专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US08729271B2 Glycine transporter inhibiting substances 有权
标题翻译：甘氨酸转运蛋白抑制物质
公开(公告)号：US08729271B2
公开(公告)日：2014-05-20
申请号：US13823574
申请日：2011-09-16
申请人： Minoru Moriya , Akito Yasuhara , Kazunari Sakagami , Hiroshi Ohta , Kumi Abe , Shuji Yamamoto , Yuko Araki , Hiroki Urabe , Xiang-Min Sun
发明人： Minoru Moriya , Akito Yasuhara , Kazunari Sakagami , Hiroshi Ohta , Kumi Abe , Shuji Yamamoto , Yuko Araki , Hiroki Urabe , Xiang-Min Sun
IPC分类号： A01N43/40 , A61K31/44 , A01N43/64 , A61K31/41 , C07D213/00 , C07D401/00 , C07D419/00
CPC分类号： C07D405/14 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:
摘要翻译：本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，焦虑障碍（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤，疼痛和睡眠障碍：

12. 发明授权

US08642510B2 Inhibitors for brassinosteroid signalling 失效
标题翻译：油菜素类固醇信号传导抑制剂
公开(公告)号：US08642510B2
公开(公告)日：2014-02-04
申请号：US12864663
申请日：2009-03-03
申请人： Claudia Jonak , Wilfried Rozhon
发明人： Claudia Jonak , Wilfried Rozhon
IPC分类号： A01N43/40 , C07D213/00 , A01P21/00
CPC分类号： C07D213/75 , A01N43/40
摘要： The invention describes a compound having the formula (I), wherein X is F, Cl, Br, or I; R1 is CH3, C2H5, C2H4R3, C2H3R3R4, C3H7, C3H6R or C3H5R3R4; R is H, CH3, C2H5, C2H4R3 or C2H3R3R4; and R3 and R4 are, independently, X, OH or NH2 for the treatment of plants, for increasing plant growth.
摘要翻译：本发明描述了具有式（I）的化合物，其中X是F，Cl，Br或I; R1是CH3，C2H5，C2H4R3，C2H3R3R4，C3H7，C3H6R或C3H5R3R4; R是H，CH 3，C 2 H 5，C 2 H 4 R 3或C 2 H 3 R 3 R 4; 并且R3和R4独立地是用于处理植物的X，OH或NH 2，用于增加植物生长。

13. 发明授权

US08604212B2 Anti-shock agent comprising diaminotrifluoromethylpyridine derivative 有权
标题翻译：包含二氨基三氟甲基吡啶衍生物的抗冲击剂
公开(公告)号：US08604212B2
公开(公告)日：2013-12-10
申请号：US13320570
申请日：2010-05-17
申请人： Shuichi Yotsuya , Hiroshi Shikama
发明人： Shuichi Yotsuya , Hiroshi Shikama
IPC分类号： C07D409/00 , C07D213/00 , A61K31/44
CPC分类号： C07D213/76 , A61K31/44 , C07D409/12
摘要： Septic shock is known to lead to, at the end stage, systematic inflammatory reaction syndrome and multiple organ failure (MOF) and cause the patients' death. In both diseases, the patient dies finally of MOF, and the infiltration by inflammatory cells plays a key role for MOF. Thus, development of therapeutic agents for septic shock by suppressing the infiltration by inflammatory cells has been desired.To provide a therapeutic or preventive agent for shock, comprising as an active ingredient a diaminotrifluoromethylpyridine derivative represented by the formula (I) or its salt: wherein X is a cycloalkylcarbonyl group, an alkenylcarbonyl group, a thiophenecarbonyl group or a benzoyl group which may be substituted by a halogen atom; and Y is an alkylsulfonyl group.
摘要翻译：脓毒性休克已知导致系统性炎症反应综合征和多器官功能衰竭（MOF），并导致患者死亡。在这两种疾病中，患者终末死亡，炎性细胞浸润对MOF起关键作用。因此，期望通过抑制炎性细胞浸润来发展用于败血性休克的治疗剂。为了提供休克用治疗剂或预防剂，其包含作为活性成分的由式（I）表示的二氨基三氟甲基吡啶衍生物或其盐：其中X是环烷基羰基，烯基羰基，噻吩羰基或苯甲酰基，其可以是被卤素原子取代; Y为烷基磺酰基。

14. 发明授权

US08586570B2 Sox-based kinase sensor 有权
标题翻译：基于Sox的激酶传感器
公开(公告)号：US08586570B2
公开(公告)日：2013-11-19
申请号：US13095298
申请日：2011-04-27
申请人： Barbara Imperiali , Elvedin Lukovic , Dora Carrico-Moniz
发明人： Barbara Imperiali , Elvedin Lukovic , Dora Carrico-Moniz
IPC分类号： A01N43/00 , A61K31/33 , A61K31/08 , A01N43/40 , A61K31/435 , A01N43/42 , A61K31/44 , A01N43/90 , A61K31/47 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07D213/00 , C07D221/18 , C07D221/22 , C07D221/02 , C07D471/02 , C07D455/02 , C07D217/00 , C07D215/00 , C07D215/38 , C07D215/12 , C07D215/14 , C07D215/36 , C07D215/16
CPC分类号： C07D471/04 , C07D215/36 , C07D221/08 , C12Q1/485
摘要： Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase.
摘要翻译：肽基传感器包含金属结合肽和一个或两个具有可在激酶存在下磷酸化的羟基氨基酸的激酶识别序列。

15. 发明授权

US08535901B2 Peptidase substrates 有权
标题翻译：肽酶底物
公开(公告)号：US08535901B2
公开(公告)日：2013-09-17
申请号：US13386578
申请日：2010-07-28
申请人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
发明人： Arthur James , Sylvain Orenga , John Perry , Vindhya Salwatura , Stephen Stanforth
IPC分类号： C12Q1/37 , C07K4/00 , C07D213/00
CPC分类号： C12Q1/37 , C12Q1/04 , G01N33/84
摘要： The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U and V are N, N+R or CZ4, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
摘要翻译：本发明涉及下式（I）的化合物用于检测肽酶活性和/或pH变化的用途：根据该化合物：Y1是肽，H或烷基; W1，W2，W3和W4独立地为H，Br，Cl，F，I，烷基，烷氧基，硫代甲基，全氟烷基，硝基，氰基，羧基（包括其酯或酰胺）或其任何组合; n = 0,1或2; U和V是N，N + R或CZ4，R是H，烷基，芳烷基，芳基，烷酰基或烷基磺酰基; Z 1，Z 2，Z 3和Z 4独立地为H，Br，Cl，F，I，烷基，芳基，烷氧基，全氟烷基，硝基，氰基，羧基，磺酰基，包括羧基或磺酰基酯或酰胺及其盐。

16. 发明授权

US08288165B2 Molecular heterobimetallic chemodosimetric sensor for the detection of biogenic amines 有权
标题翻译：用于检测生物胺的分子异双金属化学计量传感器
公开(公告)号：US08288165B2
公开(公告)日：2012-10-16
申请号：US12797763
申请日：2010-06-10
申请人： Hon-Wah Lam , Cheuk-Fai Chow
发明人： Hon-Wah Lam , Cheuk-Fai Chow
IPC分类号： G01N33/02 , G01N33/00 , C07D213/04 , C07D213/00
CPC分类号： G01N31/22 , G01N33/0054 , G01N33/02 , Y02A50/246 , Y10T436/173845 , Y10T436/175383
摘要： The invention relates to using heterobimetallic coordination polymers and their uses as chemodosimeters for sensing materials for the screening of specific biogenic amines.
摘要翻译：本发明涉及使用异双金属配位聚合物及其用作化学计量计来检测特定生物胺的筛选材料。

17. 发明授权

US08278319B2 Substituted spiroamine compounds 失效
标题翻译：取代的螺胺化合物
公开(公告)号：US08278319B2
公开(公告)日：2012-10-02
申请号：US12608543
申请日：2009-10-29
申请人： Melanie Reich , Stefan Oberboersch , Stefan Schunk , Ruth Jostock , Sabine Hees , Michael Engels
发明人： Melanie Reich , Stefan Oberboersch , Stefan Schunk , Ruth Jostock , Sabine Hees , Michael Engels
IPC分类号： A61K31/44 , C07D213/00
CPC分类号： C07D401/12 , C07D221/20
摘要： Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.
摘要翻译：对应于式（I）的取代的螺胺化合物其中m，n，o，p，Q，r，s，t，R1，R2，R3，R4a，R4b，R5a，R5b，R6a，R6b，R7，R8， R9，R10和R11具有定义的含义; 制备这些化合物的方法，含有这些化合物的药物组合物和使用取代的螺胺用于治疗或抑制由缓激肽1受体介导的疼痛和/或其它病症。

18. 发明授权

US08263627B2 Pyridyl amide T-type calcium channel antagonists 有权
标题翻译：吡啶酰胺T型钙通道拮抗剂
公开(公告)号：US08263627B2
公开(公告)日：2012-09-11
申请号：US13008161
申请日：2011-01-18
申请人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
发明人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
IPC分类号： A61K31/445 , A61K31/415 , C07D213/00 , C07D213/72
CPC分类号： C07D413/12 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D411/12
摘要： The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译：本发明涉及作为T型钙通道拮抗剂的吡啶酰胺化合物，其可用于治疗或预防其中涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。

19. 发明授权

US08158805B2 Azapeptide derivatives 有权
公开(公告)号：US08158805B2
公开(公告)日：2012-04-17
申请号：US12755184
申请日：2010-04-06
申请人： Scott L. Harbeson , Roger D. Tung
发明人： Scott L. Harbeson , Roger D. Tung
IPC分类号： A61K31/44 , C07D213/00
CPC分类号： C07D213/42 , C07F9/58
摘要： This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.

20. 发明申请

US20120083642A1 IONIC LIQUIDS, THE METHOD FOR PREPARING THE SAME AND METHOD FOR REMOVING ACETYLENES FROM OLEFIN MIXTURES USING THE IONIC LIQUIDS 有权
标题翻译：离子液体，其制备方法和使用离子液体从烯烃混合物中除去乙烯的方法
公开(公告)号：US20120083642A1
公开(公告)日：2012-04-05
申请号：US12970346
申请日：2010-12-16
申请人： Hyun Joo Lee , Byoung Sung Ahn , Hoon Sik Kim , Jin-Hyung Kim , Gyeong Taek Gong
发明人： Hyun Joo Lee , Byoung Sung Ahn , Hoon Sik Kim , Jin-Hyung Kim , Gyeong Taek Gong
IPC分类号： C07C7/10 , C07D207/08 , C07D213/00 , C07D233/02
CPC分类号： C07D295/088 , C07C7/10 , C07C309/68 , C07D207/08 , C07D233/02 , C07D233/60 , C07F1/08 , C07C11/02
摘要： There are provided an ionic liquid having ether group(s) in which a copper(I) compound is included, a method for preparing the same, and a method for removing traces amounts of acetylene-based hydrocarbon compounds included in olefin by absorption or extraction using the same. When the disclosed solution is used, oxidation of Cu(I) to Cu(II) is prevented since CuX is stabilized by the ionic liquid. Thus, selective removal efficiency of acetylenic compounds is improved greatly while the removal performance is retained for a long period of time. Further, since the solution according to the present disclosure is applicable as an extractant as well as an absorbent, the associated operation is simple and apparatus cost can be decreased.
摘要翻译：提供了具有其中包含铜（I）化合物的醚基的离子液体，其制备方法和通过吸收或提取除去烯烃中痕量的乙炔类烃化合物的方法使用相同当使用所公开的溶液时，防止Cu（I）氧化为Cu（II），因为CuX被离子液体稳定。因此，在除去性能长时间保持的同时，炔属化合物的选择性除去效率大大提高。此外，由于根据本公开的溶液可用作萃取剂和吸收剂，因此相关操作简单，并且可以降低装置成本。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式