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1. 发明申请

US20220017556A1 METHODS FOR PRODUCING STEREOISOMERICALLY ENRICHED CARBOHYDRATE-BASED SURFACTANTS 有权
公开(公告)号：US20220017556A1
公开(公告)日：2022-01-20
申请号：US17489477
申请日：2021-09-29
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Jeanne E. Pemberton , Tyler Roberts
IPC分类号： C07H15/14 , C07H15/06 , C07H1/00 , C07H15/04 , C07F9/94 , C07F3/00
摘要： The present disclosure discusses methods for producing stereoisomerically enriched carbohydrate-based surfactants. In particular, methods of the invention include producing stereoisomerically enriched hydrophobic portion of the carbohydrate-based surfactants.

2. 发明授权

US10556873B2 Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using 有权
公开(公告)号：US10556873B2
公开(公告)日：2020-02-11
申请号：US14834516
申请日：2015-08-25
申请人： Hyun-Soon Chong
发明人： Hyun-Soon Chong
IPC分类号： C07D255/02 , C07F9/94 , C07K16/40 , C07D413/12 , C07J43/00 , C07F1/08 , A61K49/10 , C07F5/00
摘要： Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacycicododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.

3. 发明授权

US10519178B2 Bi-nuclear main group metal phosphorescent emitter 有权
公开(公告)号：US10519178B2
公开(公告)日：2019-12-31
申请号：US15314256
申请日：2015-04-24
申请人： Siemens Aktiengesellschaft
发明人： Ana-Maria Krestel , Anna Maltenberger , Marina A Petrukhina , Guenter Schmid
IPC分类号： C07F9/94 , H01L51/00 , C09K11/06 , C07F15/00 , H01L51/50
摘要： A bi-nuclear phosphorescent emitter according to the following formula is disclosed. The emitter may include metal atoms M1 and M2, fluorescent emitter ligands LF, LF′, terminal ligands LT, LT′, and bridging ligands LV, LV′, wherein M1 and M2 are In, Tl, Sn, Pb, Sb, and Bi; LF and LF′ are comprise substituted or non-substituted C6-C70 aromatics or heteroaromatics; LV and LV′ are fluorinated or non-fluorinated, bi-dentate C2-C30 heteroalkyl or heteroaromatics; LT and LT′ are fluorinated or non-fluorinated, mono-, bi-, or tri-dentate C2-C30 O—, S—, N, heteroalkyl or heteroaromatics; and n and m are 1 or 2 independently of one another.

4. 发明授权

US10377778B2 Lead and thorium compounds 有权
公开(公告)号：US10377778B2
公开(公告)日：2019-08-13
申请号：US16219072
申请日：2018-12-13
申请人： Sciencons AS
发明人： Roy Hartvig Larsen
IPC分类号： C07F7/24 , C07F3/00 , C07F9/94 , A61P35/04 , C07B59/00 , A61K51/04 , A61P35/00
摘要： The present invention relates complexes comprising a PSMA targeting compound linked to a radionuclide, such as 212Pb or 227Th. These compounds, and pharmaceutical compositions comprising them, can be used for medical applications. These applications include the treatment of prostate cancer, and the complexes allow for dual targeting of cancers.

5. 发明授权

US10305047B2 Main group metal complexes as p-dopants for organic electronic matrix materials 有权
公开(公告)号：US10305047B2
公开(公告)日：2019-05-28
申请号：US15383579
申请日：2016-12-19
申请人： Siemens Aktiengesellschaft , OSRAM OLED GMBH
发明人： Anna Maltenberger , Marina A. Petrukhina , Guenter Schmid , Jan Hauke Wemken
IPC分类号： C08F4/20 , C08F36/16 , H01L51/00 , C07F9/94 , C09K11/06 , H01L51/50
摘要： A metal complex of a metal from groups 13 to 16 uses a ligand of the structure (I), where R.sup.1 and R.sup.2 can independently be oxygen, sulfur, selenium, NH or NR.sup.4, where R.sup.4 an alkyl or aryl and can be connected to R.sup.3. R.sup.3 is an alkyl, long-chain alkyl, alkoxy, long-chain alkoxy, cycloalkyl, halogenalkyl, aryl, arylene, halogenaryl, heteroaryl, heteroarylene, heterocycloalkylene, heterocycloalkyl, halogenheteroaryl, alkenyl, halogenalkenyl, alkynyl, halogenalkynyl, ketoaryl, halogenketoaryl, ketoheteroaryl, ketoalkyl, halogenketoalkyl, ketoalkenyl, halogenketoalkenyl, where in suitable radicals, one or more non-adjacent CH.sup.2-groups can be substituted independently of one another by —O—, —S—, —NH—, —NR.sup.o-, —SiR.sup.oR.sup.oo-, —CO—, —COO—, —OCO—, —OCO—O—, —SO.sub.2-, —S—CO—, —CO—S—, —CY1═CY2 or —C.dbd.C—, specifically in such a way that O and/or S atoms are not connected directly to one another, are likewise optionally substituted with aryl- or heteroaryl preferably containing 1 to 30 C atoms, as a dopant for matrix materials in organic electronic components.

6. 发明授权

US09499575B2 Synthesis of carbohydrate-based surfactants 有权
标题翻译：碳水化合物基表面活性剂的合成
公开(公告)号：US09499575B2
公开(公告)日：2016-11-22
申请号：US14041251
申请日：2013-09-30
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Jeanne E. Pemberton , Robin L. Polt , Raina M. Maier , Clifford S. Coss
IPC分类号： C07H9/04 , C07H13/04 , C07H15/04 , C07H15/06 , C07H1/00 , C07F9/94 , C07H15/14 , C07F3/00
CPC分类号： C07H15/14 , C07F3/003 , C07F9/94 , C07H1/00 , C07H15/04 , C07H15/06
摘要： The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound.
摘要翻译：本发明提供了基于碳水化合物的表面活性剂及其制备方法。制备碳水化合物基表面活性剂的方法包括使用糖基化启动子将碳水化合物或其衍生物与疏水性化合物连接。

7. 发明授权

US09499574B2 Arsenoplatin anti-cancer agents 有权
标题翻译：阿尔斯诺铂抗癌药
公开(公告)号：US09499574B2
公开(公告)日：2016-11-22
申请号：US14421982
申请日：2013-08-14
申请人： Northwestern University
发明人： Denana U. Miodragovic , Thomas V. O'Halloran
IPC分类号： C07F19/00 , C07F15/00 , C07F15/04 , C07F9/90 , C07F9/94 , C07F9/70
CPC分类号： C07F19/005 , C07F9/70 , C07F9/902 , C07F9/94 , C07F15/0013 , C07F15/0066 , C07F15/045
摘要： Disclosed are compound having the structure of formula (I): wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base and Y1 and Y2 are independently oxygen- or sulfur-containing substituents, conjugates containing compounds of formula (I) and their use as chemotherapy agents.

8. 发明授权

US09499466B2 Diene-based carboxylate anion and salt thereof, and polymerizable or curable composition thereof 有权
标题翻译：二烯系羧酸根阴离子及其盐及其可聚合或可固化的组合物
公开(公告)号：US09499466B2
公开(公告)日：2016-11-22
申请号：US13877751
申请日：2011-10-05
申请人： Tomomasa Kaneko
发明人： Tomomasa Kaneko
IPC分类号： C07C57/13 , C07C59/60 , C07F5/00 , C07F7/00 , C07F7/22 , C08F136/20 , C07C69/734 , C07F9/00 , C07F9/94 , C07F15/02 , C07F15/04
CPC分类号： C07C57/13 , C07C59/60 , C07C69/734 , C07F5/00 , C07F7/003 , C07F7/2224 , C07F9/005 , C07F9/94 , C07F15/025 , C07F15/045 , C08F136/20
摘要： The claimed invention provides a novel compound not having been studied before, that is, a diene carboxylate anion that contains a specific structure, and a salt thereof. The claimed invention further provides a diene carboxylate anion and a salt thereof, especially a metal salt thereof, which are easily soluble in general organic solvents, reactive diluents, and resins, may be in a liquid state at normal temperature depending on the structure, and have high polymerizability. Polymerization/curing of these produces a resin to which many ionic bonds and a metal are introduced, providing various properties such as hardness, scratch resistance, anti-fingerprint property, gas-barrier property, water vapor barrier property, oxygen absorption property, ultraviolet protection, infrared protection, color development and coloring, high refractive index, adhesion, various catalytic abilities, fluorescence ability and light-emitting ability, optical amplification, dispersibility, and antistatic properties. In addition, the anion and the salt can be used for raw materials for functional fine particles and for metal nanoparticle composites, and also for MOD materials. The claimed invention also provides an advantageous method for producing the diene carboxylate anion and the salt thereof.
摘要翻译：要求保护的发明提供了一种未经过研究的新化合物，即含有特定结构的二烯羧酸盐阴离子及其盐。要求保护的发明还可以提供一种易于溶于一般有机溶剂，反应性稀释剂和树脂的二烯羧酸盐阴离子及其盐，特别是其金属盐，在常温下可根据结构处于液态，具有高聚合性。这些聚合/固化产生了引入许多离子键和金属的树脂，提供了各种性能，例如硬度，耐擦伤性，抗指纹性，阻气性，水蒸气阻隔性，氧吸收性，紫外线防护红外线保护，显色和着色，高折射率，附着力，各种催化能力，荧光能力和发光能力，光学放大，分散性和抗静电性能。此外，阴离子和盐可用于功能性细颗粒和金属纳米颗粒复合材料的原料，也可用于MOD材料。所要求保护的发明还提供了制备二烯羧酸根阴离子及其盐的有利方法。

9. 发明申请

US20150344508A1 NITROGEN-RICH MACROCYCLIC LIGANDS, CHELATION COMPLEXES THEREOF, AND PROCESS FOR SELECTIVE CHELATION OF RADIOACTIVE BISMUTH IONS WITH THE LIGANDS 审中-公开
标题翻译：硝酸化大分子配体，其螯合复合物及其与配体的放射性双相离子选择性螯合的方法
公开(公告)号：US20150344508A1
公开(公告)日：2015-12-03
申请号：US14703253
申请日：2015-05-04
申请人： Los Alamos National Security, LLC
发明人： Justin Wilson , Eva Birnbaum , Kevin John , Francois Nortier , Michael Fassbender , Valery Radchenko , Jonathan Ward Engle
IPC分类号： C07F9/94 , C07F7/24 , C07D401/14
CPC分类号： C07F9/94 , C07D401/14 , C07F7/24
摘要： Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.
摘要翻译：从包括放射性核素放射性核素离子的混合物中选择性螯合放射性核素离子包括将配体暴露于含有放射性核素离子和放射性核素离子的水溶液中，由此铋放射性核素离子选择性螯合配体以形成放射性核素的阳离子络合物离子。并从放射性核素离子中分离出放射性核素离子的阳离子络合物。配体具有基于12元环的环的结构，并且可以包括可以用用于靶向α治疗的生物靶向载体衍生化的侧链官能团。

10. 发明申请

US20130216478A1 Non-Invasive Diagnostic Agents of Cancer and Methods of Diagnosing Cancer, Especially Leukemia and Lymphoma 有权
标题翻译：癌症的非侵入性诊断剂和诊断癌症，特别是白血病和淋巴瘤的方法
公开(公告)号：US20130216478A1
公开(公告)日：2013-08-22
申请号：US13854560
申请日：2013-04-01
申请人： STC.UNM
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： C07F9/94 , C07F5/00 , A61K51/04
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

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