些酶的存在或不存在是有关生物相关疾病或缺陷的有用指标。酶还可用于监测发酵罐和食品工业中的微生物生长，并且在酶联免疫吸附测定（ELISA）和培养中细菌种类的表征中是重要的。公开了用于酶测定的试剂，其包括与要测定的给定酶的底物辅音，用显色基团标记，所述显色基团在给定酶的作用下被释放以产生有色产物。还公开了用于测定包含本发明的试剂的酶的试剂盒。

100. 发明授权

US4652501A Operation of microbial fuel cells 失效
标题翻译：微生物燃料电池的运行
公开(公告)号：US4652501A
公开(公告)日：1987-03-24
申请号：US755779
申请日：1985-07-17
申请人： Hugh P. Bennetto , Gerard M. Delaney , Jeremy R. Mason , John L. Stirling , Sibel Roller , Christopher F. Thurston , Donald R. White, Jr.
发明人： Hugh P. Bennetto , Gerard M. Delaney , Jeremy R. Mason , John L. Stirling , Sibel Roller , Christopher F. Thurston , Donald R. White, Jr.
IPC分类号： C12M1/36 , H01M8/04 , H01M8/16
CPC分类号： H01M8/04447 , H01M8/04186 , H01M8/04619 , H01M8/04753 , H01M8/04798 , H01M8/0494 , H01M8/16 , Y02E60/527
摘要： In operation of a microbial fuel cell it has been found that improved efficiency results if the microbes are kept `hungry`, i.e. the cell is run under conditions of fuel supply and load such that electrical output is dependent on fuel concentration, rather than as is conventionally the case being run under excess fuel so that power output is concentration independent.A method and apparatus are described to enable fuel cells to be run under energetic or coulombic efficiency control.
摘要翻译：在微生物燃料电池的运行中已经发现，如果微生物保持“饥饿”，则电池在燃料供应和负载的条件下运行，使得电输出取决于燃料浓度，而不是如此通常情况下，在过量燃料下运行，使得功率输出是浓度独立的。描述了一种方法和装置，以使燃料电池能够在能量或库仑效率控制下运行。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式