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31. 发明授权

US11236081B2 Crystalline salts of corydalmine 有权
公开(公告)号：US11236081B2
公开(公告)日：2022-02-01
申请号：US16612379
申请日：2018-11-29
申请人： Zheng Yang
发明人： Zheng Yang , Zheng Jane Li , Zhicong Shi
IPC分类号： C07D455/03
摘要： The present disclosure relates to crystalline salt forms of the following Compound (1), also known as l-corydalmine or l-CDL, and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in methods for the treatment of chronic pain, anxiety, insomnia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome, et al.

32. 发明授权

US10538547B2 Mangiferin-6-O-calcium salt and preparation process thereof 有权
公开(公告)号：US10538547B2
公开(公告)日：2020-01-21
申请号：US16231960
申请日：2018-12-25
申请人： CHANGZHOU DEZE MEDICAL SCIENCE CO., LTD
发明人： Houlei Teng , Wei Wu
IPC分类号： C07H1/00 , C07H1/06 , C07H7/04 , C07H7/06 , C07D455/03
摘要： The present invention provides a mangiferin-6-O-calcium salt and a preparation process thereof. In addition, use of the mangiferin-6-O-calcium salt as defined in claim 1 as an intermediate in the preparation of a mangiferin-6-O-berberine salt is also provided.

33. 发明授权

US10106540B2 HDAC6 inhibitors and their uses 有权
公开(公告)号：US10106540B2
公开(公告)日：2018-10-23
申请号：US15329175
申请日：2015-08-04
申请人： Universität Regensburg , Friedrich-Schiller-Universität Jena , Universitätsklinikum Jena
发明人： Siavosh Mahboobi , Andreas Sellmer , Herwig Pongratz , Michel Leonhardt , Oliver Krämer , Frank-Dietmar Böhmer , Gerhard Kelter
IPC分类号： C07D471/18 , A61K31/529 , C07D471/22 , C07D455/03 , C07C259/10 , C07C259/06 , C07D471/14
摘要： The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

34. 发明授权

US09856251B2 Substituted berbines and processes for their synthesis 有权
公开(公告)号：US09856251B2
公开(公告)日：2018-01-02
申请号：US15235312
申请日：2016-08-12
申请人： Mallinckrodt LLC
发明人： Peter X. Wang , Frank W. Moser , Gary L. Cantrell , Christopher W. Grote
IPC分类号： C07D455/03 , C07D217/20 , B01J31/22
CPC分类号： C07D455/03 , B01J31/2295 , B01J2231/643 , B01J2531/821 , C07D217/20
摘要： The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.

35. 发明授权

US09708310B2 Phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof, preparation method and use thereof 有权
公开(公告)号：US09708310B2
公开(公告)日：2017-07-18
申请号：US15015279
申请日：2016-02-04
申请人： Ta-Hsien Chuang , Chien-Fu Li , Chia-Chen Tsai , Chi-Fen Chang , Chieh-Yu Peng
发明人： Ta-Hsien Chuang , Chien-Fu Li , Chia-Chen Tsai , Chi-Fen Chang , Chieh-Yu Peng
IPC分类号： C07D455/03
CPC分类号： C07D455/03
摘要： A phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof was synthesized, which exhibits potent activity as an anticancer agent against, such as breast cancer, lung cancer, and prostate cancer.

36. 发明申请

US20160248019A1 Novel Compound, and Light-Emitting Element and Electronic Device Comprising Same 审中-公开
标题翻译：新型化合物，发光元件和包含其的电子器件
公开(公告)号：US20160248019A1
公开(公告)日：2016-08-25
申请号：US14647582
申请日：2013-11-28
申请人： LMS CO., LTD
发明人： Jeong Og CHOI , Joon Ho JUNG , Oh Kwan KWON
IPC分类号： H01L51/00 , C07D455/04 , C07D455/03
CPC分类号： H01L51/0061 , C07D455/03 , C07D455/04 , C07D471/06 , C07D487/14 , H01L51/0052 , H01L51/0059 , H01L51/006 , H01L51/0071 , H01L51/0072 , H01L51/0073 , H01L51/0074 , H01L51/0081 , H01L51/0085 , H01L51/0094 , H01L51/5016 , H01L51/5056 , H01L51/506 , H01L51/5064 , H01L51/5088 , H01L51/5096 , H01L2251/308 , H01L2251/5361
摘要： The present invention suggest a novel compound for improving the capability of injecting and/or transporting a hole in a light-emitting element, and a light-emitting element and an electronic device including the same, and may improve the light-emitting efficiency of the light-emitting element, and increase the lifespan thereof. In addition, the present invention may improve thermal stability (heat resistance) of the light-emitting element.
摘要翻译：本发明提出了一种用于提高发光元件中的孔的注入和/或传输能力的新型化合物，以及包含该发光元件的发光元件和电子器件，并且可以提高发光元件的发光效率发光元件，延长寿命。此外，本发明可以提高发光元件的热稳定性（耐热性）。

37. 发明授权

US09340543B2 Helquat derivatives, preparation thereof, and use thereof as medicaments 有权
标题翻译：葫芦巴衍生物，其制备及其用途作为药物
公开(公告)号：US09340543B2
公开(公告)日：2016-05-17
申请号：US14655999
申请日：2014-01-17
申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I.
发明人： Filip Teply , Miroslav Hajek
IPC分类号： C07D471/22 , C07D401/10 , C07D455/03 , A61K31/44 , A61P35/00
CPC分类号： C07D471/22 , C07D401/10 , C07D455/03
摘要： The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl; up to three of S1,2, S1′,2′, S3,4 and S3′, 4′ are present, each of S1,2, S1′,2′, S3,4 and S3′,4′ independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms; one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2′, and 4′ are substituted with a substituent R3 of general formula II or general formula III wherein R4 is substituted or unsubstituted aryl; T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms; and anions (X1)− and (X2)− independently represent anions of pharmaceutically acceptable salts.The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
摘要翻译：本发明提供通式I的helquat衍生物，其中取代基R 1和R 2独立地选自H和C 1至C 3烷基; 存在S1,2，S1'，2'，S3,4和S3'，4'中的三个，S1,2，S1'，2'，S3,4和S3'，4'各自独立地表示由具有3-6个碳原子的二价烃链组成的连接体; 一个或两个选自具有描述符2,4，2'和4'的碳原子的原子被通式II或通式III的取代基R3取代，其中R4是取代或未取代的芳基; T1和T2独立地表示具有2-5个碳原子的二价烃链; 而阴离子（X1） - 和（X2） - 独立地代表药学上可接受的盐的阴离子。螺旋衍生物可用作治疗与增加的细胞增殖相关的疾病如药物疾病的药物。

38. 发明申请

US20160126476A1 NOVEL COMPOUND, LIGHT EMITTING DEVICE COMPRISING SAME, AND ELECTRONIC DEVICE 审中-公开
标题翻译：新型化合物，包含其的发光装置和电子装置
公开(公告)号：US20160126476A1
公开(公告)日：2016-05-05
申请号：US14763836
申请日：2014-01-28
申请人： LMS CO., LTD
发明人： Jeong Og CHOI , Joon Ho JUNG , Oh Kwan KWON
IPC分类号： H01L51/00 , C07D455/03
CPC分类号： H01L51/0072 , C07D455/03 , C07D455/04 , C07D471/04 , C09K11/06 , H01L51/0052 , H01L51/0058 , H01L51/0059 , H01L51/0074 , H01L51/0085 , H01L51/5056 , H01L51/506 , H01L51/5064 , H01L51/5088 , H01L51/5096
摘要： A novel compound for improving the hole injection and transport properties in a light emitting device, a light emitting device including the compound, and an electronic device including a light emitting device are provided.
摘要翻译：提供一种用于改善发光器件中的空穴注入和传输特性的新型化合物，包括该化合物的发光器件和包括发光器件的电子器件。

39. 发明授权

US08101760B2 Glucocorticoid receptor modulator and methods of use 失效
标题翻译：糖皮质激素受体调节剂及其使用方法
公开(公告)号：US08101760B2
公开(公告)日：2012-01-24
申请号：US12305295
申请日：2007-07-12
申请人： Matthew William Carson , Michael Joseph Coghlan
发明人： Matthew William Carson , Michael Joseph Coghlan
IPC分类号： C07D455/03 , C07D313/10 , A61K31/4353
CPC分类号： C07D491/044
摘要： The present invention provides Compound (I): Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and methods for the treatment of inflammatory and immune disorders comprising administering to a patient in need thereof an effective amount of Compound (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供化合物（I）：化合物（I）或其药学上可接受的盐; 包含化合物（I）与一种或多种药学上可接受的载体，赋形剂或稀释剂组合的药物组合物; 以及用于治疗炎症和免疫疾病的方法，包括向有需要的患者施用有效量的化合物（I）或其药学上可接受的盐。

40. 发明授权

US5874427A Substituted heteroaromatic 5-HT.sub.1F agonists 失效
标题翻译：取代的杂芳族5-HT1F激动剂
公开(公告)号：US5874427A
公开(公告)日：1999-02-23
申请号：US59768
申请日：1998-04-14
申请人： Sandra A. Filla , Joseph H. Krushinski, Jr. , John Mehnert Schaus
发明人： Sandra A. Filla , Joseph H. Krushinski, Jr. , John Mehnert Schaus
IPC分类号： A61P25/04 , A61K31/437 , A61K31/4375 , A61K31/55 , A61P25/06 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： C07D455/00 , C07D471/04
摘要： This invention provides novel 5-HT.sub.1F agonists of the Formula ##STR1## in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
摘要翻译：本发明提供了本发明的新颖的5-HT1F激动剂，其中X，Y，E，R，A，B和n如说明书中所定义，其可用于治疗偏头痛及相关疾病。

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