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1. 发明申请

US20230137844A1 PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD 有权
公开(公告)号：US20230137844A1
公开(公告)日：2023-05-04
申请号：US17977451
申请日：2022-10-31
申请人： TORAY INDUSTRIES, INC. , NATIONAL CANCER CENTER
发明人： Satoshi KONDOU , Hitoshi NOBUMASA , Satoko KOZONO , Hiroko SUDO , Junpei KAWAUCHI , Takahiro OCHIYA , Nobuyoshi KOSAKA
IPC分类号： C12Q1/6886 , G01N37/00 , C12N15/09 , C12M1/34 , G01N33/574 , C12M1/00 , G01N33/53 , C12Q1/68
摘要： An object of the present invention is to provide a kit or a device for the detection of prostate cancer and a method for detecting prostate cancer. The present invention provides a kit or a device for the detection of prostate cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample of a subject, and a method for detecting prostate cancer, comprising measuring the miRNA in vitro.

2. 发明申请

US20230136600A1 Method and device for screening antigen epitope polypeptide 有权
公开(公告)号：US20230136600A1
公开(公告)日：2023-05-04
申请号：US17911143
申请日：2021-03-12
申请人： ICARBONX (ZHUHAI) COMPANY LIMITED
发明人： Yingrui LI , Jian WANG , Hancheng ZHENG , Binghang LIU , Mingchen YAN , Jiamin CAO , Zhenyu LI , Linghao SHEN , Danni LI , Qiuxia DING , Jing SUN , Zhiying LIANG , Jun WANG
IPC分类号： G01N33/68 , G01N33/569 , G01N33/53
摘要： Provided is a method and a device for screening an antigen epitope polypeptide. The screening method includes: predicting one or more antigen epitopes with all proteome sequences of a target coronavirus to obtain a predicted epitope region; screening a polypeptide with a differential response to a positive serum sample infected by the target coronavirus and a control serum sample with a polypeptide chip technology, and recording the polypeptide as a differential peptide fragment; comparing the differential peptide fragment with all proteome sequences of the target coronavirus to obtain a first conserved motif region; screening regions meeting epitope screening conditions from the predicted epitope region and the first conserved motif region to obtain the antigen epitope, wherein the epitope screening conditions comprise a non-phosphorylation region and/or an extracellular region of the target coronavirus.

3. 发明申请

US20230133866A1 INTEGRATED PHOTONIC SYSTEMS AND METHODS FOR BIOSENSING 有权
公开(公告)号：US20230133866A1
公开(公告)日：2023-05-04
申请号：US17918102
申请日：2021-04-09
申请人： SiPhox Inc.
发明人： Diedrik Rene Vermeulen , Michael Dubrovsky , Sarat Gundararapu
IPC分类号： G01N33/543 , G01N1/44 , G01N1/42 , G01N1/38 , G01N1/14 , G01N35/00 , G01N21/01 , G01N33/53
摘要： Disclosed herein are integrated photonics systems (3800) for biosensing including an interrogator photonic circuit (3802) and cartridge (3804) and methods using these systems. The cartridge (3804) comprises a sensor photonic integrated subcircuit. The cartridge (3804) is configured to receive a biological sample. The interrogator photonic circuit (3802) is optically coupled to the cartridge (3804) an comprises: (i) a light source (3806) configured to generate light; and (ii) one or more waveguides configured to carry the light, wherein the light is used to determine a characteristic of the biological sample in the cartridge (3804). A system can have an assembly of a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality. An output port of a first subset of the subcircuits can be configured to be aligned with an input port of a second subset of the subcircuits. At least one subcircuit can be configured to be removed from the first integrated photonics assembly and connected to a second integrated photonics assembly having a second functionality. The first integrated photonics assembly can be different from the second integrated photonics assembly and the first functionality can be different from the second functionality.

4. 发明授权

US11639928B2 Methods and systems for characterizing analytes from individual cells or cell populations 有权
公开(公告)号：US11639928B2
公开(公告)日：2023-05-02
申请号：US17680209
申请日：2022-02-24
申请人： 10X GENOMICS, INC.
发明人： Tarjei Sigurd Mikkelsen , Eswar Prasad Ramachandran Iyer , Andrew Kohlway , Luigi Jhon Alvarado Martinez , Katherine Pfeiffer , Andrew D. Price
IPC分类号： G01N33/532 , C12N15/85 , G01N33/543 , G01N33/548 , C12N15/10 , C12Q1/6806 , G01N33/50 , G01N33/53 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/569 , C40B70/00 , C40B30/04 , C40B50/06 , C07K14/74 , C12Q1/6804
摘要： The present disclosure provides methods of processing or analyzing a sample. A method for processing a sample may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule), barcoding the probe-nucleic acid molecule complex, and performing extension, denaturation, and amplification processes. A method for processing a sample may comprise hybridizing first and second probes to adjacent or non-adjacent target regions of a nucleic acid molecule (e.g., an RNA molecule), linking the first and second probes to provide a probe-linked nucleic acid molecule, and barcoding the probe-linked nucleic acid molecule. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well. One or more processes of the methods described herein may be performed on a cell, such as a permeabilized cell.

5. 发明授权

US11639926B2 Detection device, sample solution loading device, test strip loading board and test strip 有权
公开(公告)号：US11639926B2
公开(公告)日：2023-05-02
申请号：US17744555
申请日：2022-05-13
申请人： Institute of Quality Standard and Testing Technology for Agro-Products, CAAS
发明人： Jing Wang , Zhen Cao , Hui Li
IPC分类号： G01N33/53 , G01N33/543 , G01N35/10 , G01N35/00
摘要： A detection device, the device comprising a sample liquid bearing device (300), test strips (200), a test strips bearing plate (100) and a signal acquisition positioning assisting device, wherein the sample liquid bearing device (300) comprises two or more samples cells (320) used for containing sample liquid, each of the test strips (200) at least comprises an identity information bearing part (250), a developing part (220) and a capillary part (210), the test strip bearing plate (100) is used for placing the test strips (200) in the same circular ring in a circumferential array radial manner, and the signal acquisition positioning assisting device is arranged on the test strip bearing plate and is used for positioning the test strips.

6. 发明授权

US11634756B2 Spatially encoded biological assays 有权
公开(公告)号：US11634756B2
公开(公告)日：2023-04-25
申请号：US17972350
申请日：2022-10-24
申请人： Prognosys Biosciences, Inc.
发明人： Mark S. Chee
IPC分类号： C12Q1/68 , C12Q1/6804 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q1/6841 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C40B30/04 , G01N33/53 , G01N33/68 , B01L3/00 , C40B60/04 , G01N33/543
摘要： The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

7. 发明授权

US11634491B2 Checkpoint blockade and microsatellite instability 有权
公开(公告)号：US11634491B2
公开(公告)日：2023-04-25
申请号：US17739278
申请日：2022-05-09
申请人： The Johns Hopkins University
发明人： Luis Diaz , Bert Vogelstein , Kenneth W. Kinzler , Nickolas Papadopoulos , Dung Le , Drew M. Pardoll , Suzanne L. Topalian
IPC分类号： G01N31/00 , G01N33/53 , C07K16/28 , C12Q1/6886 , C07K16/30 , C07K16/40 , A61K39/00
摘要： Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.

8. 发明申请

US20230123164A1 COMPOSITION USING URINE SAMPLE FOR DIAGNOSIS OF KIDNEY DISEASE 有权
公开(公告)号：US20230123164A1
公开(公告)日：2023-04-20
申请号：US17907432
申请日：2021-04-12
申请人： BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION , SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人： Seung Seob SON , Tae Rim KIM , Eun Young LEE , Nam-Jun CHO , Sung Il YUN , Jun Hong PARK , Han-Oh PARK
IPC分类号： G01N33/68 , G01N33/53
摘要： The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic kidney disease can advantageously predict the plausibility of progression into end-stage renal disease in advance.

9. 发明授权

US11618025B2 Apparatus and method for on-chip microfluids dispensing 有权
公开(公告)号：US11618025B2
公开(公告)日：2023-04-04
申请号：US16648009
申请日：2018-08-01
申请人： University of Macau
发明人： Yanwei Jia , Haoran Li , Ren Shen , Cheng Dong , Tianlan Chen , Jie Gao , Pui-ln Mak , Rui Paulo da Silva Martins
IPC分类号： B01L3/00 , G01N33/53
摘要： Provided is an apparatus, system and method for on-chip microfluids dispensing. The apparatus comprising a substrate; a plurality of first electrodes arranged one next to another on the substrate; a dielectric layer above and enclosing the plurality of first electrodes; and a second electrode on the substrate, wherein each of the plurality of first electrodes is in electric communication with a respective first driving signal input; wherein the second electrode is in electric communication with a second driving signal input; wherein the plurality of first electrodes define a continuous fluid path along a longitudinal direction for retaining microfluids, and wherein the second electrode is arranged within the continuous fluid path and defines a jetting position and an adjacent mixing position within the continuous fluid path.

10. 发明申请

US20230100215A1 METHODS FOR IN SITU TRANSCRIPTOMICS AND PROTEOMICS 有权
公开(公告)号：US20230100215A1
公开(公告)日：2023-03-30
申请号：US17938329
申请日：2022-10-05
申请人： Singular Genomics Systems, Inc.
发明人： Eli N. GLEZER , Hu CANG , Zhenmin HONG
IPC分类号： C12Q1/6841 , C12Q1/6804 , G01N33/53
摘要： Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.

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