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31. 发明授权

US08361740B2 Peptide standards 有权
标题翻译：肽标准
公开(公告)号：US08361740B2
公开(公告)日：2013-01-29
申请号：US12597872
申请日：2008-05-02
申请人： Charles Turner , Raymond Neil Dalton
发明人： Charles Turner , Raymond Neil Dalton
IPC分类号： C12Q1/37 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： G01N33/6848 , C07B59/008 , C07K14/76
摘要： The invention relates to methods for making a peptide standard for mass spectrometry said method comprising (a) identifying endopeptidase cleavage sites in a parent polypeptide sequence of interest; (b) selecting peptide sequences from said parent polypeptide which are defined by endopeptidase cleavage sites of step (a); (c) adding a C-terminal extension to each selected sequence; wherein if the endopeptidase cleavage site is C-terminal to its recognition sequence then the C-terminal extension comprises 1 to 6 amino acids, wherein if the endopeptidase cleavage site is N-terminal to its recognition sequence then the C-terminal extension comprises said recognition sequence, wherein if the endopeptidase cleavage site is within its recognition sequence then the C-terminal extension comprises the remainder of said recognition sequence C-terminal to the cleavage site; and (d) synthesizing a peptide having the extended amino acid sequence of step (c). The invention also relates to peptide standards and methods of analysing samples.
摘要翻译：本发明涉及制备用于质谱的肽标准物的方法，所述方法包括（a）鉴定感兴趣的亲本多肽序列中的内肽酶切割位点; （b）选择由步骤（a）的内肽酶切割位点定义的所述亲本多肽的肽序列; （c）向每个选择的序列添加C-末端延伸; 其中如果内肽酶切割位点是其识别序列的C-末端，则C-末端延伸包含1-6个氨基酸，其中如果内肽酶切割位点是其识别序列的N末端，那么C-末端延伸包括所述识别序列，其中如果内肽酶切割位点在其识别序列内，那么C末端延伸包括切割位点C末端的所述识别序列的剩余部分; 和（d）合成具有步骤（c）的延伸氨基酸序列的肽。本发明还涉及分析样品的肽标准和方法。

32. 发明申请

US20120315653A1 SEPSIS TEST 有权
标题翻译： SEPSIS测试
公开(公告)号：US20120315653A1
公开(公告)日：2012-12-13
申请号：US13342669
申请日：2012-01-03
申请人： Kenneth Alun BROWN , Sion Marc LEWIS
发明人： Kenneth Alun BROWN , Sion Marc LEWIS
IPC分类号： G01N33/566 , G01N33/577
CPC分类号： G01N33/56911 , G01N2333/7055 , G01N2333/70553 , G01N2333/70596 , G01N2800/26
摘要： There is provided a method for determining whether a subject has a bacterial infection comprising: identifying an abnormal expression of one or more of CD49e, CD 14, CD11c, CD49f, and CD29 on leucocytes in a sample obtained from the subject; wherein an abnormal expression of CD49e, CD 14, CD11c, CD49f or CD29 is indicative of the subject having a bacterial infection.
摘要翻译：提供了一种用于确定受试者是否具有细菌感染的方法，其包括：从获自受试者的样品中鉴定白细胞上的CD49e，CD14，CD11c，CD49f和CD29中的一种或多种的异常表达; 其中CD49e，CD14，CD11c，CD49f或CD29的异常表达指示受试者具有细菌感染。

33. 发明申请

US20120157422A1 MARKER 审中-公开
标题翻译：标记
公开(公告)号：US20120157422A1
公开(公告)日：2012-06-21
申请号：US13263159
申请日：2010-04-06
申请人： Lucilla Poston , Paul Seed , Gillian Lachelin
发明人： Lucilla Poston , Paul Seed , Gillian Lachelin
IPC分类号： A61K31/57 , G01N33/74
CPC分类号： G01N33/689 , G01N33/743 , G01N2800/368
摘要： The invention provides a method for identifying whether a pregnant subject has an increased risk of preterm labour comprising measuring the progesterone concentration in a sample obtained from the subject, wherein a reduced progesterone concentration is indicative of an increased risk of preterm labour and delivery.
摘要翻译：本发明提供了一种用于鉴定怀孕受试者是否具有增加的早产风险的方法，包括测量从受试者获得的样品中的孕酮浓度，其中降低的孕酮浓度表示早产和分娩的风险增加。

34. 发明申请

US20120149737A1 Therapeutic Aryl-Amido-Aryl Compounds and Their Use 审中-公开
标题翻译：治疗性芳酰胺基芳基化合物及其用途
公开(公告)号：US20120149737A1
公开(公告)日：2012-06-14
申请号：US13391207
申请日：2010-09-01
申请人： Jonathan Patrick Thomas Corcoran , Sarkis Barret Kalindjian , Alan David Borthwick , David Reginald Adams , Jane Theresa Brown , David Michel Adrien Taddei , Jason John Shiers
发明人： Jonathan Patrick Thomas Corcoran , Sarkis Barret Kalindjian , Alan David Borthwick , David Reginald Adams , Jane Theresa Brown , David Michel Adrien Taddei , Jason John Shiers
IPC分类号： A61K31/4409 , C07D213/56 , A61P25/28 , A61K31/192 , A61K31/235 , A61K31/167 , C07C235/84 , C07C235/56
CPC分类号： C07C235/84 , C07C233/75 , C07C235/56 , C07C237/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/30 , C07D213/80 , C07D213/81 , C07D237/24
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, are (selective) retinoic acid receptor α (RARα) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARα, and in the treatment of diseases and conditions that are mediated by RARα, that are ameliorated by the activation of RARα, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimer's disease, early stage Alzheimer's disease, intermediate stage Alzheimer's disease, late stage Alzheimer's disease, cognitive impairment, and mild cognitive impairment.
摘要翻译：本发明一般涉及治疗化合物的领域，更具体地涉及以下式的某些芳基 - 酰氨基 - 芳基化合物（为了方便起见，统称为“AAA化合物”），其特别是（选择性的）视黄酸受体α（RARα）激动剂。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途（选择性地）激活RARα，以及在治疗由RARα介导的疾病和病症中的应用，通过RARα等的激活改善，包括认知障碍，记忆障碍，记忆缺陷，老年痴呆，阿尔茨海默病，早期阿尔茨海默氏病，中期阿尔茨海默病，晚期阿尔茨海默氏病，认知障碍和轻度认知障碍。

35. 发明申请

US20120071337A1 METHODS 审中-公开
标题翻译：方法
公开(公告)号：US20120071337A1
公开(公告)日：2012-03-22
申请号：US13146121
申请日：2010-01-26
申请人： Simon Harold Lovestone , Andreas Christian Güntert , James Campbell , Helen Louise Byers , Darragh P.W. O'Brien
发明人： Simon Harold Lovestone , Andreas Christian Güntert , James Campbell , Helen Louise Byers , Darragh P.W. O'Brien
IPC分类号： C40B30/04 , C07K7/06 , G01N27/00 , C40B40/10 , G01N33/566 , C12Q1/37
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient. Other markers are C1 protease inhibitor and ceruloplasmin. Both blood samples and tissue samples have been investigated.
摘要翻译：本发明提供了一种帮助受试者中阿尔茨海默病的诊断或预后监测的方法，所述方法包括：提供从所述患者获得的血液样品; 测定所述样品中存在的凝溶胶蛋白的量; 将所述样品中存在的凝溶胶蛋白的量与来自健康受试者的样品中存在的参考量的凝溶胶蛋白进行比较，其中来自所述患者的样品中凝血酶蛋白水平的检测低于参考样品中的凝溶胶蛋白水平，表明增加患有阿尔茨海默病的可能性。其他标记物是C1蛋白酶抑制剂和血浆铜蓝蛋白。血液样本和组织样本均已被调查。

36. 发明申请

US20110210728A1 ENHANCING SIGNALS 有权
标题翻译：增强信号
公开(公告)号：US20110210728A1
公开(公告)日：2011-09-01
申请号：US12935202
申请日：2009-03-27
申请人： Samuel Somasundaram , Andreas Jakobsson , Michael Rowe , John Smith , Naveed Razzaq Butt , Erik Gudmundson , Kaspar Althoefer
发明人： Samuel Somasundaram , Andreas Jakobsson , Michael Rowe , John Smith , Naveed Razzaq Butt , Erik Gudmundson , Kaspar Althoefer
IPC分类号： G01R33/12
CPC分类号： G01R33/441 , G01N24/08 , G01N24/10 , G01R33/4616 , G01R33/4625 , G01R33/5608
摘要： A method of testing a sample comprising the steps of: applying an excitation to the sample; detecting a response signal from the sample; processing a first part and a second part of the response signal; and determining from the second part of the response signal information with which to enhance the first part of the response signal.
摘要翻译：一种测试样品的方法，包括以下步骤：向样品施加激发; 检测来自样品的响应信号; 处理响应信号的第一部分和第二部分; 并从响应信号的第二部分确定用于增强响应信号的第一部分的信息。

37. 发明申请

US20110019608A1 METHOD AND SYSTEM FOR FREQUENCY RELAYING 有权
标题翻译：频率继电方法与系统
公开(公告)号：US20110019608A1
公开(公告)日：2011-01-27
申请号：US12844099
申请日：2010-07-27
申请人： Mischa Dohler , Abdol Hamid Aghvami , Fatin Said , Seyed Ali Ghorashi
发明人： Mischa Dohler , Abdol Hamid Aghvami , Fatin Said , Seyed Ali Ghorashi
IPC分类号： H04B7/14 , H04B7/216 , H04B7/212
CPC分类号： H04W52/46 , H04B7/2606 , H04L5/0007 , H04L5/0032 , H04L5/0037 , H04L5/0048 , H04L27/2655 , H04L41/0893 , H04W84/22
摘要： A method of transmitting data across an electronic data communication system comprising a plurality of terminals that can send and receive data in the form of electromagnetic waves to and from at least one of the terminals, which method comprises the steps of: (a) identifying at least one control terminal, at least one target terminal and at least two relaying terminals from the plurality of terminals; and (b) using the control terminal to instruct the at least two relaying terminals to receive and relay data intended for the at least one target terminal, so that the at least one target terminal can receive data directly from at least one terminal and from the at least two relaying terminals, thereby increasing capacity of the system.
摘要翻译：一种通过电子数据通信系统发送数据的方法，该电子数据通信系统包括可以以至少一个终端的电磁波的形式发送和接收数据的多个终端，所述方法包括以下步骤：（a）至少一个控制终端，至少一个目标终端和来自所述多个终端的至少两个中继终端; 以及（b）使用所述控制终端指示所述至少两个中继终端接收和中继预定用于所述至少一个目标终端的数据，使得所述至少一个目标终端可以直接从至少一个终端接收数据，并且从至少两个中继终端，从而增加系统的容量。

38. 发明申请

US20100297011A1 ISOLATED PEPTIDES AND USES THEREOF 有权
标题翻译：分离的肽及其用途
公开(公告)号：US20100297011A1
公开(公告)日：2010-11-25
申请号：US12666416
申请日：2008-06-27
申请人： Mark Peakman , Ruben Varela Calvino
发明人： Mark Peakman , Ruben Varela Calvino
IPC分类号： A61K49/00 , C07K14/00 , C07K16/00 , C07H21/00 , C12N15/63 , C12N1/21 , C07K16/18 , C07K14/725 , A61K38/28 , A61K31/7088 , A61K39/395 , A61K38/17 , G01N33/50 , G01N33/53 , A61P3/10
CPC分类号： C07K14/62 , A61K38/00 , C07K7/06 , G01N33/505 , G01N33/6893 , G01N2800/042
摘要： The present invention provides isolated preproinsulin-derived peptides of 8 or 9 amino acids, comprising the amino acid sequence WGPDPAA (SEQ ID NO: 1), isolated Class I peptide-HLA complexes presenting said peptides and isolated molecules having binding affinity for said peptides and/or said peptide-HLA complexes. Such compositions are useful in the treatment of Type 1 diabetes mellitus (T1DM).
摘要翻译：本发明提供了8或9个氨基酸的分离的前胰岛素原衍生肽，其包含氨基酸序列WGPDPAA（SEQ ID NO：1），呈现所述肽的分离的I型肽-HLA复合体和对所述肽具有结合亲和力的分离的分子， /或所述肽-HAA复合物。这样的组合物可用于治疗1型糖尿病（T1DM）。

39. 发明申请

US20100047779A1 BIOMARKERS 失效
标题翻译：生物标志
公开(公告)号：US20100047779A1
公开(公告)日：2010-02-25
申请号：US12195979
申请日：2008-08-21
申请人： Asif Naeem Butt , Ramasamyiyer Swaminathan
发明人： Asif Naeem Butt , Ramasamyiyer Swaminathan
IPC分类号： C12Q1/68 , C12Q1/34 , C12Q1/32
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The present invention provides circulating biomarkers for conditions associated with metabolic syndrome, including diabetes mellitus, hypertension and congestive heart failure. The biomarkers include plasma DNA, neuron-specific enolase, 11β-hydroxysteroid dehydrogenase, rhodopsin, retinoschisin, RPE65 and cardiac troponin T. Methods and kits for detecting these biomarkers in the prediction, monitoring and diagnosing of disease are provided, particularly for determining mRNA levels thereof in a subject's blood.
摘要翻译：本发明提供了与代谢综合征相关的病症的循环生物标志物，包括糖尿病，高血压和充血性心力衰竭。生物标志物包括血浆DNA，神经元特异性烯醇化酶，11α-羟基类固醇脱氢酶，视紫红质，视网膜素样蛋白，RPE65和心肌肌钙蛋白T.提供了用于在预测，监测和诊断疾病中检测这些生物标志物的方法和试剂盒，特别是用于确定mRNA 受试者血液中的水平。

40. 发明申请

US20090317457A1 ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN B-4 审中-公开
标题翻译：淋巴细胞蛋白B-4的抗炎和治疗效果
公开(公告)号：US20090317457A1
公开(公告)日：2009-12-24
申请号：US12471334
申请日：2009-05-22
申请人： Michael Girardi , Robert E. Tigelaar , Michael A. Sherling , John Shires , Adrian C. Hayday , Efstathios Theodoridis
发明人： Michael Girardi , Robert E. Tigelaar , Michael A. Sherling , John Shires , Adrian C. Hayday , Efstathios Theodoridis
IPC分类号： A61K9/127 , A61K38/16 , A61K9/10 , A61K31/7088
CPC分类号： C07K14/57581 , A61K38/00
摘要： The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant. The invention also provides a method of promoting wound healing in a subject comprising administering to the subject a composition comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant. The invention also relates to methods of treating the above mentioned conditions in a subject comprising administering to the subject a nucleic acid encoding a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant. The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-β4 polypeptide or a functional lymphoid thymosin-β4 polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种治疗受试者的炎性病症的方法，包括对受试者施用包含淋巴样胸腺素-β4多肽或功能性淋巴样胸腺素-β4多肽变体的组合物。本发明还提供了一种促进受试者中伤口愈合的方法，包括向受试者施用包含淋巴样胸腺素-β4多肽或功能性淋巴样胸腺素-β4多肽变体的组合物。本发明还涉及治疗受试者中的上述病症的方法，其包括向受试者施用编码淋巴样胸腺素-β4多肽或功能性淋巴样胸腺素-β4多肽变体的核酸。本发明还涉及包含淋巴样胸腺素-β4多肽或功能性淋巴样胸腺素-β4多肽变体或其盐和药学上可接受的载体的药物组合物。

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