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21. 发明申请

US20140243576A1 PARTICLE ACCELERATOR AND MEDICAL EQUIPMENT 有权
标题翻译：颗粒加速器和医疗设备
公开(公告)号：US20140243576A1
公开(公告)日：2014-08-28
申请号：US14171910
申请日：2014-02-04
申请人： Kabushiki Kaisha Toshiba
发明人： Akiko Kakutani , Kiyokazu Sato , Takeshi Yoshiyuki , Takashi Yazawa
IPC分类号： H05H13/04 , A61N5/10
CPC分类号： H05H13/04 , A61N5/1077 , A61N2005/1088
摘要： One embodiment of a particle accelerator includes: a particle source from which a particle beam is extracted with a beam pulse width of not greater than 2 μsec; a linear accelerator for accelerating the particle beam extracted from the particle source; a synchrotron for receiving the particle beam transported thereto from the linear accelerator and causing the particle beam to circulate in order to accelerate it until it gets to a predetermined energy level; a bump electromagnet for shifting the circulating path of the particle beam each time it makes a full turn; and a control unit for controlling the extent of magnetic excitation of the bump electromagnet and for controlling the timing of magnetic excitation of the bump electromagnet according to the pulse timing of the particle source.
摘要翻译：粒子加速器的一个实施例包括：粒子束以束脉冲宽度不大于2微秒从其中提取出的粒子束; 用于加速从粒子源提取的粒子束的线性加速器; 同步加速器，用于接收从线性加速器传送到其上的粒子束，并使粒子束循环，以加速它直至达到预定的能级; 用于在每次完全转动时移动粒子束的循环路径的凸块电磁体; 以及控制单元，用于控制凸块电磁体的磁激励程度，并根据粒子源的脉冲定时来控制凸块电磁体的磁激励定时。

22. 发明申请

US20120267543A1 SYNCHROTRON AND PARTICLE THERAPY SYSTEM USING THE SAME 有权
标题翻译：使用该方法的SYNCHROTRON AND PARATLE THERAPY SYSTEM
公开(公告)号：US20120267543A1
公开(公告)日：2012-10-25
申请号：US13449948
申请日：2012-04-18
申请人： Fumiaki NODA , Kazuo HIRAMOTO , Takahiro YAMADA
发明人： Fumiaki NODA , Kazuo HIRAMOTO , Takahiro YAMADA
IPC分类号： H01J3/26 , H05H13/04
CPC分类号： H05H13/04 , A61N5/10 , A61N2005/1087 , H05H7/10 , H05H2007/002
摘要： Disclosed herein are provided an arrangement of devices suitable to downsize a synchrotron, a synchrotron using such an arrangement, and a particle therapy system using the synchrotron. In the synchrotron, a plurality of deflection magnets and a single defocusing quadrupole magnet are arranged between a first extraction deflector and a second extraction deflector. The defocusing quadrupole magnet is arranged between deflection magnets among the plurality of deflection magnets, a focusing quadrupole magnet is arranged on the side of an inlet of the first extraction deflector, and a focusing quadrupole magnet is arranged on the side of an outlet of the second extraction deflector.
摘要翻译：本文公开了适用于使用这种布置来缩小同步加速器，同步加速器的装置的装置以及使用同步加速器的颗粒治疗系统。在同步加速器中，多个偏转磁体和单个散焦四极磁体布置在第一提取偏转器和第二提取偏转器之间。散焦四极磁体设置在多个偏转磁体中的偏转磁体之间，聚焦四极磁体布置在第一提取偏转器的入口侧，并且聚焦四极磁体布置在第二抽出偏转磁体的出口侧提取偏转器。

23. 发明授权

US08084965B2 All-Ion accelerator and control method of the same 有权
标题翻译：全离子加速器和控制方法相同
公开(公告)号：US08084965B2
公开(公告)日：2011-12-27
申请号：US11912986
申请日：2006-04-18
申请人： Ken Takayama , Yoshito Shimosaki , Kota Torikai , Yoshio Arakida
发明人： Ken Takayama , Yoshito Shimosaki , Kota Torikai , Yoshio Arakida
IPC分类号： H05H13/04
CPC分类号： H05H13/04 , H05H15/00
摘要： An accelerator that can accelerate by itself all ions up to any energy level allowed by the magnetic fields for beam guiding, and provides an all-ion accelerator in which with trigger timing and a charging time of an induced voltage applied to an ion beam injected from a preinjector by induction cells for confinement and acceleration used in an induction synchrotron, digital signal processors for confinement and acceleration and pattern generators for confinement and acceleration generate gate signal patterns for confinement and acceleration on the basis of a passage signal of the ion beam and an induced voltage signal for indicating the value of the induced voltage applied to the ion beam, and intelligent control devices for confinement and acceleration perform feedback control of on/off of the induction cells for confinement and acceleration.
摘要翻译：一种加速器，其本身可以加速所有离子直到由磁场允许的任何能级用于光束引导，并且提供全离子加速器，其中触发定时和施加到从...注入的离子束的感应电压的充电时间用于感应同步加速器中使用的用于限制和加速的感应电池的预注射器，用于限制和加速的数字信号处理器以及用于限制和加速的图案发生器，基于离子束的通过信号产生用于限制和加速的门信号图案，用于指示施加到离子束的感应电压的值的感应电压信号，用于限制和加速的智能控制装置执行用于限制和加速的感应电池的开/关的反馈控制。

24. 发明申请

US20110313232A1 Multi-Field Charged Particle Cancer Therapy Method and Apparatus 有权
标题翻译：多场带电粒子治疗方法与装置
公开(公告)号：US20110313232A1
公开(公告)日：2011-12-22
申请号：US13254431
申请日：2009-03-04
申请人： Vladimir Egorovich Balakin
发明人： Vladimir Egorovich Balakin
IPC分类号： A61N5/10 , H01J3/14 , H05H13/04 , G01N21/00
CPC分类号： H05H13/04 , A61N5/10 , A61N5/1064 , A61N5/1081 , A61N2005/0641 , A61N2005/1087 , G21K1/087 , G21K1/093 , G21K1/10 , H05H7/10
摘要： The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field charged particle cancer therapy method and apparatus coordinated with negative ion beam creation, ion beam focusing, charged particle acceleration, patient rotation, and/or patient respiration. Preferably, the charged particle therapy is performed on a patient in a partially immobilized and repositionable position. Proton delivery is preferably timed to patient respiration via control of charged particle beam injection, acceleration, and/or targeting methods and apparatus.
摘要翻译：本发明一般涉及固体癌的治疗。更具体地，本发明涉及与负离子束产生，离子束聚焦，带电粒子加速，患者旋转和/或患者呼吸协调的多场带电粒子癌治疗方法和装置。优选地，带电粒子治疗在部分固定和可重新定位的位置对患者进行。质子递送优选地通过控制带电粒子束注射，加速度和/或靶向方法和装置而定时到患者呼吸。

25. 发明申请

US20110284762A1 CHARGED PARTICLE EXTRACTION APPARATUS AND METHOD OF USE THEREOF 有权
标题翻译：充填颗粒萃取装置及其使用方法
公开(公告)号：US20110284762A1
公开(公告)日：2011-11-24
申请号：US13197480
申请日：2011-08-03
申请人： Vladimir Balakin
发明人： Vladimir Balakin
IPC分类号： G21K1/08 , H05H13/04
CPC分类号： A61N5/10 , A61N2005/1087 , H05H7/10 , H05H13/04
摘要： The invention comprises a charged particle beam extraction method and apparatus optionally used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil element of a set of foils. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream where thickness of a selected foil is a function of energy of circulating charged particles. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.
摘要翻译：本发明包括带电粒子束提取方法和装置，可选地与癌肿瘤的带电粒子束放射治疗一起使用。该系统使用射频（RF）空腔系统来诱导带电粒子流的振荡。带电粒子流的足够的幅度调制使得带电粒子流撞击一组材料，例如一组箔的箔元件。箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，从而允许将还原能带电粒子流与原始带电粒子流物理分离，其中所选择的箔片的厚度是循环带电粒子的能量的函数。然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

26. 发明授权

US07838855B2 Charged particle irradiation system 有权
标题翻译：带电粒子照射系统
公开(公告)号：US07838855B2
公开(公告)日：2010-11-23
申请号：US12141603
申请日：2008-06-18
申请人： Yusuke Fujii , Hisataka Fujimaki , Kazuo Hiramoto
发明人： Yusuke Fujii , Hisataka Fujimaki , Kazuo Hiramoto
IPC分类号： A61N5/00 , H05H13/04 , G21K5/10
CPC分类号： A61N5/1048 , A61N2005/1087 , G21K5/04
摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.
摘要翻译：将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置目标位置。控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

27. 发明申请

US20100219776A1 MULTI-ENERGY FREQUENCY-MULTIPLYING PARTICLE ACCELERATOR AND METHOD THEREOF 有权
标题翻译：多能量频率加速粒子加速器及其方法
公开(公告)号：US20100219776A1
公开(公告)日：2010-09-02
申请号：US12088275
申请日：2007-10-11
申请人： Yaohong Liu , Chuanxiang Tang , Haifeng Hu , Zhiqiang Chen , Yuanjing Li , Huaibi Chen , Huaping Tang , Jinsheng Liu , Jianjun Gao
发明人： Yaohong Liu , Chuanxiang Tang , Haifeng Hu , Zhiqiang Chen , Yuanjing Li , Huaibi Chen , Huaping Tang , Jinsheng Liu , Jianjun Gao
IPC分类号： H05H13/04
CPC分类号： H05H15/00
摘要： A multi-energy frequency-multiplying particle accelerator and a method thereof are disclosed in order to overcome the drawbacks of the existing accelerator, such as single energy level, beam current and operating frequency limited by a single power source. The accelerator comprises a pulse power generation unit for generating N pulse signals with different power levels, N is equal to or greater than 2; N microwave power generation units for, under the control of a control signal, generating N microwaves with different energy levels based on said N pulse signals, respectively; a power mixing unit having N entrances and one exit and for inputting a corresponding microwave among said N microwaves from each of said N entrances and outputting said N microwaves from said one exit; a particle beam generation unit for generating N particle beams in synchronization with said N is microwaves; and an accelerating unit for using said N microwaves to accelerate said N particle beams, respectively. Since the multi-energy frequency-multiplying particle accelerator of the present invention can output alternately particle beams of different energy levels and thus has improved operating frequency and multiplied power, it will find a wider application prospect in the field of radiograph imaging, radioactive medicine and radiation processing industry.
摘要翻译：公开了一种多能量倍频粒子加速器及其方法，以克服现有加速器的缺点，例如单个能级，射束电流和由单个电源限制的工作频率。加速器包括用于产生具有不同功率电平的N个脉冲信号的脉冲发电单元，N等于或大于2; N个微波发电单元，用于在控制信号的控制下，分别基于所述N个脉冲信号产生具有不同能级的N个微波; 功率混合单元，具有N个入口和一个出口，并用于从所述N个入口中的每一个在所述N个微波之间输入相应的微波，并从所述一个出口输出所述N个微波; 用于与所述N同步地产生N个粒子束的粒子束产生单元是微波; 以及加速单元，用于分别使用所述N个微波加速所述N个粒子束。由于本发明的多能量倍频粒子加速器能够交替输出不同能量级的粒子束，因此具有改善的工作频率和倍增功率，在放射成像，放射性药物和放射性药物领域中将具有更广泛的应用前景辐射加工业。

28. 发明申请

US20100155621A1 MULTI-AXIS / MULTI-FIELD CHARGED PARTICLE CANCER THERAPY METHOD AND APPARATUS 有权
标题翻译：多轴/多场充电颗粒癌治疗方法和装置
公开(公告)号：US20100155621A1
公开(公告)日：2010-06-24
申请号：US12714504
申请日：2010-02-28
申请人： Vladimir Balakin
发明人： Vladimir Balakin
IPC分类号： A61N5/00 , H05H13/04
CPC分类号： H05H7/10 , A61N5/10 , A61N2005/1087 , H05H13/04
摘要： The invention relates to method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.
摘要翻译：本发明涉及治疗实体癌的方法和装置。更具体地，本发明包括多轴和/或多场带电粒子癌症治疗系统。系统独立地控制患者平移位置，患者旋转位置，二维束轨迹，递送的束能，递送的束强度，带电粒子传递的时间和/或辐射进入健康组织的分布。该系统与负离子束源，同步加速器，患者定位，成像和/或靶向方法和装置一起操作，以在分布辐射进入健康组织的同时向肿瘤递送有效且均匀的辐射。

29. 发明授权

US06972552B2 Method for the precise measurement of dependency on amplitude and phase of a plurality of high frequency signals and a device for carrying out said method 有权
标题翻译：用于精确测量多个高频信号的幅度和相位的方法以及用于执行所述方法的装置的方法
公开(公告)号：US06972552B2
公开(公告)日：2005-12-06
申请号：US10839592
申请日：2004-05-05
申请人： Rok Ursic
发明人： Rok Ursic
IPC分类号： G01R1/20 , G01R13/28 , G01R19/00 , G01R19/25 , G01R25/00 , H05H13/04 , G01N27/00
CPC分类号： H05H13/04 , G01R19/0061 , G01R19/2509
摘要： A method and device for measurement of dependency on amplitude and phase of a plurality of high frequency signals used primarily with a synchrotron accelerator of elementary particles, includes alternately directing, with a radio frequency (RF) switch, each analogue input signal to each of a plurality of RF processing units; amplifying each analogue input signal in each RF processing unit in order to adjust signals to the measuring range of a plurality of analogue digital converters; directing each amplified analogue input signal to each of a plurality of analogue digital converters; converting the analogue signals to digital signals; directing the digital signals to a plurality of amplification correctors; correcting the digital signals by means of correcting signals from an amplification equalizer; collecting corrected digital signals in a digital switch and directing the ordered recombined number of digital signals to each of a plurality of digital receivers; and filtering the recombined number of digital signals in a plurality of low-pass filters.
摘要翻译：用于测量主要与基本粒子的同步加速器一起使用的多个高频信号的幅度和相位的依赖性的方法和装置包括以射频（RF）开关交替地将每个模拟输入信号指向多个RF处理单元; 放大每个RF处理单元中的每个模拟输入信号，以便将信号调整到多个模拟数字转换器的测量范围; 将每个放大的模拟输入信号引导到多个模拟数字转换器中的每一个; 将模拟信号转换为数字信号; 将数字信号引导到多个放大校正器; 通过校正来自放大均衡器的信号来校正数字信号; 在数字开关中收集校正的数字信号，并将有序重组数量的数字信号引导到多个数字接收机的每一个; 以及对多个低通滤波器中的数字信号的重组数进行滤波。

30. 发明申请

US20050205806A1 Particle therapy system 失效
标题翻译：粒子治疗系统
公开(公告)号：US20050205806A1
公开(公告)日：2005-09-22
申请号：US11128195
申请日：2005-05-13
申请人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
发明人： Masahiro Tadokoro , Shunji Kakiuchi , Hiroshi Akiyama , Mamoru Katane , Koji Matsuda
IPC分类号： G21K1/02 , A61N5/10 , G21K5/04 , H05H7/10 , H05H13/04 , G21K5/10 , A61N5/00 , H05H3/02
CPC分类号： A61N5/1048 , A61N5/1075 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , G21K5/04
摘要： A particle therapy system capable of measuring energy of a charged particle beam even during irradiation of the charged particle beam is provided. A beam delivery (irradiation) system comprises a block collimator constituted by a pair of collimator members, and an energy detector mounted to one of the collimator members to be disposed on the upstream side thereof. When the pair of collimator members are moved in directions away from each other, a beam passage is formed between them. The energy detector constitutes an energy measuring device together with a signal processing unit. A part of the ion beam having reached the interior of the irradiation nozzle is irradiated to a patient through the beam passage. When a part of the remaining ion beam enters the energy detector, electric charges generate in the energy detector. The signal processing unit determines energy of the ion beam based on a position within the energy detector at which electric charges have generated in maximum amount.
摘要翻译：提供了即使在带电粒子束的照射期间也能够测量带电粒子束的能量的粒子治疗系统。射束（照射）系统包括由一对准直器构件构成的块准直器，以及安装在准备器件中的一个待设置在其上游侧的能量检测器。当一对准直器构件沿彼此远离的方向移动时，在它们之间形成梁通道。能量检测器与信号处理单元一起构成能量测量装置。已经到达照射喷嘴内部的离子束的一部分通过束通道照射到患者身上。当剩余离子束的一部分进入能量检测器时，在能量检测器中产生电荷。信号处理单元基于能量检测器内以最大量产生电荷的位置来确定离子束的能量。

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