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21. 发明授权

US4548888A Photographic products employing novel nondiffusible hydrazone dye-releasing compounds 失效
标题翻译：摄影产品采用新型不扩散腙染料释放化合物
公开(公告)号：US4548888A
公开(公告)日：1985-10-22
申请号：US669144
申请日：1984-11-07
申请人： Michael W. Crawley
发明人： Michael W. Crawley
IPC分类号： C07D213/61 , C07D213/64 , C07D213/71 , C07D213/73 , C07D213/77 , C09B26/02 , G03C7/00 , G03C8/10 , G03C1/40 , G03C5/54
CPC分类号： C07D213/73 , C07D213/61 , C07D213/64 , C07D213/71 , C07D213/77 , C09B26/02 , G03C8/10
摘要： Photographic elements, diffusion transfer assemblages, coordination complexes and processes are described which employ a novel nondiffusible hydrazone compound capable of releasing at least one diffusible yellow dye or dye precursor thereof having the formula: ##STR1## wherein: (a) Z.sup.1 and Z.sup.2 each independently represents the atoms necessary to complete a 5- or 6-membered aromatic heterocyclic ring;(b) CAR represents a ballasted carrier moiety capable of releasing the diffusible yellow dye moiety or precursor thereof as a function of development;(c) R represents hydrogen, an alkyl or substituted alkyl group of from 1 to about 12 carbon atoms, an aryl or substituted aryl group of from about 6 to about 12 carbon atoms, a substituted or unsubstituted 5- or 6-membered aromatic heterocyclic ring, or CAR, and(d) n is 0, 1 or 2, with the proviso that when n is 0, then R is CAR.
摘要翻译：描述了摄影元件，扩散转移组合物，配位络合物和方法，其使用能够释放至少一种具有下式的至少一种可扩散的黄色染料或染料前体的新型不扩散腙化合物：其中：（a）Z1和Z2各自独立地表示完成5-或6-元芳族杂环所必需的原子; （b）CAR表示能够释放作为显影的函数的可扩散的黄色染料部分或其前体的压载载体部分; （c）R表示氢，1至约12个碳原子的烷基或取代的烷基，约6至约12个碳原子的芳基或取代的芳基，取代或未取代的5或6元芳族杂环环或CAR，（d）n为0,1或2，条件是当n为0时，R为CAR。

22. 发明授权

US4496566A Naphthyridine derivatives 失效
标题翻译：萘啶衍生物
公开(公告)号：US4496566A
公开(公告)日：1985-01-29
申请号：US333181
申请日：1981-12-21
申请人： Jun-ichi Matsumoto , Shinichi Nakamura
发明人： Jun-ichi Matsumoto , Shinichi Nakamura
IPC分类号： A01N43/90 , A23L3/3544 , A61K31/495 , A61P31/04 , C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , A61K31/47 , C07D401/04
CPC分类号： C07D213/75 , C07D213/74 , C07D213/77 , C07D471/04
摘要： A 1,8-naphthyridine compound of the formula ##STR1## wherein R.sub.1 is a lower alkyl group, and the esters and salts thereof. The 1,8-naphthyridine compound of the formula (I) in which R.sub.1 is a methyl group is useful as an antibacterial agent.
摘要翻译：其中R1是低级烷基的式“IMAGE”的1,8-萘啶化合物及其酯和盐。其中R 1为甲基的式（I）的1,8-萘啶化合物可用作抗菌剂。

23. 发明授权

US4451479A Therapeutically active 3-amino-1-halogenated phenyl-2-pyrazolines and their C4 and C5 analogs 失效
标题翻译：治疗活性的3-氨基-1-卤代苯基-2-吡唑啉及其C4和C5类似物
公开(公告)号：US4451479A
公开(公告)日：1984-05-29
申请号：US432607
申请日：1982-10-04
申请人： John P. Dusza , Joseph P. Joseph , Seymour Bernstein
发明人： John P. Dusza , Joseph P. Joseph , Seymour Bernstein
IPC分类号： A01N43/56 , C07C45/75 , C07C47/21 , C07D213/77 , C07D231/06 , C07D401/04 , C07D403/04 , C07D417/04 , A61K31/415
CPC分类号： C07D213/77 , C07C255/00 , C07C45/75 , C07C47/21 , C07D231/06 , C07D401/04 , C07D403/04 , C07D417/04 , Y10S514/825 , Y10S514/826
摘要： A method of meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, treating pain or treating bacterial and fungal infections in mammals using 3-amino-1-halogenated phenyl-2-pyrazolines and their C4 and C5 analogs.
摘要翻译：一种改善关节炎疾病的炎症和/或进行性关节恶化特征的方法，通过使用3-氨基-1-卤代苯基-2-酮，可以预防哮喘症状和过敏性疾病的发作，治疗疼痛或治疗哺乳动物的细菌和真菌感染，吡唑啉及其C4和C5类似物。

24. 发明授权

US4448780A N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof 失效
标题翻译： N-（低级烷基）-N' - [5-（吡啶基）-2-吡啶基]脲及其强心使用
公开(公告)号：US4448780A
公开(公告)日：1984-05-15
申请号：US414602
申请日：1982-09-03
申请人： George Y. Lesher
发明人： George Y. Lesher
IPC分类号： C07D213/72 , C07D213/75 , C07D213/77 , C07D213/22 , A61K31/44
CPC分类号： C07D213/75 , C07D213/72 , C07D213/77
摘要： N-R.sub.1 -N-(6-R-5-PY-2-pyridinyl)ureas, where R.sub.1 is lower-alkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, or acid-addition salts thereof. Said compounds (I) or pharmaceutically acceptable acid-addition salts thereof are useful as cardiotonic agents. The preparation and cardiotonic use of said compounds are shown.
摘要翻译： N-R1-N-（6-R-5-PY-2-吡啶基）脲，其中R1是低级烷基，R是氢或低级烷基，PY是4-或3-吡啶基或4-或3- - 具有一个或两个低级烷基取代基的吡啶基或其酸加成盐。所述化合物（I）或其药学上可接受的酸加成盐可用作强心剂。显示了所述化合物的制备和强心使用。

25. 发明授权

US4436911A Heterocyclic amidinoureas 失效
标题翻译：杂环脒基脲
公开(公告)号：US4436911A
公开(公告)日：1984-03-13
申请号：US262811
申请日：1981-05-12
申请人： William L. Studt , Harry K. Zimmerman , George H. Douglas
发明人： William L. Studt , Harry K. Zimmerman , George H. Douglas
IPC分类号： C07D207/00 , C07D207/14 , C07D207/22 , C07D207/34 , C07D207/46 , C07D207/50 , C07D209/08 , C07D209/40 , C07D213/00 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/38 , C07D215/42 , C07D215/58 , C07D217/08 , C07D217/22 , C07D233/88 , C07D239/42 , C07D261/14 , C07D263/48 , C07D265/30 , C07D275/02 , C07D275/03 , C07D295/28 , C07D307/22 , C07D307/66 , C07D333/36 , C07D333/38 , C07D498/00 , C07D498/04 , C07D521/00 , C07D213/77 , A61K31/44
CPC分类号： C07D213/75 , C07D207/14 , C07D207/34 , C07D207/46 , C07D209/08 , C07D209/40 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/38 , C07D215/42 , C07D215/58 , C07D217/08 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/88 , C07D239/42 , C07D249/08 , C07D261/14 , C07D263/48 , C07D265/30 , C07D275/03 , C07D295/32 , C07D307/22 , C07D307/66 , C07D333/36 , C07D333/38
摘要： This invention relates to a novel class of heterocyclic amidinourea and heterocylic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.
摘要翻译：本发明涉及一类杂环脒基和杂环脒基硫脲化合物，其中杂环取代为1-N脲氮原子。这些化合物显示药物活性，并且可以并入用于产生抗溃疡，抗分泌，解痉药，抗精神病，心血管，止泻药或抗寄生虫作用的药物制剂中。

26. 发明授权

US4352803A Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof 失效
标题翻译：新型萘啶衍生物，其中间体，其制备方法及其用途
公开(公告)号：US4352803A
公开(公告)日：1982-10-05
申请号：US264824
申请日：1981-05-18
申请人： Jun-ichi Matsumoto , Yoshiyuki Takase , Yoshiro Nishimura
发明人： Jun-ichi Matsumoto , Yoshiyuki Takase , Yoshiro Nishimura
IPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , A61K31/495
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , Y10S514/96 , Y10S514/962
摘要： This invention relates to 1,8-naphthyridine compounds of the formula ##STR1## wherein X is a halogen atom especially fluorine atom,R.sub.1 is an ethyl group or a vinyl group, andR.sub.2 is a hydrogen atom or a lower alkyl group, their salts and processes for the preparation of them.The 1,8-naphthyridine compounds and their salts are useful as antibacterial agents and intermediates thereof.
摘要翻译：本发明涉及下式的1,8-萘啶化合物，其中X是卤原子，特别是氟原子，R 1是乙基或乙烯基，R 2是氢原子或低级烷基，它们的盐以及它们的制备过程。 1,8-萘啶化合物及其盐可用作抗菌剂及其中间体。

27. 发明授权

US4312875A 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof 失效
标题翻译： 5-（吡啶基）-6-（低级烷基）-2（1H） - 吡啶酮，1,2-二氢-2-氧代-5-（吡啶基）-6-（低级烷基）烟酸和低级烷基酯及其强心使用
公开(公告)号：US4312875A
公开(公告)日：1982-01-26
申请号：US204726
申请日：1980-11-06
申请人： George Y. Lesher , Chester J. Opalka, Jr. , Donald F. Page
发明人： George Y. Lesher , Chester J. Opalka, Jr. , Donald F. Page
IPC分类号： A61K31/44 , A61K31/4418 , A61P9/04 , C07D213/50 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/77 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/04 , A61K31/455
CPC分类号： C07D213/85 , C07D213/50 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/77 , C07D213/80 , C07D213/82
摘要： 1-R.sub.1 -6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones or 1-R.sub.1 -1,2-dihydro-2-oxo-6-(lower-alkyl)-5-(pyridinyl)nicotinic acids or lower-alkyl esters thereof or pharmaceutically-acceptable acid-addition or cationic salts thereof are useful as cardiotonic agents, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl. These compounds are prepared by hydrolyzing the corresponding 3-cyano compounds to produce the corresponding 3-carboxylic acids and then either by decarboxylating or esterifying the acids.
摘要翻译： 1-R1-6-（低级烷基）-5-（吡啶基）-2（1H） - 吡啶酮或1-R1-1,2-二氢-2-氧代-6-（低级烷基）-5-（吡啶基）烟酸或其低级烷基酯或其药学上可接受的酸加成盐或阳离子盐可用作强心剂，其中R 1是氢，低级烷基或低级 - 羟基烷基。通过水解相应的3-氰基化合物制备相应的3-羧酸，然后通过使酸脱羧或酯化来制备这些化合物。

28. 发明授权

US4207104A Photographic products and processes employing novel nondiffusible heterocyclylazonaphthol dye-releasing compounds 失效
标题翻译：使用新型非扩散性杂环基萘并苯酚染料释放化合物的摄影产品和方法
公开(公告)号：US4207104A
公开(公告)日：1980-06-10
申请号：US002127
申请日：1979-01-09
申请人： Derek D. Chapman , E-Ming Wu
发明人： Derek D. Chapman , E-Ming Wu
IPC分类号： C07C66/00 , C07D213/65 , C07D213/70 , C07D213/73 , C07D213/77 , C09B29/15 , G03C8/10 , G03C5/54 , G03C1/10 , G03C1/40 , G03C7/00
CPC分类号： C07D213/70 , C07C66/00 , C07D213/65 , C07D213/73 , C07D213/77 , C09B29/103 , G03C8/10
摘要： Photographic elements, diffusion transfer assemblages and processes are described which employ a novel nondiffusible compound having a releasable 2-(2-heterocyclylazo)-1-naphthol dye moiety which contains a nitrogen atom adjacent to the point of attachment to the azo linkage. The compound contains a ballasted carrier moiety which is capable of releasing the diffusible azo dye under alkaline conditions. The dye is transferred imagewise to an image-receiving layer where it is contacted with metal ions to form a metal-complexed azo dye transfer image of excellent stability.
摘要翻译：描述了摄影元件，扩散转移组合和方法，其使用具有可释放的2-（2-杂环基偶氮）-1-萘酚染料部分的新型不扩散化合物，其含有与偶氮键连接点相邻的氮原子。该化合物含有能在碱性条件下释放可扩散偶氮染料的压载载体部分。将染料成像转移到图像接收层，在其中与金属离子接触以形成具有优异稳定性的金属络合偶氮染料转移图像。

29. 再颁专利

USRE29640E Certain substituted 2,6-diamino-4-methyl-nicotinitriles the corresponding nicotinamides and derivatives thereof 失效
标题翻译：某些取代的2,6-二氨基-4-甲基 - 烟腈相应的烟酰胺及其衍生物
公开(公告)号：USRE29640E
公开(公告)日：1978-05-23
申请号：US711863
申请日：1976-08-05
申请人： Gunther Lamm , Johannes Dehnert
发明人： Gunther Lamm , Johannes Dehnert
IPC分类号： C07D213/74 , C07D213/77 , C07D213/82 , C07D213/85 , C09B29/42 , C09B31/153 , C09B62/82
CPC分类号： C07D213/74 , C07D213/77 , C07D213/82 , C07D213/85 , C09B29/3639 , C09B31/153 , C09B62/82
摘要： 2,3,6- AND PREFERABLY ALSO 4-SUBSTITUTED PYRIDINE DERIVATIVES BEARING THE RADICAL OF AMMONIA OR A PRIMARY AMINE IN THE 2- AND 6-POSITIONS. The compounds are eminently suitable as coupling components for the production of azo dyes, the coupling taking place in the 5-position.

30. 发明授权

US3943132A Process for the preparation of hydrazones 失效
标题翻译：制备腙的方法
公开(公告)号：US3943132A
公开(公告)日：1976-03-09
申请号：US406467
申请日：1973-10-15
申请人： Jean-Pierre Schirmann , Henri Mathais , Pierre Tellier , Francis Weiss
发明人： Jean-Pierre Schirmann , Henri Mathais , Pierre Tellier , Francis Weiss
IPC分类号： C07D213/77 , C07B43/00 , C07C20060101 , C07C67/00 , C07C241/00 , C07C251/76 , C07C251/82 , C07C251/84 , C07C251/86 , C07D20060101 , C07C109/14 , C07C109/16 , C07C109/18
CPC分类号： C07C249/16 , C07C251/76 , C07C251/84
摘要： This invention relates to a method of preparing hydrazones of the formula ##EQU1## in which R.sub.1 and R.sub.2, which may be identical or different, represent a linear alkyl radical of from 1 to 12 carbon atoms, a branched alkyl or cycloalkyl radical of from 3 to 12 carbon atoms, an aromatic radical of from 6 to 12 carbon atoms having a benzene or naphthalene nucleus, or a radical of from 5 to 12 carbon atoms having a pyridine nucleus, or R.sub.1 and R.sub.2 together form a linear or branched alkylene radical of from 3 to 12 carbon atoms in which one of the carbon atoms of the chain may be replaced by an oxygen atom, all of the above radicals being unsubstituted or substituted by one or more atoms or groups such as chlorine, bromine, fluorine, or iodine atoms or hydroxy, ether, carboxylic acid, carboxylic amide or ester, nitrile, nitro, or sulphonic acid or amide groups, or one of the two radicals R.sub.1 and R.sub.2 may be a hydrogen atom, and in which R.sub.3 and R.sub.4, which may be identical or different, represent a hydrogen atom, a linear alkyl or cycloalkyl radical of from 3 to 12 carbon atoms, in which one of the carbon atoms of the cycloalkyl radical may be replaced by an oxygen atom, or an aromatic hydrocarbon radical of from 6 to 12 carbon atoms or R.sub.3 and R.sub.4 together represent a linear or branched alkylene radical of from 3 to 11 carbon atoms, the above radicals being unsubstituted or substituted by atoms or groups such as chlorine, bromine, fluorine, ethylenic groups, nitro, hydroxy, alkoxy, or carboxylic acid or ester radicals , which comprises reacting a primary or secondary amine of the formulaWherein R.sub.1 and R.sub.2 are as defined above, ammonia, and a carbonyl compound of the formulaWherein R.sub.3 and R.sub.4 are as defined above, with a peroxide compound.
摘要翻译：本发明涉及制备式R 1 R 3 ANGLE NN = C ANGLE（I）R 2 R 4的腙的方法，其中可以相同或不同的R 1和R 2表示1至12个碳原子的直链烷基，支链具有3至12个碳原子的烷基或环烷基，具有苯或萘核的6至12个碳原子的芳族基团或具有吡啶核的5至12个碳原子的基团，或者R 1和R 2一起形成具有3至12个碳原子的直链或支链亚烷基，其中链中的一个碳原子可以被氧原子代替，所有上述基团都是未取代的或被一个或多个原子或基团取代，例如氯，溴，氟或碘原子或羟基，醚，羧酸，羧酰胺或酯，腈，硝基或磺酸或酰胺基，或两个基团R 1和R 2之一可以是氢原子，其中 R3和R4可以相同或相同不同的是氢原子，具有3-12个碳原子的直链烷基或环烷基，其中环烷基的一个碳原子可以被氧原子取代，或6-12的芳族烃基碳原子或R3和R4一起表示具有3至11个碳原子的直链或支链亚烷基，上述基团是未取代的或被诸如氯，溴，氟，烯基，硝基，羟基，烷氧基，或羧酸或酯基，其包括使式WHEREIN R 1和R 2如上所定义的伯胺或仲胺与氨过氧化合物与式WHEREIN R 3和R 4如上定义的羰基化合物反应。

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