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31. 发明授权

US07600511B2 Apparatus and methods for delivery of medicament to a respiratory system 有权
标题翻译：用于将药物递送到呼吸系统的装置和方法
公开(公告)号：US07600511B2
公开(公告)日：2009-10-13
申请号：US10284068
申请日：2002-10-30
申请人： John Power , Desmond Regan , Declan Moran
发明人： John Power , Desmond Regan , Declan Moran
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M16/08 , A61M15/0085 , A61M16/04 , A61M16/049 , A61M16/06 , A61M2205/8206 , A61M2205/8262 , A61M2209/082
摘要： Apparatus and methods are provided for delivery of a medicament to a respiratory system. A reservoir is provided for a liquid medicament with the reservoir having a liquid medicament inlet port and a medicament outlet. An aerosol generator is provided at the medicament outlet of the reservoir for aerosolizing the liquid medicament. A connector entrains the aerosolized medicament from the aerosol generator with a gas.
摘要翻译：提供了用于将药物递送到呼吸系统的装置和方法。为液体药物提供储存器，储存器具有液体药物入口和药物出口。气雾发生器设置在储存器的药物出口处，用于使液体药物雾化。连接器用气体夹带来自气溶胶发生器的雾化药剂。

32. 发明申请

US20080274131A1 Molecular antigen arrary 审中-公开
标题翻译：分子抗原可以是arrary
公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

33. 发明公开

US20230338587A1 METHOD OF TREATING PSMA-EXPRESSING CANCERS 审中-公开
公开(公告)号：US20230338587A1
公开(公告)日：2023-10-26
申请号：US18023217
申请日：2021-08-30
申请人： ADVANCED ACCELERATOR APPLICATIONS INTERNATIONAL SA , Advanced Accelerator Applications USA, Inc. , Novartis Pharma AG
发明人： Germo GERICKE , Jose-Maria GIMENEZ ANARU , Darshan DALAL
IPC分类号： A61K51/04 , A61K45/06
CPC分类号： A61K51/0497 , A61K51/0402 , A61K45/06
摘要： The present invention relates to combinations for use and methods of treating cancers that express prostate specific membrane antigen (PSMA). In particular, the invention provides novel therapies based on the combination of a PSMA therapeutic agent, such as radiolabeled Compound I, and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR agonists, TGF-β inhibitors, IL15/IL-15RA, PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors.

34. 发明公开

US20230321285A1 METHOD OF TREATING PSMA-EXPRESSING CANCERS 审中-公开
公开(公告)号：US20230321285A1
公开(公告)日：2023-10-12
申请号：US18023212
申请日：2021-08-30
申请人： ADVANCED ACCELERATOR APPLICATIONS INTERNATIONAL SA , Advanced Accelerator Applications USA, Inc. , Novartis Pharma AG
发明人： Germo GERICKE , Jose-Maria GIMENEZ ANARU , Darshan DALAL
IPC分类号： A61K51/04 , A61K39/395 , A61K38/17 , A61K38/20
CPC分类号： A61K51/0497 , A61K39/3955 , A61K38/1793 , A61K38/2086 , A61K38/1774
摘要： The present invention relates to combinations for use and methods of treating cancers that express prostate specific membrane antigen (PSMA). In particular, the invention provides novel therapies based on the combination of a PSMA therapeutic agent, such as radiolabeled Compound of the Formula I, and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR agonists, TGF-β inhibitors, IL15/IL-15RA complex, PD-1 inhibitors, PD-L1 inhibitors, and CTLA-4 inhibitors.

35. 发明授权

US10762980B2 Computer-implemented methods of determining protein viscosity 有权
公开(公告)号：US10762980B2
公开(公告)日：2020-09-01
申请号：US14891906
申请日：2014-05-16
申请人： Massachusetts Institute of Technology , Novartis Pharma AG
发明人： Bernhardt Levy Trout , Bernhard Helk , Neeraj Jagdish Agrawal
IPC分类号： G16B15/00 , G01N33/68 , G01N11/00
摘要： Provided herein are high-throughput methods for identifying a candidate antibody based on viscosity of the candiate antibody.

36. 发明授权

US09358229B2 JAK PI3K/mTOR combination therapy 有权
标题翻译： JAK PI3K / mTOR联合治疗
公开(公告)号：US09358229B2
公开(公告)日：2016-06-07
申请号：US13571525
申请日：2012-08-10
申请人： Alessandro M. Vannucchi , Costanza Bogani , Niccolo Bartalucci
发明人： Alessandro M. Vannucchi , Costanza Bogani , Niccolo Bartalucci
IPC分类号： A61K31/519 , A61K31/4745
CPC分类号： A61K31/4745 , A61K31/519 , A61K2300/00
摘要： Provided herein is a combination therapy comprising a JAK kinase inhibitor and a dual PI3K/mTOR inhibitor, as well as methods of treating various cancers through the use of such a combination therapy.
摘要翻译：本文提供了包含JAK激酶抑制剂和双重PI3K / mTOR抑制剂的组合疗法，以及通过使用这种组合疗法治疗各种癌症的方法。

37. 发明申请

US20150202281A1 Molecular Antigen Array 审中-公开
标题翻译：分子抗原阵列
公开(公告)号：US20150202281A1
公开(公告)日：2015-07-23
申请号：US13906139
申请日：2013-05-30
申请人： CYTOS BIOTECHNOLOGY AG , NOVARTIS PHARMA AG
发明人： Wolfgang A. RENNER , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

38. 发明授权

US08869794B1 Aerosolization apparatus with capsule puncturing member 有权
标题翻译：具有胶囊穿刺构件的气溶胶装置
公开(公告)号：US08869794B1
公开(公告)日：2014-10-28
申请号：US10821652
申请日：2004-04-09
申请人： Jon David Tuckwell , Thomas Christopher St. Quintin
发明人： Jon David Tuckwell , Thomas Christopher St. Quintin
IPC分类号： A61M15/00 , B65D83/04 , G07F11/66
CPC分类号： A61M15/0041 , A61M11/003 , A61M15/003 , A61M15/0035 , A61M2202/064 , A61M2205/195 , A61M2206/16
摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. A puncturing mechanism is provided within the housing and comprising a puncture member. The puncture member comprises a forward end shaped to form a cutting edge that is effective in cutting the wall of the capsule to create an opening into the capsule. The puncture member also comprises a trailing end shaped so that it has a non-cutting surface that does not cut the wall of the capsule when the trailing end is inserted into the opening created by the forward end. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule.
摘要翻译：雾化装置包括限定具有一个或多个空气入口的室的壳体。该腔室的大小适于接收含有可雾化药物制剂的胶囊。穿刺机构设置在壳体内并且包括穿刺构件。穿刺构件包括成形为形成切割边缘的前端，切割边缘有效地切割胶囊的壁以形成到胶囊中的开口。穿刺构件还包括后端成形，使得其具有当后端插入由前端形成的开口中时不切割胶囊的壁的非切割表面。端部与壳体相关联。端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。

39. 发明授权

US08168223B1 Engineered particles and methods of use 有权
标题翻译：工程粒子和使用方法
公开(公告)号：US08168223B1
公开(公告)日：2012-05-01
申请号：US09886296
申请日：2001-06-21
申请人： Thomas E. Tarara , Jeffry G. Weers , Alexey Kabalnov , Ernest G. Schutt , Luis A. Dellamary
发明人： Thomas E. Tarara , Jeffry G. Weers , Alexey Kabalnov , Ernest G. Schutt , Luis A. Dellamary
IPC分类号： A61K9/14 , A61K9/127
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y02A50/472 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
摘要翻译：提供的工程颗粒可用于将生物活性剂递送到患者的呼吸道。颗粒可以以干粉形式或以包含非水连续相的稳定分散体的形式使用。在特别优选的实施方案中，颗粒可以与吸入装置如干粉吸入器，计量剂量吸入器或喷雾器结合使用。

40. 发明申请

US20100163021A1 SYSTEM FOR DELIVERING NEBULIZED CYCLOSPORINE AND METHODS OF TREATMENT 审中-公开
标题翻译：递送环磷酰胺系统和治疗方法
公开(公告)号：US20100163021A1
公开(公告)日：2010-07-01
申请号：US12280120
申请日：2007-02-22
申请人： Johnny Lai
发明人： Johnny Lai
IPC分类号： A61M11/00
CPC分类号： A61M16/105 , A61M16/0093 , A61M16/1065
摘要： Systems comprising a pressurized delivery device and a formulation of cyclosporine coupled to an exhalation filter or trap that is capable of preventing cyclosporine from escaping into the local environment are provided. An apparatus for use in the system comprises either an exhalation filter and a pressurized delivery device, wherein the exhalation filter is capable of providing high filter efficiency and maintaining low filter resistance after usage with the formulation, or a trap which provides a means for expired gas to be released into a solvent chamber containing a solvent with a high affinity for cyclosporine. These systems may be used to treat patients with pulmonary disorders, organ transplant patients such as lung transplant patients, and other immune-related disorders.
摘要翻译：提供了包括加压输送装置和联合到呼出过滤器或捕集器的环孢菌素制剂的系统，其能够防止环孢菌素逃逸到局部环境中。用于该系统的装置包括呼气过滤器和加压输送装置，其中呼气过滤器能够在配制剂使用后提供高过滤效率并保持较低的过滤阻力，或提供呼出气体的装置被释放到含有对环孢菌素具有高亲和力的溶剂的溶剂室中。这些系统可用于治疗肺部疾病患者，器官移植患者如肺移植患者和其他免疫相关疾病。

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