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1. 发明申请

US20180022679A1 HETEROGENEOUS METAL-FREE CATALYST 审中-公开
公开(公告)号：US20180022679A1
公开(公告)日：2018-01-25
申请号：US15670732
申请日：2017-08-07
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： Richard G. Blair
IPC分类号： C07C51/36 , C07C49/784 , B01J27/24 , C01B21/064 , C07C5/03 , B01J37/00 , C07C253/00 , C07C231/00 , B01J37/34 , C07C9/08 , C07C9/22 , C07C15/18 , C07C15/16 , C07C255/03 , C07C255/07 , C07C233/11 , C07C57/30 , C07C45/62 , B01J35/02
CPC分类号： C07C51/36 , B01J27/24 , B01J35/02 , B01J37/00 , B01J37/0036 , B01J37/343 , B01J2231/643 , B01J2231/645 , C01B21/0648 , C01P2002/85 , C01P2004/03 , C07C5/03 , C07C45/62 , C07C231/00 , C07C253/00 , C07C2527/24 , C07C9/08 , C07C9/22 , C07C15/18 , C07C15/16 , C07C255/03 , C07C255/07 , C07C233/11 , C07C57/30 , C07C49/784
摘要： The inventive concepts disclosed and/or claimed herein relate generally to catalysts and, more particularly, but not by way of limitation, to a heterogeneous, metal-free hydrogenation catalyst containing frustrated Lewis pairs. In one non-limiting embodiment, the heterogeneous, metal-free catalyst comprises hexagonal boron nitride (h-BN) having frustrated Lewis pairs therein.

2. 发明授权

US09637443B2 Graphene quantum dots and method of making 有权
公开(公告)号：US09637443B2
公开(公告)日：2017-05-02
申请号：US14261936
申请日：2014-04-25
申请人： University of North Dakota
发明人： Julia Xiaojun Zhao , Xu Wu
IPC分类号： A61K9/00 , C07C235/00 , H01L29/12 , H01L29/16 , H01L51/00 , A61K49/00 , B01J31/04 , C07C231/00 , G01N33/50 , G01N33/58 , C01B31/04 , B82Y40/00 , H01L51/50 , B82Y30/00
CPC分类号： C07C235/00 , A61K49/0017 , B01J31/04 , B01J2231/62 , B82Y30/00 , B82Y40/00 , C01B32/182 , C07C231/00 , G01N33/5005 , G01N33/588 , H01L29/127 , H01L29/1606 , H01L51/0045 , H01L51/502
摘要： A method for forming a graphene quantum dot product includes adding an organic starting material to a vessel and heating the organic starting material to a temperature within 20° C. of the organic starting material's boiling temperature for a time no longer than ten minutes to form graphene quantum dots. A method for sensing a graphene quantum dot includes forming a graphene quantum dot, exciting the graphene quantum dot with light having a first wavelength, measuring light emitted by the excited graphene quantum dot at a second wavelength different from the first wavelength. A graphene quantum dot includes carbon atoms and nitrogen atoms where the nitrogen atoms are present within the graphene quantum dot at a level between 6.0% and 11.0% of a level of carbon atoms present in the graphene quantum dot.

3. 发明授权

US09518074B2 Method for producing fluorine-containing substituted compound and fluorine-containing substituted compound 有权
公开(公告)号：US09518074B2
公开(公告)日：2016-12-13
申请号：US14986238
申请日：2015-12-31
申请人： Kyoto University , Taiyo Nippon Sanso Corporation
发明人： Junichi Yoshida , Aiichiro Nagaki
IPC分类号： C07F7/22 , C07C231/10 , C07F9/50 , C07C29/40 , C07C45/45 , C07F7/08 , C07C29/62 , C07C33/20 , C07C45/00 , C07C49/80 , C07C231/00 , C07C233/13 , C07C233/15 , C07F7/12 , C07F9/28 , C07C33/46 , C07C33/48
CPC分类号： C07F7/2208 , C07C29/40 , C07C29/62 , C07C33/20 , C07C33/46 , C07C33/483 , C07C45/00 , C07C45/455 , C07C49/80 , C07C231/00 , C07C231/10 , C07C233/13 , C07C233/15 , C07F7/0805 , C07F7/12 , C07F7/122 , C07F9/28 , C07F9/5022 , C07F9/5068 , C07C233/07 , C07C233/05 , C07C49/233
摘要： A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.

4. 发明授权

US09464034B2 Carbon-based fluorescent tracers as oil reservoir nano-agents 有权
标题翻译：碳基荧光示踪剂作为油藏纳米剂
公开(公告)号：US09464034B2
公开(公告)日：2016-10-11
申请号：US13469459
申请日：2012-05-11
申请人： Mazen Y. Kanj , Mohammad Harunar Rashid , Emmanuel Giannelis
发明人： Mazen Y. Kanj , Mohammad Harunar Rashid , Emmanuel Giannelis
IPC分类号： C07C233/00 , E21B49/00 , C07C231/00 , B82Y35/00 , C07C227/18 , C09K9/02
CPC分类号： C09K11/06 , B82Y20/00 , B82Y40/00 , C01B32/15 , C07C215/08 , C07C227/18 , C07C231/02 , C07C235/74 , C07H15/04 , C09K9/02 , C09K11/65 , C09K2208/10 , C09K2211/10 , E21B47/1015 , E21B49/00 , E21B49/008 , Y10S977/773 , Y10S977/774 , Y10S977/896 , Y10S977/95 , Y10T428/2982
摘要： Carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs are provided. The carbon-based fluorescent nano-agents being inexpensive means of analyzing, among other properties, the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and can be subsequently recovered for determinations of flow rates and retention times.
摘要翻译：提供了用于油藏分析的碳基荧光纳米剂示踪剂。碳基荧光纳米剂是廉价的手段，用于分析地层的孔隙率等特性。纳米容器适合注入石油储存器，随后可以回收以确定流速和保留时间。

5. 发明授权

US09221747B2 Method of making fatty acid N-acylalkanolamines 有权
标题翻译：制备脂肪酸N-酰基链烷醇胺的方法
公开(公告)号：US09221747B2
公开(公告)日：2015-12-29
申请号：US13869099
申请日：2013-04-24
申请人： Iowa State University Research Foundation, Inc.
发明人： Tong Wang , Xiaosan Wang
IPC分类号： C07C231/00 , C12P13/00 , C07C231/02
CPC分类号： C07C231/02 , C07C233/18 , C07C233/20
摘要： The present invention relates to methods for making a fatty acid N-acylalkanolamine having the formula: One of the methods comprises the steps of providing a vinyl ester of a fatty acid having the formula: providing a primary or secondary alkanolamine having the formula: NHR1R2; and reacting the vinyl ester of the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine. The other method comprises the steps of providing a fatty acid; purifying the fatty acid; providing a primary or secondary alkanolamine having the formula: NHR1R2; reacting the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine; and purifying the formed fatty acid N-acylalkanolamine.
摘要翻译：本发明涉及制备具有下式的脂肪酸N-酰基链烷醇胺的方法：一种方法包括以下步骤：提供具有下式的脂肪酸的乙烯基酯：提供具有下式的伯或仲链烷醇胺：NHR1R2; 并在有效形成脂肪酸N-酰基烷醇胺的条件下使脂肪酸的乙烯基酯与链烷醇胺反应。另一方法包括提供脂肪酸的步骤; 净化脂肪酸; 提供具有下式的伯或仲链烷醇胺：NHR1R2; 在有效形成脂肪酸N-酰基链烷醇胺的条件下使脂肪酸与链烷醇胺反应; 并纯化形成的脂肪酸N-酰基链烷醇胺。

6. 发明授权

US09029587B2 Method for producing aqueous acrylamide solution 有权
公开(公告)号：US09029587B2
公开(公告)日：2015-05-12
申请号：US14117754
申请日：2012-05-21
申请人： Makoto Kanou , Norifumi Hagiya
发明人： Makoto Kanou , Norifumi Hagiya
IPC分类号： C07C255/06 , C07C231/00 , C12P13/02 , C07C231/06
摘要： There is provided a method for producing an aqueous acrylamide solution by reacting a composition including acrylonitrile with water to produce acrylamide, in which the composition including acrylonitrile includes 3 to 15 mg of propionitrile per 1 kg of the total weight of the composition including acrylonitrile. According to the present invention, a production method with which it is possible to suppress acrylamide polymerization without lowering quality and thereby obtain a stable aqueous acrylamide solution can be provided.

7. 发明授权

US08916610B2 Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same 有权
标题翻译：去甲替林-GABA缀合物的酸加成盐及其制备方法
公开(公告)号：US08916610B2
公开(公告)日：2014-12-23
申请号：US13825369
申请日：2011-09-22
申请人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Mazal Shaul , Efrat Halbfinger
发明人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Mazal Shaul , Efrat Halbfinger
IPC分类号： A01N37/30 , A61K31/205 , C07C57/02 , C07C57/18 , C07C231/00 , C07C237/06 , C07C57/15 , C07C231/12 , C07C231/02 , C07C51/41
CPC分类号： C07C57/15 , C07B2200/13 , C07C51/412 , C07C231/02 , C07C231/12 , C07C237/06 , C07C2603/32
摘要： An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
摘要翻译：公开了去甲替林-GABA缀合物的酸加成盐，去甲替林-GABA缀合物的富马酸加成盐的新结晶形式及其制备方法。还公开了上述形式的去甲替林-GABA缀合物在治疗CNS障碍中的用途，特别是用于治疗疼痛。在制备去甲替林-GABA缀合物的大规模方法中进一步公开。

8. 发明授权

US08697898B2 Medical application of lipid derivatives of dopamine and the methods of their production 有权
标题翻译：多巴胺脂质衍生物的医学应用及其制备方法
公开(公告)号：US08697898B2
公开(公告)日：2014-04-15
申请号：US13303935
申请日：2011-11-23
申请人： Mieczyslaw Pokorski , Dominika Zajac , Zbigniew Czarnocki , Piotr Roszkowski
发明人： Mieczyslaw Pokorski , Dominika Zajac , Zbigniew Czarnocki , Piotr Roszkowski
IPC分类号： C07C231/00 , C07C233/00
CPC分类号： C07C231/02 , A61K31/165 , C12P13/02 , C12Y201/01006 , C07C233/20
摘要： A medical application of N-oleoyl-dopamine and 3′-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3′-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.
摘要翻译： N-油酰多巴胺和3'-O-甲基-N-油酰多巴胺的药物应用用于制备用于治疗或预防由于多巴胺缺乏引起的干扰或状态的药物，优选选自涵盖氧缺乏的组（缺氧）在麻醉和清醒的哺乳动物中，呼吸大气中的氧气（常氧），对哺乳动物的缺氧的呼吸反应，缺乏多巴胺与哺乳动物脑膜系统的结合，多巴胺代谢途径的紊乱，多巴胺的状态通过将化合物全面引入哺乳动物生物体中，由病态或遗传因素引起的缺陷以及与生物衰老的生理过程相关的条件下。还公开了一种在体外制备3'-O-甲基-N-油酰 - 多巴胺的方法。

9. 发明授权

US08637705B2 Amphiphilic oxalamide organogelators designed for gelation of organic solvents, water and hydrocarbon commercial fuels 失效
标题翻译：设计用于凝胶化有机溶剂，水和烃商业燃料的两亲草酰胺有机凝胶
公开(公告)号：US08637705B2
公开(公告)日：2014-01-28
申请号：US12733479
申请日：2008-09-04
申请人： {hacek over (Z)}inić Mladen , Makarević Janja
发明人： {hacek over (Z)}inić Mladen , Makarević Janja
IPC分类号： C07C231/00
CPC分类号： C07C233/56 , A61K8/042 , A61K8/44 , C07C231/02
摘要： The compounds of general formula (I) wherein: R1 is hydrogen, phenyl, C1-6 alkyl which can be further substituted with R3, R3 is 5- or 6-membered aromatic or heteroaromatic ring system which can be further substituted with benzyl or hydroxyl groups; R2 is OR4, NHR4, R4 is hydrogen, C1-6 alkyl or benzyl n is an integer from 1 to 12 or the salts of compounds mentioned which can form gels with commercial fuels, organic solvents and water.
摘要翻译：通式（I）的化合物其中：R 1是氢，苯基，可以被R 3进一步取代的C 1-6烷基，R 3是可被苄基或羟基进一步取代的5-或6-元芳族或杂芳族环系团体 R 2是OR 4，NHR 4，R 4是氢，C 1-6烷基或苄基，n是1至12的整数，或者可以与商业燃料，有机溶剂和水形成凝胶的化合物的盐。

10. 发明授权

US08623833B2 Compositions and methods for enhancing drug delivery across and into epithelial tissues 失效
标题翻译：用于增强穿过和进入上皮组织的药物递送的组合物和方法
公开(公告)号：US08623833B2
公开(公告)日：2014-01-07
申请号：US12816358
申请日：2010-06-15
申请人： Jonathan B. Rothbard , Paul A. Wender , P. Leo McGrane , Lalitha V. S. Sista , Thorsten A. Kirschberg
发明人： Jonathan B. Rothbard , Paul A. Wender , P. Leo McGrane , Lalitha V. S. Sista , Thorsten A. Kirschberg
IPC分类号： A61K38/08 , A61K38/16 , C12P13/10 , C07C231/00
CPC分类号： A61K47/48346 , A61K31/155 , A61K31/337 , A61K31/436 , A61K31/496 , A61K31/573 , A61K38/00 , A61K38/13 , A61K47/54 , A61K47/55 , A61K47/555 , A61K47/557 , A61K47/62 , A61K47/64 , A61K47/645 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/146 , B82Y5/00 , C07K7/06 , C07K7/64
摘要： This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
摘要翻译：本发明提供用于增强药物和其它药物穿过上皮组织包括皮肤，胃肠道，肺上皮，眼组织等的递送的组合物和方法。组合物和方法也可用于穿过内皮组织，包括血脑屏障。与非共轭化合物相比，组合物和方法使用具有足够的胍基或脒基侧链部分的递送增强转运蛋白，以增强与试剂缀合的化合物跨越组织的一个或多个层的递送。递送增强聚合物包括例如优选长度在约6和25个残基之间的聚精氨酸分子。

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