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1. 发明授权

US09795140B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto 有权
公开(公告)号：US09795140B2
公开(公告)日：2017-10-24
申请号：US15092646
申请日：2016-04-07
申请人： Dow AgroSciences LLC
发明人： Timothy P. Martin , Joseph D. Eckelbarger , Ronald Ross, Jr. , Kyle DeKorver , Ronald J. Heemstra , Daniel I. Knueppel , Peter Vednor , Ricky Hunter , David A. Demeter , Tony K. Trullinger , Erich Baum , Zoltan Benko , Nakyen Choy , Gary Crouse , John F. Daeuble, Sr. , Fangzheng Li , Jeff Nissen , Michelle Riener , Tom Sparks , Frank Wessels , Maurice Yap
IPC分类号： A01N53/00 , A01N43/90 , C07D207/273 , A01N43/82 , C07D307/33 , C07D277/36 , C07D263/26 , C07D261/12 , C07D333/48 , C07D307/52 , C07D277/30 , C07D213/56 , C07C237/22 , C07D333/60 , C07D233/80 , C07D487/04 , A01N43/707 , A01N43/653 , A01N43/60 , A01N43/40 , A01N41/10 , A01N37/34 , A01N37/22 , C07D253/07 , C07D241/20 , C07C317/14 , C07C233/65 , C07C233/63 , C07D209/49 , C07C381/10 , C07D205/04 , C07C237/42 , C07D207/10 , C07D207/452 , C07C255/29 , C07C255/57 , C07D285/06 , C07D295/32 , C07D305/08 , C07C255/46 , C07D213/75 , C07C255/60 , C07C259/10 , C07D213/81 , C07D213/84 , C07D309/14 , C07D213/89 , C07D215/227 , C07C271/28 , C07C271/66 , C07D231/12 , C07D331/04 , C07D231/56 , C07D333/36 , C07D233/36 , C07C311/08 , C07C311/46 , C07D235/30 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07D249/08 , C07C331/12 , C07D215/38
CPC分类号： A01N53/00 , A01N37/22 , A01N37/34 , A01N41/10 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/707 , A01N43/82 , A01N43/90 , C07C233/63 , C07C233/65 , C07C237/22 , C07C237/42 , C07C255/29 , C07C255/46 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/28 , C07C271/66 , C07C311/08 , C07C311/46 , C07C317/14 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07C331/12 , C07C381/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/273 , C07D207/452 , C07D209/49 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/227 , C07D215/38 , C07D231/12 , C07D231/56 , C07D233/36 , C07D233/80 , C07D235/30 , C07D241/20 , C07D249/08 , C07D253/07 , C07D261/12 , C07D263/26 , C07D277/30 , C07D277/36 , C07D285/06 , C07D295/32 , C07D305/08 , C07D307/33 , C07D307/52 , C07D309/14 , C07D331/04 , C07D333/36 , C07D333/48 , C07D333/60 , C07D487/04
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

2. 发明申请

US20170166576A1 IRE-1alpha INHIBITORS 有权
公开(公告)号：US20170166576A1
公开(公告)日：2017-06-15
申请号：US15349872
申请日：2016-11-11
申请人： MannKind Corporation
发明人： Qingping Zeng , Warren S. Wade , John Bruce Patterson
IPC分类号： C07D487/08 , C07D207/14 , C07D207/08 , C07D213/74 , C07D295/108 , C07D249/06 , C07D207/16 , C07D401/12 , C07D213/38 , C07D211/26 , C07D211/58 , C07D401/04 , C07D295/26 , C07D295/32 , C07D277/12 , C07D263/34 , C07D409/12 , C07D307/68 , C07D333/38 , C07D277/18 , C07D295/112
CPC分类号： C07D487/08 , C07C59/74 , C07C65/30 , C07C69/738 , C07C235/78 , C07C235/84 , C07D207/08 , C07D207/14 , C07D207/16 , C07D211/26 , C07D211/58 , C07D211/62 , C07D211/66 , C07D211/98 , C07D213/36 , C07D213/38 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/26 , C07D239/38 , C07D249/06 , C07D263/34 , C07D277/12 , C07D277/18 , C07D277/42 , C07D277/56 , C07D295/108 , C07D295/112 , C07D295/185 , C07D295/192 , C07D295/26 , C07D295/32 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The invention provides compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

3. 发明申请

US20150166469A1 NEPRILYSIN INHIBITORS 有权
公开(公告)号：US20150166469A1
公开(公告)日：2015-06-18
申请号：US14516866
申请日：2014-10-17
申请人： Erik Fenster , Melissa Fleury , Adam D. Hughes
发明人： Erik Fenster , Melissa Fleury , Adam D. Hughes
IPC分类号： C07C235/78 , A61K45/06 , C07D207/08 , A61K31/4015 , C07D213/75 , A61K31/44 , C07D261/04 , A61K31/42 , C07D295/32 , A61K31/5375 , C07D205/04 , A61K31/397 , C07D207/14 , A61K31/40 , A61K31/495 , C07D491/107 , A61K31/197
CPC分类号： C07C243/38 , A61K31/192 , A61K31/197 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/42 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C233/56 , C07C235/12 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C235/80 , C07C243/24 , C07C243/32 , C07C259/04 , C07C2601/08 , C07C2601/16 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/60 , C07D211/62 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/86 , C07D213/87 , C07D233/06 , C07D239/36 , C07D261/02 , C07D261/04 , C07D265/30 , C07D295/32 , C07D307/68 , C07D309/08 , C07D401/04 , C07D405/06 , C07D491/107 , C07D493/10
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

4. 发明申请

US20140256702A1 NEPRILYSIN INHIBITORS 有权
标题翻译： NEPRILYSIN抑制剂
公开(公告)号：US20140256702A1
公开(公告)日：2014-09-11
申请号：US14196624
申请日：2014-03-04
申请人： Erik Fenster , Melissa Fleury , Adam D. Hughes
发明人： Erik Fenster , Melissa Fleury , Adam D. Hughes
IPC分类号： A61K31/5375 , A61K31/197 , C07D207/09 , A61K31/40 , C07D213/56 , C07D491/107 , C07D261/04 , A61K31/42 , C07D295/32 , C07D205/04 , A61K31/397 , C07D207/14 , C07C235/34 , A61K31/44
CPC分类号： C07C243/38 , A61K31/192 , A61K31/197 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/42 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C233/56 , C07C235/12 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C235/80 , C07C243/24 , C07C243/32 , C07C259/04 , C07C2601/08 , C07C2601/16 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/60 , C07D211/62 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/86 , C07D213/87 , C07D233/06 , C07D239/36 , C07D261/02 , C07D261/04 , C07D265/30 , C07D295/32 , C07D307/68 , C07D309/08 , C07D401/04 , C07D405/06 , C07D491/107 , C07D493/10
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R1-R5和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

5. 发明申请

US20120309648A1 INTEGRATED MICROFLUIDICS FOR HIGHLY PARALLEL SCREENING OF CHEMICAL REACTIONS 审中-公开
标题翻译：综合微流化学高效平行筛选化学反应
公开(公告)号：US20120309648A1
公开(公告)日：2012-12-06
申请号：US12667861
申请日：2008-07-07
申请人： Hsian-Rong Tseng , Jinyi Wang , Guodong Sui , Kym F. Faull , Yanju Wang , Wei-Yu Lin
发明人： Hsian-Rong Tseng , Jinyi Wang , Guodong Sui , Kym F. Faull , Yanju Wang , Wei-Yu Lin
IPC分类号： C40B60/12 , C40B30/08
CPC分类号： B01F13/0059 , B01F5/102 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00389 , B01J2219/00479 , B01J2219/00702 , B01J2219/0072 , B01L3/5027 , C07C247/10 , C07C247/12 , C07C247/14 , C07C323/59 , C07C2601/08 , C07C2601/14 , C07D211/68 , C07D213/42 , C07D213/74 , C07D215/42 , C07D235/14 , C07D295/13 , C07D295/32 , C07D307/52 , C07D311/14 , C07D317/28 , C07D333/20 , C40B40/04 , C40B50/08 , C40B60/12 , G01N2035/00544
摘要： A microfluidic system has a microfluidic mixer and a sample storage component that is in fluid connection with the microfluidic mixer. The microfluidic mixer has a mixing section; a target molecule input section that is in fluid connection with the mixing section, the target molecule input section being suitable to provide a fluid into the mixing section that contains molecules to be targeted by chemical reactions; a first reagent input section that is in fluid connection with the mixing section, the first reagent input section being structured to selectively provide a first reagent selected from a plurality of reagents to test a chemical reaction with the target molecules; a second reagent input section that is in fluid connection with the mixing section, the second reagent input section being structured to selectively provide a second reagent selected from a plurality of reagents to test a chemical reaction with the target molecules and said first reagent; and a neutral fluid input section that is in selectable fluid connection with the sample storage component, the neutral fluid input section being structured to selectively provide a neutral fluid into the sample storage component between successive samples provided to the sample storage component to separate successive samples in a stratified arrangement.
摘要翻译：微流体系统具有微流控混合器和与微流体混合器流体连接的样品存储组件。微流体混合器具有混合部分; 与混合部分流体连接的目标分子输入部分，靶分子输入部分适合于通过化学反应将含有分子的流体提供给混合部分; 与所述混合部分流体连接的第一试剂输入部，所述第一试剂输入部构造成选择性地提供选自多种试剂的第一试剂，以测试与所述靶分子的化学反应; 与所述混合部分流体连接的第二试剂输入部，所述第二试剂输入部构造成选择性地提供选自多种试剂的第二试剂，以测试与所述靶分子和所述第一试剂的化学反应; 以及中性流体输入部分，其与所述样品存储部件可选择性地流体连接，所述中性流体输入部分被构造成在提供给所述样品存储部件的连续样品之间选择性地将中性流体提供到所述样品存储部件中，以将分层安排。

6. 发明授权

US07812040B2 Histamine-3 receptor antagonists 失效
标题翻译：组胺-3受体拮抗剂
公开(公告)号：US07812040B2
公开(公告)日：2010-10-12
申请号：US11917501
申请日：2006-06-12
申请人： Travis T Wager
发明人： Travis T Wager
IPC分类号： A61K31/4245 , A61K31/423 , A61K31/4155 , A61K31/40 , C07D271/08 , C07D263/58 , C07D231/14 , C07D207/04
CPC分类号： C07D241/24 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D231/14 , C07D231/18 , C07D231/40 , C07D239/30 , C07D261/18 , C07D263/38 , C07D263/58 , C07D285/14 , C07D295/096 , C07D295/26 , C07D295/32 , C07D309/08 , C07D319/18 , C07D333/34 , C07D333/62
摘要： This invention is directed to a compound of the formula Ia or Ib, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式Ia或Ib化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法疾病，肥胖，头晕，癫痫，晕车，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用化合物我如上所述。

7. 发明申请

US20100253213A1 LATENT CURING AGENTS, EPOXY RESIN COMPOSITIONS CONTAINING THE SAME, SEALING MATERIALS, AND ORGANIC EL DISPLAYS 有权
标题翻译：专利固化剂，含有它们的环氧树脂组合物，密封材料和有机EL显示器
公开(公告)号：US20100253213A1
公开(公告)日：2010-10-07
申请号：US12681271
申请日：2008-12-26
申请人： Hiroaki Tamatani , Mitsuaki Chida , Yugo Yamamoto , Yuichi Ito , Takashi Nakano , Naritoshi Yoshimura
发明人： Hiroaki Tamatani , Mitsuaki Chida , Yugo Yamamoto , Yuichi Ito , Takashi Nakano , Naritoshi Yoshimura
IPC分类号： H05B33/04 , C07C243/00 , C08L63/00
CPC分类号： C08L63/00 , C07C243/40 , C07C271/28 , C07D295/32 , C08G59/54 , H01L51/5246
摘要： The invention aims to provide latent curing agents which exert high low-temperature curing properties when used together with ionically polymerizable compounds and which exhibit high storage stability at room temperature. Latent curing agents for ionically polymerizable compounds which agents each contain a hydroxyl-free amine imide compound having an N—N bond energy of 100 to 210 kJ/mol as determined by B3LYP functional theory method.
摘要翻译：本发明旨在提供当与离子聚合性化合物一起使用时具有高低温固化性能的潜在性固化剂，并且在室温下表现出高的储存稳定性。用于离子可聚合化合物的潜在固化剂，其各自含有通过B3LYP功能理论方法测定的具有100至210kJ / mol的N-N键能量的无羟基胺酰亚胺化合物。

8. 发明授权

US07390924B2 Terphenyl derivatives, preparation thereof, compositions containing same 失效
标题翻译：三联苯衍生物，其制备方法，含有它们的组合物
公开(公告)号：US07390924B2
公开(公告)日：2008-06-24
申请号：US10511040
申请日：2003-04-10
申请人： Francis Barth , Serge Martinez , Murielle Rinaldi-Carmona
发明人： Francis Barth , Serge Martinez , Murielle Rinaldi-Carmona
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
CPC分类号： C07D295/32 , C07C69/76 , C07C233/65 , C07C233/69 , C07C233/78 , C07C2602/22 , C07D209/16 , C07D211/16 , C07D211/98
摘要： The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB1 cannabinoid receptors.
摘要翻译：本发明涉及下式的三联苯衍生物及其制备方法及包含它们的药物组合物。这些化合物相对于CB1大麻素受体表现出拮抗剂活性。

9. 发明申请

US20070117793A1 Compounds Which Inhibit Beta-Secretase Activity and Methods of Use 有权
标题翻译：抑制β-分泌酶活性的化合物和使用方法
公开(公告)号：US20070117793A1
公开(公告)日：2007-05-24
申请号：US11463558
申请日：2006-08-09
申请人： Arun Ghosh , Nagaswamy Kumaragurubaran , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa Swanson , Sudha Ankala , Jordan Tang , Geoffrey Bilcer
发明人： Arun Ghosh , Nagaswamy Kumaragurubaran , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa Swanson , Sudha Ankala , Jordan Tang , Geoffrey Bilcer
IPC分类号： A61K31/551 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/473 , A61K31/4709 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4184
CPC分类号： C07D213/74 , C07C233/78 , C07C311/08 , C07C311/29 , C07C2601/14 , C07D207/09 , C07D209/14 , C07D211/26 , C07D213/36 , C07D213/40 , C07D213/61 , C07D213/65 , C07D215/12 , C07D233/64 , C07D235/14 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/108 , C07D295/13 , C07D295/205 , C07D295/32 , C07D307/52 , C07D307/62 , C07D309/04 , C07D317/58 , C07D417/12 , C07D493/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译：本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。

10. 发明申请

US20060270609A1 Inhibitors for the soluble epoxide hydrolase 有权
公开(公告)号：US20060270609A1
公开(公告)日：2006-11-30
申请号：US11256685
申请日：2005-10-20
申请人： Bruce Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John Newman
发明人： Bruce Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John Newman
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07D295/088 , C07C233/06 , C07C233/08 , C07C235/14 , C07C275/26 , C07C311/04 , C07C311/05 , C07C311/18 , C07C311/41 , C07C311/51 , C07C323/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/18 , C07C2603/74 , C07D209/18 , C07D213/04 , C07D233/61 , C07D233/64 , C07D279/12 , C07D295/13 , C07D295/32 , C07D403/06 , C07K5/0205
摘要： Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.

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