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    • 31. 发明授权
    • Process for unsaturated quaternary ammonium salt
    • 不饱和季铵盐的方法
    • US07973195B2
    • 2011-07-05
    • US12507122
    • 2009-07-22
    • Mohan NairC. Joseph Calbick
    • Mohan NairC. Joseph Calbick
    • C07C69/52
    • C07C213/08Y02P20/582C07C219/08
    • An unsaturated quaternary ammonium salt is produced by a process that includes reacting methyl chloride in a first vessel with a stoichiometric excess of an unsaturated tertiary amine in the presence of water to form a reaction mixture that includes the unsaturated quaternary ammonium salt and residual unsaturated tertiary amine. The reaction mixture is transferred to a second vessel and phase separated to yield a first fraction in which the unsaturated quaternary ammonium salt is concentrated, and a second fraction in which the residual unsaturated tertiary amine is concentrated. At least a portion of the second fraction is recycled from the second vessel to the first vessel for use in the reaction with methyl chloride. The process, which is preferably operated continuously, allows the use of reduced reaction pressures compared to processes utilizing a stoichiometric excess of methyl chloride, and it also reduces or eliminates the problems associated with recycling methyl chloride and removing methyl chloride from the unsaturated quaternary ammonium salt product.
    • 不饱和季铵盐通过包括在水存在下使第一容器中的甲基氯与化学计量过量的不饱和叔胺反应以形成包含不饱和季铵盐和残余不饱和叔胺的反应混合物的方法来生产 。 将反应混合物转移到第二容器中并进行相分离,得到其中不饱和季铵盐被浓缩的第一级分和残留的不饱和叔胺浓缩的第二级分。 第二级分的至少一部分从第二容器再循环到第一容器中以用于与甲基氯反应。 与使用化学计量过量的氯甲烷的方法相比,优选连续操作的方法允许使用降低的反应压力,并且还减少或消除与循环甲基氯并从不饱和季铵盐中除去甲基氯相关的问题 产品。
    • 37. 发明授权
    • Embolization using degradable crosslinked hydrogels
    • 栓塞使用可降解的交联水凝胶
    • US07838699B2
    • 2010-11-23
    • US10389708
    • 2003-03-14
    • Alexander SchwarzHongmin Zhang
    • Alexander SchwarzHongmin Zhang
    • C07C69/52C07C239/00C08F20/00A61F13/00
    • A61K9/0019A61K9/06A61K9/146A61K31/74A61K31/765A61K31/77A61K47/32A61K49/0002
    • One aspect of the present invention relates to a method of temporarily embolizing a blood vessel using a hydrolytically degradable crosslinked hydrogel as an embolus. In certain embodiments, the hydrolytically degradable crosslinked hydrogel substantially hydrolyzes only at about physiological pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel is stable at low pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound. It is to be understood that both the foregoing general description and the following detailed description are exemplary, and are intended to provide further explanation of the invention as claimed.
    • 本发明的一个方面涉及一种使用水解可降解交联水凝胶作为栓塞临时栓塞血管的方法。 在某些实施方案中,水解可降解的交联水凝胶仅在约生理pH下基本水解。 在该方法的某些实施方案中,水解可降解的交联水凝胶在低pH下是稳定的。 在该方法的某些实施方案中,水解可降解的交联水凝胶包含标记分子,例如染料,不透射线或MRI可见化合物。 应当理解,上述一般描述和以下详细描述都是示例性的,并且旨在提供对所要求保护的本发明的进一步说明。
    • 39. 发明授权
    • Polymer compound, negative resist composition, and method of forming resist pattern
    • 高分子化合物,负性抗蚀剂组合物和形成抗蚀剂图案的方法
    • US07820360B2
    • 2010-10-26
    • US12065990
    • 2006-08-17
    • Jun IwashitaAyako Kusaka
    • Jun IwashitaAyako Kusaka
    • G03F7/00G03F7/004C07C69/52
    • C08F220/28C08F220/26G03F7/0046G03F7/0382Y10S430/114Y10S430/115Y10S430/128Y10S430/146
    • There are provided a polymer compound which can form a resist pattern with excellent resolution, and a negative resist composition containing the polymer compound and a resist pattern-forming method thereof.The present invention is a polymer compound containing a structural unit (a0) represented by a general formula (a0-1) shown below. (wherein, R represents a hydrogen atom, a halogen atom, an alkyl group or a halogenated alkyl group; and R0 represents an alkyl group containing a hydroxyl group.) Also, the present invention is a negative resist composition, including: an alkali soluble resin component (A), an acid generator component (B) that generates acid upon exposure, and a cross-linking agent (C), wherein the alkali soluble resin component (A) contains a polymer compound (A1) having a structural unit (a0) represented by the general formula (a0-1) shown above.
    • 提供了可以形成具有优异分辨率的抗蚀剂图案的高分子化合物和含有该高分子化合物的抗蚀剂组合物及其抗蚀剂图案形成方法。 本发明是含有下述通式(a0-1)表示的结构单元(a0)的高分子化合物。 (其中,R表示氢原子,卤素原子,烷基或卤代烷基,R 0表示含有羟基的烷基)。另外,本发明是负极性抗蚀剂组合物,其包含:碱溶性 树脂组分(A),暴露时产生酸的酸产生剂组分(B)和交联剂(C),其中碱溶性树脂组分(A)含有具有结构单元的高分子化合物(A1) a0),由上述通式(a0-1)表示。