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21. 发明公开

US20240164368A1 TISSUE PRESERVATION SYSTEM 审中-公开
公开(公告)号：US20240164368A1
公开(公告)日：2024-05-23
申请号：US18520265
申请日：2023-11-27
申请人： The Curators of the University of Missouri , The Trustees of Columbia University in the City of New York
发明人： James L. Cook , Clark T. Hung , Eric Lima , Aaron Stoker
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/021 , A01N1/0242 , A01N1/0263 , A01N1/0284
摘要： The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.

22. 发明公开

US20240150372A1 OXA-IBOGAINE ANALOGUES FOR TREATMENT OF SUBSTANCE USE DISORDERS 审中-公开
公开(公告)号：US20240150372A1
公开(公告)日：2024-05-09
申请号：US18546772
申请日：2022-02-17
申请人： The Trustees of Columbia University in the City of New York , High Point University
发明人： Dalibor Sames , Vaclav Havel , Scott Hemby
IPC分类号： C07D491/22 , A61P25/36 , A61P29/00 , C07D471/22
CPC分类号： C07D491/22 , A61P25/36 , A61P29/00 , C07D471/22
摘要： The present invention provides a method of treating a subject afflicted with a substance use disorder (SUD) comprising administering to the subject an effective amount of a compound having the structure:

wherein
A is a ring structure, with or without substitution;
X1 is C or N;
X2 is N, O, or S;
Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
Y2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
Y3 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
Y4 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
Y6 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), -(haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl);
α and β are each present or absent and when present each is a bond,

wherein either α or β is present, and
when α is present, then X1 is C and X2 is S or O, or
when β is present, then X1 is N and X2 is N; and

R1, R2, R3 and R4 are each independently —H, -(alkyl), -(alkenyl), -(alkynyl), -(haloalkyl), -(cycloalkyl), -(aryl), -(heteroaryl), -(heteroalkyl), -(hydroxyalkyl), -(alkyl)-(aryl), -(alkyl)- (heteroaryl), -(alkyl)-(cycloalkyl), -(alkyl)-OH, -(alkyl)-O-(alkyl), —OH, —NH2, —OAc, —CO2H, —CN, OCF3, halogen, —CO2—(C2-C12 alkyl), C(O)—NH2, —C(O)—NH-(alkyl), C(O)—NH-(aryl), —O-alkyl, —O-alkenyl, —O-alkynyl, —O-aryl, —O-(heteroaryl), —NH-alkyl, —NH-alkenyl, —NH-alkynyl, —NH-aryl, —NH-(heteroaryl), —O—C(O) (alkyl), or —C(O)—N(alkyl)2,

or a pharmaceutically acceptable salt or ester thereof, so as to thereby treat the subject afflicted with the substance use disorder (SUD).

23. 发明授权

US11975290B2 Cyclopropeneimines for capture and transfer of carbon dioxide 有权
公开(公告)号：US11975290B2
公开(公告)日：2024-05-07
申请号：US17655206
申请日：2022-03-17
申请人： International Business Machines Corporation , The Trustees of Columbia University in the City of New York
发明人： James L. Hedrick , Nathaniel H. Park , Luis M. Campos , Dino Wu , Daniel Malinowski
IPC分类号： B01D53/62 , B01D53/14 , B01D53/78
CPC分类号： B01D53/62 , B01D53/1475 , B01D53/1493 , B01D53/78 , B01D2252/2053 , B01D2257/504
摘要： A process, composition, and apparatus for carbon dioxide (CO2) sequestration are disclosed. The process includes passing air containing the CO2 through a cyclopropeneimine (CPI)-functionalized material. The composition includes a CPI-functionalized material that reacts with CO2 when mixed with air containing the CO2. The apparatus includes a component for providing a CPI-functionalized material and mixing the material with CO2 gas.

24. 发明公开

US20240138918A1 SYSTEMS AND METHODS FOR AUGMENTED REALITY GUIDANCE 审中-公开
公开(公告)号：US20240138918A1
公开(公告)日：2024-05-02
申请号：US18321450
申请日：2023-05-22
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Steven Feiner , Gabrielle Loeb , Alon Grinshpoon , Shirin Sadri , Carmine Elvezio
IPC分类号： A61B34/10 , G06F3/16 , G06N20/00 , G06T19/00
CPC分类号： A61B34/10 , G06F3/167 , G06N20/00 , G06T19/006 , A61B2034/107 , A61B2034/108
摘要： Certain embodiments include a method for assisting a clinician in performing a medical procedure on a patient using augmented reality guidance. The method can include obtaining a three-dimensional model of an anatomic part of the patient. The method can also include aligning the three-dimensional model with data to form augmented reality guidance for the medical procedure. In addition, the method can include presenting the augmented reality guidance to the clinician during the medical procedure using an augmented reality three-dimensional display.

25. 发明授权

US11968974B2 Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs 有权
公开(公告)号：US11968974B2
公开(公告)日：2024-04-30
申请号：US16244283
申请日：2019-01-10
申请人： The Trustees of Columbia University in the City of New York
发明人： Matthew Bacchetta , Scott Chicotka , Kenmond Fung , Brandon Guenthart , John O'Neill , Gordana Vunjak-Novakovic
IPC分类号： C12M3/00 , A01N1/00 , A01N1/02 , A61J1/00 , A61M1/16 , C12M1/00 , C12M1/34 , A61M1/36 , A61M1/38
CPC分类号： A01N1/021 , A01N1/02 , A01N1/0247 , A61J1/00 , A61M1/16 , C12M29/12 , C12M29/14 , C12M41/16 , A01N1/0278 , A61M1/3621 , A61M1/38 , A61M2210/1039
摘要： Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

26. 发明公开

US20240125865A1 Systems and Methods for Pulse-Injection Diagnostics and Prognostics for Lithium-Ion Batteries 审中-公开
公开(公告)号：US20240125865A1
公开(公告)日：2024-04-18
申请号：US18376576
申请日：2023-10-04
申请人： The Trustees of Columbia University in the City of New York
发明人： Alan Gen Li , Alan C. West , Matthias Preindl
IPC分类号： G01R31/392 , G01R31/367 , G01R31/3835
CPC分类号： G01R31/392 , G01R31/367 , G01R31/3835
摘要： Disclosed are systems, methods, and other implementations, including a method for managing battery performance that includes measuring voltage response data for a lithium-ion battery in response to a current pulse perturbation injected into the lithium-ion battery, and determining in real-time, based on the measured voltage response data, resultant degradation data representative of estimated physical degradation of the lithium-ion battery.

27. 发明公开

US20240093407A1 SYSTEMS AND METHODS FOR DISASSEMBLING TWO-DIMENSIONAL VAN DER WAALS CRYSTALS INTO MACROSCOPIC MONOLAYERS AND REASSEMBLING INTO ARTIFICIAL LATTICES 审中-公开
公开(公告)号：US20240093407A1
公开(公告)日：2024-03-21
申请号：US18522460
申请日：2023-11-29
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Fang Liu , Xiaoyang Zhu , James Hone , Sang Hoon Chae
IPC分类号： C30B33/00 , B32B7/02 , B32B18/00 , B32B37/00 , B32B37/18 , B32B43/00 , C23C14/16 , C23C14/30 , C30B29/46 , C30B29/68
CPC分类号： C30B33/00 , B32B7/02 , B32B18/00 , B32B37/025 , B32B37/18 , B32B43/006 , C23C14/16 , C23C14/30 , C30B29/46 , C30B29/68 , B32B2315/02 , C01G41/00
摘要： Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice. In certain embodiments, the composition can include two or more macroscopic single crystal monolayers adapted from a bulk van der Waals crystal, where the single crystal monolayers are configured for assembly into an artificial lattice based on one or more properties.

28. 发明公开

US20240093183A1 SYSTEMS AND METHODS FOR MULTIMODAL PROFILING 审中-公开
公开(公告)号：US20240093183A1
公开(公告)日：2024-03-21
申请号：US18339789
申请日：2023-06-22
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Elena E. Kandror , Abbas Haider Rizvi , Thomas Maniatis
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1096 , C12Q1/6806
摘要： The present disclosure relates to the methods and systems for multimodal profiling. The method can include stabilizing a target, performing a tagmentation on the target using an agent, and generating a library using a reverse transcriptase enzyme. The agent can include a Tn5 transposome complex, a Tn5 transposase reagent, or a combination thereof, and the Tn5 transposome complex or the Tn5 transposase reagent can be loaded with an adapter. The reverse transcriptase enzyme can be configured to transcribe DNA from both a DNA template and an RNA template and perform a terminal transferase activity by template switching and an introduction of an adapter sequence into a cDNA and a transposed chromatin of the target.

29. 发明公开

US20240075454A1 CYCLOPROPENIMINES FOR ACTIVATION OF CARBON DIOXIDE 审中-公开
公开(公告)号：US20240075454A1
公开(公告)日：2024-03-07
申请号：US17821074
申请日：2022-08-19
申请人： International Business Machines Corporation , The Trustees of Columbia University in the City of New York
发明人： Dino Wu , Luis M. Campos , Nathaniel H. Park , James L. Hedrick , Junho Kwon
IPC分类号： B01J20/26 , B01D53/62 , B01D53/78 , B01D53/96 , B01J20/34
CPC分类号： B01J20/26 , B01D53/62 , B01D53/78 , B01D53/96 , B01J20/3425 , B01J20/3475 , B01D2251/206 , B01D2257/504 , B01D2258/06
摘要： A process, composition, and apparatus for carbon dioxide (CO2) conversion are disclosed. The CO2 conversion comprises reacting CO2 with a cyclopropenimine (CPI) to activate the CO2 and transferring the activated CO2 to generate a product of the transferring. The transferring also generates a conjugate acid of the CPI. The process further comprises regenerating the CPI from the conjugate acid.

30. 发明授权

US11918828B2 Apparatus, method, and system for selectively effecting and/or killing bacteria 有权
公开(公告)号：US11918828B2
公开(公告)日：2024-03-05
申请号：US17321987
申请日：2021-05-17
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Gerhard Randers-Pehrson , David Jonathan Brenner , Alan Bigelow
IPC分类号： A61N5/06 , A61B18/18 , A61L2/00
CPC分类号： A61N5/0624 , A61B18/18 , A61L2/0047 , A61N5/0601 , A61B2018/1807 , A61N5/0616 , A61N2005/0654 , A61N2005/0655 , A61N2005/0661 , A61N2005/0667
摘要： Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.

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