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91. 发明授权

US09017687B1 Low acidic species compositions and methods for producing and using the same using displacement chromatography 有权
标题翻译：低酸性物质组合物和使用置换色谱法制备和使用该方法
公开(公告)号：US09017687B1
公开(公告)日：2015-04-28
申请号：US14079076
申请日：2013-11-13
申请人： AbbVie, Inc.
发明人： Chen Wang , Germano Coppola , Chris Chumsae
IPC分类号： A61K39/00 , C12P21/04 , C12P21/08 , C07K16/00 , C07K14/525 , C07K16/24 , C07K1/16
CPC分类号： C07K16/241 , A61K39/39591 , C07K1/165 , C07K14/525 , C07K16/065 , C07K2317/565
摘要： The present invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low AR compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
摘要翻译：本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及使用置换色谱法制备这种低AR组合物的方法。还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。

92. 发明授权

US09000128B2 Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof 有权
标题翻译：针对增殖诱导配体（APRIL）的抗体及其使用方法
公开(公告)号：US09000128B2
公开(公告)日：2015-04-07
申请号：US13792339
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , G01N33/53 , C07K16/28 , C07K16/24 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译：本发明涉及结合人APRIL的结合化合物。更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。

93. 发明授权

US08987419B2 Amyloid-beta binding proteins 有权
公开(公告)号：US08987419B2
公开(公告)日：2015-03-24
申请号：US13085891
申请日：2011-04-13
申请人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
发明人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
IPC分类号： C12P21/08 , C07K16/00 , C07K16/18 , C07K14/47
CPC分类号： C07K16/18 , A61K39/3955 , A61K47/6835 , A61K49/00 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/92
摘要： The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.

94. 发明授权

US08987417B2 Covalently dimerized bivalent binding agents 有权
标题翻译：共价二聚二价结合剂
公开(公告)号：US08987417B2
公开(公告)日：2015-03-24
申请号：US13990083
申请日：2011-11-28
申请人： John C. Zwaagstra , Maureen D. O'Connor-McCourt , Traian Sulea , Catherine Collins , Myriam Banville , Maria L. Jaramillo
发明人： John C. Zwaagstra , Maureen D. O'Connor-McCourt , Traian Sulea , Catherine Collins , Myriam Banville , Maria L. Jaramillo
IPC分类号： C07K1/00 , C07K16/00 , C12P21/08 , C07K14/71 , A61K47/48 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： C07K14/71 , A61K47/68 , A61K47/6803 , A61K47/6817 , A61K47/6881 , C07K16/18 , C07K16/22 , C07K16/24 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/73 , G01N2333/71
摘要： The present invention addresses limitations of prior art receptor-based traps through a methodology called the clamp/click/cleave (CCC) approach. Two fusion proteins each comprising a binding domain fused to a coiled-coil are non-covalently dimerized through the coiled-coil (clamp), and the dimer so formed is stabilized by a covalent disulphide bond (click) between cysteine residues located on the fusion proteins between the binding domains and coiled-coils. Once the disulphide bond has formed, the coiled-coils are subsequently removed (cleave) by cleaving the fusions proteins at cleavage sites located between the cysteine residues and the coiled-coils to provide the covalently dimerized bivalent binding agent of the present invention. Such binding agents are useful in the treatment and diagnosis of disease states characterized by production and/or overexpression of a ligand to which the binding domains bind. The invention is particularly useful for covalently dimerized receptor-based ligand traps where the binding domains are receptor ligand-binding domains, such as those of TGF-β receptors.
摘要翻译：本发明通过称为夹/劈裂（CCC）方法的方法解决了现有技术的基于受体的陷阱的限制。每个包含与卷曲螺旋体融合的结合结构域的两个融合蛋白通过盘绕线圈（钳夹）非共价二聚，并且由此形成的二聚体通过位于融合物上的半胱氨酸残基之间的共价二硫键（点击）来稳定结合域和线圈之间的蛋白质。一旦形成二硫键，随后通过在位于半胱氨酸残基和盘绕线圈之间的切割位点切割融合蛋白来除去（切割）线圈，以提供本发明的共价二聚二价结合剂。这种结合剂可用于治疗和诊断特征在于结合结构域结合的配体的产生和/或过表达的疾病状态。本发明对于共价二聚化的基于受体的配体陷阱特别有用，其中结合域是受体配体结合结构域，例如TGF- 受体。

95. 发明授权

US08986954B2 DNA encoding function modifying Nav1.7 antibodies 有权
标题翻译： DNA编码功能修饰Nav1.7抗体
公开(公告)号：US08986954B2
公开(公告)日：2015-03-24
申请号：US14285721
申请日：2014-05-23
申请人： UCB Pharma S.A.
发明人： Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J. Wolff
IPC分类号： C07H21/04 , C12P21/08 , C12N5/10 , C07K16/18 , C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
摘要翻译：结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。

96. 发明授权

US08986685B2 Compositions and methods for increasing bone mineralization 有权
标题翻译：增加骨矿化的组合物和方法
公开(公告)号：US08986685B2
公开(公告)日：2015-03-24
申请号：US13644728
申请日：2012-10-04
申请人： UCB Pharma S.A.
发明人： Mary E. Brunkow , David J. Galas , Brian Kovacevich , John T. Mulligan , Bryan W. Paeper , Jeffrey Van Ness , David G. Winkler
IPC分类号： A61K39/395 , C07K16/18 , C12P21/08 , A61K45/06 , C07K14/51 , C07K16/22 , C12Q1/68 , G01N33/68 , A61K48/00
CPC分类号： G01N33/74 , A01K2217/05 , A01K2217/075 , A61K38/18 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/475 , C07K14/51 , C07K16/18 , C07K16/22 , C07K2317/11 , C07K2317/23 , C07K2319/00 , C12N2799/021 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6872 , G01N33/84 , G01N2333/47 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/20
摘要： Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.
摘要翻译：本文描述了包含抗硬化蛋白酶抗体和骨吸收抑制剂的药物组合物。

97. 发明授权

US08980646B2 Proteolytic and covalent antibodies 有权
标题翻译：蛋白水解和共价抗体
公开(公告)号：US08980646B2
公开(公告)日：2015-03-17
申请号：US10581294
申请日：2004-03-26
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
IPC分类号： C07K16/00 , C12P21/08 , C07K16/28 , C07K16/10 , C07K16/44 , C12Q1/37 , G01N33/68
CPC分类号： C07K16/2863 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/1063 , C07K16/44 , C07K2317/21 , C07K2317/34 , C12Q1/37 , G01N33/6854 , G01N2333/901
摘要： Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.
摘要翻译：公开了用于生产，选择和抑制催化和共价抗体的改进方法。

98. 发明授权

US08975379B2 Identification of cancer protein biomarkers using proteomic techniques 有权
标题翻译：使用蛋白质组学技术鉴定癌症蛋白质生物标志物
公开(公告)号：US08975379B2
公开(公告)日：2015-03-10
申请号：US12644677
申请日：2009-12-22
申请人： Gil G. Mor , David C. Ward , Patricia Bray-Ward
发明人： Gil G. Mor , David C. Ward , Patricia Bray-Ward
IPC分类号： C07K16/00 , C12P21/08 , C40B40/10 , A61K39/395 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N2333/4703 , G01N2333/575 , G01N2333/5756 , G01N2333/65 , G01N2333/99 , G01N2500/04 , G01N2800/52 , G06F19/00
摘要： The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
摘要翻译：所要求保护的发明描述了诊断或辅助诊断癌症的方法。所要求保护的方法基于特别适合于区分癌症受试者和健康受试者的生物标志物的鉴定。使用本文所述的独特和新颖的筛选方法鉴定这些生物标志物。本文鉴定的生物标志物也可用于癌症的预后和监测。本发明包括使用瘦蛋白，催乳素，OPN和IGF-II来诊断，预后和监测卵巢癌。

99. 发明授权

US08969530B2 Anti-clathrin heavy chain monoclonal antibody for inhibition of tumor angiogenesis and growth and application thereof 有权
标题翻译：抗网格蛋白重链单克隆抗体用于抑制肿瘤血管生成及其生长及应用
公开(公告)号：US08969530B2
公开(公告)日：2015-03-03
申请号：US13644311
申请日：2012-10-04
申请人： Academia Sinica
发明人： Han-Chung Wu , Kuo-Hua Tung
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , A61K39/395 , A61K39/00 , C07K16/18 , C07K16/30
CPC分类号： C07K16/18 , C07K16/303 , C07K2317/73
摘要： A purified monoclonal antibody, or an. antigen-binding portion thereof, which specifically binds to human clathrin heavy chain (CHC) is disclosed. The antibody, or antigen-binding portion, thereof, exhibits at least one, two, three, four, five, six, seven, or all eight of the following properties: (a) specifically binds to pancreatic adenocarcinoma cells; (b) binding to the cell surface and cytosol of cancer cells and tumor blood vessels; (c) internalized by CHC-expressing cells; (d) inhibiting tumor growth, invasion ability, migration, and angiogenesis; (e) inducing apoptosis in cancer cells and human umbilical vein endothelial cells; (f) inhibiting tumor growth and tumor blood vessels in pancreatic cancer in vivo; (g) suppressing epidermal growth factor, transferrin, and VEGF internalizations by cancer cells; and (h) suppressing hypoxia-inducible factor-1α expression and vascular endothelial growth factor secretion. Methods for inhibiting tumor cell growth and/or angiogenesis, and detecting cancer in a subject is also disclosed.
摘要翻译：纯化的单克隆抗体，或公开了与人网格蛋白重链（CHC）特异性结合的抗原结合部分。抗体或其抗原结合部分显示出以下性质中的至少一种，二种，三种，四种，五种，六种，七种或全部八种：（a）特异性结合胰腺腺癌细胞; （b）结合癌细胞和肿瘤血管的细胞表面和细胞溶质; （c）通过表达CHC的细胞内化; （d）抑制肿瘤生长，侵袭能力，迁移和血管生成; （e）诱导癌细胞和人脐静脉内皮细胞凋亡; （f）体内抑制胰腺癌肿瘤生长和肿瘤血管; （g）抑制癌细胞的表皮生长因子，转铁蛋白和VEGF内化; 和（h）抑制低氧诱导因子-1α表达和血管内皮生长因子分泌。还公开了抑制肿瘤细胞生长和/或血管发生以及检测受试者中的癌症的方法。

100. 发明授权

US08969528B2 Antibodies to hepatocyte growth factor activator 有权
标题翻译：肝细胞生长因子激活剂的抗体
公开(公告)号：US08969528B2
公开(公告)日：2015-03-03
申请号：US13765625
申请日：2013-02-12
申请人： Genentech, Inc.
发明人： Daniel K. Kirchhofer , Yan Wu
IPC分类号： C12P21/08 , C07K16/22 , C07K16/32 , C07K16/40
CPC分类号： C07K16/22 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
摘要翻译：本发明提供调节肝细胞生长因子激活功能的方法和组合物。

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