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21. 发明授权

US07893047B2 Biocide composition comprising pyrithione and pyrrole derivatives 有权
公开(公告)号：US07893047B2
公开(公告)日：2011-02-22
申请号：US11368244
申请日：2006-03-03
申请人： Craig Waldron , Robert Martin , Gareth Williams , Tina Williams, legal representative
发明人： Craig Waldron , Robert Martin , Gareth Williams
IPC分类号： A01N55/02 , A61K31/555
CPC分类号： C09D5/1625 , A01N43/36 , C09D5/14 , Y10T428/31678 , Y10T428/31699 , Y10T428/31855 , Y10T428/31906 , Y10T428/31935 , Y10T428/31989 , A01N43/40 , A01N59/16 , A01N59/20 , A01N2300/00
摘要： The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content.

22. 发明申请

US20080069935A1 COHESIVE NON-FREE FLOWING SWEETENER COMPOSITIONS INCLUDING LOW-DENSITY INGREDIENTS 审中-公开
标题翻译：包含低密度成分的非自由流动感应器组合物
公开(公告)号：US20080069935A1
公开(公告)日：2008-03-20
申请号：US11532698
申请日：2006-09-18
申请人： Renny Ison , Melanie Loades , Gareth Williams
发明人： Renny Ison , Melanie Loades , Gareth Williams
IPC分类号： A23L1/236 , A23L1/0534 , A23L1/09 , A23L1/305 , A23L1/221 , A23L1/222
CPC分类号： A23L33/175 , A23L5/00 , A23L27/30 , A23L27/33 , A23L29/244 , A23L29/30 , A23L29/35 , A23L33/125 , A23P10/20
摘要： Cohesive non-free flowing sweetener compositions, e.g., sweetener cubes, useful for adding sweetness to liquid foodstuffs, for example, beverages, having a reduced caloric burden as compared to conventional sucrose cubes, are provided. More particularly, a cohesive non-free flowing sweetener composition containing a high intensity sweetener and a low-density bulking agent, wherein a sweetener cube formed from the cohesive non-free flowing sweetener composition having the same dimensions as a conventional sucrose cube has a lower caloric burden and an equivalent sweetness. Methods of making such cohesive non-free flowing sweetener compositions are also provided.
摘要翻译：提供了与常规蔗糖立方体相比具有降低热量负担的液体食品例如饮料中的甜味剂的粘性非自由流动甜味剂组合物，例如增甜剂立方体。更具体地，含有高强度甜味剂和低密度填充剂的粘性非自由流动甜味剂组合物，其中由具有与常规蔗糖立方体相同尺寸的内聚非自由流动甜味剂组合物形成的甜味剂立方体具有较低的热量负担和相当的甜度。还提供制备这种内聚非自由流动甜味剂组合物的方法。

23. 发明申请

US20080069934A1 COHESIVE NON-FREE FLOWING SWEETENER COMPOSITIONS CONTAINING DISINTEGRANT 审中-公开
标题翻译：含有消毒剂的非自由流动感应器组合物
公开(公告)号：US20080069934A1
公开(公告)日：2008-03-20
申请号：US11532687
申请日：2006-09-18
申请人： Renny Ison , Melanie Loades , Gareth Williams
发明人： Renny Ison , Melanie Loades , Gareth Williams
IPC分类号： A23L1/236
CPC分类号： A23L27/33 , A23L27/30 , A23L27/31 , A23L27/32
摘要： Cohesive non-free flowing compositions for adding sweetness to liquid foodstuffs, for example, beverages, having a reduced caloric burden as compared to conventional sucrose cubes, are provided. More particularly, a low calorie Cohesive non-free flowing compositions containing a high intensity sweetener, a bulking agent, and a disintegrant, wherein a sweetener cube formed from the cohesive non-free flowing sweetener composition having about the same dimensions as a convention sucrose cube has a lower caloric burden and an equivalent sweetness is disclosed. Also provided are cohesive non-free flowing compositions containing sucralose, carboxymethyl cellulose, polydextrose, trehalose, and erythritol, wherein a sweetener cube formed from the cohesive non-free flowing composition having about the same dimension as a conventional sucrose cube has a lower caloric burden and a equivalent sweetness. Methods of making such sweetener cubes are also provided.
摘要翻译：提供了与常规蔗糖立方体相比具有降低热量负担的液体食品例如饮料的甜味的粘性非自由流动性组合物。更具体地，含有高强度甜味剂，填充剂和崩解剂的低热量粘性非自由流动组合物，其中由内聚非自由流动甜味剂组合物形成的甜味剂立方体具有与常规蔗糖立方体大致相同的尺寸具有较低的热量负担，并且公开了相当的甜度。还提供了含有三氯蔗糖，羧甲基纤维素，聚右旋糖，海藻糖和赤藓糖醇的内聚非自由流动组合物，其中由具有与常规蔗糖立方体相同尺寸的内聚非自由流动组合物形成的甜味剂立方体具有较低的热量负担和相当的甜度。还提供了制备这种甜味剂立方体的方法。

24. 发明授权

US5985913A Tetracyclic compounds for enhancing biosynthesis of erythropoietin, compositions containing same, and methods of use thereof 失效
标题翻译：用于增强促红细胞生成素生物合成的四环化合物，含有它们的组合物及其使用方法
公开(公告)号：US5985913A
公开(公告)日：1999-11-16
申请号：US69693
申请日：1998-04-29
申请人： Jonathan Gareth Williams , David R. Houck , David Edward Smith , Daniel Lee Rathbone , David Charles Billington , Bernard T. Golding , Eric W. Collington , John Kitchin , Nicholas Rich
发明人： Jonathan Gareth Williams , David R. Houck , David Edward Smith , Daniel Lee Rathbone , David Charles Billington , Bernard T. Golding , Eric W. Collington , John Kitchin , Nicholas Rich
IPC分类号： A61K31/352 , C07D311/94 , A61K31/35 , A61K31/365 , C07D311/78
CPC分类号： C07D311/94 , A61K31/352
摘要： The present invention provides a compound in substantially pure form having the structure: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 may independently be hydrogen, halogen, nitro, CF.sub.3, hydroxy, C.sub.1-5 alkyl, aryl or OR.sub.9, wherein R.sub.9 is C.sub.1-5 alkyl, wherein R.sub.10 is COC.sub.1-5 alkyl; or wherein any two consecutive R groups may be members of a C.sub.5 -C.sub.6 membered ring, and wherein the intracyclic-dashed line represents a covalent bond which may be present or absent, with the proviso that when R.sub.10 is present, the exocyclic-covalent bond is absent, and when R.sub.10 is absent, the exocyclic-covalent bond is present, and with the proviso that when R.sub.10 is absent, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen and when R.sub.10 is absent, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen when either R.sub.1, R.sub.2, R.sub.3, or R.sub.4 is hydroxy, or R2 is carboethoxy. The present invention further provides a composition comprising the compound described above in an amount effective to modulate cellular expression of a mammalian gene encoding erythropoietin and a carrier.
摘要翻译：本发明提供具有以下结构的基本上纯的形式的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8各自独立地为氢，卤素，硝基，CF 3，羟基，C 1-5烷基，芳基或OR9，其中R9为C1-5烷基，其中R10为COC1-5烷基; 或其中任何两个连续的R基团可以是C 5 -C 6的环的成员，并且其中所述环内虚线表示可以存在或不存在的共价键，条件是当R 10存在时，所述环外共价键为当不存在R 10时，存在环外共价键，条件是当R 10不存在时，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8不能全部为氢，当R 10为当R 1，R 2，R 3或R 4为羟基或R 2为乙氧基乙氧基时，R 5，R 6，R 7和R 8不能全部为氢。本发明还提供一种包含上述化合物的组合物，其量可有效调节编码促红细胞生成素和载体的哺乳动物基因的细胞表达。

25. 发明申请

US20170252917A1 WORKBENCH 审中-公开
公开(公告)号：US20170252917A1
公开(公告)日：2017-09-07
申请号：US15450433
申请日：2017-03-06
申请人： GARETH WILLIAMS
发明人： GARETH WILLIAMS
IPC分类号： B25H1/14 , B25H1/02 , B25H1/08 , B25H1/06
CPC分类号： B25H1/14 , B25H1/02 , B25H1/04 , B25H1/06 , B25H1/08 , B25H1/12
摘要： A workbench comprising a first support, a second support and a first work surface, in which said first support comprises a leg structure with an upper end, in which said first work surface comprises a first end, in which said upper end and said first end comprise a connection means to releasably connect them together, and in which said connection means comprises a first pair of parallel elongate troughs provided on either said upper end or said first end, and a first pair of parallel elongate flanges provided on the other of said upper end or said first end, which first pair of flanges is shaped and configured to be releasably engagable in said first pair of troughs.

26. 发明授权

US08618140B2 P38 MAP kinase inhibitors 有权
公开(公告)号：US08618140B2
公开(公告)日：2013-12-31
申请号：US13616696
申请日：2012-09-14
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
IPC分类号： A61K31/4439 , C07D401/02
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12
摘要： There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.

27. 发明授权

US08500838B2 Method and associated kit utilizing international organization for standardization container filter house 有权
标题翻译：方法和相关套件利用国际组织标准化集装箱过滤房
公开(公告)号：US08500838B2
公开(公告)日：2013-08-06
申请号：US12780160
申请日：2010-05-14
申请人： Anthony Richard Pike , Alun Gareth Williams
发明人： Anthony Richard Pike , Alun Gareth Williams
IPC分类号： B01D46/00
CPC分类号： B01D46/42 , B01D46/0013 , B01D46/002 , B01D46/0045 , B01D46/10 , B01D46/429 , B01D46/446 , B01D46/448 , B01D2279/60
摘要： A method of using a modular International Organization for Standardization (ISO) filter house for filtering process fluids is provided. The filter house includes a self-contained rectangular cuboid enclosure having the outside dimension of a standard, transportable ISO shipping container. The filter house has apertures for fluid flow inlet and fluid flow outlet, and a filter element for removing impurities from the fluid flow. The method includes creating one standard filter house design to be used in any multiple to meet various flow requirements. The method further includes creating a common fluid connection between the filter houses and process equipment so that the filter houses operate in parallel. A kit of modular components for filtration of a fluid is also provided. The kit includes an external structure of an ISO shipping container, vanes to direct fluid flow, and a filter element. The kit also includes apertures that allow fluid communication between the interior of the shipping container and the exterior of the shipping container.
摘要翻译：提供了一种使用模块化国际标准化组织（ISO）过滤器过滤器过滤器的方法。过滤房包括一个独立的矩形长方体外壳，具有标准的可运输的ISO运输容器的外部尺寸。过滤器室具有用于流体流入口和流体流出口的孔，以及用于从流体流中去除杂质的过滤元件。该方法包括创建一个标准过滤器房屋设计，以便在任意多个位置使用以满足各种流量要求。该方法还包括在过滤器室和处理设备之间创建公共流体连接，使得过滤器室并行操作。还提供了一套用于过滤流体的模块化部件。该套件包括ISO运输容器的外部结构，用于引导流体流动的叶片和过滤元件。套件还包括允许运输容器的内部和运输容器的外部之间流体连通的孔。

28. 发明申请

US20130156826A1 RESPIRATORY FORMULATIONS AND COMPOUNDS FOR USE THEREIN 有权
标题翻译：呼吸配方及其使用的化合物
公开(公告)号：US20130156826A1
公开(公告)日：2013-06-20
申请号：US13805471
申请日：2011-06-17
申请人： Peter John Murray , Stuart Thomas Onions , Jonathan Gareth Williams , Kevin Joly
发明人： Peter John Murray , Stuart Thomas Onions , Jonathan Gareth Williams , Kevin Joly
IPC分类号： C07D471/04 , C07D475/02 , C07D473/30
CPC分类号： C07D471/04 , A61K9/0075 , A61K31/437 , A61K31/4985 , C07D473/30 , C07D475/02 , C07D487/04 , Y10T428/2982
摘要： The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).
摘要翻译：本发明涉及包含式（I）化合物的呼吸制剂：以及所述化合物和组合物在治疗中的用途，例如治疗炎性疾病或呼吸障碍，特别是炎性介导和/或病毒介导的呼吸障碍如哮喘和COPD或治疗或预防病毒感染，例如流感病毒，鼻病毒或RSV感染。本发明还延伸到某些新的式（I）化合物。

29. 发明申请

US20130040962A1 P38 MAP Kinase Inhibitors 有权
标题翻译： P38 MAP激酶抑制剂
公开(公告)号：US20130040962A1
公开(公告)日：2013-02-14
申请号：US13639959
申请日：2011-04-08
申请人： John King-Underwood , Peter John Murray , Jonathan Gareth Williams , Ildiko Buck , Stuart Thomas Onions
发明人： John King-Underwood , Peter John Murray , Jonathan Gareth Williams , Ildiko Buck , Stuart Thomas Onions
IPC分类号： C07D401/12 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/496 , A61K31/444 , C07D409/14 , C07D405/14 , C07D403/12 , A61K31/506 , A61P11/00 , A61P11/06 , A61P11/02 , A61P27/02 , A61P17/00 , A61P17/06 , A61P1/04 , A61P29/00 , A61P19/02 , A61P1/18 , A61P21/00 , A61P35/00 , A61P35/04 , A61K31/4439
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： There is provided a compound of formula (I): wherein: J represents (A): or (B): compositions comprising same, processes for preparing said compounds and use thereof in treatment, particularly in the treatment of inflammatory disease, such as asthma, COPD and 15 rheumatoid arthritis.
摘要翻译：提供式（I）的化合物：其中：J表示（A）：或（B）：包含其的组合物，制备所述化合物的方法及其在治疗中的用途，特别是治疗炎性疾病如哮喘，COPD和15种类风湿关节炎。

30. 发明授权

US08106091B2 Inhibitors of IKK-beta serine-threonine protein kinase 失效
标题翻译： IKK-β丝氨酸 - 苏氨酸蛋白激酶抑制剂
公开(公告)号：US08106091B2
公开(公告)日：2012-01-31
申请号：US12447271
申请日：2007-10-29
申请人： David Charles Festus Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathon Gareth Williams
发明人： David Charles Festus Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathon Gareth Williams
IPC分类号： A61K31/381 , C07D333/36
CPC分类号： C07D333/38
摘要： Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is a radical of formula R-L1-Y1—(CH2)z—, wherein: z is 0 or 1; R is a radical of formula (X) or (Y) R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R6 is hydrogen, or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl or heteroaryl or —(C═O)R3, —(C═O)OR3, or —(C═O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl; Y1 is a bond, —(C═O)—, —S(O2)—, —C(═O)O—, —OC(═O)—, —(C═O)NR3—, —NR3(C═O)—, —S(O2)NR3—, —NR3S(O2)—, or —NR3(C═O)NR4—, wherein R3 and R4 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent linker radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, Alk1 and Alk2 are as defined in the claims.
摘要翻译：式（IA）或（IB）的化合物是IkB激酶（IKK）活性的抑制剂，可用于治疗自身免疫性和炎性疾病：其中R 7为氢或任选取代的（C 1 -C 6）烷基; 环A是任选取代的5-13个环原子的芳基或杂芳基环; Z是式R-L1-Y1-（CH2）z-的基团，其中：z是0或1; R是式（X）或（Y）的基团，R 1是羧酸基团（-COOH）或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R 6是氢或任选取代的C 1 -C 6烷基，C 3 -C 7环烷基，芳基或杂芳基或 - （C = O）R 3， - （C = O）OR 3或 - （C = O）NR 3，其中R 3是氢或任选取代的（C 1 -C 6）烷基; Y1是一个键， - （C = O） - ， - S（O 2） - ， - C（= O）O-，-OC（= O） - ， - （C = O）NR 3 - ， - NR 3 （O） - ， - S（O 2）NR 3 - ， - NR 3 S（O 2） - 或-NR 3（C = O）NR 4 - ，其中R 3和R 4独立地是氢或任选取代的（C 1 -C 6）式 - （Alk1）m（Q）n（Alk2）p的二价连接基团其中m，n，p，Q，Alk1和Alk2如权利要求中所定义。

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