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    • 21. 发明申请
    • Methods for detecting bacterial pathogens
    • 检测细菌病原体的方法
    • US20050244918A1
    • 2005-11-03
    • US11006025
    • 2004-12-07
    • John WalshJones Hyman
    • John WalshJones Hyman
    • C12Q1/04C12Q1/10C12Q1/14G01N33/569
    • G01N33/56916C12Q1/04C12Q1/10C12Q1/14G01N33/56938
    • The present invention provides for methods for detecting bacterial pathogens in a sample. A preferred method includes the steps of: (a) suspending a sample comprising a medium and microorganisms, the microorganisms suspected of comprising bacterial pathogens; (b) mixing the sample, an adsorbent and a first solution in a vessel; (c) separating the adsorbent and said microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; (d) adding a second solution to the vessel to resuspend the adsorbent and the microorganisms; and (e) detecting agglutination of the adsorbent wherein the agglutination of the adsorbent signifies bacterial pathogens are present in the sample.
    • 本发明提供了检测样品中细菌病原体的方法。 优选的方法包括以下步骤:(a)悬浮包含培养基和微生物的样品,所述微生物涉嫌包含细菌病原体; (b)将样品,吸附剂和第一溶液混合在容器中; (c)从培养基和大部分第一溶液中分离吸附剂和微生物并从容器中除去介质和大部分第一溶液; (d)向容器中加入第二溶液以使吸附剂和微生物重新悬浮; 和(e)检测吸附剂的凝集,其中吸附剂的凝集表示细菌病原体存在于样品中。
    • 22. 发明申请
    • Process for preparing a chewable pet food
    • 制备咀嚼型宠物食品的方法
    • US20050220970A1
    • 2005-10-06
    • US10999524
    • 2004-11-30
    • Paul DempseyJohn Walsh
    • Paul DempseyJohn Walsh
    • A23K1/00A23K1/14A23K1/16A23K1/18
    • A23K50/42A23K20/147A23K40/20A23K40/25Y10S426/805
    • A process for preparing an extrudable product suitable for forming into a chewable pet food and comprising between about 56% to about 80% dry wheat gluten mix, between about 9% to about 28% liquid plasticizer mix and between about 8% to about 18% moisture by weight of the product is disclosed. The process comprises mixing the dry wheat gluten mix with water in an extruder, to form a moist wheat gluten mix, and mixing the moist wheat gluten mix with a liquid plasticizer mix and extruding at a temperature of less than 70° C. to form the extrudable product. The invention also relates to the extrudable product and to the chewable pet food formed therefrom by means of either further extrusion or injection moulding.
    • 一种制备适于形成可咀嚼宠物食品的可挤出产品的方法,包括约56%至约80%干小麦面筋混合物,约9%至约28%液体增塑剂混合物和约8%至约18% 公开了按重量计的产品的湿度。 该方法包括将干燥的小麦面筋混合物与水在挤出机中混合,形成潮湿的小麦谷蛋白混合物,并将湿的小麦面筋混合物与液体增塑剂混合物混合并在低于70℃的温度下挤出,形成 可挤出产品。 本发明还涉及可挤出产品和通过进一步挤出或注射成型由其形成的可咀嚼宠物食品。
    • 24. 发明申请
    • Methods for detecting bacterial pathogens
    • 检测细菌病原体的方法
    • US20050124026A1
    • 2005-06-09
    • US11005668
    • 2004-12-07
    • John WalshJones Hyman
    • John WalshJones Hyman
    • C12Q1/04C12Q1/14G01N33/569
    • G01N33/56938C12Q1/14
    • The present invention provides for methods for detecting Staphylococcus aureus in a sample. A preferred method includes the steps of: (a) mixing a sample comprising a medium and microorganisms with a first solution in a vessel, the microorganisms suspected of comprising Staphylococcus aureus; (b) separating the microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; (c) adding a second solution to the vessel to resuspend the microorganisms; and (d) detecting Staphylococcus aureus in the resulting suspension of step (c) by using an agglutination test.
    • 本发明提供了在样品中检测金黄色葡萄球菌的方法。 优选的方法包括以下步骤:(a)将包含培养基和微生物的样品与容器中的第一溶液混合,所述微生物涉及金黄色葡萄球菌; (b)从培养基和大部分第一溶液中分离微生物并从容器中除去介质和第一溶液的体积; (c)向容器中加入第二溶液以重悬微生物; 和(d)通过使用凝集试验在步骤(c)的所得悬浮液中检测金黄色葡萄球菌。
    • 25. 发明授权
    • Automated laser diode test system
    • 自动激光二极管测试系统
    • US06873172B2
    • 2005-03-29
    • US10146709
    • 2002-05-14
    • Paul CorneliusJohn WalshYong Yim
    • Paul CorneliusJohn WalshYong Yim
    • H01S5/00H01S5/042G01R31/26
    • H01S5/0014H01S5/0021H01S5/042
    • An automated laser diode testing and burn-in system is disclosed. Initial device data is obtained by applying current to the device at room temperature and measuring the device parameters. The device is then subjected to a burn-in process at higher temperatures. Device performance is monitored throughout the burn-in process. Upon termination of the burn-in process the devices are cooled to room temperature and the post burn-in device power is measured again under the same test conditions. If the device parameters have changed by more than a particular amount the device is rejected. Otherwise, the device is accepted and installed in the next level assembly. The test system disclosed herein achieves significant advantages over prior art in cost and throughput by combining an easy to load laser test fixture with automatic device hold down feature, heating capability, computer program driven test protocol capable of performing initial laser measurements, calibrating each laser and photodetector pair, burn-in test, post burn-in measurements, failed device detection, storage of laser test history records and enabling remote access to such records. The invention eliminates the need for numerous labor intensive ergonomically difficult steps and costly test fixtures.
    • 公开了一种自动化激光二极管测试和老化系统。 通过在室温下将电流施加到器件并测量器件参数来获得初始器件数据。 然后在较高温度下对该装置进行老化过程。 在整个烧录过程中监视器件性能。 在老化过程结束后,将器件冷却至室温,并在相同的测试条件下再次测量后置式老化装置的功率。 如果设备参数已经改变了超过特定的量,则设备被拒绝。 否则,设备被接受并安装在下一级程序集中。 本文所公开的测试系统通过将容易加载的激光测试夹具与自动装置保持特征,加热能力,能够执行初始激光测量的计算机程序驱动测试协议,校准每个激光器以及 光电检测器对,老化测试,后期老化测量,设备检测失败,激光测试历史记录的存储和远程访问这些记录。 本发明消除了对许多劳动密集的人体工程学困难的步骤和昂贵的测试夹具的需要。
    • 27. 发明授权
    • Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity
    • 具有平滑肌松弛和/或肥大细胞稳定和/或抗炎活性的吲哚化合物
    • US06297399B1
    • 2001-10-02
    • US09092902
    • 1998-06-08
    • John WalshNeil FrankishHelen SheridanWilliam Byrne
    • John WalshNeil FrankishHelen SheridanWilliam Byrne
    • C07C30300
    • C07C311/20C07C13/465C07C35/32C07C35/52C07C43/188C07C45/46C07C45/511C07C45/62C07C45/65C07C45/673C07C45/68C07C45/71C07C45/74C07C49/67C07C49/683C07C49/697C07C49/755C07C59/86C07C65/36C07C69/007C07C69/013C07C69/738C07C69/76C07C69/92C07C215/44C07C225/20C07C233/32C07C251/44C07C309/66C07C2602/08C07C49/80
    • Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 to R13, in formula (8) R1 and R3 and R13 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing heretro atoms containing one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. X is a bond, O, or NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO2, when X is a bond any of R8 and R13; R8 and R12; R8 and R9 may together represent a double bond, in formula (7) any one or more of R2, 1R2 R3, 1R3; R9, 1R9; R10, 1R10; R11, 1R11; R12, 1R12 may together represent oxo, and in formula (8) any one or more of R1, 1R1, R3, 1R3; R9, 1R9; R10, 1R10; R11, 1R11; R12; 1R12 may together represent oxo.
    • 通式(7)和(8)的茚满化合物及其药物用途,特别是实现所述的平滑肌松弛活性和/或肥大细胞稳定活性和/或抗炎活性,其中在式(7)R2至R13中, 在式(8)中,R 1和R 3和R 13选自一个或多个相同或不同的:H,卤素,羟基,烷氧基,芳氧基,乙酰氧基,羧基,烷基羰基,氢羰基,氨基,酰胺基,烷基氨基, ,氧化胺基,偶氮基,氰基,肼基,酰肼基,腙基,酰亚胺基,亚氨基醚基,脲基,肟,硝基,硝酸根,亚硝酸根,亚硝基,腈,含有一个或多个 的N,O或S,芳烷基,单和多亚苄基芳基,取代的芳基,硫醇,硫脲基,苯硫醇基,磺酸基,亚砜基,砜基,含有1-10个碳原子的烷基或含3- 8 可以是饱和或不饱和的,可以是饱和或不饱和的取代的烷基或环烷基的碳原子。 当X是R 8和R 13中的任一个时,X是键,O或NR(其中R是酰基,烷基或磺酸酯基),S,SO或SO 2。 R8和R12; R 8和R 9可以一起表示双键,在式(7)中,R 2,R 2,R 3,R 3 3中的任何一个或多个; R9,1R9; R10,1R10; R11,1R11; R 12,R 12可以一起代表氧代,并且在式(8)中,R1,1R1,R3,1R3, R9,1R9; R10,1R10; R11,1R11; R12; 1R12可以一起代表氧代。
    • 28. 发明授权
    • Reversible spray tip
    • 可逆喷头
    • US5749528A
    • 1998-05-12
    • US578864
    • 1995-12-27
    • Danuta H. CareyJohn D. GeberthJohn WalshDaniel S. Hosley
    • Danuta H. CareyJohn D. GeberthJohn WalshDaniel S. Hosley
    • B05B15/00B05B15/02B05B1/28
    • B05B15/0283B05B15/001
    • There is provided a reversible spray tip or nozzle used with a spray gun or like device for hydraulically atomizing and spraying liquids such as paint. The spray tip includes a plastic housing having a forward extending spray tip guard integral therewith, a cylindrically shaped rotatable turret member diametrically received for rotation in the housing and having a diametric bore therethrough for receipt of a spray tip insert, and an elongated seal insert axially received in the housing upstream from the turret member. A securing nut rotatably mounted to the housing at the spray gun end thereof secures the reversible spray tip to the discharge end of the spray gun. The enhanced sealing effectiveness of the reversible spray tip permits effective sealing of the assembly by finger tightening of the securing nut.
    • 提供了一种与喷枪或类似装置一起使用的可逆喷嘴或喷嘴,用于水力雾化和喷涂液体如油漆。 喷嘴包括塑料壳体,其具有与其一体的前向延伸的喷射尖端防护件,圆柱形可旋转转盘构件,其直径地容纳在壳体中旋转并具有穿过其中的直径孔,用于接收喷射尖端插入件,并且沿轴向 在炮塔构件上游的住房中收到。 在喷枪端可旋转地安装到壳体上的固定螺母将可逆喷雾头固定到喷枪的排放端。 可逆喷雾头的增强的密封效果允许通过固定螺母的手指紧固来有效地密封组件。
    • 30. 发明授权
    • Talking tracheostomy tube
    • 说话气管造口管
    • US4573460A
    • 1986-03-04
    • US610417
    • 1984-05-15
    • Edward H. SzachowiczJohn Walsh
    • Edward H. SzachowiczJohn Walsh
    • A61L29/00A61F2/20A61M16/04A61M25/00
    • A61F2/20A61F2/203A61M16/0427A61M16/0459A61M16/0465A61M16/0488A61M16/0497
    • A talking tracheostomy tube according to the teachings of the present invention is shown in the preferred embodiment as including an inner cannula removably received within an outer cannula. The tracheostomy tube further includes, in the preferred embodiment, a first cuff for sealing between the outer cannula and the trachea for substantially preventing air introduced through the inner cannula to escape from the trachea through the larynx. In the preferred embodiment, air is introduced into the trachea above the first cuff by ports directionally drilled through the outer cannula and in fluid communication with a secondary passageway formed by and between the inner and outer cannulas. The inner end of the secondary passageway is formed by a sealing obstruction integrally formed in the inside surface of the outer cannula adjacent the inner end for the sealing receipt of the inner cannula. The outer end of the secondary passageway is sealed by a collar integrally formed on the outer end of the inner cannula which abuts and seals within a recess of a collar integrally formed on the outer end of the outer cannula. In its preferred form of the present invention, the tracheostomy tube further includes a second cuff for sealing between the outer cannula and the stoma of the patient for preventing the secondary air introduced through the ports from escaping through the stoma in the neck of the patient.
    • 根据本发明的教导,说明的气管切开管在优选实施例中被示出为包括可拆卸地容纳在外套管内的内套管。 在优选实施例中,气管切开管还包括用于密封外插管和气管之间的第一套筒,用于基本上防止通过内插管引入的空气通过喉部从气管中逸出。 在优选实施例中,空气通过定向穿过外套管的端口被引入到第一套管上方的气管中,并且与由内外套管形成的第二通道流体连通。 第二通道的内端由密封阻塞形成,密封阻塞整体地形成在外套管的内表面上,邻近内端,用于密封接收内插管。 第二通道的外端由整体形成在内套管的外端上的轴环密封,所述套环邻接并密封在整体形成在外套管的外端上的轴环的凹部内。 在本发明的优选形式中,气管造口管还包括用于在外套管和患者的造口之间密封的第二袖带,用于防止通过端口引入的二次空气逸出通过患者颈部的造口。