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1. 发明申请

US20230137741A1 METHODS AND COMPOSITIONS FOR ANALYTE QUANTIFICATION 有权
公开(公告)号：US20230137741A1
公开(公告)日：2023-05-04
申请号：US17930324
申请日：2022-09-07
申请人： MATTERWORKS INC
发明人： Timothy KASSIS , Jefferson PRUYNE , Mark D. SIMON , Mimoun CADOSCH DELMAR AKERMAN , Jennifer CAMPBELL , Ana HENRIQUES DA COSTA , Laura KOLINSKY , John M. GEREMIA
IPC分类号： C12M1/34 , G01N30/72
摘要： Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.

2. 发明申请

US20230137145A1 MICROFLUIDIC DEVICE FOR A 3D TISSUE STRUCTURE 有权
公开(公告)号：US20230137145A1
公开(公告)日：2023-05-04
申请号：US17917816
申请日：2021-04-08
申请人： River BioMedics B.V.
发明人： Marcelo CATARINO RIBEIRO , Tom Mathijs Paulus Maria BOONEN
IPC分类号： C12M3/00 , C12M3/06 , C12M1/12 , C12M1/00 , C12N5/077 , C12M1/34
摘要： Microfluidic device comprising at least one cell culture unit for forming, culturing, growing and/or maintaining a 3D tissue structure such as a 3D strip of cardiac tissue, wherein the at least one cell culture unit comprises: a respective culture chamber for culturing cells having a chamber outlet opening; and a cell supply channel arranged to guide a microfluidic flow of liquid holding cells between a channel inlet and a channel outlet, wherein the cell supply channel is provided with a flow inhibitor which is operable to selectively provide a flow inhibiting state or a flow permitting state depending on a fluid pressure at the flow inhibitor, wherein, in the flow inhibiting state, the flow inhibitor is configured to substantially inhibit liquid flow between the cell supply channel and the culture chamber, wherein, in the flow permitting state, the flow inhibitor is configured to permit such liquid flow such that the cell supply channel is in liquid communication with the culture chamber to supply the culture chamber with cells, wherein the culture chamber is provided with at least two mutually spaced apart elastic support structures which extend in the culture chamber and which are configured for elastically supporting a tissue formed in the culture chamber, in particular a cultured 3D tissue formed from the cells, wherein the elastic support structures are elastically deformable, in particular flexible, in particular to vary a mutual distance of said support structures under influence of a varying contraction force between said support structures.

3. 发明申请

US20230136078A1 ANIMAL-DERIVED BACTERIA ACCELERATED CULTURE DEVICE WITH A DETECTION DEVICE 有权
公开(公告)号：US20230136078A1
公开(公告)日：2023-05-04
申请号：US17898063
申请日：2022-08-29
申请人： ANIMAL PRODUCTS QUALITY AND SATETY CENTER OF SHANDONG PROVINCE
发明人： SHAONING LIU , TENG GUO , ZHI CHEN , BING SHAO , YANLIN BU , LIANGZHI ZHU , QI ZHANG , CHENGJUN ZHANG , XIUGUANG FENG , WEI ZHANG , QING LI , XIAOFEI LIU , YUNFENG HOU
IPC分类号： C12M1/34 , C12M1/12
摘要： An animal-derived bacteria accelerated culture device includes: a bacteria accelerated incubator; support fixed feet installed on a lower end of the bacteria accelerated incubator; limit fixed frames installed on an end of the bacteria accelerated incubator facing away from the support fixed feet, each the limit fixed frame being provided with a limit fixed groove and a first fixed pin hole; a detection frame installed on an upper end of the bacteria accelerated incubator. By controlling working detection heads to detect bacteria inside the bacteria accelerated incubator, detection results are transmitted to a processing work case through detection positioning brackets for analysis and processing, and data is displayed by a data display device, the staff can adjust parameters such as temperature, potential of hydrogen (pH), oxygen, nutrients, etc. of the bacteria accelerated incubator through displayed values, thus improving the work quality and efficiency.

4. 发明授权

US11640664B2 Culturing assistance device, observation device and program 有权
公开(公告)号：US11640664B2
公开(公告)日：2023-05-02
申请号：US16519560
申请日：2019-07-23
申请人： NIKON CORPORATION
发明人： Tetsuya Koike , Satoshi Takahashi , Yasujiro Kiyota , Shunji Watanabe
IPC分类号： G06T7/00 , C12M1/12 , C12M1/34 , C12M1/36
摘要： A culturing assistance device includes an image acquisition unit configured to acquire a captured image of cells during culturing at determined times, a storage control unit configured to store the captured image acquired by the image acquisition unit and event information indicating an event related to culturing of the cells, and a learning unit configured to learn a relationship between the stored captured image and the stored event information.

5. 发明申请

US20230131609A1 BIOLOGICAL FILTRATION SYSTEMS AND CONTROLLING METHODS THEREOF 有权
公开(公告)号：US20230131609A1
公开(公告)日：2023-04-27
申请号：US18048505
申请日：2022-10-21
申请人： ALIT BIOTECH (SHANGHAI) CO., LTD.
发明人： Yu LIU , Rui CHEN
IPC分类号： B01D35/26 , B01D35/153 , B01D29/60 , B01D36/00 , B01D35/147 , C12M1/00 , C12M1/34
摘要： The embodiments of the disclosure provide a biological filtration system and a controlling method for the biological filtration system. The biological filtration system for filtering a solution in a bioreactor, comprises: a filter device having a top end and a bottom end, one of the top end and the bottom end being in fluid communication with the bioreactor for filtering the solution in the bioreactor; a liquid chamber in fluid communication with the other one of the top end and the bottom end for storing a solution in the filter device; a positive pressure pump, in fluid communication with the liquid chamber, for driving a solution to flow from the liquid chamber to the bioreactor; and a negative pressure pump, in fluid communication with the liquid chamber, for driving a solution to flow from the bioreactor to the liquid chamber.

6. 发明申请

US20230121360A1 INTERCONNECTED PHOTOSYNTHESIS MATRIX AND BIO-ENERGY PRODUCTION SYSTEMS 有权
公开(公告)号：US20230121360A1
公开(公告)日：2023-04-20
申请号：US17785664
申请日：2022-02-01
申请人： Kohane Technologies, LLC
发明人： Michael Kohane , Matthew Kohane
IPC分类号： C12M1/00 , C12M1/34
摘要： An interconnected photosynthesis matrix and bio-energy production system. More specifically, a self-sustaining bio-system that uses the bio-energy production system, which comprises a selection process, an extraction process, and a transfer process, to create an energy enhanced organism and then uses the energy from the energy enhanced organisms for human use and/or for the second portion of the system, the photosynthesis matrix, where photosynthesis takes place. The energy is extracted from the energy enhanced organism by creating an energy rich homogenate, and then the energy is transferred to the grid, to an energy storage device, or to the photosynthesis matrix. The photosynthesis matrix consumes carbon dioxide and reduces carbon dioxide concentration while producing glucose, which it then provides to the bio-energy production system. The two systems work together in a feedback loop to allow continuous chemical reactions.

7. 发明授权

US11629327B2 System and method for growing algae 有权
公开(公告)号：US11629327B2
公开(公告)日：2023-04-18
申请号：US16487854
申请日：2018-02-20
申请人： Vaxa Technologies Ltd
发明人： Ohad Bashan , Oded Bashan , Stephen Drummey
IPC分类号： B01F35/22 , C12M1/36 , C12M1/00 , C12M1/06 , C12M1/34 , B01F23/20 , B01F23/231 , B01F35/21 , B01F35/221 , B01F101/44
摘要： An algae cultivation system may include: a plurality of panels within a cultivation container, positioned along a first axis perpendicular to the gravitational force, wherein a cultivation volume is created between each pair of panels, and wherein the cultivation volumes are fluidly coupled so as to allow horizontal flow therebetween along the first axis; at least one first sparger, to distribute a first fluid into the container at a first operating flow rate; at least one second sparger, to distribute a second fluid into the container at a second operating flow rate; and at least one controller, to control the first operating flow rate and the second operating flow rate. The first operating flow rate may be adapted to allow turbulent mixing the algae in the cultivation container, and the second operating flow rate may be adapted to allow assimilation of materials in a liquid in the cultivation container.

8. 发明授权

US11629326B2 Modular storage units for perfusion and/or incubation of one or more specimens and storage assemblies 有权
公开(公告)号：US11629326B2
公开(公告)日：2023-04-18
申请号：US16502795
申请日：2019-07-03
申请人： Advanced Solutions Life Sciences, LLC
发明人： Michael W. Golway , Scott Douglas Cambron
IPC分类号： C12M1/00 , C12M1/34 , G01N1/28 , C12M1/36
摘要： A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.

9. 发明授权

US11628442B2 Method and system for reaction vessel with multisided energy sources 有权
公开(公告)号：US11628442B2
公开(公告)日：2023-04-18
申请号：US16654484
申请日：2019-10-16
申请人： Kryptos Biotechnologies, Inc.
发明人： Jun Ho Son
IPC分类号： B01L7/00 , B01J19/00 , B01J19/08 , C12M1/00 , C12M1/34
摘要： Embodiments include a reaction vessel having a reaction chamber defined by opposing first and second interior-facing surfaces of the housing; a first light absorbing layer conforming to the first interior-facing surface of the housing component; and a second light absorbing layer conforming to the second interior-facing surface of the housing component; a first energy source configured to direct light through the housing at the first light absorbing layer; and a second energy source configured to direct light through the housing at the second light absorbing layer.

10. 发明申请

US20230111370A1 MICROORGANIC DETECTION SYSTEM USING A DEEP LEARNING MODEL 有权
公开(公告)号：US20230111370A1
公开(公告)日：2023-04-13
申请号：US17904854
申请日：2021-05-12
申请人： NEOGEN FOOD SAFETY US HOLDCO CORPORATION
发明人： Thanh Quoc Tran , Huge Eugene Watson
IPC分类号： G06T7/00 , G06T5/00 , C12M1/34 , C12M1/00
摘要： Aspects of the present disclosure relate to a method of colony enumeration. The method includes identifying colony forming units of microorganisms in a combined image using a pretrained deep learning model on a colony enumeration device. The method can include providing a plurality of identification characteristics of the colony forming units to an interaction component such that the interaction component can project at least some of the plurality of identification characteristics onto the combined image.

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