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    • 23. 发明授权
    • System and method to measure dissociation constants
    • 测量离解常数的系统和方法
    • US08859295B2
    • 2014-10-14
    • US13214355
    • 2011-08-22
    • Richard BrownBurleigh HutchinsErnesto Freire
    • Richard BrownBurleigh HutchinsErnesto Freire
    • G01N33/566G01N35/10G01N33/68
    • G01N21/6486G01N1/38G01N33/6803G01N35/1065G01N35/1072
    • A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a protein in the absence of the ligand. A particular point is selected from this curve, such as the point at which 90% of the protein is unfolded. The molarity of chemical denaturant is determined for this selected point. A one point test is then performed for the protein with a predetermined concentration of the particular ligand. The fraction of protein which is unfolded at this point is then used to determine the dissociation constant for the ligand. This constant is used to quickly determine whether a particular ligard is well suited to be considered a potential drug candidate against that protein target.
    • 公开了用于确定特定配体的解离常数的系统和方法。 根据某些实施方案,该方法在不存在配体的情况下产生蛋白质的化学变性曲线。 从该曲线中选择特定的点,例如90%蛋白质展开的点。 测定化学变性剂的摩尔浓度。 然后对具有预定浓度的特定配体的蛋白进行一点测试。 然后将此处展开的蛋白质的级分用于确定配体的解离常数。 该常数用于快速确定特定的基因是否非常适合被认为是针对该蛋白质靶标的潜在药物候选物。
    • 24. 发明申请
    • Method for redundant controller synchronization for bump-less failover during normal and program mismatch conditions
    • 冗余控制器同步的方法,用于在正常和程序不匹配条件下进行无凹陷故障转移
    • US20070168058A1
    • 2007-07-19
    • US11331886
    • 2006-01-13
    • Richard KephartKimberly CostlowMichael DurbinXu ChengRichard Brown
    • Richard KephartKimberly CostlowMichael DurbinXu ChengRichard Brown
    • G05B9/02
    • G05B9/03G06F11/2028G06F11/2038G06F11/2097
    • The present invention relates generally to process control systems and devices and, more particularly, to an apparatus for and a method of implementing redundant controller synchronization for bump-less failover during normal and mismatch conditions at the redundant controllers. The redundant controllers are configured to transmit state information of the process control areas of the primary controller to the backup controller that is necessary for synchronizing the redundant controllers but is not typically transmitted to other devices during the performance of process control functions. Synchronization messages are transmitted from the primary controller to the backup controller each time one of the control areas executes to perform process control functions. In other aspects, the redundant controllers are configured to determine state information at the backup controller from other process control network information during a fallover of the primary controller where a mismatch condition exists between the control areas of the two controllers during the downloading of reconfigurations, and to initialize the backup controller at startup when the mismatch condition exists.
    • 本发明一般涉及过程控制系统和设备,更具体地,涉及一种在冗余控制器的正常和不匹配条件下实现冗余控制器同步以实现无凸起故障转移的装置和方法。 冗余控制器被配置为将主控制器的过程控制区域的状态信息传送到备份控制器,该备份控制器是在执行过程控制功能期间通常不发送到其他设备的同步冗余控制器所必需的。 每次执行一个控制区域以执行过程控制功能时,同步消息从主控制器发送到备用控制器。 在其他方面,冗余控制器被配置为在主控制器的翻转期间从其他过程控制网络信息确定备用控制器的状态信息,其中在重新配置的下载期间两个控制器的控制区域之间存在不匹配条件,以及 当不匹配条件存在时,在启动时初始化备份控制器。
    • 25. 发明申请
    • APPARATUS FOR DETERMINING FLOW RATES OF BIOLOGICAL FLUIDS
    • 用于确定生物流体流量的装置
    • US20070000848A1
    • 2007-01-04
    • US11427402
    • 2006-06-29
    • Kyungyoon MinRichard Brown
    • Kyungyoon MinRichard Brown
    • B01D33/15
    • A61M1/3693A61M1/3696
    • An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.
    • 一种装置包括将包含具有不同密度的第一和第二组分的第一流体输送到旋转室中的入口,使得界面在第一位置处在这些部件的至少部分之间形成。 至少一个出口去除第一和第二组分中的至少一个。 控制器适于引入第一流体并且可操作以将界面从第一位置移动到第二位置,并且将界面从朝向第一位置的方向从第二位置移动并将界面返回到第二位置。 该控制器可操作以至少部分地基于界面从第二位置移动到第二位置之间的时间间隔来确定第一或第二组件的流量。 至少一个感测组件适于感测界面的位置。