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21. 发明授权

US09522938B2 Phl p 5a derivatives having reduced allergeneity and retained T-cell reactivity 有权
标题翻译： Phl p 5a衍生物具有降低的变应原性和保留的T细胞反应性
公开(公告)号：US09522938B2
公开(公告)日：2016-12-20
申请号：US14146364
申请日：2014-01-02
申请人： Merck Patent GmbH
发明人： Martin Wald , Oliver Cromwell , Andreas Nandy , Helga Kahlert , Bernhard Weber , Helmut Fiebig
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12N15/09 , C12P21/04 , C07K14/415 , A61K39/35 , A61K39/00
CPC分类号： C07K14/415 , A61K39/35 , A61K2039/55505 , A61K2039/55561
摘要： The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
摘要翻译：本发明涉及Pooideae组5变应原的变体的制备和用途，其特征在于与已知的野生型变应原相比具有减少的IgE反应性，并且同时通过与T淋巴细胞的基本保留的反应性。这些低变应原过敏原变体可用于具有草花粉过敏的患者或草花粉过敏的预防性免疫治疗的特异性免疫治疗（hyposensitisation）。

22. 发明授权

US09393218B2 Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers 有权
标题翻译：使用来自聚氨酯组的成膜护发聚合物和含有这些聚合物的药物制剂和贴剂
公开(公告)号：US09393218B2
公开(公告)日：2016-07-19
申请号：US11643948
申请日：2006-12-22
申请人： Ines Zurdo Schroeder , Patrick Franke , Stefan Bracht , Claus-Michael Lehr , Ulrich Schäfer
发明人： Ines Zurdo Schroeder , Patrick Franke , Stefan Bracht , Claus-Michael Lehr , Ulrich Schäfer
IPC分类号： A61K9/70 , A61Q19/00 , A61K8/87 , A61K8/02 , A61K31/00 , A61K31/215 , A61K31/34 , A61K31/35 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/517 , A61K31/52 , A61K31/522 , A61K31/54 , A61K31/55 , A61K31/70 , A61K36/00 , A61K36/28 , A61K36/82 , A61K36/886 , A61K38/28 , A61K38/29
CPC分类号： A61K9/7069 , A61K8/0208 , A61K8/87 , A61K9/7015 , A61K31/00 , A61K31/215 , A61K31/34 , A61K31/35 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/517 , A61K31/52 , A61K31/522 , A61K31/54 , A61K31/55 , A61K31/70 , A61K36/00 , A61K36/28 , A61K36/82 , A61K36/886 , A61K38/28 , A61K38/29 , A61Q19/00 , A61K2300/00
摘要： The subject of this application is the use of film-forming polyurethanes that are used in hair care agents or mixtures of these polyurethanes with other polymers in pharmaceutical preparations for dermal or transdermal administration of active ingredients, as well as patches and pharmaceutical preparations that contain these hair care polyurethanes.
摘要翻译：本申请的主题是使用成膜聚氨酯，其用于护发剂或这些聚氨酯与其它聚合物的混合物在药物制剂中用于皮肤或透皮给药活性成分，以及包含这些的贴剂和药物制剂头发护理聚氨酯。

23. 发明授权

US09359561B2 Process for hydrotreating heavy hydrocarbon feeds with switchable reactors including at least one step of progressive switching 有权
标题翻译：用可切换反应器加氢处理重质烃进料的方法，包括至少一个逐步切换步骤
公开(公告)号：US09359561B2
公开(公告)日：2016-06-07
申请号：US13979038
申请日：2011-12-20
申请人： Frederic Bazer-Bachi , Mathieu Digne , Jan Verstraete , Nicolas Marchal , Cecile Plain
发明人： Frederic Bazer-Bachi , Mathieu Digne , Jan Verstraete , Nicolas Marchal , Cecile Plain
IPC分类号： C10G65/04 , C10G45/72 , C10G45/02 , C10G45/04 , C10G65/00
CPC分类号： C10G45/04 , C10G65/00 , C10G65/04 , C10G2300/202 , C10G2300/205 , C10G2300/206 , C10G2300/208
摘要： Process for hydrotreating a heavy hydrocarbon fraction using a system of switchable fixed bed guard zones each containing at least one catalyst bed including at least one step during which the flow of feed supplied to the first guard zone brought into contact with the feed is partly displaced to the next guard zone downstream, preferably progressively.
摘要翻译：使用可切换的固定床防护区域的系统对重质烃馏分进行加氢处理的方法，每个装置包含至少一个催化剂床，所述催化剂床包括至少一个步骤，在该步骤期间，供给到与进料接触的第一防护区的进料流部分地位移到下一个保护区下游，优选地逐渐。

24. 发明授权

US09157690B2 Distribution system and heat exchanger apparatus 有权
标题翻译：配电系统和热交换器
公开(公告)号：US09157690B2
公开(公告)日：2015-10-13
申请号：US13338728
申请日：2011-12-28
申请人： Helmut Kreis , Wolfgang Sussmann , Thomas Hecht , Jorg Dietrich , Michael Baus , Rudolf Wanke
发明人： Helmut Kreis , Wolfgang Sussmann , Thomas Hecht , Jorg Dietrich , Michael Baus , Rudolf Wanke
IPC分类号： F28F9/02 , F28D3/04
CPC分类号： F28F9/026 , F28D3/04 , F28F9/0265 , Y10T137/8593
摘要： The invention relates to a distribution system (1) for distributing a fluid (15) into a container (27) from a fluid inlet (26) of the container (27). Distribution system (1) comprises one or more guide plates that form a guide section (2) and a distribution section (3) that adjoins the guide section (2). Distribution section (3) has regions (4, 5) with openings (8, 9) for allowing fluid (17) to pass through. The invention also relates to a heat exchanger device (100) that has a container (27) with a fluid inlet (26), with at least one heat exchanger block (28) that is arranged in the container (27). A distribution system (101) according to the invention is arranged in the container (27) above the heat exchanger block (28).
摘要翻译：本发明涉及一种用于将流体（15）从容器（27）的流体入口（26）分配到容器（27）中的分配系统（1）。分配系统（1）包括形成引导部分（2）的一个或多个引导板和邻接引导部分（2）的分配部分（3）。分配部分（3）具有用于允许流体（17）通过的具有开口（8,9）的区域（4,5）。本发明还涉及一种热交换器装置（100），其具有带有流体入口（26）的容器（27），其中至少一个热交换器块（28）布置在容器（27）中。根据本发明的分配系统（101）布置在热交换器块（28）上方的容器（27）中。

25. 发明授权

US09125813B2 Process for producing glucomannan gel particles 有权
标题翻译：生产葡甘聚糖凝胶颗粒的方法
公开(公告)号：US09125813B2
公开(公告)日：2015-09-08
申请号：US11087870
申请日：2005-03-24
申请人： Tadahiko Takata
发明人： Tadahiko Takata
IPC分类号： A61K35/12 , A61K8/04 , A61K8/73 , A61Q5/02 , A61Q11/00 , A61Q19/10 , C08J3/075 , C08J3/14
CPC分类号： A61K8/044 , A61K8/042 , A61K8/73 , A61K2800/28 , A61K2800/412 , A61Q5/02 , A61Q11/00 , A61Q19/10 , C08J3/075 , C08J3/14 , C08J2305/14
摘要： A particulate glucomannan gel is produced by dissolving glucomannan-rich flour in water, precipitating glucomannan from the solution with ethanol, treating the precipitated glucomannan with an alkali to transform to water-insoluble, irreversible hydrogel particles, recovering and drying the hydrogel particles, and milling dried particles to a desired particle size. The resulting gel particles are incorporated into hygienic or cosmetic preparations as a deposit-cleaning agent.
摘要翻译：通过将富含富马酸葡聚糖的粉末溶解在水中，用乙醇从溶液中沉淀葡甘露聚糖，用碱处理沉淀的葡甘露聚糖，转化成水不溶性的不可逆水凝胶颗粒，回收和干燥水凝胶颗粒，并研磨干燥的颗粒至所需的颗粒尺寸。所得凝胶颗粒作为沉积物清洁剂掺入卫生或化妆品制剂中。

26. 发明授权

US08920632B2 Process for catalytic cracking with a recycle of an olefinic cut removed upstream of the gas separation section in order to maximize propylene production 有权
标题翻译：为了使丙烯生产最大化，使用在气体分离部分上游除去的烯属切断物进行再循环的催化裂化方法
公开(公告)号：US08920632B2
公开(公告)日：2014-12-30
申请号：US13101221
申请日：2011-05-05
申请人： Frederic Feugnet , Romain Roux
发明人： Frederic Feugnet , Romain Roux
IPC分类号： C10G11/00 , C07C4/06 , C10G11/18
CPC分类号： C10G11/18 , C07C4/06 , C07C2529/70 , C10G2300/1011 , C10G2300/104 , C10G2300/1044 , C10G2300/1088 , C10G2300/4081 , C10G2400/02 , C10G2400/20 , Y02P30/48 , C07C11/06
摘要： The present invention describes a process for the production of gasoline and for the co-production of propylene employing a catalytic cracking unit having at least one principal reactor operating in riser mode or in downer mode, processing a conventional heavy feed, and in which the principal reactor further processes a feed primarily constituted by olefinic C4, C5 and C6 cuts introduced upstream or as a mixture with said heavy feed, said olefinic feed deriving from the inter-stage of the wet gas compressor, i.e. upstream of the separation section of the catalytic cracking unit.
摘要翻译：本发明描述了一种生产汽油和使用催化裂解装置共同生产丙烯的方法，所述催化裂化装置具有至少一个主反应器，其操作在提升管模式或下降模式，加工常规重料，其中主要反应器进一步处理主要由上游引入的烯烃C4，C5和C6馏分构成的进料或与所述重质进料混合的所述烯烃进料，所述烯烃进料源自湿气压缩机的中间阶段，即催化分离段的上游开裂单元

27. 发明授权

US08647537B2 Oxide sintered body and sputtering target 有权
标题翻译：氧化物烧结体和溅射靶
公开(公告)号：US08647537B2
公开(公告)日：2014-02-11
申请号：US13119838
申请日：2009-09-14
申请人： Futoshi Utsuno , Kazuyoshi Inoue , Hirokazu Kawashima , Masashi Kasami , Koki Yano , Kota Terai
发明人： Futoshi Utsuno , Kazuyoshi Inoue , Hirokazu Kawashima , Masashi Kasami , Koki Yano , Kota Terai
IPC分类号： H01B1/02
CPC分类号： H01L29/242 , C04B35/01 , C04B35/6261 , C04B35/645 , C04B2235/3217 , C04B2235/3224 , C04B2235/3225 , C04B2235/3286 , C04B2235/3409 , C04B2235/441 , C04B2235/443 , C04B2235/449 , C04B2235/5409 , C04B2235/5436 , C04B2235/5445 , C04B2235/604 , C04B2235/656 , C04B2235/6567 , C04B2235/6585 , C04B2235/72 , C04B2235/76 , C04B2235/761 , C04B2235/77 , C23C14/086 , C23C14/3414 , H01L21/02565 , H01L29/7869
摘要： An oxide sintered body includes indium oxide and gallium solid-solved therein, the oxide sintered body having an atomic ratio “Ga/(Ga+In)” of 0.001 to 0.12, containing indium and gallium in an amount of 80 atom % or more based on total metal atoms, and having an In2O3 bixbyite structure.
摘要翻译：氧化物烧结体包括固溶于其中的氧化铟和镓，所述氧化物烧结体的原子比“Ga /（Ga + In）”为0.001〜0.12，含有基于80原子％以上的量的铟和镓总金属原子，并具有In2O3二氧化硅结构。

28. 发明授权

US08323800B2 Method of bonding to gold surface and resultant combinations 有权
标题翻译：粘合到金表面和结合组合的方法
公开(公告)号：US08323800B2
公开(公告)日：2012-12-04
申请号：US12481291
申请日：2009-06-09
申请人： Daniel Haines , David Yuhas , Eric Urruti
发明人： Daniel Haines , David Yuhas , Eric Urruti
IPC分类号： B32B15/08 , B32B17/06 , B32B37/02
CPC分类号： C03C27/048 , C09J5/06 , C09J2400/123 , C09J2400/143 , C09J2400/163 , Y10T428/31612 , Y10T428/31678
摘要： The present invention relates to a method of bonding a gold surface to a second surface which comprises heating a hybrid organic-inorganic melting gel >50° C., applying the melting gel to either the gold surface or the second surface. The melting gel is heated to above 130° C. until the melting gel has cured sufficiently to bond the surfaces together. The invention also relates to a combination of a gold surface and a second surface that is bonded together with a hybrid organic-inorganic melting gel. In another aspect of the invention the hybrid organic-inorganic melting gel is heated to a workable viscosity and cast into a film, sheet, block or lens. The cast gel is cured or partially cured and then applied between the gold surface and the second surface. Additional uncured melting gel may be applied. The construct is heated to above 130° C. until the melting gel has cured sufficient to bond the surfaces together.
摘要翻译：本发明涉及一种将金表面粘合到第二表面上的方法，其包括加热> 50℃的杂化有机 - 无机熔融凝胶，将熔融凝胶施加到金表面或第二表面上。将熔融的凝胶加热至130℃以上，直到熔融的凝胶充分固化以将表面粘合在一起。本发明还涉及金表面和与混合有机 - 无机熔融凝胶结合在一起的第二表面的组合。在本发明的另一方面，将混合有机 - 无机熔融凝胶加热至可行的粘度并浇铸成膜，片，块或透镜。浇铸凝胶固化或部分固化，然后施加在金表面和第二表面之间。可以应用另外的未固化的熔融凝胶。将构造体加热至130℃以上，直到熔融凝胶固化足以将表面粘合在一起。

29. 发明授权

US07718050B2 Process of mild hydrocracking including a dilution of the feedstock 有权
标题翻译：轻度加氢裂化的方法，包括原料稀释
公开(公告)号：US07718050B2
公开(公告)日：2010-05-18
申请号：US11449867
申请日：2006-06-09
申请人： Christophe Gueret , Thierry Chapus , Damien Hudebine
发明人： Christophe Gueret , Thierry Chapus , Damien Hudebine
IPC分类号： C10G57/00 , B01J8/18
CPC分类号： C10G69/04 , C10G11/18 , C10G47/00
摘要： The invention relates to a process for FCC pretreatment by mild hydrocracking of a hydrocarbon feedstock that comprises a vacuum distillate fraction or a deasphalted oil or else a mixture of these two fractions, said primary feedstock, to produce gas oil and an effluent having an initial boiling point of more than 320° C., said effluent (FCC feedstock) then being subjected to a catalytic cracking, process in which at least 85% by weight of said primary feedstock ends above 375° C. and at least 95% by weight of said primary feedstock ends below 650° C., whereby the mild hydrocracking is performed under an absolute pressure of 2 to 12 MPa and at a temperature of between 300 and 500° C., characterized in that the hydrocarbon feedstock also comprises a lighter hydrocarbon fraction, a so-called secondary feedstock, of which at least 50% by weight ends below 375° C. and at least 80% ends above 200° C.
摘要翻译：本发明涉及通过烃原料的轻度加氢裂化来进行FCC预处理的方法，所述烃原料包括真空蒸馏馏分或脱沥青油，或者所述主要原料的这两个馏分的混合物，以产生瓦斯油和具有初始沸点的流出物所述流出物（FCC原料）然后进行催化裂化，其中至少85重量％的所述主要原料在375℃以上终止，并且至少95重量％所述主要原料终止于650℃以下，由此在2至12MPa的绝对压力和300至500℃的温度下进行轻度加氢裂化，其特征在于，烃原料还包含较轻的烃馏分，所谓的二次原料，其中至少50重量％终止于375℃以下且至少80％在200℃以上结束。

30. 发明授权

US07615565B2 VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines 失效
标题翻译： VEGFR-2和VEGFR-3抑制性邻氨基苯甲酰胺吡啶
公开(公告)号：US07615565B2
公开(公告)日：2009-11-10
申请号：US11525091
申请日：2006-09-22
申请人： Andreas Huth , Ludwig Zorn , Martin Kruger , Stuat Ince , Karl-Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
发明人： Andreas Huth , Ludwig Zorn , Martin Kruger , Stuat Ince , Karl-Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
IPC分类号： A61K31/47 , C07D217/22
CPC分类号： C07D213/72 , C07D401/02
摘要： VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as intermediate products for the production of the compounds are described. The compounds according to the invention can be used as or in the case of tumor or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as, e.g., stent-induced restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver, mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g., stents, as immunosuppressive agents, as a support in scar-free healing, senile keratosis and contact dermatitis. The compounds according to the invention can also be used as VEGFR-3 inhibitors in the case of lymphangiogenesis.
摘要翻译：描述了VEGFR-2和VEGFR-3抑制性邻氨基苯酰胺吡啶酰胺，其作为用于治疗由持续血管发生引起的疾病的药物的制备和用途，以及用于制备化合物的中间产物。根据本发明的化合物可用于或在肿瘤或转移生长的情况下，牛皮癣，卡波西肉瘤，再狭窄，例如支架诱导的再狭窄，子宫内膜异位，克罗恩病，霍奇金病，白血病; 关节炎，如类风湿关节炎，血管瘤，血管纤维瘤; 眼睛疾病如糖尿病性视网膜病变，新生血管性青光眼; 肾脏疾病如肾小球性肾炎，糖尿病肾病，恶性肾硬化，血栓性微血管病综合征，移植排斥反应和肾小球病; 纤维化疾病，如肝硬化，肾小球膜细胞增生性疾病，动脉硬化，神经组织损伤，以及球囊导管治疗后血管再狭窄的抑制，血管修复术或机械装置用于保持血管开放的诸如例如作为免疫抑制剂的支架，作为无疤痕愈合的支持，老年角化病和接触性皮炎。在淋巴管生成的情况下，根据本发明的化合物也可以用作VEGFR-3抑制剂。

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