专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170037030A1 AUTOTAXIN INHIBITORS 审中-公开
标题翻译：维生素抑制剂
公开(公告)号：US20170037030A1
公开(公告)日：2017-02-09
申请号：US15305602
申请日：2015-04-21
申请人： Vikki FURMINGER , Owen HUGHES , Darren LEGRAND , Emily STANLEY , Christopher THOMSON , Gareth WILLIAMS
发明人： Vikki Furminger , Owen Rhys Hughes , Darren Mark Legrand , Emily Stanley , Christopher Thomson , Gareth Williams
IPC分类号： C07D401/12 , A61K31/454
CPC分类号： C07D401/12 , A61K31/454 , A61K45/06 , C07D211/26 , C07D211/34 , C07D211/58 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.
摘要翻译：本发明涉及自体吸收素抑制剂的新化合物，其制备方法，药物组合物和含有它们的药物及其在治疗ATX依赖性或ATX介导的疾病或病症中的用途。

2. 发明授权

US08293748B2 p38 MAP kinase inhibitors 有权
标题翻译： p38 MAP激酶抑制剂
公开(公告)号：US08293748B2
公开(公告)日：2012-10-23
申请号：US13121999
申请日：2009-10-02
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
IPC分类号： A61K31/496 , A61K31/505 , A61K31/4427 , C07D403/02 , C07D403/14 , C07D401/02 , C07D401/14
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12
摘要： There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.
摘要翻译：特别是提供式（I）化合物，其中R 1，Ar，L，X，R 3和Q如说明书中用于治疗，特别是治疗炎性疾病的说明书中所定义。

3. 发明申请

US20120077863A1 GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS 审中-公开
标题翻译：作为小分子载体的甘氨酸取代的双 - 聚双环
公开(公告)号：US20120077863A1
公开(公告)日：2012-03-29
申请号：US13203667
申请日：2010-03-01
申请人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
发明人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
IPC分类号： A61K31/713 , C12N5/071 , A61K31/155 , C07C279/08 , C07H21/02
CPC分类号： C07D277/18 , C07C279/08 , C07C279/24 , C07C323/60 , Y02P20/55
摘要： A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein —X1, X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substituted with one or more substituents selected from alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 and COOH; W is absent or is O, S or NH; R1, R2, R3 and R4 are each independently selected from H, alkyl, aryl and a protecting group Pi; R7, R8 and R9 are each independently selected from H, alkyl, halo, CF3, OH, alkoxy, CN, NO2 and COOH; —q is 1, 2, 3 or 4; q′ is 0, 1, 2 or 3, where q+q′ equals 4; p and r are each independently 1, 2, 3, 4 or 5; p′ and r′ are each independently 0, 1, 2, 3 or 4, where p+p′ and r+r′ each equal 5; and —n is 0, 1, 2, 3, 4, 5 or 6.
摘要翻译：式I化合物或其药学上可接受的盐，其中-X1，X2和X3各自独立地为Y为亚烷基，亚烯基或亚炔基，其各自可以任选地被一个或多个选自烷基，卤素，CF 3，OH，烷氧基，NH 2，CN，NO 2和COOH; W不存在或是O，S或NH; R1，R2，R3和R4各自独立地选自H，烷基，芳基和保护基团Pi; R 7，R 8和R 9各自独立地选自H，烷基，卤素，CF 3，OH，烷氧基，CN，NO 2和COOH; -q为1,2,3或4; q'为0,1,2或3，其中q + q'等于4; p和r各自独立地为1,2,3,4或5; p'和r'各自独立地为0,1,2,3或4，其中p + p'和r + r'各自等于5; 和-n是0，1，2，3，4，5或6。

4. 发明申请

US20110277628A1 METHOD AND ASSOCIATED KIT UTILIZING INTERNATIONAL ORGANIZATION FOR STANDARDIZATION CONTAINER FILTER HOUSE 有权
标题翻译：使用国际标准化容器过滤器房屋的方法和相关工具包
公开(公告)号：US20110277628A1
公开(公告)日：2011-11-17
申请号：US12780160
申请日：2010-05-14
申请人： Anthony Richard Pike , Alun Gareth Williams
发明人： Anthony Richard Pike , Alun Gareth Williams
IPC分类号： B01D46/46 , B01D50/00
CPC分类号： B01D46/42 , B01D46/0013 , B01D46/002 , B01D46/0045 , B01D46/10 , B01D46/429 , B01D46/446 , B01D46/448 , B01D2279/60
摘要： A method of using a modular International Organization for Standardization (ISO) filter house for filtering process fluids is provided. The filter house includes a self-contained rectangular cuboid enclosure having the outside dimension of a standard, transportable ISO shipping container. The filter house has apertures for fluid flow inlet and fluid flow outlet, and a filter element for removing impurities from the fluid flow. The method includes creating one standard filter house design to be used in any multiple to meet various flow requirements. The method further includes creating a common fluid connection between the filter houses and process equipment so that the filter houses operate in parallel. A kit of modular components for filtration of a fluid is also provided. The kit includes an external structure of an ISO shipping container, vanes to direct fluid flow, and a filter element. The kit also includes apertures that allow fluid communication between the interior of the shipping container and the exterior of the shipping container.
摘要翻译：提供了一种使用模块化国际标准化组织（ISO）过滤器过滤器过滤器的方法。过滤房包括一个独立的矩形长方体外壳，具有标准的可运输的ISO运输容器的外部尺寸。过滤器室具有用于流体流入口和流体流出口的孔，以及用于从流体流中去除杂质的过滤元件。该方法包括创建一个标准过滤器房屋设计，以便在任意多个位置使用以满足各种流量要求。该方法还包括在过滤器室和处理设备之间创建公共流体连接，使得过滤器室并行操作。还提供了一套用于过滤流体的模块化部件。该套件包括ISO运输容器的外部结构，用于引导流体流动的叶片和过滤元件。套件还包括允许运输容器的内部和运输容器的外部之间流体连通的孔。

5. 发明申请

US20110262897A1 IMAGING TECHNIQUES USING A TRIDENTATE LIGAND 审中-公开
标题翻译：使用三态仪的成像技术
公开(公告)号：US20110262897A1
公开(公告)日：2011-10-27
申请号：US13122361
申请日：2009-10-05
申请人： J. A. Gareth Williams , Julia A. Weinstein , Stanley W. Botchway , John Haycock
发明人： J. A. Gareth Williams , Julia A. Weinstein , Stanley W. Botchway , John Haycock
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/567 , C07H21/04 , C12N7/00 , C07K14/00 , C07K16/00 , C07H21/02 , C12Q1/68 , C12Q1/02
CPC分类号： G01N33/84 , A61K49/0002 , A61K49/001 , A61K49/0019
摘要： The present invention relates to microscopy and, in particular, Time-resolved Emission Imaging Microscopy (TREM). The Invention relates to the use of a transition metal complex having a tridentate ligand in an imaging technique. The transition metal is preferably platinum.
摘要翻译：本发明涉及显微镜，特别涉及时间分辨发射成像显微镜（TREM）。本发明涉及在成像技术中使用具有三齿配体的过渡金属络合物。过渡金属优选为铂。

6. 发明申请

US20100087515A1 IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS 失效
标题翻译： IKK-BETA丝氨酸蛋白激酶激酶抑制剂
公开(公告)号：US20100087515A1
公开(公告)日：2010-04-08
申请号：US12513206
申请日：2007-10-29
申请人： David Festus Charles Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathan Gareth Williams
发明人： David Festus Charles Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathan Gareth Williams
IPC分类号： A61K31/381 , C07D333/38 , C12N9/99 , A61P35/00 , A61P37/00 , A61P29/00 , A61P1/00 , A61P11/00
CPC分类号： C07D333/38
摘要： Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is (a) a radical of formula R1R2CHNH—Y-L1-X1—(CH2)z— wherein: z is 0 or 1; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; Y is a bond, —C(═O)—, —S(═P)2-, —C(═O)O—, —C(═O)NR3-, —C(═S)—NR3, —C(═NH)—NR3 or —S(═O)2NR3— wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L is a divalent linker radical of formula -(Alk1)m(Q)(Alk2)p- wherein m, n, p, Q, AIk1 and AIk2 are as defined in the claims.
摘要翻译：式（IA）或（IB）的化合物是IkB激酶（IKK）活性的抑制剂，可用于治疗自身免疫性和炎性疾病：式（A）和（B）其中R 7为氢或任选取代的（C1- C6）烷基; 环A是任选取代的5-13个环原子的芳基或杂芳基环; Z是（a）式R1R2CHNH-Y-L1-X1-（CH2）z-的基团，其中：z为0或1; R 1是羧酸基团（-COOH）或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R2是天然或非天然α氨基酸的侧链; Y是键，-C（= O） - ， - S（= O）2 - ， - C（= O）O-，-C（= O）NR 3 - ， - C（= NH）-NR 3或-S（= O）2 NR 3 - ，其中R 3是氢或任选取代的C 1 -C 6烷基; L1是式 - （Alk1）m（Q）（Alk2）p的二价连接基团，其中m，n，p，Q，Alk1和Alk2如权利要求中所定义。

7. 发明申请

US20100003242A1 COMPOSITIONS AND METHODS FOR BINDING SPHINGOSINE-1-PHOSPHATE 有权
标题翻译：用于结合磷脂酸1-磷酸酯的组合物和方法
公开(公告)号：US20100003242A1
公开(公告)日：2010-01-07
申请号：US12258383
申请日：2008-10-24
申请人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David Gareth Williams
发明人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David Gareth Williams
IPC分类号： A61K39/395 , C07K16/00 , C12N15/63 , C12N5/00 , C12N5/06 , A61P43/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译：本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。

8. 外观设计

USD528590S1 Swing out guillotine 有权
标题翻译：摆出断头台
公开(公告)号：USD528590S1
公开(公告)日：2006-09-19
申请号：US29225375
申请日：2005-03-16
申请人： Simon David Bathard , Gareth Williams Humphreys Davies
设计人： Simon David Bathard , Gareth Williams Humphreys Davies

9. 发明申请

US20060160791A1 Wood preservative formulations 审中-公开
标题翻译：木材防腐剂配方
公开(公告)号：US20060160791A1
公开(公告)日：2006-07-20
申请号：US11284527
申请日：2005-11-21
申请人： Gareth Williams , Michael Bacon
发明人： Gareth Williams , Michael Bacon
IPC分类号： B32B21/02 , A01N33/12 , B32B21/10 , A01N43/50
CPC分类号： A01N43/653 , A01N43/88 , Y10T428/249925 , A01N33/12 , A01N2300/00
摘要： The invention provides a preservative composition comprising, in synergistic proportions, an oxathiazine compound plus one or more of a quaternary ammonium compound and a triazole compound as well as methods of treating wood and other material with said compositions.
摘要翻译：本发明提供一种防腐组合物，其包含协同比例的恶噻嗪化合物加上一种或多种季铵化合物和三唑化合物，以及用所述组合物处理木材和其它材料的方法。

10. 发明授权

US06342634B2 Calixarenes and their use for sequestration of metals 失效
标题翻译：杯芳烃及其用于金属螯合的用途
公开(公告)号：US06342634B2
公开(公告)日：2002-01-29
申请号：US09880126
申请日：2001-06-14
申请人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
发明人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
IPC分类号： C07C23300
CPC分类号： C07C235/20 , C07C235/24 , C07C327/42 , C07C2603/92 , C07D273/00 , C22B3/002 , G01N27/3335 , Y02P10/234
摘要： Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4, are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers
摘要翻译：公开了式（I）的“酸酰胺”杯芳烃，其中：L是[-CH 2 - ]或[-O-CH 2 -O-]，并且在每个芳基R5之间可以相同或不同，是H，卤素或 C 1 -C 10脂族烃基，C 6 -C 20芳基，其中任何一个可任选被一个或多个卤代或氧代基团取代或被一个或多个氧代基团间隔，并且R 5可以在每个芳基上相同或不同; R1包含任选保护的羧基; R2，R3和R4中的两个基团是H; R2，R3和R4不为H的一个基团包含酰胺基。酰胺基团可以与第二杯咖啡连接以形成二聚体。还公开了使用这种杯芳烃用于金属螯合的方法，特别是镧系元素和锕系元素的方法。还公开了本发明的杯芳烃的杯芳烃二聚体衍生物。还公开了制备杯芳烃和二聚体的方法

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式