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1. 发明授权

US09730929B2 Substituted aminoimidazopyridazines 有权
公开(公告)号：US09730929B2
公开(公告)日：2017-08-15
申请号：US14123511
申请日：2012-05-30
申请人： Knut Eis , Florian Pühler , Ludwig Zorn , Arne Scholz , Philip Lienau , Mark Jean Gnoth , Ulf Bömer , Judith Günther , Jörg Fanghänel , Daniel Korr
发明人： Knut Eis , Florian Pühler , Ludwig Zorn , Arne Scholz , Philip Lienau , Mark Jean Gnoth , Ulf Bömer , Judith Günther , Jörg Fanghänel , Daniel Korr
IPC分类号： C07D487/04 , A61K31/5025 , C07D519/00 , A61K45/06
CPC分类号： A61K31/5025 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

2. 发明申请

US20130252890A1 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS 审中-公开
标题翻译： 6,7-二氢-5H-苯并[7]蒽醌衍生物，其制备方法，包括它们的药物制剂及其用于生产药物的用途
公开(公告)号：US20130252890A1
公开(公告)日：2013-09-26
申请号：US13806845
申请日：2011-06-21
申请人： Tim Wintermantel , Carsten Möller , Ulrich Bothe , Reinhard Nubbemeyer , Ludwig Zorn , Dirk Kosemund , Antonius Ter Laak , Rolf Bohlmann , Lars Wortmann , Donald Bierer
发明人： Tim Wintermantel , Carsten Möller , Ulrich Bothe , Reinhard Nubbemeyer , Ludwig Zorn , Dirk Kosemund , Antonius Ter Laak , Rolf Bohlmann , Lars Wortmann , Donald Bierer
IPC分类号： C07C317/28 , A61K38/22 , A61K31/18 , A61K31/216 , A61K31/165 , A61K31/277 , C07C323/25 , A61K31/145
CPC分类号： C07C317/28 , A61K31/145 , A61K31/165 , A61K31/18 , A61K31/216 , A61K31/277 , A61K38/22 , C07B59/001 , C07B2200/05 , C07C323/25 , C07C2601/02 , C07C2601/14 , C07C2602/12
摘要： The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.
摘要翻译：本发明涉及选择性雌激素受体调节剂（SERM）及其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是出血性疾病，骨质疏松症，子宫内膜异位症，肌瘤，激素依赖性肿瘤，用于激素替代疗法和避孕。

3. 发明授权

US07202260B2 VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones 失效
标题翻译： VEGFR-2和VEGFR-3抑制性邻氨基苯甲酰胺吡啶酮
公开(公告)号：US07202260B2
公开(公告)日：2007-04-10
申请号：US10866078
申请日：2004-06-14
申请人： Andreas Huth , Martin Krueger , Ludwig Zorn , Stuart Ince , Rolf Bohlmann , Karl Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
发明人： Andreas Huth , Martin Krueger , Ludwig Zorn , Stuart Ince , Rolf Bohlmann , Karl Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
IPC分类号： C07D401/01 , C07D213/02 , A61K31/44
CPC分类号： C07D213/64
摘要： Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected.
摘要翻译：选择新型VEGFR-2和VEGFR-3抑制性邻氨基苯甲酰胺吡啶酮及其作为用于治疗由持续性血管生成引发的疾病的药物的用途。

4. 发明授权

US07148357B2 VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines 失效
公开(公告)号：US07148357B2
公开(公告)日：2006-12-12
申请号：US10631018
申请日：2003-07-31
申请人： Andreas Huth , Ludwig Zorn , Martin Kruger , Stuat Ince , Karl-Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
发明人： Andreas Huth , Ludwig Zorn , Martin Kruger , Stuat Ince , Karl-Heinz Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
IPC分类号： C07D401/10
CPC分类号： C07D413/14 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D417/04
摘要： VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as intermediate products for the production of the compounds are described. The compounds according to the invention can be used as or in the case of tumor or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as, e.g., stent-induced restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver, mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g., stents, as immunosuppressive agents, as a support in scar-free healing, senile keratosis and contact dermatitis. The compounds according to the invention can also be used as VEGFR-3 inhibitors in the case of lymphangiogenesis.

5. 发明申请

US20050090477A1 Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-halogen steroids that can be produced therefrom, their process for production and use as well as pharmaceutical prepartions that contain these compounds, as well as 7-substituted estra-1,3,5(10)-trienses that can be produced therefrom 失效
标题翻译：用于生产7-取代的11-羟基类固醇，可由其制备的7,17-取代的11-卤素类固醇，其生产和使用方法以及含有这些化合物的药物制剂的微生物过程，以及7- 取代的雌-1,3,5（10） - 三核苷酸
公开(公告)号：US20050090477A1
公开(公告)日：2005-04-28
申请号：US10625559
申请日：2003-07-24
申请人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.
摘要翻译：描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示。

6. 发明授权

US3975630A Method of guiding a light beam on an optical signal track 失效
标题翻译：在光信号轨道上引导光束的方法
公开(公告)号：US3975630A
公开(公告)日：1976-08-17
申请号：US567283
申请日：1975-04-11
申请人： Karl-Ludwig Zorn
发明人： Karl-Ludwig Zorn
IPC分类号： G02B7/28 , G11B7/09 , G11B7/00 , G05B1/00
CPC分类号： G11B7/0908
摘要： The principle of the Foucault knife edge method of testing lenses is utilized by providing an imperfect focus of the reading light beam on the signal track of a moving optical record and detecting the lateral distribution of light beyond the track to produce a tracking control while a centered detector utilizes the same light beam to read the information on the track. Since the Foucault principle is used and not ordinary shadow effect, the method is operable just as much with a translucent track on an opaque record as with an opaque track on a translucent record.
摘要翻译：通过在移动光学记录的信号轨道上提供读取光束的不完全聚焦并检测光超出轨道的光的横向分布来产生跟踪控制，同时以中心为中心来利用测试透镜的傅科刀刃法的原理检测器利用相同的光束读取轨道上的信息。由于使用了福柯原理而不是普通的阴影效果，该方法与半透明记录上的不透明轨道上的不透明记录上的半透明轨道一样可操作。

7. 发明申请

US20090297454A1 Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use 审中-公开
标题翻译：含全氟烷基的络合物，其制备方法及其用途
公开(公告)号：US20090297454A1
公开(公告)日：2009-12-03
申请号：US12469234
申请日：2009-05-20
申请人： Heiko SCHIRMER , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko SCHIRMER , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61K49/06 , C07D225/00 , A61K49/04 , A61K31/555
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译：本发明涉及权利要求中特征的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如如在MRT淋巴瘤和血液池成像中。

8. 发明申请

US20050054654A1 VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines 失效
标题翻译： VEGFR-2和VEGFR-3抑制性邻氨基苯甲酰胺吡啶
公开(公告)号：US20050054654A1
公开(公告)日：2005-03-10
申请号：US10870491
申请日：2004-06-18
申请人： Andreas Huth , Ludwig Zorn , Martin Krueger , Stuart Ince , Karl Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
发明人： Andreas Huth , Ludwig Zorn , Martin Krueger , Stuart Ince , Karl Thierauch , Andreas Menrad , Martin Haberey , Holger Hess-Stumpp
IPC分类号： C07D213/61 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D43/02 , A61K31/497 , A61K31/501 , A61K31/506 , C07D41/02
CPC分类号： C07D213/61 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as intermediate products for the production of the compounds are described. The compounds according to the invention can be used as or in the case of tumor or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as, e.g., stent-induced restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver; mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g., stents, as immunosuppressive agents, as a support in scar-free healing, senile keratosis and contact dermatitis. The compounds according to the invention can also be used as VEGFR-3 inhibitors in the case of lymphangiogenesis.
摘要翻译：描述了VEGFR-2和VEGFR-3抑制性邻氨基苯酰胺吡啶酰胺，其作为用于治疗由持续血管发生引起的疾病的药物的制备和用途，以及用于制备化合物的中间产物。根据本发明的化合物可用于或在肿瘤或转移生长的情况下，牛皮癣，卡波西肉瘤，再狭窄，例如支架诱导的再狭窄，子宫内膜异位，克罗恩病，霍奇金病，白血病; 关节炎，如类风湿关节炎，血管瘤，血管纤维瘤; 眼睛疾病如糖尿病性视网膜病变，新生血管性青光眼; 肾脏疾病如肾小球性肾炎，糖尿病肾病，恶性肾硬化，血栓性微血管病综合征，移植排斥反应和肾小球病; 纤维化疾病，如肝硬化; 肾小球膜细胞增生性疾病，动脉硬化，神经组织损伤，以及球囊导管治疗后血管假体中或使用机械装置用于保持血管开放（例如，支架）作为免疫抑制剂的抑制，作为免疫抑制剂无疤痕愈合，老年角化病和接触性皮炎的支持。在淋巴管生成的情况下，根据本发明的化合物也可以用作VEGFR-3抑制剂。

9. 发明授权

US06790842B1 11&bgr; LONG-CHAIN SUBSTITUTED ESTRATRIENES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11&bgr; LONG-CHAIN SUBSTITUTED ESTATRIENES, AND THEIR USE FOR PRODUCING MEDICAMENTS 失效
标题翻译： 11β长链取代的ESTRATRIENES，其生产方法，含有11β长链取代的ESTATRIRIES的药物制剂及其用于生产药物的用途
公开(公告)号：US06790842B1
公开(公告)日：2004-09-14
申请号：US10018429
申请日：2002-05-07
申请人： Rolf Bohlmann , Nikolaus Heinrich , Jorg Kroll , Gerhard Sauer , Karl-Heinrich Fritzemeier , Christa Hegele-Hartung , Jens Hoffmann , Rosemarie Lichtner , Ludwig Zorn
发明人： Rolf Bohlmann , Nikolaus Heinrich , Jorg Kroll , Gerhard Sauer , Karl-Heinrich Fritzemeier , Christa Hegele-Hartung , Jens Hoffmann , Rosemarie Lichtner , Ludwig Zorn
IPC分类号： A61K3158
CPC分类号： C07J1/00
摘要： This invention describes a 11&bgr;-long-chain-substituted estratriene of general formula (I), in which R11 is a long-chain radical that has a nitrogen atom and optionally a sulfur atom, which in addition can be functionalized in the terminal position with a perfluoroalkyl group or an optionally substituted arly radical. The compound can have antiestrogenic or tissue-selective estrogenic properties and be suitable for the production of pharmaceutical agents.
摘要翻译：本发明描述了通式（I）的11b-长链取代的雌三烯，其中R 11是具有氮原子和任选的硫原子的长链基团，其还可以在具有全氟烷基或任选取代的芳基的末端位置。该化合物可以具有抗雌激素或组织选择性雌激素特性，并且适用于生产药剂。

10. 发明授权

US4734794A Device for recording and reproducing audio signals on flat rectangular recording media 失效
标题翻译：用于在平面矩形记录介质上记录和再现音频信号的装置
公开(公告)号：US4734794A
公开(公告)日：1988-03-29
申请号：US814788
申请日：1985-12-30
申请人： Gottfried Mehnert , Karl-Ludwig Zorn
发明人： Gottfried Mehnert , Karl-Ludwig Zorn
IPC分类号： G11B25/04 , G11B5/58
CPC分类号： G11B25/04
摘要： Apparatus for recording and reproducing audio signals on flat rectangular recording media comprising a magnetic coating or the like on at least one side. A magnetic head on a swing arm moves across the magnetic media in mutually parallel lines guided by a heart-shaped cam, the recording medium being stationary during recording and reproducing so its visible surface can be examined without difficulty. The heart-shaped cam is of asymmetric configuration, and the magnetic head is pivotably mounted on one end of the swing arm which carries between its ends a cam follower peg which continually engages the heart-shaped cam while under spring loading. The other end of said swing arm is pivotably mounted on a sliding carriage plate which is moved stepwise perpendicularly to the chord of the curved path of movement of the magnetic head for each line. The stepwise perpendicular movement of the sliding carriage plate is produced by a mechanism which is controlled by the reversal of direction of the magnetic head.
摘要翻译：用于在平坦的矩形记录介质上记录和再现音频信号的装置，包括在至少一个侧面上的磁性涂层等。摇臂上的磁头在由心形凸轮引导的相互平行的线中移动穿过磁性介质，记录介质在记录和再现期间是静止的，因此可以毫无困难地检查其可见表面。心形凸轮具有不对称构型，并且磁头可枢转地安装在摆动臂的一端，该端部在其端部之间承载凸轮从动栓，该弹簧从动栓在弹簧加载期间与心形凸轮连续接合。所述摆臂的另一端可枢转地安装在滑动滑架板上，该滑动滑板平行于每个线的磁头的弯曲运动路径的弦线逐步移动。滑动滑架板的逐步垂直运动通过由磁头的方向反转来控制的机构产生。

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