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21. 发明授权

US07696379B2 Acetylene derivatives 失效
标题翻译：乙炔衍生物
公开(公告)号：US07696379B2
公开(公告)日：2010-04-13
申请号：US11912626
申请日：2006-04-24
申请人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
发明人： Ralf Glatthar , Thomas J. Troxler , Thomas Zoller , Joachim Nozulak
IPC分类号： C07C231/00 , C07D263/02 , C07D261/02 , C07D249/08 , C07D233/00 , C07C237/00 , A61K31/33 , A61K31/16
CPC分类号： C07C235/54 , C07C233/22 , C07C233/23 , C07C233/74 , C07C235/14 , C07C235/36 , C07C235/78 , C07C237/38 , C07C317/44 , C07D233/90 , C07D249/08 , C07D249/10 , C07D307/68
摘要： The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
摘要翻译：本发明提供式（I）化合物，其中R 1表示氢或烷基; R2表示未取代或取代的杂环，或者R2表示未取代或取代的芳基; R3表示烷基或卤素; X代表单键或烷二基，任选地被一个或多个氧原子或游离碱或酸加成盐形式的羰基或羰基氧基中断，其制备及其用作药物。

22. 发明授权

US07653424B2 Apparatus for measuring blood glucose concentrations 有权
标题翻译：用于测量血糖浓度的装置
公开(公告)号：US07653424B2
公开(公告)日：2010-01-26
申请号：US11377609
申请日：2006-03-16
申请人： Wayne Front March
发明人： Wayne Front March
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： An apparatus for measuring ocular and/or blood glucose levels comprises (a) an irradiating means (10) for irradiating light onto the eye (1) of a user from outside the cornea of the eye to excite an ocular glucose sensor in contact with an ocular fluid, said sensor being able to emit a total fluorescence having first and a second wavelength bands; (b) an optical path splitting means (11) for splitting said total fluorescence into a first fluorescence and a second fluorescence, said first fluorescence and said second fluorescence traveling along first and second optical paths; (c) a first detecting means (14) located in the first optical path; (d) a second detecting means (17) located in the second optical path; (e) a calculating means for calculating the intensity ratio of the first fluorescence to the second fluorescence and for determining an ocular glucose concentration in the ocular fluid; and (f) an arithmetic means for converting the ocular glucose concentration into a blood glucose concentration.
摘要翻译：一种用于测量眼睛和/或血糖水平的装置包括（a）用于从眼睛的角膜外侧将光照射到使用者的眼睛（1）上的照射装置（10），以激发与眼睛和/或血糖水平接触的眼葡萄糖传感器眼液，所述传感器能够发射具有第一和第二波长带的总荧光; （b）用于将所述总荧光分解为第一荧光和第二荧光的光路分离装置（11），所述第一荧光和所述第二荧光沿着第一和第二光路行进; （c）位于第一光路中的第一检测装置（14）（d）位于第二光路中的第二检测装置（17）（e）计算装置，用于计算第一荧光与第二荧光的强度比，并用于确定眼液中的眼葡萄糖浓度; 和（f）用于将眼葡萄糖浓度转换成血糖浓度的算术装置。

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