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1. 发明授权

US11957724B2 Phage therapy of 有权
公开(公告)号：US11957724B2
公开(公告)日：2024-04-16
申请号：US17038442
申请日：2020-09-30
申请人： ERYTECH PHARMA
发明人： Flavie Pouillot , Hélène Blois
IPC分类号： A61K35/76 , A01N63/40 , C07K14/005 , C12N7/00 , C12Q1/18 , G01N33/569
CPC分类号： A61K35/76 , A01N63/40 , C07K14/005 , C12N7/00 , C12Q1/18 , G01N33/56916 , C12N2795/00021 , C12N2795/00022 , C12N2795/00031 , C12N2795/00032 , C12N2795/00071 , C12N2795/10121 , C12N2795/10122 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , C12N2795/10221 , C12N2795/10222 , C12N2795/10231 , C12N2795/10232 , C12N2795/10271 , G01N2333/245 , G01N2800/52
摘要： The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.

2. 发明公开

US20240069022A1 METHOD AND KIT FOR DETECTING PRESENCE AND/OR AMOUNT OF BACTERIA OF ENTEROBACTERIACEAE IN FOOD/DRINK SAMPLE, ENVIRONMENTAL SAMPLE, OR BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：US20240069022A1
公开(公告)日：2024-02-29
申请号：US18272540
申请日：2022-01-14
申请人： ASAHI KASEI KABUSHIKI KAISHA
发明人： Katsuyoshi TAKAHASHI , Kotaro ODA , Mika SUGATA
IPC分类号： G01N33/569 , C07K16/12
CPC分类号： G01N33/56916 , C07K16/1228 , G01N2333/24 , G01N2469/10
摘要： Provided is a method that enables the presence and/or amount of bacteria of Enterobacteriaceae in a food/drink sample, an environmental sample, or a biological sample to be detected easily and efficiently in a short amount of time. Said method includes a step for simultaneously detecting, on the basis of an antigen-antibody reaction, the presence and/or amount of bacteria of Enterobacteriaceae of at least two different genera in a sample.

3. 发明授权

US11899021B2 Luciferase-based thermal shift assays 有权
公开(公告)号：US11899021B2
公开(公告)日：2024-02-13
申请号：US18150018
申请日：2023-01-04
申请人： Promega Corporation
发明人： Melanie Dart , Lance P. Encell , Thomas Kirkland , Thomas Machleidt , Matthew Robers , Brock F. Binkowski , Keith Wood , Ce Shi
IPC分类号： C12Q1/66 , C12Q1/68 , G01N21/64 , G01N33/53 , G01N33/58 , G01N33/68 , G01N33/569
CPC分类号： G01N33/6845 , C12Y113/12007 , G01N21/6428 , G01N33/56916 , G01N33/581 , G01N33/582 , G01N2021/6432 , G01N2021/6439 , G01N2333/90241 , G01N2500/04 , G01N2500/10
摘要： Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).

4. 发明公开

US20240043510A1 ANTI-ETEC ADHESIN PROTEIN ANTIBODIES AND METHODS OF USE 审中-公开
公开(公告)号：US20240043510A1
公开(公告)日：2024-02-08
申请号：US18351189
申请日：2023-07-12
申请人： University of Massachusetts
发明人： Mark S. KLEMPNER , Yang WANG , Lisa CAVACINI , Alla AMCHESLAVSKY
IPC分类号： C07K16/12 , G01N33/569 , A61P31/04
CPC分类号： C07K16/1232 , G01N33/56916 , A61P31/04 , G01N2333/245 , C07K2317/569 , C07K2317/565 , A61K2039/505
摘要： The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.

5. 发明授权

US11774448B2 Method for analyzing microorganism 有权
公开(公告)号：US11774448B2
公开(公告)日：2023-10-03
申请号：US17232258
申请日：2021-04-16
申请人： SHIMADZU CORPORATION
发明人： Yuko Fukuyama
IPC分类号： G01N33/569 , G01N33/68 , H01J49/00
CPC分类号： G01N33/56916 , G01N33/6851 , H01J49/0036
摘要： [OBJECT] To enable accurate identification of a specific serotype of Salmonella bacteria in a method for analyzing a microorganism using a MALDI-MS.
[MEANS FOR SOLVING PROBLEM] The present invention is a method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota. Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota. Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella bacteria is contained in a sample which contains either Schwarzengrund or Montevideo, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample.

6. 发明公开

US20230277643A1 MDR E. COLI IMMUNOGEN 审中-公开
公开(公告)号：US20230277643A1
公开(公告)日：2023-09-07
申请号：US18057957
申请日：2022-11-22
申请人： Janssen Pharmaceuticals, Inc.
发明人： Eszter NAGY , Gábor NAGY , Valéria SZIJÁRTO , Zóltan MAGYARICS , Irina MIRKINA , Luis GAUCHALLA , Adriana BADARAU , Gerhild ZAUNER , Jolanta LUKASIEWICZ
IPC分类号： A61K39/108 , G01N33/569 , C07K16/12
CPC分类号： A61K39/0258 , C07K16/1232 , G01N33/56916 , A61K2039/505 , G01N2333/245 , G01N2469/10
摘要： The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.

7. 发明公开

US20230192824A1 Antigen Binding Proteins to Class 5 ETEC Adhesins 审中-公开
公开(公告)号：US20230192824A1
公开(公告)日：2023-06-22
申请号：US17915870
申请日：2021-03-31
申请人： United States of America as Represented by the Secretary of the Navy
发明人： Yang Liu , Stephen Savarino
IPC分类号： C07K16/12 , G01N33/569 , A61P31/04
CPC分类号： C07K16/1232 , A61P31/04 , G01N33/56916 , A61K39/00 , C07K2317/21 , C07K2317/24 , C07K2317/622
摘要： Antigen binding proteins that interact with class 5 ETEC adhesins, compositions comprising said antigen binding proteins, and methods of preventing or treating ETEC related disorders in a subject in need thereof comprising administering to said subject a therapeutically effective amount of one or more of said compositions are described.

8. 发明授权

US10620202B2 Method for confirming the presence of an analyte 有权
公开(公告)号：US10620202B2
公开(公告)日：2020-04-14
申请号：US12430804
申请日：2009-04-27
申请人： Mansour Samadpour
发明人： Mansour Samadpour
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/543 , C12Q1/689
CPC分类号： G01N33/56916 , C12Q1/689 , G01N33/54326 , C12Q2600/16 , G01N2333/245 , Y02A50/52
摘要： The invention provides methods and kits for the rapid confirmation of an initial analyte test result. In a preferred embodiment, the process confirms the presence of a given microbial target in a mixed culture, or a mixed enrichment media, even when the competing organisms in the mix belong to related species, or are various biotypes of the same species.

9. 发明授权

US10613105B2 Competitive immunoassay test system for detecting a pyrogen 有权
公开(公告)号：US10613105B2
公开(公告)日：2020-04-07
申请号：US14941891
申请日：2015-11-16
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： Anke Burger-Kentischer , Steffen Rupp
IPC分类号： G01N33/92 , G01N33/558 , G01N33/569 , G01N33/543
CPC分类号： G01N33/92 , G01N33/54386 , G01N33/558 , G01N33/56916 , G01N2400/50 , G01N2469/10 , G01N2800/26 , G01N2800/709
摘要： The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.

10. 发明申请

US20180246096A1 DETECTION OF SERUM ANTI-FADA ANTIBODIES AND RELATED DIAGNOSTIC METHODS 审中-公开
公开(公告)号：US20180246096A1
公开(公告)日：2018-08-30
申请号：US15970391
申请日：2018-05-03
申请人： The Trustees of Columbia University in the City of New York
发明人： Yiping HAN
IPC分类号： G01N33/569 , G01N33/574 , C07K16/12
CPC分类号： G01N33/56916 , C07K16/12 , C12Q1/689 , G01N33/56911 , G01N33/57419 , G01N33/57484 , G01N2469/20 , G01N2800/065 , G01N2800/368 , G01N2800/60
摘要： The present invention relates to detecting serum anti-FadA antibodies in test samples from a patient. Additionally, aspects of the present invention provide the basis for detection of serum anti-FadA antibody levels from test samples and correlation with various conditions of clinical relevance.

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