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11. 发明授权

US09273086B2 Protected monomer and method of final deprotection for RNA synthesis 有权
标题翻译：受保护的单体和RNA合成的最终脱保护方法
公开(公告)号：US09273086B2
公开(公告)日：2016-03-01
申请号：US13531191
申请日：2012-06-22
申请人： Douglas J. Dellinger , Joel Myerson , Agnieszka B. Sierzchala , Geraldine F. Dellinger , Zoltan Timar
发明人： Douglas J. Dellinger , Joel Myerson , Agnieszka B. Sierzchala , Geraldine F. Dellinger , Zoltan Timar
IPC分类号： C07H21/02 , C07H13/12 , C07H19/067 , A61K31/7125 , A61K31/712 , C07H19/00 , C07H19/167 , C07H21/00 , C07H23/00
CPC分类号： C07H19/067 , A61K31/712 , A61K31/7125 , C07H1/00 , C07H13/12 , C07H19/00 , C07H19/167 , C07H21/00 , C07H21/02 , C07H21/04 , C07H23/00 , Y02P20/55
摘要： A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure: wherein BP is a protected or unprotected heterocycle; R12 is a protecting group selected from a hydrocarbyl, a substituted hydrocarbyl, an aryl, and a substituted aryl; X is O or S; and PG is a thionocarbamate protecting group.
摘要翻译：使固体支持物结合的多核苷酸去保护的方法包括在足以使2'-保护的核糖核苷酸残基脱保护的条件下使多核苷酸与包含二胺的组合物接触的步骤。固体支持结合的多核苷酸具有至少一个2'-保护的核糖核苷酸残基，其具有以下结构：其中BP是被保护或未被保护的杂环; R 12是选自烃基，取代的烃基，芳基和取代的芳基的保护基; X是O或S; PG是硫代氨基甲酸酯保护基。

12. 发明授权

US09006468B2 Pesticidal compositions 有权
标题翻译：杀虫剂组合物
公开(公告)号：US09006468B2
公开(公告)日：2015-04-14
申请号：US13358090
申请日：2012-01-25
申请人： Gary D. Crouse , Thomas C. Sparks , CaSandra L. McLeod , David A. Demeter , Kristy Bryan , Annette V. Brown , William H. Dent, III , Denise P. Cudworth , Jaime S. Nugent , Ricky Hunter , Jack G. Samaritoni
发明人： Gary D. Crouse , Thomas C. Sparks , CaSandra L. McLeod , David A. Demeter , Kristy Bryan , Annette V. Brown , William H. Dent, III , Denise P. Cudworth , Jaime S. Nugent , Ricky Hunter , Jack G. Samaritoni
IPC分类号： C07D309/10 , C07D309/12 , C07H15/18 , C07H15/26 , C07H13/12 , A01N51/00 , A01N47/06 , A01N47/02 , A01N47/18 , A01N47/20 , A61K31/7064 , A61K31/7048 , A61K31/7034 , A01N43/00 , A01N43/16 , A01N43/40 , A01N43/50 , A01N43/653 , G06Q99/00
CPC分类号： C07H13/12 , A01N43/00 , A01N43/16 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/72 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82 , A01N47/02 , A01N47/06 , A01N47/18 , A01N51/00 , C07D309/10 , C07D309/12 , C07D405/14 , C07D407/14 , C07H15/18 , C07H15/26 , G06Q99/00
摘要： The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.
摘要翻译：本文件披露的发明涉及农药领域及其在防治害虫方面的应用。公开了具有以下结构的化合物。

13. 发明授权

US08895516B2 Modified saccharides, conjugates thereof, and their manufacture 有权
标题翻译：改性糖，其共轭物及其制备
公开(公告)号：US08895516B2
公开(公告)日：2014-11-25
申请号：US10526124
申请日：2003-09-01
申请人： Aldo Giannozzi , Giovanni Averani , Francesco Norelli , Paolo Costantino
发明人： Aldo Giannozzi , Giovanni Averani , Francesco Norelli , Paolo Costantino
IPC分类号： A61K31/70 , A61K31/715 , A61K31/7028 , C08B37/00 , C07H13/12 , A61K47/48
CPC分类号： C07H13/12 , A61K47/646
摘要： Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, —C(O)— or —OC(O)—; R1 is selected from H or C1-C6 alkyl; L is a C1-C12 alkylene group; and M is a masked aldehyde group. The new linker is especially useful for preparing conjugates of Neisseria meningitidis serogroup A saccharide. Conjugates having this new linker have improved immunogenicity compared to other types of conjugates.
摘要翻译：描述了具有新型接头的糖 - 蛋白质缀合物。包含新接头的缀合物由包含式（I）部分的修饰的糖制备：-A-N（R1）-L-M其中：A为键，-C（O） - 或-OC（O） - ; R1选自H或C1-C6烷基; L是C1-C12亚烷基; M为掩蔽的醛基。新接头对于制备脑膜炎奈瑟氏球菌血清群A糖的共轭物特别有用。与其他类型的缀合物相比，具有该新接头的缀合物具有改善的免疫原性。

14. 发明授权

US07304153B1 Polyol polyester synthesis 失效
标题翻译：多元醇聚酯合成
公开(公告)号：US07304153B1
公开(公告)日：2007-12-04
申请号：US08360184
申请日：1994-12-20
申请人： Donald Benjamin Appleby , David Joseph Bruno, Jr. , Patrick Joseph Corrigan , John Keeney Howie , Ju-Nan Kao , Scott David Pearson , Richard Gerard Schafermeyer , Glen Reid Wyness
发明人： Donald Benjamin Appleby , David Joseph Bruno, Jr. , Patrick Joseph Corrigan , John Keeney Howie , Ju-Nan Kao , Scott David Pearson , Richard Gerard Schafermeyer , Glen Reid Wyness
IPC分类号： C07H13/02 , C07H13/12 , C07H15/04 , C07H1/00
CPC分类号： C07H13/06 , C08G63/48
摘要： Polyol polyesters useful as nondigestible fat substitutes are prepared by improved heterogeneous interesterification processes between fatty acid esters of easily removable alcohol and polyol characterized by having one or more improvements such as using low levels of soap emulsifying agent, catalyst, and/or excess fatty acid ester; reducing the size of the polyol by mechanical means; removing extraneous particulate material during the reaction; using low temperature and/or high pressure and compensating by increasing the mass transfer area; and/or using backmixing in the initial stage(s) and plug-flow conditions in the final stage(s).
摘要翻译：用作不易消化的脂肪替代物的多元醇聚酯通过改进的容易除去的醇和多元醇的脂肪酸酯之间的异构酯交换方法来制备，其特征在于具有一个或多个改进，例如使用低含量的皂乳化剂，催化剂和/或过量的脂肪酸酯 ; 通过机械方式减少多元醇的大小; 在反应过程中除去外来颗粒物质; 使用低温和/或高压，并通过增加传质面积进行补偿; 和/或在最终阶段中的初始阶段和插件流条件下使用回混。

15. 发明授权

US06867194B2 Enzyme activated nitric oxide donors 失效
标题翻译：酶活化一氧化氮供体
公开(公告)号：US06867194B2
公开(公告)日：2005-03-15
申请号：US09925816
申请日：2001-08-09
申请人： Peng George Wang , Xuejun Wu , Xiaoping Tang
发明人： Peng George Wang , Xuejun Wu , Xiaoping Tang
IPC分类号： A61K31/706 , C07H13/12 , A61K3/785
CPC分类号： C07H13/12 , A61K31/706
摘要： Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the sugar-modified SIN-1 compositions and methods of using the compositions are also provided.
摘要翻译：提供了糖改性的SIN-1组合物。该组合物可用于响应糖和SIN-1部分之间的O-糖苷键特异的糖苷酶的水解活性产生NO。还提供了含有糖修饰的SIN-1组合物的药物组合物和使用该组合物的方法。

16. 发明授权

US06077830A Bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts 失效
标题翻译：新霉素组抗生素铋盐，其制备方法及其用途和包含这些盐的药物
公开(公告)号：US06077830A
公开(公告)日：2000-06-20
申请号：US36683
申请日：1998-03-09
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus , Gerhard Seibert
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus , Gerhard Seibert
IPC分类号： C07H13/12 , A61K31/70 , A61K31/702 , A61K31/7024 , A61K31/7135 , A61P1/00 , A61P1/04 , A61P31/04 , C07F9/94 , C07H21/00
CPC分类号： A61K31/70
摘要： The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to the invention contain antibiotics of the moenomycin group which are so-called phosphoglycolipid antibiotics and which are present individually or as a mixture, or derivatives thereof, and bismuth in defined stoichiometric ratios. They are outstandingly suitable, in particular, for controlling Helicobacter pylori and, thus, for example, for the therapy and prophylaxis of gastric disorders.
摘要翻译：本发明涉及霉霉素组的抗生素铋盐，其制备方法及其用途和包含这些盐的药物。根据本发明的盐含有呼伦霉素基团的抗生素，它是所谓的磷脂糖抗生素，它们单独存在或作为其混合物或其衍生物，以及定义化学计量比的铋。它们特别适用于控制幽门螺杆菌，因此例如用于治疗和预防胃疾病。

17. 发明授权

US5986087A Sulfonation of regenerated cellulose with sulfonated polymers and use of the thus modified fibres 失效
标题翻译：用磺化聚合物磺化再生纤维素并使用如此改性的纤维
公开(公告)号：US5986087A
公开(公告)日：1999-11-16
申请号：US952950
申请日：1997-11-21
申请人： Andreas Schrell , Bernd Huber
发明人： Andreas Schrell , Bernd Huber
IPC分类号： C08B31/12 , C08L1/00 , D01F2/06 , D01F2/10 , D01F2/24 , D06P3/60 , D06P5/22 , C07H13/12 , C07H1/00
CPC分类号： D06P5/22 , C08B31/12 , C08L1/00 , D01F2/06 , D01F2/10 , D01F2/24 , D06P3/6016
摘要： Sulfonated regenerated cellulose fiber obtained by adding a modifier to a viscose dope or alkali cellulose or cellulose solution and spinning fiber therefrom, wherefor the modifier is a starch etherified with C.sub.2 -C.sub.5 -alkylsulfonic acid radicals and having a degree of substitution of 0.1 to 3, a starch admixed with vinylsulfonic acid or a styrenesulfonic acid, or a polymeric styrenesulfonic acid or polymeric vinylsulfonic acid.
摘要翻译： PCT No.PCT / EP96 / 02081 Sec。 371日期：1997年11月21日 102（e）日期1997年11月21日PCT提交1996年5月15日PCT公布。 WO96 / 37641 PCT出版物日期：1996年11月28日通过向粘胶纤维素或碱纤维素或纤维素溶液中加入改性剂和纺丝纤维而获得的磺化再生纤维素纤维，其中改性剂是用C2-C5-烷基磺酸基团醚化并具有取代度的淀粉为0.1〜3，与乙烯基磺酸或苯乙烯磺酸混合的淀粉，或聚合苯乙烯磺酸或聚合乙烯基磺酸。

18. 发明授权

US5955100A Prodrugs their preparation and use as pharmaceuticals 失效
标题翻译：前药作为药物的制备和使用
公开(公告)号：US5955100A
公开(公告)日：1999-09-21
申请号：US449021
申请日：1995-05-24
申请人： Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
发明人： Klaus Bosslet , Jorg Czech , Dieter Hoffmann , Cenek Kolar , Fran.cedilla.ois Tillequin , Jean-Claude Florent , Michel Azoulay , Claude Monneret , Jean-Claude Jacquesy , Jean-Pierre Gesson , Michel Koch
IPC分类号： A61K31/70 , A23B4/03 , A61K9/127 , A61K31/7024 , A61K31/7028 , A61K31/7034 , A61K31/715 , A61K38/00 , A61K38/16 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , A61P43/00 , C07H13/08 , C07H13/12 , C07H15/00 , C07H15/04 , C07H15/203 , C07H15/207
CPC分类号： C07H13/08 , A61K47/48 , A61K47/48092 , C07H13/12 , C07H15/203 , Y02P20/55 , Y10S514/01
摘要： Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.
摘要翻译：描述了糖基间隔物药物化合物（前药），其制备及其作为药物的用途。

19. 发明授权

US5830872A Esters of D-mannose or of xylitol and their use as medicaments 失效
标题翻译： D-甘露糖或木糖醇的酯类及其用作药物
公开(公告)号：US5830872A
公开(公告)日：1998-11-03
申请号：US776980
申请日：1997-03-11
申请人： Pierre Jean Baldwin , Olivier Claude Eric Douillet , Philippe Rene Michel Pouillart , Gino Lino Ronco , Pierre Joseph Villa
发明人： Pierre Jean Baldwin , Olivier Claude Eric Douillet , Philippe Rene Michel Pouillart , Gino Lino Ronco , Pierre Joseph Villa
IPC分类号： C07H13/12 , A61K31/215 , A61K31/265 , A61K31/34 , A61K31/35 , A61K31/70 , A61K31/7024 , A61P7/06 , A61P35/00 , A61P35/02 , C07C69/33 , C07C69/612 , C07D317/24 , C07H1/00 , C07H13/02 , C07H13/04 , C07H13/06 , C07H15/04
CPC分类号： C07C69/614 , C07C69/003 , C07C69/612 , C07D307/20 , C07D317/24 , C07D493/04 , C07H13/04
摘要： Esters associating phenylacetic, 3-phenylpropionic, 4-phenylbutyric and n-butyric acids with Su(OH).sub.n monosaccharides or sugar alcohols, of general formula (I), in which the Su(OH).sub.n precursor is a monosaccharide or sugar alcohol, selected so that its structure or that of its derivatives ensures that internal interesterification does not take place either because the ester based on the general formula does not have a free hydroxyl grouping, or because with regard to the ester grouping, the free hydroxyl groupings are remotely located and/or badly aligned and/or bonded to a secondary carbon atom, and in which the Su(OH).sub.n monosaccharide or sugar alcohol is preferably D-mannose carrying the ester grouping on the anomeric carbon atom or else is a pentitol, for example, xylitol carrying the ester grouping on the C-1 primary carbon atom. These novel esters are useful as drugs, in particular in the treatment of haemoglobin diseases and premalignant or malignant tumours.
摘要翻译： PCT No.PCT / FR95 / 00743 Sec。 371日期1997年3月11日 102（e）日期1997年3月11日PCT归档1995年6月7日PCT公布。出版物WO96 / 03411 日期1996年2月8日将苯乙酸，3-苯基丙酸，4-苯基丁酸和正丁酸与通式（I）的Su（OH）n单糖或糖醇结合，其中Su（OH）n前体是单糖或糖醇，使得其结构或其衍生物的结构确保不发生内酯交换，因为基于通式的酯不具有游离羟基，或者由于酯基的组合，游离羟基位于远离位置和/或严格对准和/或键合到仲碳原子上，其中Su（OH）n单糖或糖醇优选在端基异碳原子上带有酯基的D-甘露糖，或者是戊糖醇，例如在C-1伯碳原子上带有酯基的木糖醇。这些新型酯可用作药物，特别是用于治疗血红蛋白疾病和癌前期或恶性肿瘤。

20. 发明授权

US5741897A Process for preparing an N-substitued aldonamide 失效
标题翻译：制备N-取代的aldonamide的方法
公开(公告)号：US5741897A
公开(公告)日：1998-04-21
申请号：US656735
申请日：1996-06-03
申请人： Burkhard Weuste , Andrea Katharina Jansen
发明人： Burkhard Weuste , Andrea Katharina Jansen
IPC分类号： C07H15/04 , C07H1/00 , C07H13/12
CPC分类号： C07H15/04
摘要： The present invention generally relates to a process for preparing an N-substituted aldonamide by reacting an aldonic acid in a polar organic solvent with an amine of the formula HNR.sup.1 (X--NR.sup.1)nR.sup.2, wherein R1 and R.about. may be the same or different and represent a hydrogen atom, a (cyclo)aliphatic or aromatic hydrocarbon separated by a hetero-atom or not, an amino acid ester, an amino acid amide, an ether amine or an N-alkanoyl alkylene diamine according to the formula R.sup.3 --C(O)N(H)--R.sup.4 --, wherein R.sup.3 =C.sub.1 -C.sub.24 alkyl or alkenyl and R.sup.4 =C.sub.2 -C.sub.22 branched or linear alkylene group, which may contain heteroatoms like N, O, and S, X is a difunctional (cyclo)aliphatic or aromatic hydrocarbon separated or not by a heteroatom or a hydrocarbon substituted hetero-atom, and n=0 or 1, with the proviso that when n=0, R.sup.1 and R.sup.2 do not stand for a hydrogen atom simultaneously, characterised in that an aqueous syrup of the aldonic acid is reacted, optionally after esterification with an alcohol with simultaneous distilling off of the water which is present, at a temperature in the range of 30.degree. to 120.degree. C., with the amine in the organic solvent, which is distilled off wholly or in part simultaneously with any water still present and/or formed.
摘要翻译：本发明一般涉及一种通过使极性有机溶剂中的醛糖酸与式HNR1（X-NR1）nR2的胺反应制备N-取代的醛酮酰胺的方法，其中R 1和R差可以相同或不同并且表示氢原子，被杂原子分开的（环）脂族或芳族烃，根据式R3-C的氨基酸酯，氨基酰胺，醚胺或N-烷酰基亚烷基二胺（O）N（H）-R4-，其中R3 = C1-C24烷基或烯基，R4 = C2-C22支链或直链亚烷基，其可以含有杂原子如N，O和S，X是双官能）被分离或不被杂原子或烃取代的杂原子分离的脂族或芳族烃，n = 0或1，条件是当n = 0时，R 1和R 2不同时代表氢原子，其特征在于任选在同时用醇酯化之后使醛糖酸的水性糖浆反应在30至120℃的温度范围内蒸馏掉有机溶剂中的胺，其与仍然存在的任何水全部或部分同时蒸馏掉，和/或形成。

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